ライフサイエンスコーパス: integral membrane protein

1 n physiological ligand, podoplanin, being an integral membrane protein.

2 e deficient-1 (sid-1) gene, which encodes an integral membrane protein.

3 implicate this pathway in the disposal of an integral membrane protein.

4 y charged group extending from a lipid or an integral membrane protein.

5 and Tat systems in the assembly of a single integral membrane protein.

6 ergent extraction, suggesting that it was an integral membrane protein.

7 in Calsyntenin is present in A36, a vaccinia integral membrane protein.

8 D of the succinate dehydrogenase complex, an integral membrane protein.

9 -terminal signal sequence, and is a type one integral membrane protein.

10 the NSm topology as a two-membrane-spanning integral membrane protein.

11 DNP MAS ssNMR studies of lipid membranes and integral membrane proteins.

12 SRP) is essential for the biogenesis of most integral membrane proteins.

13 The situation is different for integral membrane proteins.

14 he periplasmic AcrA, which bridges these two integral membrane proteins.

15 estigating the dynamic interactomes of human integral membrane proteins.

16 ble tool for biophysical characterization of integral membrane proteins.

17 control mechanisms for damaged or misfolded integral membrane proteins.

18 ces involved in the membrane organization of integral membrane proteins.

19 between structural dynamics and function of integral membrane proteins.

20 enous factors for modulating the activity of integral membrane proteins.

21 nough to accommodate several copies of other integral membrane proteins.

22 the conformation of transmembrane regions of integral membrane proteins.

23 ns, like hemagglutinin (HA), NA, and M2, are integral membrane proteins.

24 tals and high-resolution X-ray structures of integral membrane proteins.

25 r mitochondrial membrane by one, or several, integral membrane proteins.

26 modification, and deployment of secreted and integral membrane proteins.

27 Case)) binding sequence to LIMP-2 (lysosomal integral membrane protein 2), the receptor for intracell

28 Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) contributes

29 rom human cells yielded identification of 83 integral membrane proteins, along with 163 membrane-asso

30 ied an interaction between CtsP and CtsX, an integral membrane protein also required for transformati

31 s suggests that ADAM17 is regulated by other integral membrane proteins, although much remains to be

32 mponent involved in flagellar trafficking of integral membrane proteins among parasitic protozoa.

33 opy to refine the structure of an oligomeric integral membrane protein, Anabaena sensory rhodopsin (A

34 usion coefficients uncommonly high for an ER integral membrane protein and more similar to the mobili

35 ined structural information of a recombinant integral membrane protein and the major endogenous molec

36 with the outer mitochondrial membranes as an integral membrane protein and ultimately becomes associa

37 Claudins are a family of integral membrane proteins and are components of tight j

38 ernately binding to their redox partners and integral membrane proteins and exchanging electrons.

39 with cholesterol, detergents, peptides, and integral membrane proteins and formation of lipid rafts.

40 Interaction between integral membrane proteins and the lipid-bilayer compone

41 htforward mass spectrometric measurements of integral membrane proteins and their complexes, directly

42 ver, the S subunit of ECF transporters is an integral membrane protein, and the transmembrane couplin

43 zymes in the Kennedy pathway, lipins are not integral membrane proteins, and they need to translocate

44 phorylation-dependent regulation of YAP, the integral membrane protein angiomotin (AMOT) and AMOT fam

45 from all subcellular locations, including 18 integral membrane protein antigens.

46 Canonical integral membrane proteins are attached to lipid bilayer

47 Structural and functional properties of integral membrane proteins are often studied in detergen

48 Integral membrane proteins are studied with a number of

49 ndoplasmic reticulum (ER), newly synthesized integral membrane proteins are subject to a complex seri

50 When integral membrane proteins are visualized in detergents

51 Vezatin is an integral membrane protein associated with cell-cell adhe

52 AMP1 encodes an integral membrane protein associated with endoplasmic re

53 ess leads to toxic accumulation of misfolded integral membrane proteins at the cell surface, which ca

54 ght to nucleate from vesicles containing the integral membrane protein Atg9 (autophagy-related 9), CO

55 This includes the integral membrane protein ATP1A1, the phosphoinositide p

56 al method for the rational overexpression of integral membrane proteins based on computationally simu

57 ated with HycC and HycD, which are polytopic integral membrane proteins believed to anchor the core c

58 The integral membrane protein BlaR1 of Staphylococcus aureus

59 rmally induced transitions of the 13-subunit integral membrane protein bovine cytochrome c oxidase (C

60 that GBA2 is not, as previously thought, an integral membrane protein but rather a cytosolic protein

61 iculties associated with the purification of integral membrane proteins but also due to the limited a

62 We also show that quality control of integral membrane proteins by ribosome-associated comple

63 r, as recently proposed, within an accessory integral membrane protein called Pirt.

64 Gap junction channels are formed by integral membrane proteins called connexins, of which th

65 ongation of the N-terminal sequence of these integral membrane proteins can divert the nascent protei

66 Thus, integral membrane proteins can negotiate passage through

67 P-type ATPase and provides insight into how integral membrane proteins can recognize and transport p

68 lpha-amidating monooxygenase (PAM), a type I integral membrane protein, catalyze the sequential react

69 aprenyl pyrophosphate phosphatase (UppP), an integral membrane protein, catalyzes the dephosphorylati

70 nvolves insertion of the cholesterol-binding integral membrane protein caveolin-1 (Cav1) into the mem

71 cal methods to investigate the effects of an integral membrane protein, caveolin-3 (Cav3) on hERG exp

72 functional low-oligomeric pores, which mimic integral membrane protein channels in structure.

73 The aquaporin (AQP) family of integral membrane protein channels mediate cellular wate

74 Identified were two integral membrane proteins (Clmn, Nckap1) and one actin-

75 association between the cytoskeleton and the integral membrane protein compartment in the absence of

76 ne nucleotide transhydrogenase (PntAB) is an integral membrane protein complex participating in the r

77 Here we show for crystals of the integral membrane protein complex photosystem II that la

78 , the subunit stoichiometries of a series of integral membrane protein complexes, including the homom

79 Secreted and integral membrane proteins compose up to one-third of th

80 Integral membrane proteins comprise approximately 25% of

81 rs of the heme-copper oxidase superfamily of integral membrane proteins, comprising the O2-reducing,

82 HN is an oligomeric integral membrane protein consisting of an N-terminal tr

83 how that we can express methyl-labeled human integral membrane proteins cost-effectively by cell-free

84 hicles, medical imaging contrast agents, and integral membrane protein crystallisation media.

85 anced bacterial growth and normal epithelial integral membrane protein degradation, highlighting the

86 e-9 in BALF and were resistant to epithelial integral membrane protein degradation, suggesting that b

87 s and overexpressed ERdj4 associate with the integral membrane protein, Derlin-1.

88 pid bilayer are broadly understood to affect integral membrane proteins, details of these interaction

89 ppressor methodology was also applied to the integral membrane protein, diacylglycerol kinase A where

90 microsomes and demonstrate that numerous ER integral membrane proteins display RNA binding activity.

91 The transmembrane domains (TMDs) of integral membrane proteins do not merely function as mem

92 the superoxide-detoxifying enzyme (SodA), an integral membrane protein (DoxX), and a predicted thiol-

93 The integral membrane protein DsbB in Escherichia coli is re

94 The Dsc E3 ligase consists of five integral membrane proteins (Dsc1-Dsc5) and functionally

95 the spontaneous reconstitution of functional integral membrane proteins during the de novo synthesis

96 Following synthesis, integral membrane proteins dwell in the endoplasmic reti

97 The DNA phage PhiX174 encodes the integral membrane protein E whose expression leads to ho

98 ynamic interaction of AMOT with an endosomal integral membrane protein, endotubin (EDTB).

99 However, as a multisubunit, multispan, integral membrane protein, even wild type subunits of GA

100 It is also believed that CPR is an integral membrane protein exclusively.

101 pecific membrane antigen (PSMA) is a type II integral membrane protein expressed on the surface of pr

102 nkyrin polypeptides are essential for normal integral membrane protein expression in a number of cell

103 roteome analysis of an Escherichia coli K-12 integral membrane protein extract, the MAPS method in co

104 J paramyxovirus (JPV) encodes four integral membrane proteins: F, G, SH, and transmembrane

105 We found that KOC1 is an integral membrane protein facing the cytosol and stably

106 re and strictly associated with mutations in integral membrane proteins Fks1 or Fks2.

107 uires its operon partner ToxS, a periplasmic integral membrane protein, for full activity.

108 id binding to the ammonia channel (AmtB), an integral membrane protein from Escherichia coli.

109 l sorting and transport of newly synthesized integral membrane proteins from early endosomes to both

110 t is mediated by complexes formed from small integral membrane proteins from just two protein familie

111 retromer complex facilitates the sorting of integral membrane proteins from the endosome to the late

112 Most integral membrane proteins from the large CDP-alcohol ph

113 This suggests that the integral membrane protein FtsW forms a size-restricted p

114 Integral membrane protein function can be modulated by t

115 Most paramyxoviruses have two integral membrane proteins: fusion protein (F) and attac

116 static pressure (HHP) on aqueous soluble and integral membrane proteins has been investigated to some

117 The interrogation of intact integral membrane proteins has long been a challenge for

118 f the function of Smoothened (Smo), a 7-pass integral membrane protein, has defied standard biochemic

119 ay's major pharmaceutical drugs target human integral membrane proteins (hIMPs), only 30 hIMP structu

120 Integral membrane proteins (IMPs) are of great biophysic

121 Integral membrane proteins (IMPs) play crucial roles in

122 sites of hydrophobic ligand incorporation in integral membrane proteins (IMPs), where poor aqueous so

123 designed beta-strand peptides that stabilize integral membrane proteins (IMPs).

124 opportunity to compare the properties of an integral membrane protein in different artificial lipid/

125 ochondrial uncoupling protein 2 (UCP2) is an integral membrane protein in the mitochondrial anion car

126 e absence of NADPH and will transition to an integral membrane protein in the presence of stoichiomet

127 code a broadly conserved family of multipass integral membrane proteins in animals.

128 Solubilization of integral membrane proteins in aqueous solutions requires

129 oth the average number and variance of seven integral membrane proteins in brain synaptic vesicles.

130 are often used to study interactions between integral membrane proteins in cellular membranes.

131 w route to exploitation of such photovoltaic integral membrane proteins in device applications.

132 The heterologous overexpression of integral membrane proteins in Escherichia coli often yie

133 systematically localize known and predicted integral membrane proteins in Saccharomyces cerevisiae t

134 g the quality, quantity, and localization of integral membrane proteins in the cell, defects in these

135 The molecular basis for retention of integral membrane proteins in the endoplasmic reticulum

136 The abundance of integral membrane proteins in the plasma membrane is det

137 cally suited to identify PPIs of full-length integral membrane proteins in their native membrane envi

138 In a time where structural biochemistry of integral-membrane proteins in general still faces formid

139 While the downregulation of these integral membrane proteins, including CD81 and CD82, lik

140 Multi-spanning integral membrane proteins, including G-protein coupled

141 er-order oligomers is a property of numerous integral membrane proteins, including ion channels, tran

142 These domains contain integral membrane proteins, including the tetraspan prot

143 vel pathway for the insertion of a subset of integral membrane proteins into the Gram-negative outer

144 oss the cytoplasmic membrane or insertion of integral membrane proteins into the phospholipid bilayer

145 Ndc1 is a highly conserved integral membrane protein involved in insertion of both

146 M2 proton channel of influenza A virus is an integral membrane protein involved in the acidification

147 sferase (MBOAT) family, a group of polytopic integral membrane proteins involved in lipid-biosyntheti

148 Rce1p and Ste24p are integral membrane proteins involved in the proteolytic m

149 This predicted integral membrane protein is essential for controlling t

150 Structure determination of mammalian integral membrane proteins is challenging due to their i

151 The aquaporin family of integral membrane proteins is composed of channels that

152 Degradation of most integral membrane proteins is directed by the endosomal

153 overning the trafficking and localization of integral membrane proteins is limited and essentially un

154 The copper transporter (Ctr) family of integral membrane proteins is ubiquitously found in euka

155 Caveolin-3 (cav-3), an integral membrane protein, is a building block of caveol

156 d raft-like domains, whereas M2, although an integral membrane protein, is not raft associated.

157 atidic Acid Phosphatase type 2B (PPAP2B), an integral membrane protein known as lipid phosphate phosp

158 Integral membrane proteins known as porins are the major

159 , nucleosides require a specialized class of integral membrane proteins, known as nucleoside transpor

160 ions between Hh and Patched (Ptc), a 12-pass integral membrane protein, lead to modulation of the fun

161 The ectodomain of ephrin-B2, normally an integral membrane protein ligand, was conjugated to a so

162 The integral membrane protein LIMP-2 has been a paradigm for

163 ontaining (croquemort) or lacking (lysosomal integral membrane protein (LIMP) II) this glycine motif

164 The integral membrane proteins LMBD1 and ABCD4 are required

165 SCD1 is an integral membrane protein located in the endoplasmic ret

166 complexes further indicates that PSB33 is an integral membrane protein located in the vicinity of LHC

167 The thermostability of an integral membrane protein (MP) in detergent solution is

168 Integral membrane proteins (MPs) are key engineering tar

169 Integral membrane proteins (MPs) represent a class of pr

170 growing interest in studying and engineering integral membrane proteins (MPs) that play key roles in

171 m 18 different proteins, including the three integral membrane proteins Mps3, Ndc1, and Mps2.

172 the soluble protein serum albumin and to the integral membrane protein NapA shows that soluble protei

173 om lysosomes requires the cooperation of the integral membrane protein Niemann-Pick C1 (NPC1) and a s

174 mediated by the gp41 protein, a single-pass integral membrane protein of HIV.

175 Mutations in small integral membrane protein of lysosome/late endosome (SIM

176 Caveolin-1 is an integral membrane protein of plasma membrane caveolae.

177 H gene of Alcanivorax borkumensis encodes an integral membrane protein of the AbgT family of transpor

178 e report the first structural analysis of an integral membrane protein of the bacterial divisome.

179 The hpnN gene of B. multivorans encodes an integral membrane protein of the HpnN family of transpor

180 re used to establish that this protein is an integral membrane protein of the inner envelope, and spe

181 Mutations in the small integral membrane protein of the lysosome/late endosome

182 ule whose sequence is identical to the small integral membrane protein of the lysosome/late endosome.

183 cillin-binding proteins (PBPs) are essential integral membrane proteins of the bacterial cytoplasmic

184 Integral membrane proteins of the divalent anion/Na(+) s

185 The integral membrane proteins of the DP1 (deleted in polypo

186 The Orm family proteins are conserved integral membrane proteins of the endoplasmic reticulum

187 Integral membrane proteins often present daunting challe

188 nto acceptor asparagines is catalyzed by the integral membrane protein oligosaccharyltransferase (OST

189 sequon NX(S/T) of a secreted protein by the integral membrane protein oligosaccharyltransferase.

190 dentify the interfacial sites of a trimeric, integral membrane protein, OmpF, solubilised in micelles

191 in membranes determines the behavior of many integral membrane proteins or other membrane related-pro

192 Ubiquitin modification of integral membrane proteins (or "cargoes") generally acts

193 We found that two similar ER integral membrane proteins, oxysterol-binding protein (O

194 Subunit a is a 100-kDa integral membrane protein (part of V0) that possesses an

195 groups from the cytoplasm is performed by an integral membrane protein, PatA, for its transfer to pep

196 anding of the regulation and function of the integral membrane protein PEMT was improved when the enz

197 lcium pump (SERCA) is regulated by the small integral membrane proteins phospholamban (PLN) and sarco

198 endent manner via interaction with the short integral membrane proteins phospholamban (PLN) and sarco

199 ge to modulate the structural dynamics of an integral membrane protein, phospholamban (PLB), and ther

200 Integral membrane proteins play essential roles in all l

201 Sho1p, an integral membrane protein, plays a vital role in the hig

202 ETHYLENE INSENSITIVE2 (EIN2), an NRAMP-like integral membrane protein, plays an essential role in et

203 plit ubiquitin-based method for detection of integral membrane protein-protein interactions (PPIs) in

204 Ion mobility mass spectrometry of integral membrane proteins provides valuable insights in

205 ptors (GPCRs) represent the largest class of integral membrane protein receptors in the human genome.

206 eir performance and accuracy when applied to integral membrane proteins remained an open question.

207 mit the assembly and cellular trafficking of integral membrane proteins remains superficial.

208 elin O-acyltransferase (GOAT) is a polytopic integral membrane protein required for activation of ghr

209 pecific members of the tetraspanin family of integral membrane proteins required for morphogenesis an

210 The turnover of integral membrane proteins requires a specialized transp

211 Integral membrane proteins reside within the bilayer mem

212 oupled receptor (GPCR), the largest class of integral membrane proteins responsible for cellular sign

213 eurotransmitter:sodium symporters (NSSs) are integral membrane proteins responsible for the sodium-de

214 Ion pumps are integral membrane proteins responsible for transporting

215 We also show that the integral membrane protein Sap and MmpL8 are both essenti

216 a specialized membrane domain marked by the integral membrane protein Sidekick.

217 to characterize and study ligand binding to integral membrane proteins, specifically G-protein coupl

218 induced radiation damage are visible in this integral membrane protein structure.

219 n, in detergents are not well understood for integral membrane proteins such as G protein-coupled rec

220 racterization of the molecular properties of integral membrane proteins, such as topology and interdo

221 n meso crystallization to a broader range of integral membrane protein targets, the cubicon method sh

222 ustly predicted effects on expression of the integral membrane protein TatC for a set of 140 sequence

223 proteins work together to generate caveolae: integral membrane proteins termed caveolins and cytoplas

224 T is predicted to be an integral membrane protein that adopts an N(in)-C(out) to

225 Y is predicted to be an integral membrane protein that adopts an N-out C-in memb

226 iacylglycerol acyltransferase (DGAT)-2 is an integral membrane protein that catalyzes triacylglycerol

227 In Escherichia coli, FtsK is a large integral membrane protein that coordinates chromosome se

228 The serotonin transporter (SERT) is an integral membrane protein that exploits preexisting sodi

229 Human YME1L is shown to be an integral membrane protein that exposes its carboxy-termi

230 -binding cassette transporter A1 (ABCA1), an integral membrane protein that facilitates nascent HDL p

231 illomavirus is a short (44 amino acids long) integral membrane protein that forms homodimers.

232 or (Sigma1) is an endoplasmic reticulum (ER) integral membrane protein that is highly expressed in a

233 Caveolin-1 is an integral membrane protein that is the primary component

234 assays, we find that MYRF is generated as an integral membrane protein that must be processed to rele

235 P75NTR is a type I integral membrane protein that plays a key role in neuro

236 ce (BVES, also known as POPDC1 and POP1), an integral membrane protein that regulates TJ formation.

237 reflected the complexities of investigating integral membrane proteins that act on a totally insolub

238 TETRASPANIN (TET) genes encode conserved integral membrane proteins that are known in animals to

239 The tetraspanins (TSPs) are a family of integral membrane proteins that are ubiquitously express

240 t, diatoms have developed a unique family of integral membrane proteins that bind to a soluble form o

241 isaccharide transporter to the small list of integral membrane proteins that can be synthesised via i

242 ers (VITs) are a poorly understood family of integral membrane proteins that can function in iron hom

243 Glutamate transporters are integral membrane proteins that catalyse neurotransmitte

244 DHHC-S-acyltransferases are integral membrane proteins that catalyze the addition of

245 ce-nodulation-cell division efflux pumps are integral membrane proteins that catalyze the export of s

246 G protein-coupled receptors (GPCRs) are integral membrane proteins that change conformation afte

247 Adiponectin receptors (ADIPORs) are integral membrane proteins that control glucose and lipi

248 Notch and its ligands are integral membrane proteins that facilitate direct cell-c

249 se findings indicate that Asp1 to -3 are not integral membrane proteins that form structural parts of

250 G-protein-coupled receptors (GPCRs) are integral membrane proteins that have an essential role i

251 TMEM16A belongs to a family of integral membrane proteins that includes another CaCC, T

252 Integrins are integral membrane proteins that mediate cell-matrix and

253 ein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that modulate biological func

254 Neurotransmitter sodium symporters are integral membrane proteins that remove chemical transmit

255 t (Amt) proteins form a ubiquitous family of integral membrane proteins that specifically shuttle amm

256 eceptors (GPCRs) constitute a large group of integral membrane proteins that transduce extracellular

257 nucleoside transporters (ENTs) are polytopic integral membrane proteins that transport nucleosides an

258 Reaction centers (RCs) are integral membrane proteins that undergo a series of elec

259 Multidrug transporters are integral membrane proteins that use cellular energy to a

260 rmal chemical denaturation was applied to an integral membrane protein, the A2a G-protein coupled rec

261 Only one integral membrane protein, the endosomal Na+ (K+)/H+ exc

262 For integral membrane proteins, the mode of membrane associa

263 lity of the method is demonstrated with five integral membrane proteins: the beta2-adrenergic G prote

264 A subset of integral membrane proteins, therefore, requires an early

265 The phagophore is largely devoid of integral membrane proteins; thus, its shape and size are

266 The translocon is composed of the two integral membrane proteins Tim23 and Tim17, each contain

267 ble protein trafficking, processes targeting integral membrane proteins to cilia are poorly understoo

268 nocytes caused defects in the trafficking of integral membrane proteins to melanosomes with substanti

269 Targeting of most integral membrane proteins to the endoplasmic reticulum

270 n segregating the synthesis of secretory and integral membrane proteins to the ER.

271 ESCRT-I is required for the sorting of integral membrane proteins to the lysosome, or vacuole i

272 ld for endosomal protein complexes that sort integral membrane proteins to various cellular destinati

273 consistent with the Type II (N(cyt)/C(exo)) integral membrane protein topology, and extended hydroph

274 experimentally observed correlations between integral membrane protein topology, translocon mutagenes

275 protein secretion, membrane integration, and integral membrane protein topology.

276 via association with its receptor, lysosomal integral membrane protein type 2 (LIMP-2).

277 The lysosomal integral membrane protein type-2 (LIMP-2) plays a pivota

278 n of its trafficking receptor, the lysosomal integral membrane protein type-2 (LIMP-2), we studied al

279 Finding a way to determine the structures of integral membrane proteins using solution nuclear magnet

280 The endoplasmic reticulum (ER) integral membrane protein VAP is a common component of M

281 tor client of the lectin chaperone vesicular integral membrane protein, VIP36.

282 By recycling vitamin K, the two integral-membrane proteins, VKC and VKOR, maintain vitam

283 As all integral membrane proteins, voltage-gated ion channels a

284 identify interacting partners of full-length integral membrane proteins, we identified 43 novel inter

285 SLBs and particularly the behavior of their integral membrane-proteins, we used total internal refle

286 2, two closely related CUB domain-containing integral membrane proteins, were identified recently as

287 Aquaporins (AQPs) are integral membrane proteins whose function is to regulate

288 hoA fusions demonstrated it to be a bitopic, integral membrane protein with a cytoplasmic amino termi

289 on sites, we identified TMEM106B as a type 2 integral membrane protein with a highly glycosylated lum

290 ecursor protein (APP) is a large, ubiquitous integral membrane protein with a small amyloid-beta (Abe

291 Bitopic integral membrane proteins with a single transmembrane h

292 Phosphoglycosyl transferases (PGTs) are integral membrane proteins with diverse architectures th

293 ocon to block the production of secreted and integral membrane proteins with high potency.

294 oglycosyltransferases (PGTs) are families of integral membrane proteins with intriguingly diverse arc

295 te that TMTC1 and TMTC2 are both ER resident integral membrane proteins with multiple clusters of TPR

296 cleaving protease that processes many type-I integral membrane proteins within the lipid bilayer, an

297 he abundance, distribution and repertoire of integral membrane proteins within their immense, archite

298 s are transported to the cell surface by the integral membrane protein WLS (also known as Wntless, Ev

299 the rhodanese domain of the Escherichia coli integral membrane protein YgaP by NMR, X-ray crystallogr

300 solution NMR structure of the alpha-helical integral membrane protein YgaP from Escherichia coli in