ライフサイエンスコーパス: insulin-like growth factor 2

1 or necrosis factor alpha and lower levels of insulin-like growth factor 2.

2 he growth-promoting and mitogenic effects of insulin-like growth factor 2.

3 3 as a dominant driver oncogene at the IGF2 (insulin-like growth factor-2) 11p15.5 CRC amplicon, indu

4 Our results identify IGF-II (insulin-like growth factor 2), a critical regulator of s

5 Loss of SRSF3 increases expression of insulin-like growth factor 2 and the A-isoform of the in

6 he increased expression of transthyretin and insulin-like growth factor-2 and the increased phosphory

7 redictions for three case studies on leptin, insulin-like-growth-factor 2 and the inhibitor of NF-kap

8 rol region (ICR) of the genes Igf2 (encoding insulin-like growth factor 2) and H19 (fetal liver mRNA)

9 of the most studied imprinted genes encodes insulin-like growth factor 2, and aberrant imprinting an

10 iation [RalGDS/AF-6] domain family member 1, insulin-like growth factor 2, and adenomatous polyposis

11 telet-derived growth factor, angiopoietin 2, insulin-like growth factor 2, and IL-6.

12 ch as insulin, insulin-like growth factor 1, insulin-like growth factor 2, and phosphatidylcholine-sp

13 ent is found in the regulatory region of the insulin-like growth factor 2, angiotensin-converting enz

14 ontains the {tyrosine hydroxylase (TH)-(INS)-insulin-like growth factor 2 antisense (IGF2AS)-insulin-

15 endent kinase inhibitor protein 2) and Igf2 (insulin-like growth factor 2) are induced by inhibiting

16 r beta1, vascular endothelial growth factor, insulin-like growth factor 2) but not others (platelet-d

17 The imprinted regulation of H19 and Insulin-like growth factor 2 expression involves binding

18 Higher levels of apoptosis, reduced insulin-like growth factor-2 expression, and altered ant

19 t-of-origin-specific expression of the mouse insulin-like growth factor 2 gene (Igf2) and the closely

20 We further identified the insulin-like growth factor 2 gene (Igf2) as a novel IKK/

21 The insulin-like growth factor 2 gene (Igf2) is imprinted in

22 Here, we tested the hypothesis that the insulin-like growth factor 2 gene (Igf2) transcribed fro

23 Thus, the insulin-like growth factor 2/H19 enhancer is an active t

24 Here, we present an analysis of the insulin-like growth factor 2/H19 muscle enhancer.

25 roximately 10,000 human genes, we identified insulin-like growth factor 2 (IGF-2) as a potentially im

26 expression of both insulin and the adjacent insulin-like growth factor 2 (IGF-2) gene.

27 periments showed that, among other proteins, insulin-like growth factor 2 (IGF-2) is specifically exp

28 tem cell factor (SCF), thrombopoietin (TPO), insulin-like growth factor 2 (IGF-2), and fibroblast gro

29 Insulin-like growth factor-2 (IGF-2) is expressed in mos

30 The activity of the exogenous, full-length insulin-like growth factor-2 (IGF-2) P3 promoter is sign

31 The Insulin like growth factor 2 (IGF2) gene is expressed in

32 The Insulin-like growth factor 2 (Igf2) and H19 genes are im

33 The adjacent insulin-like growth factor 2 (IGF2) and H19 genes are im

34 The expression of the insulin-like growth factor 2 (Igf2) and H19 genes is imp

35 Imprinting of the mouse insulin-like growth factor 2 (Igf2) and H19 genes is reg

36 ntially methylated regions (DMRs) regulating Insulin-like Growth Factor 2 (IGF2) and H19, and how thi

37 The human insulin-like growth factor 2 (IGF2) and insulin genes ar

38 IGF2 and IGF2R code for the growth promoter insulin-like growth factor 2 (IGF2) and its inhibitor, m

39 ions in the transportation and regulation of insulin-like growth factor 2 (IGF2) and mannose 6-phosph

40 ing and in situ hybridization, we identified insulin-like growth factor 2 (IGF2) as a marker for a su

41 mitosis with un-repaired DNA through driving insulin-like growth factor 2 (IGF2) expression and Akt a

42 mouse hippocampus, induces the expression of insulin-like growth factor 2 (IGF2) for the stabilizatio

43 usly demonstrated an association between the insulin-like growth factor 2 (IGF2) gene 3'-untranslated

44 t-of-origin-specific expression of the mouse insulin-like growth factor 2 (Igf2) gene and the closely

45 The insulin-like growth factor 2 (Igf2) gene encodes a poten

46 The imprinted insulin-like growth factor 2 (IGF2) gene is expressed pr

47 the otherwise repressed maternal copy of the insulin-like growth factor 2 (IGF2) gene is expressed, l

48 The insulin-like growth factor 2 (IGF2) gene is normally imp

49 s Network detected the overexpression of the insulin-like growth factor 2 (IGF2) gene, encoding a lig

50 d Egr2-mediated activation of the endogenous insulin-like growth factor 2 (IGF2) gene.

51 Insulin-like growth factor 2 (IGF2) has previously been

52 The H19/insulin-like growth factor 2 (Igf2) ICR has a multifunct

53 We addressed this question at the H19/insulin-like growth factor 2 (Igf2) imprinted locus, the

54 Insulin-like growth factor 2 (IGF2) is an important feta

55 Insulin-like growth factor 2 (IGF2) is the major fetal g

56 The mouse insulin-like growth factor 2 (Igf2) locus is a complex g

57 IMPs, also known as insulin-like growth factor 2 (IGF2) messenger RNA (mRNA)

58 RNA-binding proteins of the IMP family (insulin-like growth factor 2 (IGF2) mRNA-binding protein

59 Dysregulation of the WNT and insulin-like growth factor 2 (IGF2) signaling pathways h

60 reviously shown that the loss of function of insulin-like growth factor 2 (igf2) suppresses MB format

61 t that Hh markedly induces the expression of insulin-like growth factor 2 (Igf2) that activates the m

62 Because insulin-like growth factor 2 (IGF2) was shown to enhance

63 oss of imprinting (LOI) in key genes such as insulin-like growth factor 2 (IGF2) which often results

64 Insulin-like growth factor 2 (IGF2), a developmentally r

65 Insulin-like growth factor 2 (Igf2), a member of the ins

66 suggest that glypican 3 forms a complex with insulin-like growth factor 2 (IGF2), and might thereby m

67 d genes: paternally expressed gene 3 (PEG3), insulin-like growth factor 2 (IGF2), and small nuclear r

68 activating enzyme, deiodinase-III (Dio3) and insulin-like growth factor 2 (Igf2), genes that are know

69 ma (HCC) biomarkers alpha-fetoprotein (Afp), insulin-like growth factor 2 (Igf2), H19, and glypican-3

70 Insulin-like growth factor 2 (IGF2), produced and secret

71 he expression of several myokines, including insulin-like growth factor 2 (IGF2), whereas RNAi and do

72 Expression of the imprinted genes H19 and insulin-like growth factor 2 (Igf2), which lie in close

73 the expression of multiple genes, including insulin-like growth factor 2 (Igf2), whose expression is

74 ss of imprinting and hypermethylation at the insulin-like growth factor 2 (IGF2)-H19 locus.

75 y and/or its recently identified target gene insulin-like growth factor 2 (IGF2).

76 an in immature neurons was the growth factor insulin-like growth factor 2 (IGF2).

77 bridization, we found that one allele of the insulin-like growth factor 2 (Igf2)/H19 imprinting contr

78 ulin-like growth factor 2 antisense (IGF2AS)-insulin-like growth factor 2 (IGF2)} gene cluster, unusu

79 e of the imprinted embryonic gene coding for insulin-like growth factor 2 (IGF2, Igf2(+m/-p)), result

80 The imprinted insulin-like growth factor-2 (IGF2) gene is an auto/para

81 Insulin-like growth factor-2 (IGF2) is a member of the i

82 (Mob1), adult obesity and diabetes (Ad), and insulin-like growth factor-2 (Igf2), map to murine regio

83 The paternally expressed gene insulin-like growth-factor 2 (Igf2) is separated by appr

84 Variants in the IMP2 (insulin-like growth factor 2 [IGF2] mRNA-binding protein

85 ts known ability to promote the abundance of Insulin-like Growth Factor 2/IGF2, we find that IMP2 str

86 ion in mutants exhibiting aberrant H19/Igf2 (insulin-like growth factor 2) imprinting.

87 factor-2 transcripts, and therefore null for insulin-like growth factor-2 in both placenta and foetus

88 2; the guanine nucleotide exchanger RasGRP2, insulin-like growth factor-2, integrin beta 4), cell mig

89 alpha-driven expression of transthyretin and insulin-like growth factor 2 is necessary for protection

90 Imprinted, maternally silenced insulin-like growth factor-2 is expressed in both the fo

91 e is 500 kb centromeric to the gene encoding insulin-like growth factor 2, it is likely to be part of

92 Recent studies on Igf2 (insulin-like growth factor 2) knockout mouse models prov

93 We focused our subsequent analyses on the Insulin-like growth factor 2 messenger RNA (mRNA)-bindin

94 C differentiation) and the downregulation of insulin-like growth factor 2 mRNA (promoter of OPC diffe

95 The gene encoding the Insulin-like Growth Factor 2 mRNA binding protein 2/IMP2

96 f the heterochronic let-7 miRNA pathway, the insulin-like growth factor 2 mRNA-binding protein 1 (IGF

97 Risk variants in the insulin-like growth factor 2 mRNA-binding protein 2 (IGF

98 Here, we determined that the RBP insulin-like growth factor 2 mRNA-binding protein 3 (IGF

99 Insulin-like growth factor 2 mRNA-binding protein-1 (IMP

100 IMP3 (insulin-like growth factor-2 mRNA binding protein 3) is

101 The insulin-like growth factor-2 mRNA-binding protein 1 (IGF

102 emand and placental supply of nutrients (the insulin-like growth factor-2-P0 KO) and one where demand

103 ull for the placenta-specific P0 transcript (insulin-like growth factor-2-P0 KO) to mice with disrupt

104 ha-spectrin, 2,3-bisphosphoglycerate mutase, insulin-like growth factor-2, porphobilinogen deaminase

105 The cation independent mannose 6-phosphate/insulin-like growth factor 2 receptor (IGF2R) functions

106 ependent kinase inhibitor 1C (Cdkn1c) or the insulin-like growth factor 2 receptor (Igf2r) leads to f

107 Insulin-like growth factor 2 receptor (IGF2R), also know

108 bors positional candidate genes, such as the insulin-like growth factor 2 receptor (IGF2R, 6q26) and

109 g binding molecules, the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P-IGF2R, CD222)

110 labeled CTGF and soluble mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF-2-R) alon

111 The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encode

112 The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2r) functi

113 own that inactivation of mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a c

114 At Igf2r (encoding insulin-like growth factor 2 receptor), a sequence calle

115 s the cation-independent mannose 6-phosphate/insulin-like growth factor 2 receptor, is the central co

116 acellular domains of the mannose 6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R), domai

117 a(-/-) tumors showed increased expression of insulin-like growth factor 2, retinoblastoma protein, an

118 nhancement was mediated by a soluble factor (insulin-like growth factor 2) secreted by monocytes.

119 can act, at least in part, independently of insulin-like growth factor-2 signaling.

120 For three of these genes--Igf2 (insulin-like growth factor 2), Slc38a4 (solute carrier f

121 pression of maternal and paternal alleles of insulin-like growth factor 2 switched to predominant exp

122 Ins-2 (encodes insulin-2) and Igf-2 (encodes insulin-like growth factor-2), that lie 90 and 115 kb 5'

123 correlated with activation of 3 promoters of insulin-like growth factor 2; these processes appeared t

124 h factor A, connective tissue growth factor, insulin-like growth factor 2, thrombospondin 1.

125 growth factor-2 in both placenta and foetus (insulin-like growth factor-2-total KO).

126 here demand and supply is more balanced (the insulin-like growth factor-2-total KO).

127 -P0 KO) to mice with disruptions of all four insulin-like growth factor-2 transcripts, and therefore

128 xpression of the trophoblast survival factor insulin-like growth factor-2 was significantly lower.

129 wth factor-alpha, preadipocyte factor-1, and insulin-like growth factor-2 were key genes differential

130 enes in the insulin-signaling pathway, e.g., insulin-like growth factor-2, were increased selectively