ライフサイエンスコーパス: insulysin

コーパス検索結果 (１語後でソート)

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1 oducts appeared to be further metabolized by insulysin.

2 re is an inverse correlation between in vivo insulysin activity levels and brain Abeta peptide levels

3 zygous for the insulysin gene trap, in which insulysin activity levels were decreased approximately 5

4 eptide levels and suggest that modulation of insulysin activity may alter the risk for Alzheimer's di

5 ulysin gene-trap mice that had no detectable insulysin activity.

6 ntly (1.6- and 1.4-fold, respectively) in an insulysin-deficient gene-trap mouse model.

7 agment of the Abeta precursor protein in the insulysin-deficient mouse also was found.

8 Insulysin (EC.3.4.22.11) has been implicated in the clea

9 In mice heterozygous for the insulysin gene trap, in which insulysin activity levels

10 tween those in wild-type mice and homozygous insulysin gene-trap mice that had no detectable insulysi

11 Insulysin has been identified as one of several protease

12 ment of an N-terminal-containing His6-tagged insulysin (His6-IDE) with proteinase K led to the initia

13 Insulysin (IDE) and neprilysin (NEP) were found to be in

14 Insulin-degrading enzyme (IDE) (insulysin) is a zinc metallopeptidase that metabolizes s

15 Insulin-degrading enzyme (IDE, insulysin) is the best characterized catabolic enzyme im

16 ral features with M16 family members such as insulysin, mitochondrial processing peptidase, nardilysi

17 To further study the action of insulysin on Abeta peptides recombinant rat insulysin wa

18 ng a rat cortical cell system, the action of insulysin on Abeta(1-40) and Abeta(1-42) was shown to el

19 en reported previously that ATP inhibits the insulysin reaction.

20 Taken together, these data suggest that insulysin specificity is directed toward the amino side

21 presence of an allosteric regulatory site on insulysin that may shift its specificity toward small pe

22 gether these results suggest that the use of insulysin to hydrolyze Abeta peptides represents an alte

23 Insulysin was further shown to prevent the deposition of

24 Recombinant rat insulysin was shown to cleave the internally quenched fl

25 insulysin on Abeta peptides recombinant rat insulysin was used.

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