ライフサイエンスコーパス: insulin gene

1 nscription factor whose activity induces the insulin gene.

2 omplexes that regulate the expression of the insulin gene.

3 e containing at least one copy of the native insulin gene.

4 3b1 activator, to the promoter region of the insulin gene.

5 is a site for PDX-1 activation in the human insulin gene.

6 c and glucose-regulated transcription of the insulin gene.

7 ing of an open, euchromatic structure of the insulin gene.

8 nsistent with their potential to express the insulin gene.

9 protein LMX1A activates transcription of the insulin gene.

10 c and glucose-regulated transcription of the insulin gene.

11 ion of the transcriptional expression of the insulin gene.

12 fic and glucose-responsive expression of the insulin gene.

13 nt and the transcriptional regulation of the insulin gene.

14 ation and regulation of transcription of the insulin gene.

15 sity of diabetes-associated mutations in the insulin gene.

16 omous program that temporarily shuts off the insulin gene.

17 e promoter regions of both the IGF-I and the insulin genes.

18 al. (2015) present evidence that deletion of Insulin genes alleviates ER stress and promotes mature b

19 , NES2Y, which lacks PDX-1 but expresses the insulin gene, allowed us to determine whether PDX-1 was

20 pression corrects the underexpression of the insulin gene and ameliorates glucose-stimulated insulin

21 In addition, MafA, a potent regulator of the Insulin gene and beta-cell function, was identified as a

22 eats (VNTR) is located upstream of the human insulin gene and correlates with the incidence of type 1

23 c and peripheral CD11c+ cells transcribe the insulin gene and display the proinsulin epitope; moreove

24 which encodes a transcription factor for the insulin gene and is important in beta-cell development,

25 in the promoter region upstream of the human insulin gene and is widely recognized as a locus of type

26 negative inhibition of transcription of the insulin gene and other beta cell-specific genes regulate

27 cription factors, regulate expression of the insulin gene and other genes critical for beta-cell func

28 d NGF stimulate the binding of ERK1/2 to the insulin gene and other promoters.

29 adiol (E2) treatment up-regulates pancreatic insulin gene and protein content in control ERalpha lox/

30 ERK1/2 are required for transcription of the insulin gene and several other genes in response to gluc

31 NOD mice with knockout of both native insulin genes and a mutated proinsulin transgene, alanin

32 sufficient to regulate the expression of the insulin genes and beta cell proliferation markers, where

33 roducts of the endocrine pancreas (Reg-1 and insulin genes) and the expression of the pancreatic tran

34 the strongest disease susceptibility is the insulin gene, and alleles yielding lower thymic insulin

35 luence transcriptional activity of the human insulin gene, and thus, may contribute to that portion o

36 The recruitment of Set9 to the insulin gene appears to be a consequence of its direct i

37 NA sequences that regulate expression of the insulin gene are located within a region spanning approx

38 ontrol sequences conserved between mammalian insulin genes are acted upon by transcription factors, l

39 In the fruit fly Drosophila, four insulin genes are coexpressed in small clusters of cells

40 Thus, insulin genes are expressed in rare cells of the thymic

41 uman insulin-like growth factor 2 (IGF2) and insulin genes are located within the same genomic region

42 ular mechanism of a clinical mutation in the insulin gene associated with diabetes mellitus.

43 m of transcriptional regulation of the human insulin gene by cyclic AMP response element modulator (C

44 e the mechanism underlying regulation of the insulin gene by Pdx-1, we performed a kinetic analysis o

45 Mutations in the insulin gene can impair proinsulin folding and cause dia

46 se observations indicate that loss of either insulin gene can influence progression to diabetes of NO

47 cs have identified dominant mutations in the insulin gene causing permanent neonatal-onset DM(2) (1-4

48 located in the promoter region of the human insulin gene, comprises a variable number of tandemly re

49 Insulin gene constructs containing three S14-based gluco

50 The authors' insulin gene constructs induced insulin expression in he

51 study, we used genomic approaches to detect insulin gene copy number variation in rodent species and

52 m by which a dominant mutation in a neuronal insulin gene, daf-28(sa191), causes constitutive entry i

53 Among the 38 C. elegans insulin genes, daf-28 is so far the only insulin mutant

54 hift assays demonstrated that the betaGK and insulin gene E-box elements formed the same cell-enriche

55 with lentivirus carrying an additional human insulin gene-enhanced secretion twofold.

56 lass 4, transcription factor 2 (Pou4f2), and insulin gene enhancer protein 1 (Isl1)--occupy key node

57 Selective activation of mammalian insulin gene enhancer-driven expression and ectopic neur

58 (-/-)), and the insulin 2 gene knockout (the insulin gene expressed in the NOD thymus).

59 Xenopus NeuroD1/BETA2 that are necessary for insulin gene expression and ectopic neurogenesis.

60 y uncovers a role of Glis3 for regulation of insulin gene expression and expands our understanding of

61 Moreover, adiponectin regulated insulin gene expression and glucose-stimulated insulin s

62 ion of cellular ultrastructure, by measuring insulin gene expression and insulin protein content, and

63 gic glucose concentrations causes defects in insulin gene expression and insulin secretion.

64 y, the Nkx2.2-repressor mice display reduced insulin gene expression and pancreatic insulin content a

65 hermore, it appears that ECs directly impact insulin gene expression and secretion and beta-cell surv

66 tein kinase C inhibitor GF109203X, protected insulin gene expression and secretion from oxidative str

67 tection against apoptosis and stimulation of insulin gene expression and secretion in pancreatic beta

68 wild type JNK overexpression suppressed both insulin gene expression and secretion.

69 nization, and 3) selective downregulation of insulin gene expression and the development of overt dia

70 ing to A elements are critical regulators of insulin gene expression and/or pancreatic development.

71 ibutes importantly to the loss of endogenous insulin gene expression as glucose toxicity develops.

72 hat high concentrations of glucose stimulate insulin gene expression by causing hyperacetylation of h

73 hat high concentrations of glucose stimulate insulin gene expression by causing hyperacetylation of h

74 Calcineurin controls insulin gene expression by ERK1/2-dependent and -indepen

75 ation of JNK is involved in the reduction of insulin gene expression by oxidative stress, and suppres

76 slets completely prevented the inhibition of insulin gene expression by palmitate.

77 ur findings show that feedback regulation of insulin gene expression coordinates DAF-16 activity amon

78 idemia, may be involved in the impairment of insulin gene expression during the manifestation of diab

79 localization to the nucleus and induction of insulin gene expression even on low glucose.

80 Alternatively, sustained basal hepatic insulin gene expression has been shown to result in fast

81 istic components underlying the differential insulin gene expression in human thymic epithelial cells

82 in coordinating and controlling the level of insulin gene expression in islet beta cells.

83 mice receiving DN-JNK overexpressing islets, insulin gene expression in islet grafts was preserved, a

84 bitory effects on both insulin secretion and insulin gene expression in pancreatic beta-cells, but by

85 A is a proto-oncoprotein and is critical for insulin gene expression in pancreatic beta-cells.

86 Induction of insulin gene expression in response to high blood glucos

87 ologic concentrations of palmitate decreases insulin gene expression in the presence of elevated gluc

88 IRE mutation could specifically affect human insulin gene expression in thymic epithelial cells throu

89 have been associated with the modulation of insulin gene expression in thymus, which is essential to

90 These data indicate that insulin gene expression is decreased on low levels of gl

91 Insulin gene expression is regulated by several islet-en

92 function, the autocrine effect of insulin on insulin gene expression is still controversial, and no c

93 abolites involved in palmitate inhibition of insulin gene expression is unknown.

94 the diabetic phenotype via a suppression of insulin gene expression mediated by the transcriptional

95 on, suggesting that fatty-acid inhibition of insulin gene expression requires activation of the ester

96 on, we provide evidence that Glis3 regulates insulin gene expression through two Glis-binding sites i

97 These results demonstrate that inhibition of insulin gene expression upon prolonged exposure of islet

98 vels of palmitate affects glucose-stimulated insulin gene expression via transcriptional mechanisms a

99 Chronically, insulin gene expression was increased after treatment wi

100 reported to mediate fatty acid inhibition of insulin gene expression, also inhibits insulin secretion

101 ermore, we show that fibroblasts, which lack insulin gene expression, also lack histone acetylation a

102 alterations in beta-cell morphology, reduced insulin gene expression, and enhanced glucose secretion

103 ivo and thereby play a role in modulation of insulin gene expression, and it provides a basis for des

104 as decrements in beta cell insulin content, insulin gene expression, and PDX-1 (STF-1) binding to th

105 nd cell viability, proliferation, apoptosis, insulin gene expression, and secretion were measured.

106 expression, modulation of self-tolerance by insulin gene expression, and strategies for the generati

107 n pancreatic islet beta cells causes loss of insulin gene expression, content, and secretion due to l

108 role of these factors in beta cell-specific insulin gene expression, IGRP gene transcription appears

109 the transcription factor PDX1, required for insulin gene expression, in embryonic pancreas organ cul

110 -1, which are involved in glucose-stimulated insulin gene expression, interact with the histone acety

111 beta-cells, as determined by FACS analysis, insulin gene expression, intracellular insulin content,

112 ions have implications for the regulation of insulin gene expression, modulation of self-tolerance by

113 e, which is readily oxidized, did not affect insulin gene expression, suggesting that fatty-acid inhi

114 ets completely suppressed glucose-stimulated insulin gene expression, suggesting that insulin regulat

115 knockdown of SRF leads to down-regulation of insulin gene expression, suggesting that SRF is required

116 own to play a role in glucose stimulation of insulin gene expression, the exact molecular mechanism(s

117 he roles of C1 and A2 elements in regulating insulin gene expression, we have systematically mutated

118 th these changes are profound alterations in insulin gene expression, which involve greatly diminishe

119 pancreatectomy that includes a reduction of insulin gene expression, which may further contribute to

120 t are required for beta cell development and insulin gene expression.

121 one acetylation in glucose regulation of the insulin gene expression.

122 hought to be islet progenitor cells, induces insulin gene expression.

123 reatic islets, which leads to stimulation of insulin gene expression.

124 thesis and secretion are caused by decreased insulin gene expression.

125 of the mechanism by which glucose stimulates insulin gene expression.

126 e synthesis prevents palmitate inhibition of insulin gene expression.

127 nsfection assays defined how Nkx2.2 affected insulin gene expression.

128 vation domain lacked the ability to activate insulin gene expression.

129 protein kinase C, preceding the decrease of insulin gene expression.

130 triacylglycerol (TAG) content and decreased insulin gene expression.

131 homeostasis via SERCA3 and (2) regulation of insulin gene expression.

132 ion may play an important role in regulating insulin gene expression.

133 ic binding activators cooperatively activate insulin gene expression.

134 ression, suggesting that SRF is required for insulin gene expression.

135 II diabetes and shown to positively regulate insulin gene expression.

136 glucose concentration-sensitive regulator of insulin gene expression.

137 ling occurs via feedback regulation of ins-7 insulin gene expression.

138 nhibition of CDK5 prevented this decrease of insulin gene expression.

139 (VEGF) is crucial for pancreas development, insulin gene expression/secretion, and (compensatory) be

140 insulin enhancer element RIPE3b and activate insulin-gene expression.

141 ke growth factor-2 (IGF2) is a member of the insulin gene family with known neurotrophic properties.

142 like growth factor 2 (Igf2), a member of the insulin gene family, is important for brain development

143 in the recruitment of pol II isoforms to the insulin gene, from an elongation isoform (Ser(P)-2) to a

144 eport 10 heterozygous mutations in the human insulin gene in 16 probands with neonatal diabetes.

145 ancer region (-340/-91 bp) of the endogenous insulin gene in beta TC-3 cells in the chromatin immunop

146 6, have been implicated in expression of the insulin gene in pancreatic beta cells.

147 It also regulates the expression of the insulin gene in response to changes in glucose and insul

148 at human Proins+ CD11c+ cells transcribe the insulin gene in thymus, spleen, and blood.

149 Insulin genes in mouse and rat compose a two-gene system

150 outhern analyses and confirmed by sequencing insulin genes in the rodent genomes.

151 th type 1 diabetes (T1D), PTPN22 1858C/T and insulin gene INS-23 A/T in progression to clinical T1D a

152 th the ubiquitous HLH protein E47, regulates insulin gene (INS) expression by binding to a critical E

153 y measuring changes in glucose-induced human insulin gene (INS) expression using a single islet in oc

154 tandem repeat (VNTR) minisatellite 5' of the insulin gene (INS) is associated with several phenotypes

155 Insulin gene (INS) mutations have recently been describe

156 Polymorphism of the insulin gene (INS) variable number of tandem repeats (VN

157 We have tested the insulin gene (INS) variable number of tandem repeats (VN

158 c analysis of HLA-DRB1, -DQA1, -DQB1 and the insulin gene (INS) was performed in the Genetics of Kidn

159 riable number tandem repeat (VNTR) 5' of the insulin gene (INS).

160 Variation at the insulin gene (INS-)VNTR (variable number of tandem repea

161 The activity of the insulin gene, Ins, in islet beta cells is thought to ari

162 zed the phylogenetic distribution of the new insulin gene (Ins1) by Southern analyses and confirmed b

163 diabetes caused by the Akita mutation in the insulin gene (Ins2(Akita)).

164 due in part to inadequate expression of the insulin gene (Ins2).

165 nced green fluorescent protein (EGFP) if the insulin gene is actively transcribed were transplanted i

166 The first Aplysia californica insulin gene is characterized and its proteolytic proces

167 The insulin gene is efficiently expressed only in pancreatic

168 c and glucose-inducible transcription of the insulin gene is mediated by the basic helix-loop-helix f

169 c islet beta cell-specific expression of the insulin gene is mediated in part by the C1 DNA-element b

170 Expression of the insulin gene is nearly exclusive to the beta cells of th

171 beta cell type-specific transcription of the insulin gene is regulated by a number of cis-acting elem

172 ibility that transcriptional activity of the insulin gene may in fact be influenced by the quaternary

173 Insulin gene mutation screening is recommended for all d

174 sequence (CATCTG) within the promoter of the insulin gene, no direct contacts are observed with the c

175 on is neither blocking the expression of the insulin genes nor the development of insulin-producing c

176 fic and glucose-responsive expression of the insulin gene, only the identity of the transcription fac

177 In man insulin gene polymorphisms are associated with disease r

178 We propose that long repeat insertion in the insulin gene promoter ('class III'), reported to result

179 oned, we examined its restorative effects on insulin gene promoter activity after reconstitution with

180 mol/l), induced a similar71-fold increase in insulin gene promoter activity in INS-1 pancreatic beta-

181 -T15 cells and primary rat islets, wild type insulin gene promoter activity was dramatically decrease

182 rtially prevented decreases in insulin mRNA, insulin gene promoter activity, DNA binding of two impor

183 By 48 h, glucose inhibits insulin gene promoter activity.

184 ombination of transcription factors with the insulin gene promoter and began to reduce transcription

185 F-beta signaling effector Smad3 occupies the insulin gene promoter and represses insulin gene transcr

186 iple protein kinases that associate with the insulin gene promoter and transiently increased insulin

187 effect of elevated glucose to stimulate the insulin gene promoter but also the chronic effect of ele

188 ic effect of elevated glucose to inhibit the insulin gene promoter depend on ERK1/2 mitogen-activated

189 anscription activators and repressors to the insulin gene promoter depends on ERK1/2 activity.

190 Earlier studies suggested that the insulin gene promoter is uniquely unmethylated in insuli

191 In NES2Y cells, glucose had no effect on the insulin gene promoter linked to a firefly luciferase rep

192 inked polymorphic region (ILPR) of the human insulin gene promoter region is reported.

193 shift assays c-Myc bound to the E-box in the insulin gene promoter region.

194 ancreatic duodenal homeobox-1 (PDX-1) to the insulin gene promoter to activate insulin gene transcrip

195 ct with each other and with sequences on the insulin gene promoter to build a transcriptional activat

196 f the glucose-sensitive RIPE3b region of the insulin gene promoter, is activated by MafA.

197 lts in hyperacetylation of histone H4 at the insulin gene promoter, which correlates with the increas

198 in loss of the glucose responsiveness of the insulin gene promoter.

199 o the glucose-responsive A2C1 element of the insulin gene promoter.

200 ption assessed with a reporter linked to the insulin gene promoter.

201 ausing hyperacetylation of histone H4 at the insulin gene promoter.

202 ausing hyperacetylation of histone H4 at the insulin gene promoter.

203 ession, also lack histone acetylation at the insulin gene promoter.

204 itutively active Akt1/PKB alpha linked to an Insulin gene promoter.

205 r CTLA-4Ig, under the control of the porcine insulin gene promoter.

206 , which binds to four sites within the human insulin gene promoter.

207 NA binding and cell-specific activity of the insulin gene promoter.

208 expression, and PDX-1 (STF-1) binding to the insulin gene promoter.

209 The review also reveals that of all the insulin gene promoters studied, the rodent insulin promo

210 study establishes that variation within the insulin gene region does influence susceptibility to LAD

211 nt with differential selection acting on the insulin gene region, most likely in the non-African ance

212 An illustration using data from the insulin-gene region in type 1 diabetes shows that the va

213 docrine development have been isolated using insulin gene regulation as a paradigm.

214 1 cells maintained normal glucose-responsive insulin gene regulation.

215 /-2609 specifically controlled by Nkx2.2, an insulin gene regulator that is required for terminal bet

216 e serotonergic genes but also to a conserved insulin gene regulatory element.

217 annels (KATP) and also carry a defect in the insulin gene-regulatory transcription factor PDX1.

218 ic beta-cell-type-specific expression of the insulin gene requires both ubiquitous and cell-enriched

219 The risk-associated insulin gene rs689 A/A genotypes were more frequent in c

220 A new member of the insulin gene superfamily (INSL5) was identified by searc

221 umber of tandem repeats at the 5' end of the insulin gene (susceptibility interval IDDM2) regulates i

222 that is reflected in their transcription of insulin genes that regulate exploration.

223 Analysis of in vivo functional efficacy of insulin gene therapy in streptozotocin-treated diabetic

224 pporting the feasibility of hepatocyte-based insulin gene-therapy for treatment of type 1 diabetes me

225 ct the acute transcriptional response of the insulin gene to glucose.

226 when extrapolating rodent-based data on the insulin gene to humans.

227 Smad3 signaling as an important regulator of insulin gene transcription and beta-cell function and su

228 ole of the TGF-beta pathway in regulation of insulin gene transcription and beta-cell function.

229 Furthermore, decreases in insulin gene transcription and binding activity of two e

230 data indicate that IR signaling can regulate insulin gene transcription and can modulate the steady-s

231 e a safe and valuable strategy for enhancing insulin gene transcription and for facilitating differen

232 ediated c-Myc overexpression suppressed both insulin gene transcription and glucose-stimulated insuli

233 hat the display of this epitope depends upon insulin gene transcription and is independent of Ag capt

234 e a critical role for the Z element in human insulin gene transcription and its regulation by glucose

235 beta-cells in the diabetic state, suppresses insulin gene transcription and secretion, but the signal

236 monstrate the central importance of BETA2 in insulin gene transcription and the importance of sequenc

237 urs results in an enhancement in the rate of insulin gene transcription assessed with a reporter link

238 of the rat insulin I promoter and activating insulin gene transcription by cooperating with the basic

239 e results suggest that the activation of the insulin gene transcription by CREM activator is mediated

240 icated in the pathological downregulation of insulin gene transcription by high glucose levels in pan

241 ged exposure of islets to palmitate inhibits insulin gene transcription by impairing nuclear localiza

242 ession of c-Myc in beta-cells suppresses the insulin gene transcription by inhibiting NeuroD-mediated

243 These results indicate that E1A inhibits insulin gene transcription by preventing communication b

244 Activation of insulin gene transcription by this member of the basic h

245 NFAT, which may either stimulate or repress insulin gene transcription during stimulatory and chroni

246 histone H4 acetylation cause stimulation of insulin gene transcription even in the absence of high c

247 y, we identified and cloned another critical insulin gene transcription factor MafA (RIPE3b1) and rep

248 Major insulin gene transcription factors, such as PDX-1 or Neu

249 ggest that at least some of the reduction of insulin gene transcription found in the diabetic state i

250 e role of glucose in the acute regulation of insulin gene transcription has remained unclear, primari

251 PDX-1 homeobox factor, which is required for insulin gene transcription in beta cells, interacted spe

252 ulin gene promoter and transiently increased insulin gene transcription in beta cells.

253 tivates the expression of ICER and represses insulin gene transcription in beta-cells.

254 investigate the nature of glucose-regulated insulin gene transcription in human islets, we first qua

255 protein beta (C/ EBPbeta) as an inhibitor of insulin gene transcription in pancreatic beta cells and

256 er PKC isoforms, leads to suppression of the insulin gene transcription in pancreatic islets.

257 Insulin gene transcription is limited to the beta cells

258 istic action of glucose and GLP-1 to promote insulin gene transcription is mediated through NFAT via

259 n (a known type 1 diabetes autoantigen), and insulin gene transcription levels in thymus inversely co

260 s, designated NESK beta-cells, have impaired insulin gene transcription responses to glucose.

261 Activation of insulin gene transcription specifically in the pancreati

262 ivation complex may be capable of activating insulin gene transcription through the E2A3/4 minienhanc

263 im domain-containing kinase (PASK) regulates insulin gene transcription via PDX-1.

264 Insulin gene transcription was decreased by blocking ace

265 Insulin gene transcription was stimulated by insulin rec

266 a-cells to elevated glucose leads to reduced insulin gene transcription, and this is associated with

267 itical regulator of pancreas development and insulin gene transcription, confer a strong predispositi

268 itic acid treatment inhibits glucose-induced insulin gene transcription, in part, by interfering with

269 pressed in the beta cells and is involved in insulin gene transcription, insulin secretion, and beta

270 more about the molecular events that reduce insulin gene transcription, we examined the effects of h

271 th beta cell-specific and glucose-responsive insulin gene transcription.

272 rhans to excessive fatty acid levels impairs insulin gene transcription.

273 iple points to transduce a glucose signal to insulin gene transcription.

274 ole in regulating pancreatic development and insulin gene transcription.

275 which correlates with the increased level of insulin gene transcription.

276 ll failure in type 2 diabetes by suppressing insulin gene transcription.

277 -1) to the insulin gene promoter to activate insulin gene transcription.

278 in regulating beta-cell function, including insulin gene transcription.

279 ynthesis and secretion through regulation of insulin gene transcription.

280 d is possibly involved in suppression of the insulin gene transcription.

281 c beta-cells in the long term by stimulating insulin gene transcription.

282 d mediates glucose-responsive stimulation of insulin gene transcription.

283 ta-cell differentiation and is essential for insulin gene transcription.

284 activator factors play an important role in insulin gene transcription.

285 lines, and it it has been shown to activate insulin gene transcription.

286 o mediates glucose-responsive stimulation of insulin gene transcription.

287 ther regulators of islet differentiation and insulin gene transcription.

288 pies the insulin gene promoter and represses insulin gene transcription.

289 s, specifically with regard to regulation of insulin gene transcription.

290 n signal transduction pathways that regulate insulin gene transcription.

291 in also results in the marked suppression of insulin gene transcription.

292 eliable reflection of acute changes to human insulin gene transcriptional rates and that glucose acut

293 Variation at the insulin gene variable number of tandem repeats (VNTR) mi

294 The insulin gene variable number tandem repeat (INS-VNTR) is

295 We examined the role of insulin gene variation (using flanking variants as surro

296 A human insulin gene was engineered to allow normal processing o

297 in the beta cell-specific expression of the insulin gene, we performed chromatin immunoprecipitation

298 atin structure and pol II recruitment at the insulin gene, we performed small interfering RNA-mediate

299 umor xenografts expressing the bioengineered insulin gene, we show that exposure to radio waves stimu

300 ntrast, the corresponding site in the rodent insulin gene, which only differs from the human at nucle