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1 ds for the development of a new class of HIV integrase inhibitor.
2 n between boceprevir and raltegravir, an HIV integrase inhibitor.
3 ter molecule could open a route to new HIV-1 integrase inhibitors.
4 and offer new catechol isosteres for use in integrase inhibitors.
5 h the identification and characterization of integrase inhibitors.
6 rmation which may guide the future design of integrase inhibitors.
7 oumermycin monomeric derivatives were active integrase inhibitors.
8 cleoside reverse transcriptase inhibitors or integrase inhibitors.
9 rus harboring resistance to first-generation integrase inhibitors.
10 dapivirine, rilpivirine, maraviroc, and new integrase inhibitors.
11 IN119 is under selection by HLA alleles and integrase inhibitors.
12 ted PI monotherapies and future options with integrase inhibitors.
13 the viral genome after intensification with integrase inhibitors.
14 viral DNA processing site for inhibition by integrase inhibitors.
15 as well as for the molecular pharmacology of integrase inhibitors.
16 oward the potential design of improved HIV-1 integrase inhibitors.
23 inding to the viral RNA genome by allosteric integrase inhibitors (ALLINIs) or through mutations with
25 avir has been shown to be non-inferior to an integrase inhibitor and superior to a non-nucleoside rev
27 reen a library of chemicals related to known integrase inhibitors and found a new compound, quinaliza
28 cell depletion, raising the possibility that integrase inhibitors and interventions directed towards
29 that is applicable to a wide range of potent integrase inhibitors and is consistent with the availabl
33 Human immunodeficiency virus type 1 (HIV-1) integrase inhibitors are in clinical trials, and raltegr
34 e between pre- and post-integration latency, integrase inhibitors are routinely used, preventing nove
36 leoside reverse transcriptase inhibitors and integrase inhibitors are used to treat infection with HI
38 The findings support guidelines recommending integrase inhibitor based regimens in first-line antiret
42 would be the only single-tablet, once-daily, integrase-inhibitor-based regimen for initial treatment
43 s given, EVG/COBI/FTC/TDF would be the first integrase-inhibitor-based regimen given once daily and t
44 progress toward a clinically effective HIV-1 integrase inhibitor can at least in part be attributed t
45 rystal structure studies illustrate specific integrase-inhibitor contacts that prevent cross-linking
47 that the rapid decay observed in patients on integrase-inhibitor-containing regimens is not necessari
51 human immunodeficiency virus type-1 (HIV-1) integrase inhibitors dolutegravir (S/GSK1349572) (3) and
53 ty of the human immunodeficiency virus (HIV) integrase inhibitor elvitegravir to comparator ritonavir
56 appears to be a more favorable effect of the integrase inhibitor EVG over efavirenz on immune activat
58 macophore of aryl beta-diketo acids (DKA) as integrase inhibitors, fails in certain cases of highly e
60 very of 10 novel, structurally diverse HIV-1 integrase inhibitors, four of which have an IC50 value l
61 linking assays to probe the binding sites of integrase inhibitors from different chemical families an
62 d virological failure with resistance in the integrase inhibitor group compared with three participan
66 human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, has limited cross-resistance to ral
68 The structures of a large number of HIV-1 integrase inhibitors have in common two aryl units separ
69 leoside reverse transcriptase inhibitors and integrase inhibitors have slopes of approximately 1, cha
70 TIs (NNRTIs), protease inhibitors (PIs), and integrase inhibitors (IIs) did not affect HK2, except fo
71 linical demonstration of the activity of any integrase inhibitor in subjects with HIV-1 resistant to
73 automated LC-MS/MS methods to quantify five integrase inhibitors in plasma with the limits of quanti
74 cleotide (e.g., human immunodeficiency virus integrase) inhibitors, in applications such as antisense
75 (DTG), a human immunodeficiency virus (HIV) integrase inhibitor (INI), would be efficacious in INI-r
78 genotypes exclude testing for resistance to integrase inhibitors ("IR testing"), although this class
81 AG1/2 and integrase and suggest that certain integrase inhibitors may have the potential to interfere
82 results further indicate that resistance to integrase inhibitors may include both integrase and LTR
83 tiretroviral drugs under study, particularly integrase inhibitors, may prove useful in treatment-naiv
85 ble long-term efficacy and safety profile in integrase-inhibitor-naive patients with triple-class res
86 curcumin analog with the recently described integrase inhibitor NSC 158393 resulted in integrase inh
87 HIV-1 integrase, we sought to determine how integrase inhibitors of the diketo acid type would affec
92 cells infected either in the presence of an integrase inhibitor or with an integrase-deficient virus
94 148R(H)(K) that reduce susceptibility to the integrase inhibitor raltegravir have been identified in
96 y acquired significant resistance to APV, an integrase inhibitor raltegravir, and a GRL-09510 congene
99 289 were randomly assigned to receive the integrase inhibitor regimen and 286 to receive the prote
100 the safety and efficacy of the single tablet integrase inhibitor regimen containing elvitegravir, cob
101 citabine, and tenofovir disoproxil fumarate (integrase inhibitor regimen) or ritonavir-boosted atazan
103 When present in certain combinations, some integrase inhibitor resistance mutations increased resis
107 on data derived from a large number of HIV-1 integrase inhibitors, similar structural features can be
108 xil fumarate, saquinavir, atazanavir, and an integrase inhibitor starting at 12 days after inoculatio
110 It has been shown that L-731988, a potent integrase inhibitor, targets a conformation of the integ
111 for T30695, which is the most potent of the integrase inhibitors that have been identified thus far.
114 significantly shorter in those receiving an integrase inhibitor- versus a protease inhibitor-based r
115 ase inhibitors, 7 protease inhibitors, and 1 integrase inhibitor was achieved in 0.25 g of meconium.
116 human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, was evaluated for distribution and
117 avir (S/GSK1349572), a once-daily, unboosted integrase inhibitor, was recently approved in the United
119 uctural leads for the development of new HIV integrase inhibitors which do not rely on this potential
120 rk has resulted in the identification of new integrase inhibitors which may be regarded as bis-caffeo
121 ence of reverse-transcriptase inhibitors and integrase inhibitors, which allows for the specific isol
122 nhibitors were quinolone antibiotics and HIV integrase inhibitors, which share common structural feat
124 tructural basis and rationale for developing integrase inhibitors with the potential for unique and n
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