ライフサイエンスコーパス: insulin receptor substrate-2

1 g proteins, insulin receptor substrate 1 and insulin receptor substrate 2.

2 th Y497F were not capable of phosphorylating insulin receptor substrate 2.

3 binding to insulin receptor substrate-1 and insulin receptor substrate-2, activation of PI3K and pro

4 results in enhanced IR signaling through the insulin receptor substrate 2-AKT pathway in beta-cells a

5 Moreover, miR-33a and -b also target the insulin receptor substrate 2, an essential component of

6 Insulin-stimulated insulin receptor substrate 2 and Akt-2 phosphorylation w

7 Insulin signaling proteins, insulin receptor substrate 2 and phosphatidylinositol 3

8 , no significant tyrosine phosphorylation of insulin receptor substrate-2 and modulation of the immed

9 IL-10 increased tyrosyl phosphorylation of insulin receptor substrate-2 and stimulated the enzymati

10 ted tyrosine phosphorylation of JAK kinases, insulin receptor substrate-2, and signal transducer and

11 uced cell growth, activation of JAK kinases, insulin receptor substrate-2, and STAT3 and expression o

12 n key insulin-signaling molecules, including insulin receptor substrate-2, and substrate metabolism t

13 ximately 40% reduction in insulin-stimulated insulin receptor substrate-2-associated phosphatidylinos

14 ciated with defects in insulin activation of insulin receptor substrate-2-associated phosphatidylinos

15 cking either insulin receptors (betaIRKO) or insulin receptor substrate 2 (betaIRS2KO).

16 cy appeared necessary for phosphorylation of insulin receptor substrate-2 but not for IGFR1 activatio

17 e-inactive Fes blocks the IL-4 activation of insulin receptor substrate-2, but not STAT6.

18 Insulin receptor substrate-2-deficient (IRS2(-/-)) mice

19 kinase 1, insulin receptor substrate 1, and insulin receptor substrate 2, factors with molecular mas

20 observed at D13S285 (LOD = 1.86), where the insulin receptor substrate 2 gene resides.

21 es IGF-I-induced tyrosine phosphorylation of insulin receptor substrate 2 (IRS-2) and inhibits IRS-2-

22 Appropriate regulation of insulin receptor substrate 2 (IRS-2) expression in pancr

23 Insulin receptor substrate 2 (IRS-2) has recently been s

24 oved insulin-stimulated insulin receptor and insulin receptor substrate 2 (IRS-2) phosphorylation, IR

25 Insulin receptor substrate 2 (IRS-2) plays a critical ro

26 ubsequent 52% decrease in insulin-stimulated insulin receptor substrate 2 (IRS-2) tyrosine phosphoryl

27 The gene encoding insulin receptor substrate 2 (IRS-2), a mediator of insu

28 that promotes beta-cell growth and survival, insulin receptor substrate 2 (IRS-2), is a member of a f

29 insulin-induced tyrosine phosphorylation of insulin receptor substrate 2 (IRS-2), whereas it had min

30 Insulin receptor substrate-2 (IRS-2) belongs to the IRS

31 wild-type (WT) and mutant hIL-4Ralpha in 32D/insulin receptor substrate-2 (IRS-2) cells.

32 related with tyrosine phosphorylation of the insulin receptor substrate-2 (IRS-2) in macrophages.

33 Insulin receptor substrate-2 (IRS-2) is a multisite dock

34 Insulin receptor substrate-2 (IRS-2) is phosphorylated o

35 In this report, we demonstrate that insulin receptor substrate-2 (IRS-2) is tyrosyl-phosphor

36 We found that insulin receptor substrate-2 (IRS-2) levels were markedl

37 Insulin receptor substrate-2 (IRS-2) plays a critical ro

38 Insulin receptor substrate-2 (IRS-2) plays an essential

39 Here we show that deletion of insulin receptor substrate-2 (IRS-2), a component of the

40 to abused drugs decreases the expression of insulin receptor substrate-2 (IRS-2; a protein involved

41 GM-CSF) induced tyrosine phosphorylation of insulin-receptor substrate-2 (IRS-2) and its association

42 ptor (Igf1r(+/-)) are bred with mice lacking insulin receptor substrate 2 (Irs2(-/-)), the resulting

43 teins involved in insulin signaling, such as insulin receptor substrate 2 (IRS2) and glucose transpor

44 The recent identification of insulin receptor substrate 2 (IRS2) as a central player

45 3-CDK4 complex, which in turn phosphorylates insulin receptor substrate 2 (IRS2) at serine 388, there

46 component of all types of diabetes, and the insulin receptor substrate 2 (IRS2) branch of signaling

47 The insulin receptor substrate 2 (Irs2) branch of the insuli

48 a/cAMP mediates these actions by stimulating insulin receptor substrate 2 (IRS2) expression.

49 Here we show that a conditional knockout of insulin receptor substrate 2 (Irs2) in mouse pancreas be

50 s, proliferation, and survival by increasing insulin receptor substrate 2 (IRS2) levels and identify

51 Insulin receptor substrate 2 (IRS2) suppression induced

52 s is sufficient to enhance the expression of insulin receptor substrate 2 (IRS2) to levels observed i

53 2)-associated binding proteins 1-3 (GAB1-3), insulin receptor substrate 2 (IRS2), docking protein 1 (

54 mice lacking insulin signaling intermediate insulin receptor substrate 2 (IRS2), we confirmed that h

55 The study also provides strong evidence that insulin receptor substrate 2 (Irs2), which is known to h

56 ronic morphine-induced downregulation of the insulin receptor substrate 2 (IRS2)-thymoma viral proto-

57 of sarcomas and found a marked induction of insulin receptor substrate-2 (IRS2) and phosphorylated A

58 The insulin receptor substrate-2 (Irs2) branch of the insuli

59 Mice lacking insulin receptor substrate-2 (Irs2) develop beta cell fa

60 hat mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increa

61 3K signaling leads to feedback inhibition of insulin receptor substrate-2 (IRS2) expression, an upstr

62 Insulin receptor substrate-2 (Irs2) is a critical mediat

63 Here, we show that, in mice, less insulin receptor substrate-2 (Irs2) signaling throughout

64 We identify insulin receptor substrate-2 (Irs2), a known cAMP-respon

65 ing through direct and indirect induction of insulin receptor substrate-2 (Irs2), an essential insuli

66 ysis occurs normally in B cells deficient in insulin receptor substrate-2 or the p85alpha subunit of

67 d the downstream signaling pathway involving insulin receptor substrate 2, phosphatidylinositol 3'-ki

68 The insulin receptor substrate 2/phosphatidylinositol 3'-kin

69 s with inhibition of NF-kappaB showed normal insulin receptor substrate-2 phosphorylation and only a

70 reduction of p85 beta specifically increases insulin receptor substrate-2 phosphorylation.

71 vity is totally due to IL-10 stimulating the insulin receptor substrate-2/PI 3-kinase/Akt pathway, wh

72 In addition, an increase in insulin receptor substrate-2 protein and a differential

73 eas insulin receptor autophosphorylation and insulin receptor substrate 2 tyrosine phosphorylation we

74 pression of glucose transporters 1 and 4 and insulin receptor substrate 2 was increased and that of p

75 sducer and activator of transcription 6, and insulin receptor substrate 2 was strikingly but transien

76 ruitment of phosphatidylinositol 3-kinase to insulin receptor substrate-2 was also detected.

77 nsulin-dependent tyrosine phosphorylation of insulin receptor substrate-2 was enhanced in the p85beta

78 The hepatic mRNA level of the HIF-2 target insulin receptor substrate-2 was higher, whereas that of

79 ic screen of HD, we found that activation of insulin receptor substrate-2, which mediates the signali

80 lts in decreased tyrosine phosphorylation of insulin receptor substrate-2 with impeded insulin signal