ライフサイエンスコーパス: intact

1 ly in situ, leaving the object unchanged and intact.

2 y DCs, even when T cell secretion of IL-2 is intact.

3 that these critical pathways were otherwise intact.

4 exploited to target Treg while leaving Tconv intact.

5 ller index facets, while {111} facets remain intact.

6 contrast, spatial and object coding remained intact.

7 ells while keeping the overall host immunity intact.

8 spectrometry evaluated that OT was absorbed intact.

9 tream of the intron as when the promoter was intact.

10 phere at silver while keeping the Ag-Fe bond intact.

11 different and the reproductive axis remained intact.

12 utside the islet, which remains more or less intact.

13 e acid, glucose and energy metabolism remain intact.

14 ctions with their physiological ligands were intact.

15 exploration while leaving random exploration intact.

16 t to activate PKC, and insulin signaling was intact.

17 o plasma and urine stability analysis showed intact (18)F-FCP at 24 h after injection.

18 Intact AAA repairs numbered 4956.

19 status in mAAQ(+) mice: T cells recognizing intact acquired MHC alloantigens proliferated, whereas t

20 An intact actomyosin network is essential for anchoring pol

21 redundant role in the maintenance of ChAT in intact adult motor neurons, the receptors become essenti

22 hanical integrity of individual BNNTs remain intact after being thermally baked at up to 850 degrees

23 While acoustic PPI remained intact and ABR thresholds recovered, the ABR wave P1-N1

24 of the bacteria, the remnant matrix remains intact and behaves as a pH-responsive hydrogel.

25 Intact and broad immune cell effector functions and spec

26 were able to confirm expression of SMAD3 in intact and degraded cartilage of the knee and hip.

27 Using this system, we analysed waters from intact and degraded peat swamp forest of Kalimantan, Ind

28 ctivities in the dorsal striatum of dopamine-intact and dopamine-depleted rats during two brain state

29 h or if the adjacent catchment is relatively intact and has a low rate of vegetation decline; (3) lan

30 Few intact and necrotic neutrophils were detected at MGAS315

31 Intact and pressurized rat superior cerebellar arteries

32 ed to between category correlations for both intact and scrambled images demonstrating distinct patte

33 These data suggest intact and stable value processing in MDD during risky d

34 ilar to those in WT animals and functionally intact, and transfer of WT platelets did not restore art

35 ated targets, and leaving methylated targets intact; and vice versa.

36 mortality (operative mortality review) after intact aneurysm repair.

37 In conclusion, in islets, intact angiotensin-(1-7) is not the primary mediator of

38 ion that is nonessential for manual skill in intact animals, but came to mediate this skill due to tr

39 synaptic vesicle exocytosis and retrieval in intact animals.

40 Only 20% degradants were formed and mostly intact anthocyanins were absorbed from the small intesti

41 ext of N-glycopeptides, N-glycoproteins, and intact antibodies.

42 e normal T-cell development and function and intact antibody response to T-dependent antigen.

43 uired signals delivered upon engagement with intact antigen.

44 d it was associated with decreased levels of intact AnxA1.

45 field of view through the entire depth of an intact aortic wall.

46 ownregulating glial activation, however, the intact apoE holoprotein does not cross the blood-brain b

47 present newly discovered fossil remains from intact archaeological layers of the open-air site 'Ein Q

48 (2.63) had reduced CXCL11 scavenging despite intact arrestin responses.

49 2+) levels in potassium chloride-constricted intact arteries isolated from mouse mesenteric tissue.

50 Herein we map the water permeability in intact arteries, using coherent anti-Stokes Raman scatte

51 the presence of integrated percepts remains intact, as shown through multivariate classification ana

52 ever, participants with depression showed an intact association between RPEs and happiness in a compu

53 that dexterity and force generation require intact attention control.

54 ial biomass to confirm the ability to detect intact bacterial species from a swab.

55 In addition, some of RB-intact basal-like type breast cancer cell lines exhibite

56 Conversely, the intact BBB restricts efficient penetration of CNS-target

57 Importantly, BPN delivery across the intact BBB, just beyond the tumor edge, was also markedl

58 llustrate how gene co-expression analysis of intact biological systems can provide insights into the

59 vascular brain tissue compartment across the intact blood-brain barrier.

60 e quantified cytosolic labile heme levels in intact, blood-stage parasites.

61 ntify, and quantify) exogenous GHB in almost intact body fluids and its high potential in the search

62 The ADC values of intact bone marrow and BMLs did not overlap.

63 ADC values were measured in intact bone marrow and major BMLs.

64 ptimized fluorophores for imaging voltage in intact brain tissue.

65 e prioritised if the catchment is relatively intact but the rate of vegetation decline is high.

66 ysis of stimulus-evoked calcium responses of intact C. elegans at various life stages.

67 cle aggregates with size up to 200 nm within intact C. elegans.

68 th extinction-rescued S1 mice and extinction-intact C57BL/6 (BL6) mice.

69 ted (2 to 10 months) muscle disease and Dysf-intact (C57BL/6 [B6]) mice.

70 This retooled INTACT can enable high-resolution monitoring of the nucl

71 from isolated proteins and from receptors in intact cancer cell membranes.

72 GCIB-SIMS in imaging high-mass signals from intact cardiolipin (CL) and gangliosides in normal brain

73 though much of the basic actin machinery was intact, Cdc42 null cells lacked the ability to polarize

74 tinct, highly intermixed cell populations in intact Ce3D-treated tissues via 3D histo-cytometry.

75 a marked increase of channel activity in the intact cell irrespective of the identity of the coassemb

76 Solid-state NMR of intact cell walls shows that, without the even-patterned

77 essential for optimal attack of alginate in intact cell walls.

78 e released from the surface of the otherwise intact cell.

79 Compound 22 was found to enter intact cells and induced cell death in a process that wa

80 to the coordination of signaling circuits in intact cells and multicellular organisms.

81 nsional images of biological samples such as intact cells in a near-native, frozen-hydrated state to

82 ork for understanding integrin activation in intact cells, including activation of integrin adhesiven

83 ial and lacks direct experimental support in intact cells.

84 P-X cross-linked to NPC1 when added to intact cells.

85 n between motor neurons could be detected in intact chimeric mice.

86 in GTs than STs and that this would require intact cholinergic neurotransmission.

87 ely to have peripheral nerve involvement, an intact circulating immunoglobulin, and lower circulating

88 be reversed by engrafting cells back into an intact CNS environment.

89 reated CNTs and simply-adsorbed GOx (ADS) on intact CNTs, respectively.

90 Cabp2(LacZ/LacZ) mice displayed intact cochlear amplification but impaired auditory brai

91 tia diagnosis, and 13.9% with a diagnosis of intact cognition.

92 he parietal cortex of 39 human subjects with intact cognition.

93 suffering from complete motor paralysis but intact cognitive and emotional processing, a state calle

94 non-helical telopeptide region compared with intact collagen fibrils.

95 of cis and trans double-bond isomers within intact complex lipid mixtures using electron impact exci

96 Whereas intact (control) monkeys shifted their choices toward th

97 h late-onset AD (LOAD), and 7001 cognitively intact controls (age at examination, >65 years) from the

98 01) were more severe in MCI than cognitively intact controls.

99 es in perceptual sensitivity mediated by the intact cortical circuits.

100 ne vesicles suggests that the presence of an intact cortical cytoskeleton is required for zinc-induce

101 to KAP1 in vitro and in vivo Accordingly, an intact CUE1 domain was required for tethering this remod

102 nts, we have demonstrated the presence of an intact de novo biosynthesis pathway for NAD(+) from tryp

103 he cysteine-biotin conjugates remained fully intact, demonstrating the ability of the FT-ICR to maint

104 , whereas hepatic insulin signaling remained intact despite profound hepatic insulin resistance.

105 -Fc on immunoblots, binding was dependent on intact disulfide bonds and N-glycans, and only two antib

106 molecule pairs with a strand derived from an intact DNA molecule.

107 Using long-term time-lapse imaging with intact Drosophila larvae, we found that dendrites grow i

108 t dividing cells with their neighbors remain intact during mitotic internalization, resulting in an u

109 MEF8 has an intact DYW domain, but possesses an unusually short PLS

110 f cerebrospinal fluid (CSF) from cognitively intact elderly patients (N = 28) with MDD and age- and g

111 diate intravasation of tumor cells across an intact endothelium.

112 ncreases the binding of 36D5 to gp120 in the intact Env trimer, consistent with CD4-induced changes i

113 allergic rhinoconjunctivitis, relates to an intact epithelial/epidermal barrier during early childho

114 ximately 40 nm diameter nanospheres remained intact even under aggressive conditions.

115 id resistance (pH = 1, HCl) but also remains intact even when immersed in saturated NaOH solution ( a

116 T567E-expressing cells adhere avidly to both intact ex vivo peritoneal explants and three-dimensional

117 dren as young as 6 years, that children show intact fear and extinction learning, and show evidence o

118 complete ensemble of wing control muscles in intact, flying flies.

119 set vasodilatation (10-15 s) in FAs remained intact following loss of ROV and was eliminated followin

120 large-scale conservation efforts to protect intact forests are necessary to slow deforestation rates

121 en used consecutively, ensures that only the intact form of the antibody is represented by the surrog

122 n signal collected from the same area of the intact fruits in a time course of a maximum of 20days.

123 he GLP-1R with the molecular structure of an intact, full-length, and functional receptor.ligand comp

124 Furthermore, intact G1/S transition (Rb-positive and low-molecular-we

125 nd gadoteridol and to quantify the amount of intact gadolinium complexes and insoluble gadolinium-con

126 tion of influenza A virus is reassortment of intact gene segments between coinfecting viruses.

127 If intact genes conveying antibiotic resistance survive the

128 istinctly increased APA staining in areas of intact glomerular capillary loops.

129 ficient catalysis was highly dependent on an intact Glu-Arg-Glu network, as only Glu --> Asp substitu

130 present a strategy for the permethylation of intact glycopeptides, obtained via controlled protease d

131 Further, we found that an intact GR dimerization interface was a prerequisite for

132 tolysis, which is associated with release of intact granules, so-called clusters of free eosinophil g

133 In addition, electron tomography data from intact heart illustrate the regular presence of caveolae

134 ross-links between an oxidized histidine and intact histidine, lysine, or cysteine residues were disc

135 h clonal expansion of CD4+ T cells harboring intact HIV-1.

136 ng continuous fields of epidermal scales and intact horn sheaths capping the body armor.

137 aused by ARPC1B loss could be rescued by the intact human ARPC1B ortholog, but not by the p.V208VfsX2

138 yo research stipulates that experiments with intact human embryos must not allow them to develop beyo

139 translational control in the formation of an intact human epidermis.

140 Recent determination of intact human gamma-secretase cryo-electron microscopy st

141 fy the response to loading of histologically intact human knee cartilage.

142 A antibodies was enhanced in the presence of intact human serum complement or purified C3a or C5a.

143 -weight RNA aptamers can permeate across the intact human skin barrier to therapeutically relevant le

144 py (TEM), we observed that a large number of intact IBDV virions were arranged in a lattice surrounde

145 eaved F(ab')2 fragments and did not bind the intact IgG counterpart.

146 In the absence of an intact IL-10 signaling, H. hepaticus induces an IL-23-dr

147 d serum immunoglobulin concentrations and an intact immune response to a T-cell-independent antigen,

148 adverse perinatal outcomes in a host with an intact immune system.

149 The RPE band appeared intact in all eyes.

150 dig short, single-tunnel burrows [2-4]-were intact in juvenile burrowers.

151 issue RBP4 expression and secretion remained intact in LRKO mice and increased as expected in the set

152 dial nasal processes, the upper lip remained intact in mutant mice.

153 n contrast, the superficial white matter was intact in recovered patients.

154 complexes, including Cul3(KLHL9/KLHL13), was intact in SCCRO-deficient cells, suggesting that SCCRO s

155 n in quiescent tumour endothelial cells with intact insulin receptors and partly prevented increases

156 Immunofluorescence of the residual intact internal limiting membrane on the retinal surface

157 ndings reflect the important relevance of an intact intestinal barrier.

158 putatively active L1 elements or full length intact L1 elements (FLIs).

159 PM was isolated from the intact leaves and size fractionated, and EPFRs on PM qua

160 for analyzing large-molecule proteins at the intact level in biological samples without digestion.

161 egeneration, and homeostatic regeneration of intact limbs.

162 based on the accurate mass measured for the intact lipid as well as highly specific diagnostic produ

163 re required for IL-1beta transport across an intact lipid bilayer.

164 IMS) has shown the full potential of mapping intact lipids in biological systems with better than 10

165 better physiologic and metabolic aspects of intact liver tissue compared with two-dimensional cultur

166 d neurons or in brain slices, but not in the intact living brain.

167 sed cryoEM to determine the structure of the intact LliK CNG channel isolated from Leptospira liceras

168 acute lung injury with two-photon imaging of intact lung tissue.

169 revent fusion between damaged phagosomes and intact lysosomes and thereby preserve endolysosomal inte

170 neurons with high temporal precision within intact mammalian brain circuitry would enable powerful e

171 santin inhibits mitochondrial respiration in intact mammalian cells and live animals.

172 We conclude that an intact Mcm10 coiled-coil interaction surface is importan

173 er, they are potent against endogenous AC in intact melanoma cells.

174 er, while recent progress has been made with intact methods for clearing, labeling, and imaging whole

175 y inactivated CD4 and CD8 genes in mice with intact MHC class I and class II molecules with the hypot

176 lators were compared in tumors from androgen-intact mice and in tumors surviving castration.

177 en concentrations similar to tumors grown in intact mice.

178 d that accurate denticle spacing requires an intact microtubule network and the microtubule minus end

179 interactions at least partially dependent on intact microtubules.

180 These data indicate that an intact MisRS system is required for gonococcal infection

181 Collectively, these results show that intact mitochondria with their mtDNA payload are transfe

182 availability on surface elevation change in intact mixed-species blocks of UK salt marsh using six o

183 Intact monkeys shifted their choice to whichever action

184 ime, to dynamically track cell behaviours in intact moving joints.

185 n Rab11A and vRNA segments in the absence of intact MT filaments, we analyzed the three-dimensional s

186 These data prove the necessity of intact MTORC1 signaling to regulate two synergistic proc

187 ensory nerves from the residual limb towards intact muscles and skin regions.

188 RVs and intact myofibers were laser microdissected from skeletal

189 We also compared the enrichment of intact N- and O-linked glycopeptides using other chromat

190 phy (HILIC) has been commonly used to enrich intact N- and O-linked glycopeptides.

191 d fucoligase for direct core fucosylation of intact N-glycoproteins.

192 and preserved ejection fraction with sternum intact (n=4).

193 CKD-RDN, n = 7) or sham procedures (control-intact, n = 6; CKD-intact, n = 7).

194 sham procedures (control-intact, n = 6; CKD-intact, n = 7).

195 Moreover, male pigs with one intact NANOS2 allele and female knockout pigs are fertil

196 ire appropriate large-scale manipulations of intact, natural habitat that is open to dispersal proces

197 Intact, near-full-genome HIV-1 DNA sequences that were d

198 profiled Schwann cells acutely purified from intact nerves and from the wound and distal regions of s

199 ke DNA or individual histone proteins, human intact NETs do not directly initiate or amplify coagulat

200 e been characterized, the mechanism by which intact NETs promote thrombosis is largely unknown.

201 characterizing visually identified cells in intact neural circuits, but it requires skill to perform

202 to manipulate gene expression temporally in intact neural circuits.

203 xpression in a rodent brain slice model with intact neuron-microglial networks exacerbated mHTTx1-ind

204 fection sites had massive numbers of and few intact neutrophils at the edge and center of the infecti

205 tes, respectively, on day 1 and were full of intact neutrophils or necrotic cells on day 2.

206 utant infection sites had massive numbers of intact neutrophils throughout the whole infection site.

207 Remarkably, Avil-cre;Sptan1(f/f) mice have intact nociception and small-diameter axons, but severe

208 Lastly, we performed depth profiling of intact nodules to reveal the location of metabolites to

209 ypeptides and embedded macromolecules within intact NPCs.

210 We observed high coherence, intact NVC, between the oscillations of SctO2 and aEEG i

211 ion in the strain bearing pohr-gfpuv with an intact ohrR gene could be induced by organic hydroperoxi

212 A total of 1657 cognitively intact older adults receiving treatment for hypertension

213 However, the content of total chemically intact omega-3 fatty acids was higher in the oil release

214 HML-2 group of HERV-K elements, still retain intact open reading frames and the capacity to produce c

215 use cats are compared in various conditions (intact or hemisected at different time points) in the sa

216 hysiologically relevant cell shape change in intact organisms.

217 mental data obtained from isolated ducts and intact pancreas under a range of experimental conditions

218 ene inactivation resulted in animals with an intact pancreas.

219 lyzed in L. donovani To test ARG function in intact parasites, we generated Deltaarg null mutants in

220 nd lumbar, serum osteocalcin, total calcium, intact parathyroid hormone, and increased serum C telope

221 of the extractable chemical mass, while the intact parent itself was negligible.

222 Fourteen TD and 12 PIGD cognitively-intact patients and 21 age- and sex-matched healthy cont

223 ically-confirmed pfhrp2-deleted samples with intact pfhrp3 locus were positive by HRP2-based RDT.

224 -rescue systems in human cells revealed that intact PIN domain and Zinc finger motifs in human hUTP23

225 ions have been proposed to support planning, intact planning in animals with damaged hippocampi has b

226 o study membrane protein interactions in the intact plasma membrane, while accounting for cell hetero

227 h wild-type but not mutant FKBP65 that lacks intact PPIase domains.

228 however, the structural characterization of intact precursor proteins has been limited.

229 Intact presynaptic mitochondrial function is critical fo

230 -kDa domain in pro-EGF, but rather expressed intact pro-EGF precursor on granular and plasma membrane

231 Remaining intact probe DNAs are then bound onto upconversion nanop

232 sly expressed in luminal cells of hormonally intact prostate but, upon androgen deprivation, exclusiv

233 yptic peptide standards for MS as well as an intact protein bearing multiple linear epitopes.

234 Mass spectrometry (MS) applications for intact protein complexes typically require electrospray

235 A dual enrichment strategy targets intact protein kinases via capture on immobilized multip

236 In top-down proteomics, intact proteins are analyzed by tandem mass spectrometry

237 mass spectrometry enabled identification of intact proteins, but this technology still faces challen

238 monstrated for the separation of mixtures of intact proteins.

239 ponses and reduced neural respiration in the intact rat, mimicking responses to glutamate excitation.

240 ve breast cancer is strictly dependent on an intact receptor ligand-binding pocket and that FES binds

241 Previous studies on relatively intact reefs with diverse and abundant fish communities

242 aquaporin-2 response to desmopressin and an intact response to furosemide.

243 an 13,000 bipolar cell axon terminals in the intact retina, we show that bipolar cell functional dive

244 The tumor cells retain high-quality intact RNA suitable for single-cell RT-qPCR as well as R

245 aptation of the "Repli-seq" assay for use in intact root tips of maize (Zea mays) that includes sever

246 LF1 indicated that the binding of AtRALF1 to intact roots is CML38-dependent.

247 h transfers into Rag1(-)(/-) mice expressing intact Roquin.

248 body-wall muscle electrophysiology inside an intact roundworm, Caenorhabditis elegans.

249 with hypophosphorylated, less abundant, but intact RSs, and accumulated hypophosphorylated NDK5 in t

250 This unknown activity of RUNX1 required an intact runt homology domain (RHD), a domain where most l

251 Unlike intact SAA1alpha, these SAA fragments failed to directly

252 The intact SAGA complex has been well characterized for its

253 The intact samples (fresh and dried cubic pieces) released s

254 rofiling was achieved from a small sample of intact sausage after 0, 2, 4, 7, 11 and 14days of drying

255 cells constituted 62% of all analyzed genome-intact sequences in memory CD4 T cells, were preferentia

256 ased heart rate and plasma renin activity in intact sheep, but these responses were significantly att

257 gentamicin solution (8 mg) or placebo into 2 intact skin sites for 2 days in 4 of 5 patients.

258 p = 0.008) lower, respectively, than that of intact SLC45A1.

259 In semi-intact SOAT1-/SOAT2-CHO cells prepared by a treatment wi

260 ined, and the entire detected gadolinium was intact soluble GBCA, while gadodiamide yielded both solu

261 trafficking of Slack channels also occurs in intact spinal cord slices and that it is carried out by

262 cessing through a mechanism that required an intact SREBP cleavage-activating protein (SCAP) pathway.

263 Here, we present intact structures for the zinc-specific SBP AztC from th

264 es in single neuron activity, and largely in intact subjects.

265 mit glial injury could significantly improve intact survival.

266 An intact t-system at the time of LVAD implantation may con

267 We also developed inexpensive methods for INTACT, T-DNA insertion mapping, and profiling of the co

268 red a separate group, of whom 3 (33%) had an intact TD.

269 antation of CAFs and tumor cells with either intact TGF-beta1 expression or devoid of TGF-beta1 in vi

270 When ELM is intact, there is a shallow decline in acuity with increa

271 However, these peptides should be absorbed intact through the intestinal barrier and reach the bloo

272 g system to measure cyclic GMP production in intact tibia, we show that FGF-induced dephosphorylation

273 The intact TIR domain was essential for TcpB to subvert the

274 Using intact tissue explants, Ncad+ MCAs were also shown to ef

275 sp90 inhibitor, to assay Hsp90 expression on intact tissue specimens with comparable contrast to in v

276 cale resolution is not readily achievable in intact tissue volumes.

277 s of molecules, cells, and structures within intact tissue.

278 Quantitative advantages of the intact-tissue approach were demonstrated compared to con

279 in visualizing and studying nanotubes within intact tissues have, however, prompted skepticism regard

280 roximal proteins and putative interactors in intact tissues, and to quantify changes caused by differ

281 ell size regulation are poorly understood in intact tissues.

282 aped curve" crossed the fixed threshold from intact to impaired pressure reactivity (pressure reactiv

283 ace on the pleckstrin homology domain and an intact TPR region are required for ASK1 activity.

284 nin polymerization are difficult to study in intact trees.

285 angiomyolipoma cells, but not in cells with intact TSC.

286 Casein fractions were kept intact under a heat treatment of 80 degrees C during 60m

287 ed to experience negative selection and stay intact under pressure of incessant mutation.

288 d a largely forested landscape that survived intact until the late 20th century.

289 also showed flexibility, with the nanowires intact up to 500 bending cycles.

290 ine patients (71 with pulmonary atresia with intact ventricular septum and 28 with virtual atresia) u

291 Patients with pulmonary atresia with intact ventricular septum deemed suitable for RV decompr

292 X-ray diffraction from synchrotron light in intact ventricular trabeculae from the rat to measure th

293 cavitation and flow rates in the stem of an intact vine during 10 d of dehydration.

294 velope (Env) glycoprotein of HIV is the only intact viral protein expressed on the surface of both vi

295 Participants with RPE65 mutations showed intact visual pathways, which became responsive and stre

296 Randomization was stratified by intact vs rupture of membranes prior to delivery.

297 of hagfish, failed to reveal evidence of an intact vwf gene.

298 ctor AvrRpt2 is bacterially delivered but is intact when AvrRpt2 is directly expressed in planta Thes

299 Intact white matter integrity with decreased NAA/Cr leve

300 e dynamics in cultured neurons as well as in intact zebrafish.