ライフサイエンスコーパス: integrative

1 nts for all four tracts, both segregated and integrative.

2 Motor, sensory, and integrative activities of the brain are coordinated by a

3 We address this ambiguity by developing an integrative allometric approach, which we apply here to

4 This proteomic procedure is here proposed as integrative/alternative to the ERM.

5 Furthermore, integrative analyses (microRNA and gene expression profi

6 data remains challenging, particularly when integrative analyses are used to combine multiple sh/sgR

7 Such integrative analyses can be used to address concerns abo

8 ted to FCRx-induced tolerance and the use of integrative analyses for identifying upstream regulators

9 Integrative analyses further found differentially expres

10 Burgeoning interest in integrative analyses has produced a rise in studies whic

11 e conducted cross-study, cross-data type and integrative analyses of the multidimensional data deposi

12 les, and developed a platform for performing integrative analysis and reconstruction of the epigenome

13 We hypothesized that an integrative analysis combining CKD GWAS and kidney eQTL

14 e different HSI data sets and by the lack of integrative analysis concepts.

15 The integrative analysis demonstrated that altered expressio

16 In summary, this integrative analysis demonstrates a complex interaction

17 Overall integrative analysis identified an interrelated gene net

18 An integrative analysis identified neuronatin (Nnat) as a p

19 sion in ESC, and demonstrates the utility of integrative analysis of a manually curated compendium of

20 In addition, based on integrative analysis of both WGCNA and transcription fac

21 Integrative analysis of ChIP-seq and microarray data set

22 eCLIP enables integrative analysis of diverse RBPs to reveal factor-sp

23 Here, we perform an integrative analysis of human NSCLC tumour samples, pati

24 infers molecular pathways and components via integrative analysis of metabolite features, without req

25 Integrative analysis of multi-omics data is becoming inc

26 hput data types, but methods are lacking for integrative analysis of multiomics experiments.

27 lic repositories creates a pressing need for integrative analysis of multiple datasets from independe

28 xture model based approach to the concordant integrative analysis of multiple large-scale two-sample

29 m, and few user-friendly resources exist for integrative analysis of NGS data from different sources

30 Using an integrative analysis of RA risk alleles, the transcripto

31 Integrative analysis of somatic mutations with transcrip

32 disease incidence is further inferred by an integrative analysis of TCGA data and the data from the

33 Further integrative analysis of the genome-wide transcriptome an

34 more light onto the pathogenesis of PTFL, an integrative analysis of these mutations was undertaken i

35 rize-collecting Steiner forest algorithm for integrative analysis of untargeted metabolomics (PIUMet)

36 We performed an integrative analysis of whole blood gene expression and

37 An integrative analysis of whole-exome and RNA-sequencing d

38 Here, we performed an integrative analysis of whole-exome sequencing and trans

39 Integrative analysis of whole-genome/exome-sequencing da

40 This integrative analysis offers an initial picture of the co

41 litates non-coding driver identification and integrative analysis points to candidates of potential c

42 The resulting integrative analysis provides a framework for understand

43 scovery of subdominant binding motifs and an integrative analysis quantifying the contribution of fac

44 Our integrative analysis reveals cell type-specific and geno

45 The integrative analysis reveals two distinct tumor types: t

46 Integrative analysis that incorporates known functional

47 Integrative analysis that incorporates such functional a

48 This work provides a novel genome-scale integrative analysis to propose putative transcriptional

49 We thus developed an integrative analysis tool, Methylation-based Gene Expres

50 stic activities both in vitro and in vivo An integrative analysis using both whole-transcriptome sequ

51 Integrative analysis using SNF further delineates group

52 Through an integrative analysis, we discovered frequent silencing o

53 efficient computational techniques for such integrative analysis.

54 Additionally, CIPHER's integrative "analysis" mode allows researchers to elicit

55 een graphene and immune cells, we propose an integrative analytical pipeline encompassing the evaluat

56 unity and glucose metabolism in a whole-body integrative and a neuronal-dependent network, will unvei

57 A repair mutY gene caused by insertion of an integrative and conjugative element.

58 Integrative and conjugative elements (ICEs) are ubiquito

59 ernomics outperforms existing algorithms for integrative and consensus clustering.

60 t are not limited to one discipline, but are integrative and relevant for physiology, psychophysiolog

61 ilable datasets and performed "-omics"-based integrative, and network topology analyses to decipher t

62 Using an integrative annotation pipeline, we assembled tissue-spe

63 We show that the integrative approach can link biologically meaningful se

64 In an integrative approach combining crystal coordinates, bioc

65 These results demonstrate that an integrative approach combining MHC isolation, peptide id

66 Diodora from Cape Verde Islands, we used an integrative approach combining molecular phylogenetics w

67 An integrative approach combining quantitative genetics, ex

68 By employing an integrative approach combining small-angle neutron scatt

69 This integrative approach demonstrates that HFD elicits a com

70 We used an integrative approach entailing transcriptomic studies in

71 ree dimensions, highlighting the need for an integrative approach for biodiversity conservation.

72 Precision medicine is an emerging integrative approach for disease prevention, early detec

73 In conclusion, this integrative approach involving chemical profiling and DN

74 Furthermore, the semi-integrative approach is evaluated which reveals that it

75 This integrative approach nominated an extracellular matrix g

76 An integrative approach of blending the data with clinical

77 Specifically, an integrative approach of gene transfer, systems and brain

78 Using an integrative approach that combines Drosophila melanogast

79 Here, using an integrative approach that combines small angle X-ray sca

80 Here, we present an integrative approach that leverages 1D functional genomi

81 A systematic review using an integrative approach to data inclusion and analysis comp

82 need for cross-disciplinary research with an integrative approach to data science, whereby basic scie

83 isting data makes it possible to take a more integrative approach to examining how the consequences o

84 nded Doppler echocardiography (ECHO)-derived integrative approach to identify asymptomatic patients w

85 We present FATHMM-indel, an integrative approach to predict the functional effect, p

86 re OMR and adverse outcome than ECHO-derived integrative approach warranting close follow-up and perh

87 vealed the superiority of our newly proposed integrative approach.

88 iological parameters can be derived using an integrative approach.

89 lapse 75%) defined by using the ECHO-derived integrative approach.

90 c research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotype

91 om model organisms, functional genomics, and integrative approaches can empower the discovery of nove

92 Integrative approaches characterizing the interactions a

93 However, integrative approaches must accommodate the challenges i

94 The multilayered integrative approaches presented here provide a roadmap

95 Comparison of our approach with other integrative approaches such as Condel, CoVEC, CAROL, CAD

96 , the co-morbidities of psoriasis, and novel integrative approaches to genome-wide association studie

97 Integrative approaches which aim at associating the comp

98 x 10(-8) cm(2) s(-1) for Nicholson and semi-integrative approaches, respectively, using 0.05 M FeCl3

99 ent genomic and computational strategies, or integrative approaches, to address specific biologic and

100 he real-time impedance responses provided an integrative assessment of the cellular consequence to GP

101 le functional annotations simultaneously for integrative association analysis with efficient computat

102 Integrative bioinformatics and reverse genetic approache

103 ided by six central questions, we propose an integrative bottom-up approach for studying the dynamics

104 role of the pulvinar in current theories of integrative brain functions supporting cognition and goa

105 eem counterintuitive given that multisensory integrative capabilities ordinarily develop during early

106 te a modern neuroscience perspective into an integrative case formulation.

107 nd biology to being inextricably linked with integrative challenges that span biology, physics, mathe

108 Using integrative cistromic, epigenomic, transcriptomic, and i

109 regions of the genome, we propose CScape, an integrative classifier for predicting the likelihood tha

110 capture, transcriptomes, CRISPR screens, and integrative clinical biomarker studies.

111 Most existing algorithms for integrative clustering assume that there is a shared con

112 Medulloblastoma subtypes identified through integrative clustering have important implications for s

113 Integrative clustering is used to identify groups of sam

114 Using an algorithm for integrative clustering that simultaneously assesses gene

115 This stratification of breast cancers into integrative clusters reveals prototypical patterns of si

116 newer classification of breast cancers into integrative clusters.

117 Integrative CNA analyses of 97 CTCs from 23 patients con

118 We developed an integrative computational framework to identify kaempfer

119 Developing integrative computational methods to analyze these diver

120 We propose here a new integrative computational pharmacogenomic approach, refe

121 xchanging mobile genetic elements, including integrative conjugative elements (ICEs), with the local

122 perfectly match the designed sequence using integrative cotransformation and clustered regularly int

123 Integrative data analysis reveals that a total of 37 gen

124 that the brain can calculate contrastive and integrative dependencies simultaneously from recent stim

125 hasize the need for a paradigm shift towards integrative disease modeling and neuroimaging biomarker-

126 fundamental role of ecological pressures on integrative energetic networks and the still poorly unde

127 utational prediction of TFBSs using a novel, integrative energy (IE) function.

128 verlapping fragments along with a simplified integrative energy function for transcription factor bin

129 ew pentamer approach along with a simplified integrative energy function improved transcription facto

130 transcription factor binding sites using an integrative energy function that combines a knowledge-ba

131 Conversely, we found that the otherwise integrative enzyme pyruvate carboxylase (TgPyC) is dispe

132 Recent integrative epigenome analyses highlight the importance

133 An integrative epigenomic approach revealed 10,504 differen

134 rds an endodermal cell fate by employing non-integrative episomal reprogramming factors in combinatio

135 We believe our study provides the first integrative evidence for a gliogenetic basis that involv

136 Our findings provide strong integrative evidence that urban blue tit nestlings are n

137 idence-based scoring scheme based on current integrative evidences, mTCTScan is able to prioritize mu

138 ypoxic gene expression in monocytes using an integrative experimental approach.

139 An integrative experimental/theoretical approach allows us

140 Integrative explanations of why obesity is more prevalen

141 An integrative expression analysis revealed that the WNT pa

142 Considering how communities change in an integrative fashion, rather than focusing on one axis of

143 nd present several examples illustrating its integrative features for hypothesis generation.

144 In this work, we used an Integrative FourD omics approach (INFO) that consists of

145 rade on public health across China within an integrative framework.

146 ta to identify novel driver genes through an integrative framework.

147 In this study, we developed an integrative functional genomics methodology to identify

148 Here we apply integrative functional genomics strategies to elucidate

149 an be seen as a manifestation of the brain's integrative functions.

150 r conducting formal hypothesis testing on an integrative gene set level is considerably sparse.

151 In this issue of Cell, Reddy et al. report integrative genetic characterization of diffuse large B

152 ipt levels, which gave rise to the field of "integrative genetics".

153 rgets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses.

154 vioral, electrophysiological, molecular, and integrative genomic analyses with focus on schizophrenia

155 Here, integrative genomic analysis identified MYST3 as a poten

156 Integrative genomic analysis of the human AD brain trans

157 Integrative genomic and proteomic analysis of non-small

158 Using an integrative genomic approach, we identify 53 genomic reg

159 We employed an integrative genomics analysis of master TFs CREB1 and Fo

160 Overall, this integrative genomics approach identified cancer hallmark

161 The present study uses an integrative genomics approach to explore mechanistic cha

162 Thus, the application of integrative genomics to an extensive cohort of clinical

163 The Integrative Genomics Viewer (IGV) was one of the first t

164 dictors is a fundamental statistical task in integrative genomics, exemplified by numerous expression

165 First, an integrative global measure may be best for species in wh

166 ising the leverage of RNA-Seq and performing integrative GWAS-eQTL analysis against gene, exon, and s

167 adversity on offspring growth, we propose an integrative hypothesis: developmental constraints and a

168 Our network presents a foundation towards integrative investigations of community-scale microbial

169 We propose a new network approach-integrative Joint Random Forest (iJRF), which characteri

170 Hence, we devised a novel, supervised, integrative learning framework to perform whole-genome m

171 d conformational landscapes complement in an integrative manner the available experimental data on [F

172 the need to consider context-dependence and integrative measurements when assessing the impact of an

173 ork has specifically examined these proposed integrative mechanisms and the causal role of these regi

174 Synaptic integrative mechanisms have profound effects on electric

175 Here we review roles for synaptic integrative mechanisms in the selection, generation and

176 Additional integrative Mendelian randomization analyses of gene exp

177 Integrative metabolomic and genomic profiling further id

178 By using integrative metabolomics in a mouse model and human biop

179 ession changes across tissues and provide an integrative method for interpretation of rare variants i

180 Here we propose a new integrative method to study this dynamic process by cons

181 In this study, we introduced an integrative method, LogicTRN, to decode TF-TF interactio

182 More sophisticated, integrative methods have been described, but commonly su

183 Finally, we describe a revised integrative model for sleep/wake regulation.

184 A tentative integrative model of supportive care for frail older peo

185 nalyze more than two genomic variables in an integrative, model-based way.

186 Integrative modeling and solution X-ray scattering studi

187 Our approach provides a new integrative modeling approach for both reliable gene dis

188 own structure and characterized it using our integrative modeling approach.

189 enging task in structural biology when using integrative modeling approaches.

190 In this work we propose an integrative modeling method for constructing high-resolu

191 rkedly increased the predictive power of the integrative modeling strategy enabling more accurate pro

192 e to combine experiment and computation into integrative models of biomolecular structure and dynamic

193 together, these findings form the basis for integrative models of fetal neurodevelopment, which prop

194 ics, here we developed a series of atomistic integrative models with available crystal structures of

195 In this study, we carried out an integrative molecular analysis to identify interactions

196 th novel statistical models to enable a more integrative monitoring and assessment of the multiple fa

197 This integrative multi-omics approach permits more detailed s

198 In parallel, integrative multi-omics investigations have generated hi

199 OR signaling pathway regulator) makes highly integrative multibranching contacts with the PP2A cataly

200 included studies were synthesised using the integrative narrative approach.

201 Integrative narrative review.

202 Our multi-layer proteomics profiling, integrative network analysis, and functional studies def

203 , we constructed Hetionet (neo4j.het.io), an integrative network encoding knowledge from millions of

204 the rich club, properties consistent with an integrative network function-these nodes are more highly

205 a scalable and widely applicable and robust integrative network modelling framework for the discover

206 Our integrative network-based methodology, exemplified in th

207 Members of the Integrative Neuroscience Initiative on Alcoholism (INIA-

208 Members of the Integrative Neuroscience Initiative on Alcoholism (INIA-

209 ogether, these perspectives contribute to an integrative, neuroscience-informed approach to case form

210 in human lung adenocarcinomas (LuADCs) using integrative omics analyses, and discover that mRNA level

211 Our findings highlight the power of integrative omics and biochemical analyses for annotatin

212 Here, we present Online Resource for Integrative Omics, a web-based resource with an intuitiv

213 Our integrative "-omics"--based analyses identified dynamic

214 Here, using integrative 'omics' analysis, we identified an arachidon

215 trong need for mapping methods, particularly integrative ones.

216 bservations not only reveal this fundamental integrative operation, but also identify quantitatively

217 The positive dependency for motion shows an integrative perceptual effect and was unexpected, althou

218 Metabolomics offers a unique integrative perspective for health research, reflecting

219 in structure and function from an explicitly integrative perspective, network neuroscience pursues ne

220 r-induced chlorophyll fluorescence (SIF), an integrative photosynthetic signal of molecular origin, c

221 wed as being reflective of the diminution of integrative physiological prowess that occurs solely as

222 ) provides a thorough assessment of exercise integrative physiology involving the pulmonary, cardiova

223 s of the enzymatic activity, and provides an integrative picture of the activation mechanism that exp

224 and genomics lies in their translational and integrative potential with other research approaches (e.

225 Collectively, this study presents an integrative procedure for -omics data exploitation, givi

226 POINTS: The present study examines dendritic integrative processes that occur in many central neurons

227 esult, they provide a means of comparing the integrative profiles among neurons and evaluating how th

228 te the general importance of fine-tuning the integrative properties of neuronal dendrites to their de

229 These findings highlight the integrative properties of subcortical neurons at the cer

230 strength of each individual synapse, and the integrative properties of the postsynaptic dendrites.

231 Thus, the matching of dendritic integrative properties with the density of innervation i

232 Our integrative proteogenomic analysis highlights the potent

233 of ECM and AM plants in a stand can provide integrative proxies for key biogeochemical processes.

234 iple soil characteristics into one variable (integrative proxies).

235 The Integrative Psychiatric Research (iPSYCH) consortium has

236 tudies underwent quality appraisal using the Integrative Quality Criteria for Review of Multiple Stud

237 Conclusion Integrative radiogenomic analysis demonstrates an associ

238 tion should be favored by interdisciplinary, integrative research organizations working simultaneousl

239 The future of dermatology lies in integrative research, in which clinicians, laboratory sc

240 this novel experimental approach provides an integrative resource to study transcriptional and metabo

241 for visual and auditory modalities, stronger integrative responses in bimodal voxels, and it was orga

242 The aim of this integrative review is to appraise healthcare professiona

243 The purpose of this integrative review is to: (1) identify the characteristi

244 Whittemore and Knafl integrative review method was used, in conjunction with

245 METHODS AND An integrative review of the literature was conducted to cr

246 An integrative review was conducted using the Whittemore an

247 An integrative review was used to identify and integrate th

248 In this integrative review, we analyzed published evidence in th

249 Integrative review.

250 l areas which had been subject to systematic/integrative reviews or meta-analyses.

251 An accompanying paper focuses on the integrative role of K(+) channels in cardiac electrophys

252 r compared to that of polar organic chemical integrative samplers (POCIS) deployed simultaneously.

253 this represents the first application of an integrative schistosomiasis transmission model at a whol

254 rative search promotes greater patience than integrative search.

255 o conditions promoting either comparative or integrative search.

256 le to acceleration versus delay framing than integrative searchers, who integrate the features of an

257 Our results show that integrative sequence analysis provides a clinically rele

258 , the framework we propose offers a scalable integrative solution to improve splicing code modeling a

259 the fabrication of the network and enhances integrative stability but also broadens the natural piez

260 We have developed an integrative, stand-alone workflow platform, named CIPHER

261 This study introduces an effective integrative strategy for drug repositioning, and identif

262 Here, we employed an integrative strategy for the repositioning of drugs as n

263 lar kinase involved in the regulation of the integrative stress response (ISR) and pro-inflammatory p

264 different eIF2alpha kinases function in the integrative stress response to inhibit general protein s

265 We used integrative structural biology to visualize the architec

266 he yeast spindle pole body (SPB) by Bayesian integrative structure modeling based on in vivo fluoresc

267 tecture of the Ecm29-proteasome complex with integrative structure modeling.

268 This integrative study improves our understanding of predispo

269 Here we perform an integrative study of Zea mays (maize) seed development i

270 To address the need for an integrative summary, we review various types of replicat

271 ction, this study used electrophysiology and integrative synaptomics in a translational nonhuman prim

272 el developed provides a sensitive and highly integrative system for identifying estrogenic chemicals,

273 mor Heterogeneity Extensible Modeling via an Integrative System), which allows for the joint analysis

274 Using an integrative systems biology approach, we also revealed t

275 Here, we employed an integrative systems immunology approach to identify tran

276 Sst-GABA DMV neurons may serve as integrative targets for modulating vagal output activity

277 The integrative taxonomic approach has helped deliver signif

278 We address the current state of integrative taxonomy by using as a case study an interna

279 Nevertheless, the general application of integrative taxonomy has not been without issue, reveali

280 Formalization of integrative taxonomy in the past decade has provided a f

281 that must be considered when undertaking an integrative taxonomy project.

282 Integrative taxonomy was applied to the genus Protaphoru

283 s study highlights the potential benefits of integrative taxonomy, particularly simultaneous use of m

284 Our integrative technique lends itself to samples such as tu

285 eveloped a force-activatable biosensor named integrative tension sensor (ITS) which directly converts

286 Whether in sign or speech, language is more integrative than the target article suggests.

287 hors' viewpoint is discussed in light of the integrative theory of numerical development along with i

288 The integrative topological indexes representing 95.96% info

289 nnectivity is reduced in both segregated and integrative tracts in the striatal associative loop in c

290 Integrative transcriptomic and proteomic analysis of miR

291 Here we adopted integrative translational and reverse-translational appr

292 Mathematical models can facilitate an integrative understanding of the complexity underlying b

293 l cell regulation are well characterised, an integrative understanding of the orchestration of these

294 Here we provided series of integrative vectors with various affinity tags, includin

295 An extended integrative view also proves advantageous in terms of co

296 A more integrative view embraces not only sign/speech and co-si

297 Integrative visualization approaches such as provided by

298 However, the lack of intuitive and integrative web servers impedes the progress of making e

299 The striatum receives segregated and integrative white matter tracts from the cortex facilita

300 C9 purified from human blood serum, using an integrative workflow combining high-resolution native ma