ライフサイエンスコーパス: integrator

1 o a CPU-based ordinary differential equation integrator.

2 ng mediated by adhesions playing the role of integrator.

3 lay diminished growth following depletion of Integrator.

4 OVEREXPRESSION OF CO1 (SOC1), another floral integrator.

5 position signal implies participation in the integrator.

6 ortly after by repression of the SOC1 floral integrator.

7 d to fusion of AV percepts in a multisensory integrator.

8 at can potentially act as a time/temperature integrator.

9 afish oculomotor velocity-to-position neural integrator.

10 nsduction, using Rap1 as a downstream signal integrator.

11 sphorylates INTS11, the catalytic subunit of Integrator.

12 ucleus (RTN), a putative CRC and chemoreflex integrator.

13 olding in time is encoded via a set of leaky integrators.

14 d at the molecular level by so-called floral integrators.

15 ated in processing units we call filters and integrators.

16 ual excitation between two effector-specific integrators.

17 The bridging integrator 1 (BIN1) gene has recently been identified in

18 Bridging integrator 1 (BIN1) is a T-tubule protein associated wit

19 Given that bridging integrator 1 (BIN1) organizes t-tubule microfolds and fa

20 athy (CNM2), caused by mutations in bridging integrator 1 (BIN1), is a mildly progressive neuromuscul

21 protein 1-like protein 1 (NAP1L1), bridging integrator 1 (Bin1, also known as amphiphysin II), and v

22 embrane deformation protein cardiac bridging integrator 1 (cBIN1 or BIN1+13+17) creates transverse-tu

23 rosophila Integrator subunits and found that Integrators 1, 4, 9, and 11 were essential for 3'-end fo

24 amphiphysin 2 (BIN1, also known as bridging integrator-1) and dynamin 2 (DNM2), two ubiquitous prote

25 tions for the N-BAR domain protein, Bridging integrator 3 (Bin3), during myogenesis in mice.

26 were essential for 3'-end formation and that Integrators 3 and 10 may be dispensable for processing.

27 Finally, flies harboring mutations in either Integrator 4 or 7 fail to complete development and accum

28 This direction can be dictated by their path integrator [5] but can also be set using terrestrial vis

29 We introduce DNA/RNA-Integrator (DR-Integrator), a statistical software tool to perform inte

30 The switch operates as a short-term integrator, a property that can improve the reliable con

31 In this work, we introduce Omics Integrator, a software package that takes a variety of '

32 ll-based complementation assay that measures Integrator activity, we determined that the IntS9 intera

33 processing of HVS pre-miRNAs also depends on Integrator activity.

34 osition was imaged throughout the oculomotor integrator after saccadic or optokinetic stimulation.

35 The ICE data integrator allows users to retrieve and combine data set

36 Omics Integrator also provides an elegant framework to incorpo

37 n that emerges as a critical transcriptional integrator among pathways regulating differentiation, pr

38 response in human cells is funneled through Integrator, an RNA polymerase II-associated complex.

39 In 2002 a neural integrator, analogous to that in the ocular motor system

40 itment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.

41 ork of linked multipolar connectors as a key integrator and determinant of K-fiber structure and func

42 Interaction between Integrator and HVS primary miRNA (pri-miRNA) substrates

43 mTORC1 is a signal integrator and master regulator of cellular anabolic pro

44 RanBP9 and RanBP10 may function as signaling integrators and dictate the efficient regulation of D(1)

45 The TRPV1 receptor functions as a molecular integrator, and blockade of this receptor modulates enha

46 hibition, that neural populations can act as integrators, and that the objective of timed behavior is

47 Genes encoding floral integrators are differentially regulated in the triple m

48 Neural integrators are involved in a variety of sensorimotor an

49 We propose Integrator as a crucial transcriptional coactivator in M

50 offers multiple deterministic and stochastic integrators, as well as tools for steady-state analysis,

51 ogates the stimulus-dependent recruitment of Integrator at immediate early genes and their enhancers.

52 ealed that these behave as phase-independent integrators at low firing rates, and switch to a phase-d

53 We conclude that the branching integrators BRC1 and BRC2 are necessary for responses to

54 ts demonstrate that HA can serve as a signal integrator by facilitating TGF-beta1-mediated CD44-EGF-R

55 ging the activity in an impaired head neural integrator, by modulating feedback, could treat dystonia

56 are capable of inhibiting the key signaling integrator c-Abl (Abl1), resulting in massive cytopathic

57 The genetically encoded fluorescent calcium integrator calcium-modulated photoactivatable ratiobetri

58 The genetically encoded fluorescent calcium integrator calcium-modulated photoactivatable ratiobetri

59 lcium-modulated photoactivatable ratiometric integrator (CaMPARI) is a genetically encoded calcium in

60 lcium-modulated photoactivatable ratiometric integrator (CaMPARI) is a genetically encoded calcium in

61 lcium-modulated photoactivatable ratiobetric integrator (CaMPARI) reports calcium influx induced by s

62 lcium-modulated photoactivatable ratiobetric integrator (CaMPARI) reports calcium influx induced by s

63 ocessing, HVS pre-miRNA 3' end processing by Integrator can be uncoupled from transcription, enabling

64 neural network consisting of coupled neural integrators captures the neural dynamics of the experime

65 e electron microscopy, we identify potential integrator cells.

66 These studies define an integrator circuit for sleep homeostasis and provide a m

67 Integrator circuit models characterized by multiple dime

68 The Data Integrator combines columns from multiple data tracks, s

69 etal junction may act as a cortical temporal integrator, combining estimates of self-motion velocity

70 The metazoan Integrator complex (INT) has important functions in the

71 Instead, the Integrator complex cleaves to generate the 3' end of the

72 The Drosophila integrator complex consists of 14 subunits that associat

73 rocessing efficiency, demonstrating that the Integrator complex does not share components with the mR

74 The Integrator Complex is a group of proteins responsible fo

75 The Integrator complex substitutes for the mRNA cleavage and

76 IntS11 forms a stable complex with Integrator complex subunit 9 (IntS9) through their C-ter

77 ed for recruitment of the gene type-specific Integrator complex to the Pol II-transcribed small nucle

78 ent purification of novel components for the Integrator complex, analyze the composition of the Media

79 aled INTS6, a gene encoding a subunit of the Integrator complex, as an in vivo Cdc73 target.

80 find that Zfp609 and Nipbl interact with the Integrator complex, which functions in RNA polymerase 2

81 The host cell Integrator complex, which recognizes the snRNA 3' end pr

82 d1 and with the RNA Polymerase II-associated Integrator complex.

83 poorly understood set of proteins called the Integrator complex.

84 nsiveness requires the catalytic activity of Integrator complex.

85 Because they are key signal integrators connecting cellular processes to clinical ou

86 This makes STN cells exceptional temporal integrators, consistent with the common view that basal

87 hin the neurovascular unit to serve as vital integrators, coordinators and effectors of many neurovas

88 The light signaling integrators DE-ETIOLATED 1 and CONSTITUTIVE PHOTOMORPHOG

89 ocation in a fashion consistent with bounded integrator decision-making frameworks.

90 Integrator depletion diminishes ERK1/2 transcriptional r

91 n (Lpd) functions as an important signalling integrator downstream of growth factor and axon guidance

92 We introduce DNA/RNA-Integrator (DR-Integrator), a statistical software tool

93 tablish the Hcrt-LC connection as a critical integrator-effector circuit that regulates NREM sleep/wa

94 ments stem from a malfunctioning head neural integrator, either intrinsically or as a result of impai

95 These leaky integrators encode the Laplace transform of their input.

96 Ocular motor neural integrators ensure that eyes are held steady in straight

97 nscription, enabling new approaches to study Integrator enzymology.

98 In the absence of Integrator, eRNAs remain bound to RNAPII and their prima

99 ter assays revealed that Isl1 operates as an integrator factor, translating the density of Lhx3 or On

100 results showed that repression of the floral integrator FLOWERING LOCUS T (FT) requires EBS.

101 iefly recapitulate the history of the neural integrator for eye movements, then further develop the i

102 nia can be predicted by deficits in a neural integrator for head motor control.

103 s, then further develop the idea of a neural integrator for head movements, and finally discuss its p

104 and that the brain RAS functions as a major integrator for RMR control through its actions at leptin

105 in signaling pathways and functions as a key integrator for the regulation of glucose and bile acid m

106 pport; and a new interactive tool, the "Data Integrator", for intersecting data from multiple tracks.

107 This process may be implemented in a bounded integrator framework.

108 ing by repressing GA biosynthesis as well as integrator gene expression and that, in response to indu

109 tude of clock genes and repressed the floral integrator gene FLOWERING LOCUS T1 independently of the

110 DNA binding activity for a subset of floral integrator genes and contributes to floral transition.

111 s indicate that allelic variation at pathway integrator genes such as FT can underlie phenotypic vari

112 ular studies have revealed that one of these integrator genes, FLOWERING LOCUS T (FT), responds to ph

113 nd elevates expression of the floral pathway integrator genes, FT and SOC1, but does not repress expr

114 an activate its own gene and those of floral integrator genes, with direct binding to the floral inte

115 e fully explained by repressing known floral integrator genes.

116 y activating expression of a small number of integrator genes.

117 Specifically, we applied the neural integrator hypothesis that originally was developed for

118 ke head movements consistent with the neural integrator hypothesis, except that additional sensory fe

119 n-on and RNAPII profiling reveals a role for Integrator in 3'-end cleavage of eRNA primary transcript

120 One such floral integrator in Arabidopsis (Arabidopsis thaliana) is the

121 We propose a role for Integrator in biogenesis of eRNAs and enhancer function

122 Here we examine the requirement of Integrator in the biogenesis of transcripts derived from

123 otropin-releasing hormone (CRH) is a central integrator in the brain of endocrine and behavioral stre

124 1 (TRPV1) receptor is a polymodal molecular integrator in the pain pathway expressed in Adelta- and

125 1 (TRPV1) channels are essential nociceptive integrators in primary afferent neurons.

126 iscusses the roles of PIFs as pivotal signal integrators in regulating plant growth and development.

127 ic of LATER, implying that there must be two integrators in series.

128 that they are actively involved as cellular integrators in the control of motility and epithelial ba

129 s of cortex, casting them as one of the main integrators in the cortical column.

130 ive view on their putative role as metabolic integrators in the liver.

131 est that Piezo1 channels function as pivotal integrators in vascular biology.

132 identified ASUN as a functional component of Integrator (INT), a multisubunit complex required for 3'

133 Integrator is a multi-subunit complex stably associated

134 Integrator is endowed with a core catalytic RNA endonucl

135 DR-Integrator is freely available for non-commercial use fr

136 An example analysis using DR-Integrator is included as supplemental material.

137 Integrator is recruited to enhancers and super-enhancers

138 Integrator is recruited to the IEGs in a signal-dependen

139 The Variant Annotation Integrator is tailored to adding functional annotations

140 robust averaging is suboptimal for a perfect integrator, it paradoxically enhances performance in the

141 rtantly, in contrast to the broad effects of Integrator knockdown on MAPK responsiveness, depletion o

142 Abnormal function of the ocular motor neural integrator leads to centripetal drifts of the eyes with

143 While the contrast integrator model performed well when target elements con

144 n, conforming to predictions derived from an integrator model.

145 The integrator models formalize hypotheses about RT correlat

146 We expand on this coupled integrator network to construct a spiking neural network

147 However, in short-term memory and integrator networks, where noise accumulates and can pla

148 in the larval zebrafish by first identifying integrator neurons using two-photon calcium imaging and

149 Integrator neurons were identified as those neurons with

150 irst conclusive evidence of synapses between integrator neurons, which have long been hypothesized by

151 ems can be generalized to other hypothalamic integrator nuclei with downstream effector/output popula

152 lar signatures that posit Tbx20 as a central integrator of a genetic program that maintains cardiomyo

153 che' for ISCs, and identify FOS as a central integrator of a niche-derived permissive signal with str

154 in complex 1 (mTORC1) functions as a central integrator of a wide range of signals that modulate prot

155 r of developmental processes and as a signal integrator of a wide variety of stress signals, such as

156 This positions mTOR as a key central integrator of acute and chronic changes in fuel status.

157 These results establish GSK3 as an integrator of Akt and Wnt signals and suggest that overc

158 hlight the role of the circadian clock as an integrator of ambient abiotic stress signals important f

159 Homer1a serves as a molecular integrator of arousal and sleep need via the wake- and s

160 entral striatum has long been proposed as an integrator of biologically significant associative infor

161 ritical rheostat for bone turnover and a key integrator of bone and energy metabolism.

162 Ca(2+), suggesting that the soma acts as an integrator of Ca(2+) activity.

163 se data indicate that miR-22 functions as an integrator of Ca(2+) homeostasis and myofibrillar protei

164 nidentified function for PDE4D as a critical integrator of cAMP/PKA and Ca(2+)/CaMKII signaling.

165 of PDF signaling suggests it is a multimodal integrator of cell autonomous clock, environmental light

166 Filamin A (FLNA) is an integrator of cell mechanics and signaling.

167 FLNA is a cytolinker protein, and an integrator of cell mechanics and signaling.

168 karyotic initiation factor 2 (eIF2) is a key integrator of cellular stress responses and an important

169 These findings identify ABCG1 as a novel integrator of cholesterol homeostasis and adaptive immun

170 NDVI was an effective integrator of climate and site differences in plant prod

171 r signals, suggesting that TSS may act as an integrator of developmental and nutritional signals in r

172 alpha2-chn is therefore a potential integrator of different types of guidance information to

173 t-rich domain, identifying this region as an integrator of diverse physiological signals that regulat

174 One major forebrain integrator of emotional responses, the amygdala, is cons

175 rapamycin (mTOR) is emerging as an important integrator of environmental cues critical for the regula

176 cts both as a developmental signal and as an integrator of environmental cues such as drought and col

177 ant hormone abscisic acid (ABA) serves as an integrator of environmental stresses such as drought to

178 myosin II (NMII) is thought to be the master integrator of force within epithelial apical junctions,

179 ings implicate hippocampal FGF2 as a central integrator of genetic and environmental factors that mod

180 e intracellular Ca2+ activity as a nonlinear integrator of glutamate-dependent neuronal activity.

181 ough dephosphorylation of NAC019, RCF2 is an integrator of high-temperature signal transduction and a

182 sults identify WDR5 as a critical epigenomic integrator of histone phosphorylation and methylation an

183 tory role for eIF4B as a common mediator and integrator of IFN-generated signals from these kinases.

184 ber 1 (TRPV1) is known as a thermosensor and integrator of inflammation-induced hyperalgesia.

185 ies in metazoan clocks implicate HSP90 as an integrator of input or output.

186 stable module that acts as a noise-buffering integrator of internal and external signals.

187 Thus, the TOR kinase acts as a central integrator of light and metabolic signals and a key regu

188 TZP (Tandem Zinc-finger-Plus3), as a signal integrator of light and photoperiodic pathways in transc

189 phosphorylation of ribosomal protein S6, an integrator of MAPK and AKT activation, whereas the low-a

190 ifies local cytoplasmic calcium as a central integrator of metabolic and proliferative signals in Dro

191 previously unidentified role as a molecular integrator of metabolic dysfunction, oxidative stress an

192 that the Wnt pathway might act as a central integrator of metabolic signals from peripheral organs t

193 o and in vivo systems to show that FoxO1, an integrator of metabolic stimuli, inhibits PPARgamma expr

194 p73 as the conserved central transcriptional integrator of multiciliogenesis.

195 cate due to the physiological function as an integrator of multiple chemical, mechanical, and tempera

196 2 decreased the levels of TRAF3, a strategic integrator of multiple IFN-inducing signals, although NS

197 ed the transcription factor Rbpj, a critical integrator of multiple Notch signals, during prenatal mo

198 Thus, PASMC FoxO1 is a critical integrator of multiple signaling pathways driving PH, an

199 elongated HYPOCOTYL5 (HY5) bZIP protein, an integrator of multiple signaling pathways, also plays an

200 hese results suggest that Topo VI acts as an integrator of multiple signals generated by reactive oxy

201 ral role in innate immunity: it serves as an integrator of multiple signals induced by receptor-media

202 The central role of WUS as an integrator of multiple signals is highlighted; in additi

203 The anterior hypothalamus (AH) is a major integrator of neural processes related to aggression and

204 , also known as STK11) tumour suppressor, an integrator of nutrient availability, metabolism and grow

205 suggest that Smed-pbx functions as a central integrator of positional information to drive patterning

206 P-cloning approach, we uncovered KLF11 as an integrator of PR signaling and proliferation in uterine

207 This interaction thus seems to be a critical integrator of proliferative and morphogenetic signaling

208 Thus, the transcription factor TT8 is an integrator of secondary metabolism and stress response.

209 ls and indicate that EBF1 functions as a key integrator of signal transduction, inflammation, and met

210 (also known as TNK2), has emerged as a major integrator of signaling from various receptor tyrosine k

211 get of rapamycin (mTOR) has emerged as a key integrator of signaling pathways that regulate these met

212 ein found in all three domains of life as an integrator of signals of the nitrogen and carbon balance

213 hese findings establish trsn as an essential integrator of sleep and metabolic state, with implicatio

214 rum should not be universally regarded as an integrator of somesthetic and motor information.

215 as able to function as a pattern-insensitive integrator of spike number that was independent of exter

216 ng an internal state that behaves as a leaky integrator of stimulus exposure.

217 tor (CRF), encoded by the CRH gene, is a key integrator of stress responses, and, as such, CRH gene v

218 Collectively, RhoGEF12 acts as an integrator of stretch-induced signaling cascades in card

219 lopment that employs the promoter of RAM1 as integrator of symbiotic (transmitted via CCaMK and CYCLO

220 r findings identify the isoform Pparg2 as an integrator of the adipose lipid metabolism coordinating

221 A key integrator of the cell's responses to starvation and oth

222 dependent protein kinase (DNA-PK), a central integrator of the DNA damage response, which caused phos

223 Acetyl-coenzyme A (AcCoA) is a major integrator of the nutritional status at the crossroads o

224 However, a molecular integrator of the PKA response in the heart is unknown.

225 of rapamycin (mTOR) is emerging as a central integrator of these signals playing a critical role in d

226 these results highlight PKA as a biochemical integrator of three major types of GPCRs and necessitate

227 These findings reveal that Smad2 is a unique integrator of transcription and signaling events and is

228 egulator of pre-mRNA splicing and a possible integrator of transcription and splicing regulation.

229 we have identified SRC-2 as an indispensable integrator of transcriptional complexes that control the

230 se regions, revealing the Vps11 CTD as a key integrator of Vps-C complex assembly, Rab signaling, and

231 ry binding protein 1 and its targets are key integrators of antibody and T follicular cell responses.

232 hus reveals these core apoptosis proteins as integrators of cell death and physiology in pancreatic b

233 amine signaling pathways implicating them as integrators of central and peripheral metabolic signals

234 erebral endothelium can serve as sensors and integrators of CNS dysfunction, releasing measurable bio

235 Mitochondria are key integrators of convergent intracellular signaling pathwa

236 rs and we now recognize primary cilia as key integrators of extracellular ligand-based signaling and

237 tate their proper function as modulators and integrators of G-protein signaling.

238 ous sclerosis proteins TSC1 and TSC2 are key integrators of growth factor signaling.

239 CA1 pyramidal neurons are the final integrators of information flow leaving the hippocampus,

240 ing members of the Lyn kinase subfamily (key integrators of interleukin-7 and pre-BCR signaling) and

241 doing so, DELLAs also play pivotal roles as integrators of internal developmental signals from multi

242 se findings in the context of PIFs acting as integrators of light and other signals.

243 Cells are sophisticated integrators of mechanical stimuli that lead to physiolog

244 The TCP transcription factors usually act as integrators of multiple growth regulatory and environmen

245 family of transcription factors functions as integrators of multiple signaling pathways by binding to

246 TRPV1 channels in sensory neurons are integrators of painful stimuli and heat, yet how they in

247 Vagal afferent neurons are therefore early integrators of peripheral signals underling homeostatic

248 reviously unrecognized role for Th1 cells as integrators of perivascular CF and cardiac dysfunction i

249 sis and advance our understanding of LXRs as integrators of phagocyte function, lipid metabolism, and

250 Cdx genes are known as integrators of posteriorizing signals from Wnt, retinoic

251 s unveil TACs as transient but indispensable integrators of SC niche components and reveal an intrigu

252 t abundant cell type in the brain, are vital integrators of signaling and metabolism.

253 ical roles in plant biology and often act as integrators of signals from multiple plant regulatory an

254 mta1 and Camta2 that have been recognized as integrators of stress responses.

255 es gene expression either indirectly as a co-integrator or through direct DNA binding.

256 e provided model implementations of filters, integrators, or both.

257 II (RNAPII)-associated multiprotein complex, Integrator, plays a critical role in both initiation and

258 in can function autonomously, restoring full integrator processing activity when introduced into a he

259 tor genes, with direct binding to the floral integrator promoter SOC1.

260 signaling, we sought to identify limiting co-integrator proteins governing DACH1 signaling.

261 are functionally involved as transcriptional integrators regulating the basal expression of the deriv

262 ters containing paused RNA polymerase 2, and Integrator similarly regulates neuronal migration.

263 h give rise to the cerebellum and the common integrator site for both these reflexes (vestibular nucl

264 tive systems can be categorized as ephemeral integrators, stable loners, and anything in between.

265 cells to identify functional domains within integrator subunit 12 (IntS12) required for snRNA 3' end

266 Although disruption of almost any integrator subunit causes snRNA misprocessing, very litt

267 interact and stabilize the putative scaffold integrator subunit, IntS1.

268 Integrator subunits 9 and 11 (IntS9/11) are thought to c

269 We tested the requirement for all Drosophila Integrator subunits and found that Integrators 1, 4, 9,

270 Functional depletion of Integrator subunits diminishes the signal-dependent indu

271 interaction between the largest and smallest integrator subunits that is essential for the 3' end for

272 2 function but also abolish binding to other integrator subunits.

273 rk on the Pol II CTD and also interacts with Integrator subunits.

274 a dominant-negative titration of endogenous Integrator subunits.

275 nts a functional ortholog of the central FTi integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SO

276 Along with the florigens, the floral integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 is

277 r (CaMPARI) is a genetically encoded calcium integrator that facilitates the study of neural circuits

278 r (CaMPARI) is a genetically encoded calcium integrator that facilitates the study of neural circuits

279 al tools, we have identified Akt as a signal integrator that links distinct facets of CTL differentia

280 Thus, APC/C is an integrator that regulates both microRNA-mediated transcr

281 software tools include a Variant Annotation Integrator that returns predicted functional effects of

282 te that the LT synthetic complex is a signal integrator that transduces extracellular signals to modu

283 ty and postinhibitory rebound (PIR), for the integrators that are typically used.

284 These vectors are leaky integrators that could be constructed from a population

285 ht, are specialized as near-perfect synaptic integrators that summate inputs over extended timescales

286 IT dendrites functioned as temporal integrators that were particularly responsive to dendrit

287 situs is commonly believed to be the "neural integrator" that accomplishes this function through the

288 ith this ion-sensitive moiety yields an "ion integrator" that permanently marks cells undergoing high

289 s, using a cascade of imperfect mathematical integrators, that reproduces the response to MVS (and mo

290 In a neural integrator, the variability and topographical organizati

291 smoothly transitions from phase independent integrator to a phase dependent mode.

292 Incorporating negative evidence allows Omics Integrator to avoid unexpressed genes and avoid being bi

293 ther suggest that RSK2 functions as a signal integrator to provide antianoikis protection to cancer c

294 a simple mechanism in which a single signal integrator triggers germination above an accumulation th

295 A computational model using coupled leaky integrator units with biophysically plausible assumption

296 group termed the velocity-to-position neural integrator (VPNI).

297 found that the miR34/SNAIL module acts as an integrator while the miR200/ZEB module acts as a three-w

298 problems in neural coding, such as neuronal integrators with irregular inputs and internal noise.

299 Maf1 is a phospho-integrator, with unfavourable growth conditions leading

300 e required to reset any errors that the path integrator would inevitably accumulate.