ライフサイエンスコーパス: insulinoma

1 actor in insulin-secreting beta-cell tumors (insulinomas).

2 y severe hypoglycemic events or diagnoses of insulinoma.

3 n pancreatic neuroendocrine tumors including insulinoma.

4 patient, there was no radiologic evidence of insulinoma.

5 tumor stroma in a mouse model of pancreatic insulinoma.

6 a successful hand-assisted enucleation of an insulinoma.

7 glycaemia especially in suppression tests of insulinoma.

8 or MR imaging) was not able to localize the insulinoma.

9 a may overlap with those in patients without insulinomas.

10 rgical resection of histologically confirmed insulinomas.

11 his difference was present in all nine human insulinomas.

12 he understanding of the molecular biology of insulinomas.

13 osits in individuals with type 2 diabetes or insulinomas.

14 est in ileal NETs and may also be helpful in insulinomas.

15 eatic beta-cell mass and detection of benign insulinomas.

16 n to be highly efficient in the detection of insulinomas.

17 s feasible and sensitive in detecting benign insulinomas.

18 ucagonlike peptide-1 receptor-overexpressing insulinomas.

19 rs (insulinomas), and also in human sporadic insulinomas.

20 endin-4 ((111)In-DTPA-exendin-4) to identify insulinomas.

21 toxic to cultured rat INS-1 (transformed rat insulinoma-1) beta-cells.

22 d 44 pancreatic primary tumors, including 12 insulinomas, 28 nonfunctioning endocrine tumors, and fou

23 Pdx1 expression was reduced in mouse insulinoma 6 (MIN6) cells by delivering small hairpin RN

24 We report that exposure of mouse insulinoma 6 cells to high concentrations of glucose res

25 cted pharmacological approaches in the mouse insulinoma-6 (Min6) cell line, we demonstrate that eleva

26 NMDAR-mediated signaling was observed in rat insulinoma 832/13 cells and in human beta-cells, indicat

27 that insulin 2 (Ins2) mRNA expression in rat insulinoma 832/13 cells is markedly increased by wild-ty

28 the RIP1-Tag2 model are well-differentiated insulinomas, a subset of tumors had lost multiple marker

29 small microparticles, mainly EXO, from mouse insulinoma and examined their activities to stimulate th

30 correctly identified 48 of 49 patients with insulinoma and excluded the diagnosis in 64 of 65 contro

31 arlier, we had cloned IG20 cDNA from a human insulinoma and had shown that IG20/MADD can encode six d

32 oligomers but not monomers in pancreatic rat insulinoma and human islet cells.

33 The co-culturing of insulinoma and islet-derived endothelial cell (iEC) line

34 c mouse models of cancer (RIP1-Tag2 model of insulinoma and MMTV-PyMT model of breast cancer).

35 abeling in human IAPP transgenic mice, human insulinoma and pancreas from humans with and without T2D

36 differential expression of proteins between insulinoma and their paired tissues by proteomic analysi

37 rigenesis; miR-204 is primarily expressed in insulinomas and correlates with immunohistochemical expr

38 TPA-exendin-4 SPECT/CT correctly detected 19 insulinomas and four additional positive lesions (two is

39 Insulinomas and gastrinomas comprise the majority of fun

40 offer higher sensitivity in the detection of insulinomas and imaging of beta-cell mass in diabetic pa

41 fore seems to be a general characteristic of insulinomas and is estimated to contribute about 90% to

42 ld-type large T antigen developed pancreatic insulinomas and lymphomas and died between 3 and 6 month

43 ckdown, in MEN1-associated beta cell tumors (insulinomas), and also in human sporadic insulinomas.

44 In particular, the areas of gastrinoma, insulinoma, and multiple endocrine neoplasia type 1 have

45 P-NETs, which include gastrinomas, insulinomas, and non-functioning tumours, occur in more

46 cid decarboxylase 65 (GAD65) autoantibodies, insulinoma antigen 2 (IA2) autoantibodies, and diabetes.

47 Insulinomas are beta-cell tumors that cause hypoglycemia

48 Insulinomas are beta-cell tumours characterised by uncon

49 Small benign insulinomas are hard to localise, leading to difficultie

50 Insulinomas are pancreatic islet tumors that inappropria

51 Pancreatic insulinomas are rare neoplasms that are present in vario

52 a subunits was detected in betaTC3 and NIT-1 insulinomas as well as in primary islets, with integrin

53 Insulinoma associated 1 (Insm1) plays an important role

54 These IPs are insulinoma-associated 1 (Insm1)(+)/BTG family member 2 (

55 The zinc-finger transcription factor insulinoma-associated 1 (Insm1, previously IA-1) is expr

56 d decarboxylase (65-kDa isoform; GAD65), and insulinoma-associated Ag-2 (IA-2), and peptides were elu

57 antibodies to glutamic acid decarboxylase or insulinoma-associated antigen 2, or diabetes were observ

58 A novel cDNA, insulinoma-associated antigen-1 (IA-1), containing five

59 GAD autoantibodies (GADAs), insulinoma-associated antigen-2 antibodies (IA-2As), and

60 acid decarboxylase autoantibodies (GADA) and insulinoma-associated antigen-2 autoantibodies (IA-2A) w

61 for insulin, glutamic acid decarboxylase, or insulinoma-associated antigen-2 autoantibodies on 2 cons

62 Insulinoma-associated protein (IA)-2beta, also known as

63 ecific for either known autoantigens (GAD65, insulinoma-associated protein 2 (IA2), IA2beta/phogrin,

64 antibodies to insulin (IAAs), GAD65 (GADAs), insulinoma-associated protein 2 (IA2As), and ZnT8 (ZnT8A

65 ere hypoglycemia nor positivity to GAD65 and insulinoma-associated protein 2 antibodies was associate

66 posttransplant autoantibodies (GAD antibody, insulinoma-associated protein 2 antigen, zinc transporte

67 IA-2 (insulinoma-associated protein 2), a major autoantigen in

68 oform of glutamic acid decarboxylase), IA-2 (insulinoma-associated protein IA-2) or insulin, alone or

69 onses to beta-cell autoantigens (proinsulin, insulinoma-associated protein, and GAD65 peptides) were

70 cell autoantibodies, insulin autoantibodies, insulinoma-associated protein-2 autoantibodies, and GAD

71 unclear why patients lose tolerance to IA-2 (insulinoma-associated tyrosine phosphatase-like protein,

72 nsulin, glutamic acid decarboxylase, and the insulinoma-associated-2 (IA-2) molecule were analyzed us

73 Similarly, in insulinoma-bearing mice, the early postnatal development

74 in 1 and rat insulin 2 promoters in the MIN6 insulinoma beta cell line.

75 induced ER stress signaling assessed in MIN6 insulinoma beta cells.

76 n fatty acyl-carnitines promoted IS from rat insulinoma beta-cells (INS-1) as well as primary mouse i

77 up B, the presence of low-Km hexokinase-I in insulinoma beta-cells (not in adjacent islets) was revea

78 effect of carbidopa on (18)F-FDOPA uptake in insulinoma beta-cells and an insulinoma xenograft model

79 Allogeneic murine insulinoma beta-TC3 cells and primary islets from BALB/C

80 n1 knockout mice develop multiple pancreatic insulinomas, but this occurs many months after loss of b

81 of exendin-4 derivatives for the imaging of insulinomas by high-resolution PET at early or late time

82 ions for reducing beta-cell proliferation in insulinomas by inhibiting phospho-HLXB9 or its interacti

83 ent potential new tracers for the imaging of insulinomas by PET.

84 Pancreatic insulinomas can be readily localized preoperatively with

85 oning and expression of mSTRPC4 from a mouse insulinoma cDNA library.

86 3C6]glucose, was compared in four clonal rat insulinoma cell 1-derived cell lines with varying degree

87 -O-(thio)triphosphate binding and INS1 832-3 insulinoma cell cAMP assays, BETP enhanced GLP-1(9-36)-N

88 aining iPLA(2)beta cDNA to prepare two INS-1 insulinoma cell clonal lines that stably overexpress iPL

89 the production of free radicals, induces rat insulinoma cell death by activation of a non-selective c

90 a cell line (PANC-1) and the endocrine human insulinoma cell line (CM) were applied for in vitro (11)

91 hermore, addition of monomeric IAPP to a rat insulinoma cell line (INS-1) resulted in decreased cell

92 in the pancreatic beta-cell line MIN6 (mouse insulinoma cell line 6) and islets of Langerhans that ag

93 LAG fusion protein was expressed in an INS-1 insulinoma cell line and then adsorbed to an anti-FLAG m

94 Clones were generated of the hamster insulinoma cell line HIT-T15 expressing a pH-sensitive f

95 kdown of PTPMT1 expression in the pancreatic insulinoma cell line INS-1 832/13 alters the mitochondri

96 red with islets of rats and mice and the rat insulinoma cell line INS-1 832/13.

97 of human islets, rat beta-cells, and the rat insulinoma cell line INS-1E were examined.

98 We employed the mouse insulinoma cell line MIN6 to perform in vitro characteri

99 cruited to the insulin promoter in the mouse insulinoma cell line MIN6 when cells are switched from h

100 ee genetically modified strains of the mouse insulinoma cell line MIN6, each of which expressed key i

101 lated by O-linked glycosylation in the mouse insulinoma cell line MIN6.

102 d insulin secretion in rodent islets and the insulinoma cell line MIN6.

103 A rat insulinoma cell line was transfected with a PARP antisen

104 B2 can be phosphorylated in Rin cells (a rat insulinoma cell line) and cultured chromaffin cells, but

105 Cells of the insulinoma cell line, betaTC3, were stably transfected w

106 In addition, incubation of an insulinoma cell line, betaTC3, with an anti-TLR4 antibod

107 lambda phage cDNA library derived from a rat insulinoma cell line, RIN 38A, was screened by a Southwe

108 Using the 832/13 rat insulinoma cell line, we demonstrate using RNA interfere

109 sing the highly glucose-sensitive 832/13 rat insulinoma cell line, we demonstrated that glucose regul

110 ith either of two shRNAs in the INS-1 832/13 insulinoma cell line.

111 ly reduced Pdx1 expression in the Min6 mouse insulinoma cell line.

112 its genomic targets in NIT-1 cells, a mouse insulinoma cell line.

113 s glucose-stimulated insulin secretion in an insulinoma cell line.

114 ion in human pancreatic islets and the INS-1 insulinoma cell line.

115 Stably transformed insulinoma cell lines (MIN6) were created with small int

116 lysis on the four most widely studied rodent insulinoma cell lines and defined their flow cytometric

117 onal activation of an early response gene in insulinoma cell lines and in rat islets.

118 ency of adenovirus-mediated gene transfer in insulinoma cell lines and rat islets and 2) the rapidity

119 the hazards of interpreting data from rodent insulinoma cell lines as modeling normal cell cycle prog

120 cell proliferation in three different rodent insulinoma cell lines by arresting the cells in G2/M pha

121 lthough many studies using rodent islets and insulinoma cell lines have been performed to determine t

122 Engineered insulinoma cell lines may represent an alternative to is

123 Rodent insulinoma cell lines may serve as a model for designing

124 rough CL and FAS is not required for GSIS in insulinoma cell lines or rat islets.

125 t-negative interference of SEL1L function in insulinoma cell lines severely impairs, whereas overexpr

126 etion from pancreatic beta-cells and related insulinoma cell lines.

127 he cell cycle at the protein level in rodent insulinoma cell lines.

128 ient to reduce the proliferation of cultured insulinoma cell lines.

129 elements are found in nuclear extracts from insulinoma cell lines; the A2.2 complex is detected only

130 ic condition, obestatin augments GSIS in rat insulinoma cells (INS-1) and in pancreatic islets from g

131 (Prolastin, human) were observed when murine insulinoma cells (MIN6) were exposed to tumor necrosis f

132 he expression profiles of glucose-responsive insulinoma cells 45 min after the addition of glucose, K

133 Loss of SIRT4 in insulinoma cells activates GDH, thereby upregulating ami

134 , and overexpression of iPLA(2)beta in INS-1 insulinoma cells amplifies, glucose-stimulated insulin s

135 y that enables the study of granule aging in insulinoma cells and beta-cells of knock-in mice through

136 echanism, we overexpressed human IAPP in rat insulinoma cells and freshly isolated human islets.

137 um signaling and energy metabolism in INS-1E insulinoma cells and human islet beta cells.

138 in NAD(P)H autofluorescence in both betaTC3 insulinoma cells and islets in a manner consistent with

139 reased IRS-2 protein expression in INS-1/832 insulinoma cells and mouse islets, whereas IRS-2 mRNA le

140 ncrease the anti-apoptotic protein Bcl-XL in insulinoma cells and mouse islets.

141 APK is activated by phosphorylation in INS-1 insulinoma cells and mouse pancreatic islets, that this

142 mall interfering RNA specific for pdx-1 into insulinoma cells and pancreatic islets to diminish endog

143 To study Set7/9 function, we depleted insulinoma cells and primary mouse islets of Set7/9 prot

144 is transiently activated by nitric oxide in insulinoma cells and rat islets following IL-1 treatment

145 both in vitro and in vivo approaches (mouse insulinoma cells and SPL-deficient mice), that SPL is a

146 are remarkably similar to those observed for insulinoma cells and suggest that this family of non-sel

147 CAP proteins were present in the nucleus of insulinoma cells and that endogenous INSM1 protein was c

148 itor thapsigargin induces apoptosis in INS-1 insulinoma cells and that this is inhibited by a bromoen

149 Rat islets and BTC3 insulinoma cells are shown by reverse transcriptase poly

150 MS4 and MS6) were examined using 832/13 rat insulinoma cells as well as rodent and human islets.

151 previously reported that apoptosis of INS-1 insulinoma cells due to thapsigargin-induced ER stress w

152 s issue, we initially demonstrated that MIN6 insulinoma cells express functional M3Rs and that RGS4 w

153 solated rat pancreatic islets, whereas INS-1 insulinoma cells expressed only EDG-1, -2, -3, and -5 mR

154 Finally, this compound protected NIT-1 insulinoma cells from interleukin-1beta and alloxan cyto

155 tion (gammaH2AX formation) in rat islets and insulinoma cells in a nitric oxide- and ATM-dependent ma

156 To this end, we have cultured INS-1 insulinoma cells in increasing concentrations of interle

157 kine-resistant cell lines by growth of INS-1 insulinoma cells in iteratively increasing concentration

158 Recordings of Kv2.1 currents from INS-1 insulinoma cells incubated with AA (5 mum) and subjected

159 ckdown of Pdx1 gene expression in mouse MIN6 insulinoma cells induced apoptotic cell death with an in

160 Consistently, CDK4 knockdown in INS-1 insulinoma cells inhibited glucose-stimulated cell cycle

161 or the spatiotemporal evolution of pH in rat insulinoma cells loaded with SNARF-1.

162 retrograde transport in isolated islets and insulinoma cells mimicked the phenotype of Asna1(beta-/-

163 ria from liver, pancreatic islets, and INS-1 insulinoma cells or adding glucose to intact INS-1 cells

164 ne expression was knocked down in mouse MIN6 insulinoma cells resulting in apoptotic cell death that

165 n, and short interfering RNA to PDX1 in Min6 insulinoma cells results in the induction of normally un

166 d with GG-labeled encapsulated mouse betaTC6 insulinoma cells returned to normal within 1 week after

167 LA(2)beta) activity in pancreatic islets and insulinoma cells suggest that iPLA(2)beta participates i

168 tion of iPLA(2)beta in pancreatic islets and insulinoma cells suppresses, and overexpression of iPLA(

169 cently reported on a method for selection of insulinoma cells that are resistant to the cytotoxic eff

170 Subjecting insulinoma cells to oxidative stress induces iPLA(2)beta

171 consumption could also be observed at single insulinoma cells using the electrode.

172 rin expression in human pancreas and in MIN6 insulinoma cells was studied by Western blot, PCR, confo

173 Such events in INS-1 insulinoma cells were found to include activation of cas

174 ulated in vitro by chronic culture of 832/13 insulinoma cells with high concentrations of free fatty

175 KN93 reduced arachidonate release from INS-1 insulinoma cells, and both inhibit insulin secretion.

176 aling significantly reduces proliferation of insulinoma cells, and expression of Hedgehog signaling t

177 glucose dependent insulin secretion in NIT-1 insulinoma cells, and high insulin expression in the pre

178 th rat and human pancreatic islets and INS-1 insulinoma cells, and its attachment to cellular protein

179 ed p125 tyrosine phosphorylation in beta-TC3 insulinoma cells, beta-HC9 cells, and in freshly isolate

180 e peroxynitrite generation by rat islets and insulinoma cells, either with or without phorbol 12-myri

181 lucose-stimulated insulin secretion from rat insulinoma cells, INS-1, were effectively inhibited by 5

182 most potent GHRH agonist MR403 was tested on insulinoma cells, isolated rat islets, and adrenal beta-

183 extrans to study insulin granule dynamics in insulinoma cells, normal mouse islets, and primary pancr

184 In betaTC3 insulinoma cells, PDE7A1 co-localizes with PKA II in the

185 Isl-1(L/L); Pdx1-CreER(Tm) mice and betaTC3 insulinoma cells, respectively.

186 ed in electrophysiological recordings of rat insulinoma cells, which are known to express K(V)2 chann

187 Smad3 action in promoter-reporter assays in insulinoma cells.

188 XA2 protein but not RNA expression in INS-1E insulinoma cells.

189 cycling and/or cytosolic NADPH production in insulinoma cells.

190 le and by small interfering RNA silencing in insulinoma cells.

191 rates in primary rat beta-cells to those in insulinoma cells.

192 , and release of insulin from mouse beta-TC6 insulinoma cells.

193 n-activated protein kinase in pancreatic and insulinoma cells.

194 plifies insulin secretory responses in INS-1 insulinoma cells.

195 demonstrated by RT-PCR in rodent islets and insulinoma cells.

196 e obtained using primary rat islets or Min-6 insulinoma cells.

197 loid deposition, and cytotoxicity in RIN-m5F insulinoma cells.

198 s into the tricarboxylic acid (TCA) cycle in insulinoma cells.

199 ucose-mediated transcriptional regulation in insulinoma cells.

200 26RFa stimulates insulin production by MIN6 insulinoma cells.

201 cked down Irs2 gene expression in mouse MIN6 insulinoma cells.

202 tion and revealed an antiapoptotic effect on insulinoma cells.

203 ted for enhancer activity in 832/13 and MIN6 insulinoma cells.

204 Neuroendocrine pancreatic cancer (insulinoma) cells that do not produce insulin-like growt

205 ulin mRNA was increased more than 50-fold in insulinomas compared with normal islets, and this differ

206 We aimed to prospectively assess the insulinoma detection rate of single-photon emission CT i

207 ydroxy-l-phenylalanine ((18)F-FDOPA) PET for insulinoma diagnosis.

208 t the pathway level that the majority of the insulinomas display mutations, copy number variants and/

209 taneously with phosphatase-on-the-granule-of-insulinoma-enhanced green fluorescent protein.

210 on level of caspase 8 is markedly reduced in insulinomas from Men1(+/-) mice.

211 days after injection for the demarcation of insulinomas from the kidneys represent current limitatio

212 Recently, we identified Insulinoma-Glucagonoma clone 20 (IG20) that can render c

213 Patients with insulinoma had lower glucose levels and higher insulin a

214 d targeted sequencing revealed that 14 of 43 insulinomas harbored the identical somatic mutation in t

215 Proteomic study on insulinoma has been rarely reported.

216 Reasoning that insulinomas hold the "genomic recipe" for beta cell expa

217 using distinct clinical endocrine syndromes (insulinoma [hypoglycemia], gastrinoma [Zollinger-Ellison

218 ry liposomal delivery system, was used in an insulinoma ICR/SCID mouse model to prevent hypoglycemic

219 A accumulation in RIN-m5F cells but improved insulinoma imaging in vivo.

220 TA-exendin-4 PET/CT correctly identified the insulinoma in 4 of 4 patients, whereas (111)In-DOTA-exen

221 -exendin-4 SPECT/CT correctly identified the insulinoma in only 2 of 4 patients.

222 vity, pericytes on capillary-size vessels in insulinomas in RIP-Tag2 transgenic mice expressed both d

223 idney uptake, enabling a better detection of insulinomas in the tail and head of the pancreas.

224 tently, siRNA-mediated Shp2-knockdown in rat insulinoma INS-1 832/13 cells resulted in decreased insu

225 is expressed in human islets and pancreatic insulinoma INS-1 and MIN6 cells.

226 We have previously described rat insulinoma INS-1-derived cell lines with robust or poor

227 binding to the extracellular surface of rat insulinoma INS-1E cells that stably expressed a tagged h

228 ZnT8A binding was detected on live rat insulinoma INS-1E cells, and the binding specificity was

229 on of the JNK pathway in human islets and in insulinoma (INS 832/13) cells.

230 tudy demonstrates that lactogens protect rat insulinoma (INS-1) cells and primary mouse beta cells ag

231 We subjected insulinoma (INS-1) cells to adenoviral expression of UCP

232 in both primary mouse beta-cells and in rat insulinoma (INS-1) cells, indicating a direct effect on

233 creening of a cDNA library prepared from rat insulinoma (INS-1) cells, we identified a novel protein,

234 independent robustly glucose-responsive rat insulinoma (INS-1-derived) cell lines and in primary rat

235 Insulinoma is a medical case in which the person is reco

236 Ga-DOTA-exendin-4 PET/CT in detecting hidden insulinomas is feasible.

237 tion, operative management, and follow-up of insulinomas is undetermined.

238 Stimulation of the MIN6 insulinoma line and primary rat islets with CRF also act

239 Using the Ins-1 rat insulinoma line, we demonstrate that activated Rap1A, bu

240 viability and mitochondrial activity of rat insulinoma m5F (RINm5F) cells.

241 at understanding the molecular complexity of insulinoma may be a valuable approach to diabetes drug d

242 ant with increased translation efficiency in insulinomas might explain how these tumours maintain hig

243 suppression of Pdx1 increases death of mouse insulinoma MIN6 beta-cells associated with dissipation o

244 s and target genes of phospho-HLXB9 in mouse insulinoma MIN6 beta-cells.

245 this study, microarray analysis of the mouse insulinoma MIN6 cell line revealed that the transcriptio

246 trated that down-regulation of Nck1 in mouse insulinoma MIN6 cells results in faster dephosphorylatio

247 his study, we introduced an shRNA into mouse insulinoma MIN6 cells to deplete Pdx1 and found that exp

248 Moreover, CNO treatment of mouse insulinoma (MIN6) cells expressing the Rq(R165L) constru

249 Mouse insulinoma (MIN6) cells were administered with fatty aci

250 nic kidney cell line 293T (HEK293T) or mouse insulinoma (MIN6) cells.

251 that decrease insulin secretion from murine insulinoma MIN6B1 cells in response to the GLP-1 analog

252 A mouse insulinoma model was created with NIT-1 cells.

253 An ICR/SCID mouse insulinoma model was used to show that insulinoma-specif

254 D3 overexpression protected the NOD-derived insulinoma NIT-1 cell line from cytokine-induced apoptos

255 se 1/2 and nuclear factor-kappaB pathways in insulinoma NIT-1 cells, and inhibitors of either pathway

256 hese two genes were transfected into a mouse insulinoma (NIT) cell line to ascertain insulinoma-speci

257 ded with reduced Cblb and increased c-Met in insulinomas of two mouse models of menin loss.

258 Finally, exposure of insulinomas or beta cells to glutamine induced Akt phosp

259 ed the weak transfer of ZnT8 reactivity from insulinomas or primary beta-cells to APC for presentatio

260 rom excessive beta-cell proliferation (e.g., insulinoma) or insufficient beta-cell mass (e.g., diabet

261 and can be due either to beta-cell tumours (insulinomas) or beta-cell hyperplasia.

262 Insulinomas (pancreatic islet beta cell tumors) are the

263 ms a therapeutically targetable mechanism of insulinoma pathogenesis.

264 secretion by perifused fragments of 10 human insulinomas permitted their subdivision into three funct

265 erize the genomic and molecular landscape of insulinomas relative to normal beta cells.

266 We have recently demonstrated that insulinoma-released EXOs can stimulate the autoimmune re

267 Recent biochemical diagnostic guidelines for insulinomas require demonstration of hypoglycemia with i

268 Sixty-one patients with a diagnosis of insulinoma requiring surgery at a tertiary care center b

269 ificantly down-regulated and up-regulated in insulinomas, respectively.

270 perplasia) and one false negative (malignant insulinoma) result was identified in separate patients b

271 ionality would suppress proliferation of rat insulinoma (Rin) cells comparably to wild-type Cx37 (Cx3

272 tumor-associated Ag in spontaneously arising insulinomas (RIP-Tag2-HA mice), a high proportion of clo

273 racted RNA from nine laser-captured surgical insulinoma samples and from isolated islets of nine dono

274 mouse insulinoma model was used to show that insulinoma-specific cytotoxicity can be accomplished by

275 ascertain insulinoma-specific expression and insulinoma-specific cytotoxicity in vitro.

276 Insulinoma-specific cytotoxicity using the suicide gene

277 ouse insulinoma (NIT) cell line to ascertain insulinoma-specific expression and insulinoma-specific c

278 he use of the rat insulin promoter (RIP) for insulinoma-specific expression of a reporter gene.

279 The data suggest that the RIP is an insulinoma-specific promoter.

280 NA-binding motifs, was isolated from a human insulinoma subtraction library.

281 LTZ mice developed insulinomas that specifically had LN metastases; metasta

282 Human insulinomas thus show distinct, though not completely he

283 normal balb/c mice, diabetic ob/ob mice, and insulinoma tissue.

284 e genomic and epigenetic landscapes of human insulinomas to gain insight into possible pathways for t

285 or beta cell expansion, we surveyed 38 human insulinomas to obtain insights into therapeutic pathways

286 We used insulinomas transfected with the CIITA transactivator, w

287 ta and pHLXB9 can serve as novel targets for insulinoma treatment and have implications for understan

288 ransiently transfected islet-derived hamster insulinoma tumor and betaTC-3 cells revealed that the pr

289 the islet-derived mouse betaTC-3 and hamster insulinoma tumor cell lines.

290 made from single mouse beta-cells or hamster insulinoma tumor cells in current clamp at 30-35 degrees

291 Insulinoma was excluded in 65 patients; follow-up for a

292 ess T Ag from the RIP and develop pancreatic insulinomas, we demonstrate that epitope IV- but not epi

293 t is involved in insulin production by human insulinomas, we extracted RNA from nine laser-captured s

294 ed specimens from each patient, and multiple insulinomas were identified in one.

295 Multiple insulinomas were noted in 8% of cases and were more comm

296 ents histologic diagnosis confirmed a benign insulinoma, whereas one patient refused surgery despite

297 ndolent but ultimately malignant, except for insulinomas, which predominantly are benign.

298 preclinical research specifically focused on insulinomas, with potential translational implications.

299 FDOPA uptake in insulinoma beta-cells and an insulinoma xenograft model in mice.

300 Insulinoma xenografts in carbidopa-treated mice showed s