ライフサイエンスコーパス: insurmountable

1 achieve elimination is substantial, but not insurmountable.

2 nch-to-bedside translation, but they are not insurmountable.

3 we speculate that CA's toxicity might not be insurmountable.

4 ies, but the 1 GeV barrier has so far proven insurmountable.

5 ralizing antibodies (NAbs) have often seemed insurmountable.

6 ver, there are challenges that have remained insurmountable.

7 ical barriers to xenotransplantation are not insurmountable.

8 h TMX-1 suggests that these problems are not insurmountable.

9 and selectivity of this protein is rooted in insurmountable activation barriers to the binding of lig

10 anism and structural components required for insurmountable activity of a GnRHR antagonist.

11 us, although it can seem that pathogens gain insurmountable advantages by mimicking cellular componen

12 The inhibitory effects of candesartan were insurmountable, and a vasodepressor or vasodilator respo

13 Drugs that exhibit insurmountable antagonism are proposed to provide improv

14 Therefore, the insurmountable antagonism observed in the functional ass

15 Quantitative analyses of the insurmountable antagonism of CCR5 internalization by the

16 he amino terminus of hGnRHR also ablates the insurmountable antagonism of TAK-013.

17 A mechanistic understanding of the insurmountable antagonism of the angiotensin II type 1 (

18 ide had the opposite effect on cAMP, causing insurmountable antagonism of the concentration-effect cu

19 f action of 5 from insurmountable to partial insurmountable antagonism while it had no effect on that

20 ation- and time-dependent manner, suggesting insurmountable antagonism.

21 or of 5 and converted 6's surmountable to an insurmountable antagonism.

22 and in addition may offer new insights into insurmountable antagonism.

23 as a tool to elucidate the mechanism of its insurmountable antagonism.

24 he acid-base group contacts are critical for insurmountable antagonism.

25 TAK-013 behaves as an insurmountable antagonist at the human receptor (hGnRHR)

26 that GIV3727 likely acts as an orthosteric, insurmountable antagonist of hTAS2R31.

27 In functional studies, QAW039 behaved as an insurmountable antagonist of PGD2-stimulated [(35)S]-GTP

28 (mGnRHR-P203S/V300L) converts TAK-013 to an insurmountable antagonist.

29 th Gln(257) in transmembrane 6 distinguishes insurmountable antagonists and that abolishing these int

30 rtan and EXP3174 are competitive, reversible insurmountable antagonists of the AT(1) receptor.

31 We propose that leaning ability of insurmountable antagonists on Gln(257) in the wild-type

32 We have administered the insurmountable AT(1) antagonist Candesartan, s.c. via os

33 locker that can induce both surmountable and insurmountable AT1 receptor blockade and provide support

34 characteristics of senescence but is not an insurmountable barrier to further growth.

35 Alloimmunization can present a virtually insurmountable barrier to kidney transplantation.

36 y T cells in the recipient poses a sometimes insurmountable barrier to long-term graft survival and t

37 cid backbone structure may not have posed an insurmountable barrier to the emergence of functionality

38 tionally silent proviruses poses a currently insurmountable barrier to the eradication of the human i

39 Thus, the nucleosome is not necessarily an insurmountable barrier to transcript elongation by pol I

40 g regions of a protein does not introduce an insurmountable barrier to transmembrane movement.

41 type 1 (HIV-1) proviruses currently pose an insurmountable barrier to viral eradication in infected

42 ntly infected with HIV represent a currently insurmountable barrier to viral eradication in infected

43 titive or noncompetitive and surmountable or insurmountable based on functional antagonism.

44 sely, the mutation hNK(3)-Y315F enhanced the insurmountable behavior of 5 and converted 6's surmounta

45 t in an insurmountable manner, indicating an insurmountable blockade of AT1 receptors.

46 human P2X4 in the presence of BX430 shows an insurmountable blockade, indicating a noncompetitive all

47 carcinoma, there is hope that the seemingly insurmountable burden of this disease will come under be

48 ereas at hNK(3), they differ in that 5 is an insurmountable but 6 a surmountable antagonist.

49 These barriers are not insurmountable but will require a concerted effort to ov

50 caused the appearance of inhibition that was insurmountable by 5-HT.

51 erene monomalonate adducts are unaltered and insurmountable by increased concentrations of arginine,

52 None of these causes is insurmountable; by designing strategies that systematica

53 a naive fly genome to overcome the initially insurmountable challenge imposed by a newly encountered

54 ponses to HIV through vaccination remains an insurmountable challenge.

55 Increasing population has posed insurmountable challenges to agriculture in the provisio

56 in the natural world, infants would face an insurmountable computational problem.

57 Thus, antagonism can be surmountable or insurmountable depending on the signaling pathways measu

58 Major, almost insurmountable, deterrents exist to the use of the small

59 Here, we report that this previously insurmountable electronic repulsion may be overcome thro

60 brane hydrocarbon core and water presents an insurmountable energetic penalty to burial of electric c

61 dth will introduce significant (and probably insurmountable) error variation into radiographic outcom

62 These challenges, however, are in no way insurmountable for users with knowledge of the general C

63 baboon-to-human transplants may represent an insurmountable hurdle in the race to save lives.

64 data are being reported, and many previously insurmountable hurdles have been overcome by developing

65 s more O2 than it can supply CO2, leading to insurmountable imbalances in both carbon and oxygen.

66 motivational properties and are perceived as insurmountable impediments.

67 Based on our results showing insurmountable inhibition of ADP-induced Ca(2+) release

68 have demonstrated that analogues 1 and 2 are insurmountable inhibitors of MTII agonist activity at th

69 in in females is not sufficient to induce an insurmountable level of dosage compensation, suggesting

70 Although not insurmountable, logistic challenges of 24-h urine collec

71 e-response curve to AngII to the right in an insurmountable manner, indicating an insurmountable bloc

72 ect competitive antagonism and an apparently insurmountable mechanism that only occurs after preincub

73 Both compounds exhibit an insurmountable mode of antagonism at hNK(1), whereas at

74 e that tolerance to tumor antigens is not an insurmountable obstacle and points to modulation of APC

75 The blood brain barrier (BBB) is often an insurmountable obstacle for a large number of candidate

76 rties of the skin pose a significant but not insurmountable obstacle for development of new effective

77 uctures, and the design challenge remains an insurmountable obstacle for the large number of proteins

78 y inevitable protein corona appears to be an insurmountable obstacle to wider application of function

79 ing are helping to overcome these previously insurmountable obstacles and improve the future of pepti

80 ggesting that opposing polymerases represent insurmountable obstacles for each other.

81 Position effects also represent potentially insurmountable obstacles to the rigorous functional comp

82 omplex challenge for researchers, but not an insurmountable one.

83 What we previously thought of as insurmountable physical and chemical barriers to life, w

84 d, nevertheless, be expected to guarantee an insurmountable physical block to polyspermy.

85 Although myocardial damage/loss remains an insurmountable problem for adult mammals, the same is no

86 lex polymers has created daunting, sometimes insurmountable problems for their chemical analysis.

87 o a dead-end as the trans intermediates have insurmountable rotation barriers that prohibit formation

88 inspired sensors to overcoming a previously-insurmountable size constraint in engineered sound-local

89 n monoclonal antibodies (MAbs) and perceived insurmountable technical, financial, and logistical hurd

90 stacles, such as a lack of data, rather than insurmountable theoretical difficulties.

91 hly desirable, but the task has proven to be insurmountable to date.

92 F264Y converted the mode of action of 5 from insurmountable to partial insurmountable antagonism whil

93 hat abolishing these interactions transforms insurmountable to surmountable antagonism.

94 structure of TTR, creating a barrier that is insurmountable under physiological conditions.

95 Inhibition of NR1A/2B receptors is insurmountable with respect to glutamate and glycine and