ライフサイエンスコーパス: integrin

1 K, nor did EDTA-mediated inactivation of the integrin.

2 regulating alphaIIbbeta3 versus alpha5beta1 integrin.

3 a kink in the transmembrane domain of beta3-integrin.

4 ntly up-regulate the FN receptor alpha5beta1 integrin.

5 ord by blocking the adhesion molecule alpha4-integrin.

6 h E353 to mediate its high affinity to beta1-integrin.

7 ich are transduced to Fn through alpha5beta1 integrin.

8 32 (low affinity IgG receptor) and alphaMss2 integrin.

9 nd the angiogenesis biomarker alpha V beta 3 integrin.

10 lung using beta2 rather than beta1 or alpha4 integrins.

11 x interplay between these distinct epidermal integrins.

12 he expression of hemidesmosomal alpha6/beta4-integrins.

13 tronger and clearly detectable for all three integrins.

14 t cell beta1 integrin but not other cellular integrins.

15 at least in part, involve the activation of integrins.

16 ways, which are the downstream regulators of integrins.

17 (lymphocyte-associated antigen 1) and alpha4 integrins.

18 functions, including the activation of beta2-integrins.

19 ations can regulate the adhesive function of integrins.

20 rin-integrin (PSI) domain of inactive, beta3 integrins.

21 dhesion complexes formed by the nonactivated integrins.

22 nity compared with other Arg-Gly-Asp binding integrins.

23 integrins, but not alpha4, alpha5, or alpha6 integrins.

24 We observed that beta1-integrins accumulate on the luminal membrane of upper-ai

25 N-terminal head domain contains both the F3 integrin-activating domain and ABD1, whereas the C-termi

26 t has also been shown to negatively regulate integrin activation and adhesion.

27 n along this molecular axis (i.e. modulating integrin activation and controlling actin polymerization

28 toplasmic shuttling of ICAP1 influences both integrin activation and KRIT1 localization, presumably i

29 e integrins and support a molecular model of integrin activation by cytoskeletal force.

30 Signaling events driving integrin activation have previously been discussed conce

31 vide a necessary framework for understanding integrin activation in intact cells, including activatio

32 human erythroleukemia (HEL) cells and beta1 integrin activation in macrophage-like RAW264.1 cells.

33 Integrin activation is required for neutrophil functions

34 Impaired integrin activation on neutrophils is the hallmark of le

35 consequences of individual N-glycan site on integrin activation remain unclear.

36 NF receptor-associated factor 6), leading to integrin activation via the SFK (Src family kinase)-Syk

37 cytoskeletal protein essential in mediating integrin activation, has been previously shown to be inv

38 ll-molecule CD11b agonist LA1 led to partial integrin activation, reduced IFN-I responses in WT but n

39 ing Jurkat T cells as a model to study CD103 integrin activation, we demonstrated a key role of serin

40 ion associated with the switchblade model of integrin activation, where the development of tensile fo

41 opment of tensile force yields physiological integrin activation.

42 ion impairs the ability of ICAP1 to suppress integrin activation.

43 iates numerous cellular responses, including integrin activation.

44 nction of individual N-glycan sites in beta3 integrin activation.

45 itecture of the K2 FERM domain in regulating integrin activation.

46 ile force by the cytoskeleton, across ligand-integrin-adaptor complexes.

47 ctivity and reduced localization of SERTs to integrin adhesion complexes in synapses of KI mice.

48 engagement of the synergy site that enhances integrin adhesion force.

49 ed for surface expression of beta1 and beta2 integrin adhesion molecules by using flow cytometry.

50 ILC2s express high levels of beta1 and beta2 integrin adhesion receptors.

51 we show that FlnA negatively regulates beta2 integrin adhesion to complement component iC3b and ICAM-

52 ion in intact cells, including activation of integrin adhesiveness by application of tensile force by

53 Defective integrin affinity regulation in the genetic absence of C

54 AK-dependent activation of the rho module of integrin affinity triggering mediates chemokine-induced

55 elial cells upregulate and internalize beta4-integrin along with its matrix substrate, laminin.

56 Our data demonstrate that integrin alpha v (alphaV) recruited Src kinase and that

57 identified a pathway involving activation of integrin alpha3 in TA cells that signals through an LATS

58 , including the scavenger receptor MARCO and integrin alpha3beta1.

59 n macrophages and adipocytes mediated by the integrin alpha4 and its counter-receptor VCAM-1, respect

60 igand for very late Ag-4 (VLA-4; also called integrin alpha4beta1) binding cells in granulomas, and c

61 Inducible elimination of integrin alpha5 abrogates the epithelial-organizing effe

62 reduced IE binding to the receptors CD36 and integrin alpha5beta1, while hemoglobin AS did not modify

63 An SNP near integrin alpha6 (ITGA6) reached genome-wide significance

64 Interestingly, myotubes lacking integrin alpha7beta1, a laminin-receptor, also show a si

65 tion and metastatic progression by employing integrin alpha9beta1, abolishing actin stress fiber form

66 adhesion and colony formation as mediated by integrin alpha9beta1.

67 Leukocyte-specific integrin alphaDbeta2 (CD11d/CD18) is dramatically upregu

68 ses of alpha and dense-granule secretion and integrin alphaIIbbeta3 activation, and aggregation were

69 Integrin alphaIIbbeta3 has served as an excellent model

70 Expression of wild-type Rasa3 in integrin alphaIIbbeta3-expressing CHO cells blocked Rap1

71 n important role for Rasa3 in PI3K-dependent integrin alphaIIbbeta3-mediated outside-in signaling and

72 pressing CHO cells blocked Rap1 activity and integrin alphaIIbbeta3-mediated spreading on fibrinogen.

73 1143678 substitutes Pro(1146) for Ser in the integrin alphaM cytoplasmic tail.

74 e expression levels of IL-6 and TNF-alpha in integrin alphaM(PS)beta2 BMDMs were significantly higher

75 MDMs were significantly higher than those of integrin alphaM(wild-type)beta2 BMDMs, and they showed f

76 The leukocyte integrin alphaMbeta2 (CR3 or Mac-1) has both proinflamma

77 The leukocyte integrin Mac-1 (also known as integrin alphaMbeta2, or CD11b/CD18) is crucial for leuk

78 Integrins alphaMbeta2 and alphaXbeta2 are homologous adh

79 The level of expression of integrins alphav and beta3 and the amount of assembled F

80 e-based nanoparticle therapy that recognizes integrin alphavbeta3 (alphavbeta3-MPs of approximately 1

81 e FAK signaling downstream of the Pro32Pro33 integrin alphavbeta3 suppresses SERT activity.

82 Integrin alphaVbeta3 surface expression was specifically

83 The cell surface molecule, integrin alphavbeta3, is activated through HSC adhesion

84 ulation of 5-HT homeostasis and behaviors by integrin alphavbeta3, revealing an important role for in

85 that are addicted to aberrant signaling from integrin alphavbeta3, which activates a PAK4-YAP/TAZ sig

86 describe that IL-1beta specifically bound to integrins alphavbeta3 and alpha5beta1.

87 ented lung metastasis with downregulation of integrin alphavbeta6 and no toxicity.

88 Here we show how integrin alphaVbeta6 binds pro-TGF-beta1 in an orientati

89 hat the interaction between the nonactivated integrin and a ligand resulted in the activation of foca

90 sence of extradomain A activates alpha4beta1 integrin and augments osteoblast differentiation.

91 es tensin production to regulate alpha5beta1-integrin and fibrillar adhesion assembly and thus reveal

92 the consistent up-regulation of alpha5beta1 integrin and FN in many tumors and their correlation wit

93 beta1D integrin and other costameric proteins were lost from th

94 However, the contribution of integrin and Src kinase interaction to lung fibrosis has

95 as coordinately regulated by the alpha4beta1 integrin and the innate immune receptor toll-like recept

96 tip decorated with recombinant alphaIIbbeta3 integrins and (RGD)P2Y2R expressed on cell membranes.

97 intracellular forces can orient cell surface integrins and support a molecular model of integrin acti

98 ein that couples cell adhesion by activating integrins and the induction of membrane protrusions by a

99 "knottin"-RGD peptide to surface-immobilized integrins and, thus, enables quantification of the bindi

100 fferential control of transcription by AT1R, integrins, and calcium channels.

101 Functional integrin antagonism does not contribute significantly to

102 However, multiple integrin antagonist drug candidates have failed to show

103 Anti-integrin antibodies also lowered the C3 binding to cells

104 eta1-integrin internalization via anti-beta1-integrin antibodies or the RGD peptide ligand-or by gene

105 e ligand-binding betaI and alphaI domains of integrin are the best-studied von Willebrand factor A do

106 Integrins are heterodimeric transmembrane receptors cons

107 ve different binding affinity to alphavbeta3 integrin, are reported from isolated proteins and from r

108 aortic endothelial cells, BA increased beta1-integrin-Arg-Gly-Asp-peptide affinity by 18% with a tran

109 a mediterranea as a model, we identify beta1-integrin as a crucial regulator of blastema architecture

110 Using alphaLbeta2 integrin as a model, we found that the residue volume at

111 In this work, we instead exploit these integrins as a target for antibody Fc effector functions

112 ligation enhanced its interaction with beta2 integrins, as revealed by fluorescence lifetime imaging

113 associates in a complex with the alpha7beta1 integrin at the sarcolemma and Ptrh2 expression is decre

114 In addition, an N-linked sugar of the integrin attaches to the previously identified HS bindin

115 d Arp2/3, active myosin-II localization, and integrin-based adhesion dynamics.

116 Focal adhesions (FAs) are integrin-based transmembrane assemblies that connect a c

117 tensile force takes when applied through the integrin beta-subunit.

118 We found that actin, Arp2/3, vinculin and integrin-beta first accumulated at the cell's leading ed

119 In our studies, we found that both MARCO and integrin beta1 play a role in the activation of the Src

120 Inhibition of integrin beta1/Src blocked collagen-induced resistance t

121 SiRNA knockdown of integrin beta3 and inhibition of Akt activity significan

122 ocalization microscopy (SMLM) to investigate integrin beta3 and paxillin in rat embryonic fibroblasts

123 Notably, this novel defined LSD1/integrin beta3 axis, was also detected in human lung ade

124 hiatric disorders.SIGNIFICANCE STATEMENT The integrin beta3 Leu33Pro coding polymorphism has been ass

125 hat the Pro33 coding variation in the murine integrin beta3 recapitulates the sex-dependent neurochem

126 Integrin beta3 regulates cell polarity and migration whe

127 During IFNgamma stimulation, integrin beta3 signaling enhanced STAT1-mediated gene ex

128 nts with elevated blood 5-HT levels, linking integrin beta3, 5-HT, and ASD risk.

129 many single-factor ECMs, in part through an integrin beta3-mediated pathway.

130 led by multiple molecular characteristics of integrin beta3.

131 uired and the proliferation was mediated via integrin beta3/Akt signaling in EOMA cells.

132 Notably, periostin and integrin-beta3 were highly colocalized in biopsy specime

133 ifferentiation (cytokeratin 19, connexin 43, integrin beta4, and gamma-glutamyltranspeptidase), where

134 eed, we find that a basal epithelial marker, integrin-beta4 (ITGB4), can be used to enable stratifica

135 However, we know little about how integrins bind macromolecular ligands in the extracellul

136 owth factor-beta1 precursor (pro-TGF-beta1), integrins bind to the prodomain, apply force, and releas

137 issue regrowth and regeneration, yet not all integrin binding can lead to tissue repair.

138 of the Lys residues to Glu markedly reduced integrin binding of E128K IL-1beta, suggesting that the

139 contrast, materials that promote alphavbeta3 integrin binding promoted endothelial sprout clumping in

140 asma or to purified VWF depending on the VWF integrin binding site.

141 Integrin binding to bioengineered hydrogel scaffolds is

142 cking conformational changes induced by weak integrin binding to the Lys mutants.

143 K mutation in the IL1R-binding site enhanced integrin binding.

144 ta, suggesting that the Lys residues mediate integrin binding.

145 motif differs in the presence and absence of integrin binding; differences extend well outside the in

146 n metabolic homeostasis suggest that the RGD integrin-binding domain of IGFBP-1 may be a promising ca

147 The RGD integrin-binding domain of IGFBP-1, through integrin eng

148 lori, an outcome that required the predicted integrin-binding homology region of ImaA.

149 The conformation of the prodomain integrin-binding motif differs in the presence and absen

150 ighly sensitive competition ELISA to measure integrin-binding of RGD-peptides in high-throughput with

151 inding functions of the F2 subdomain and the integrin-binding properties of its F3 subdomain.

152 Furthermore, we report that calcium and integrin-binding protein 2 binds to the components of th

153 s a region with remote homology to bacterial integrin-binding proteins.

154 The integrin-binding sites on iC3b remain incompletely chara

155 clo[RGDfK] (as reported by Piras et al.), as integrin-binding was much stronger and clearly detectabl

156 erved as an excellent model for the study of integrin biology, and it has become clear that integrin

157 ro1A represents an important novel player in integrin biology, with key functions in PMN trafficking

158 control and EVL/VASP dKO T cells upon alpha4 integrin blockade.

159 and recognizing Siglec-8 in combination with integrin blocking antibodies, pharmacologic inhibitors,

160 intramolecular interaction is released, the integrin-bound talin head retains the ability to inhibit

161 ectly affected the amount of host cell beta1 integrin but not other cellular integrins.

162 membrane expression and activation of beta1 integrins, but not alpha4, alpha5, or alpha6 integrins.

163 Activation of transmembrane receptor integrin by talin is essential for inducing cell adhesio

164 Engagement of integrins by the extracellular matrix initiates signalin

165 ell outside the interface and illustrate how integrins can remodel extracellular matrix.

166 In vivo blocking of beta2 integrins (CD18) significantly reduced ILC2 numbers in t

167 he extreme C terminus of K2 is essential for integrin co-activation and highlight the importance of a

168 CM attachment to the ECM is mediated by integrin complexes localized at the muscle adhesion site

169 tides were delivered to cells with different integrin concentrations.

170 and-binding affinity and free energy of each integrin conformational state on the cell surface, toget

171 Further, using beta1 integrins containing a HaloTag in combination with membr

172 Importantly, beta1 integrins containing an extracellular pH-sensitive pHluo

173 These beta1 integrins control distinct antifungal effector functions

174 both undermining talin binding to the beta3-integrin cytoplasmic tail and inducing a kink in the tra

175 -Jun N-terminal kinase 1 that was also beta2-integrin dependent; pharmacologic inhibition of these ki

176 However, its role in the regulation of beta2 integrin-dependent adhesion, as well as in other cellula

177 novel pathway involving regulation of beta2-integrin-dependent adhesion, NADPH oxidase, and a subset

178 Thus, FlnA is a negative regulator of beta2 integrin-dependent cell adhesion and reactive oxygen spe

179 We found that beta1 integrin-dependent cell adhesion is critical for support

180 chymal cells both in vivo and in vitro beta1 integrin-dependent cell adhesion relied on the relocatio

181 idney collecting system development requires integrin-dependent cell-extracellular matrix interaction

182 hat Siglec-8 engagement promotes rapid beta2-integrin-dependent eosinophil adhesion.

183 ep of transendothelial migration in a alpha4 integrin-dependent manner.

184 is or chemotaxis but is a critical driver of integrin-dependent processes.

185 -selectin-mediated vaso-occlusion induced by integrin-dependent sickle-red blood cell-leukocyte adhes

186 STAT1), via an IFN-independent but EGFR- and integrin-dependent signaling pathway.

187 unction mutation, alpha2E336A, in the alpha2-integrin did not prevent the activation of FAK, nor did

188 n vivo blocking of beta1 integrins or alpha4 integrins did not affect lung ILC2 numbers.

189 rrection of ceramide levels-normalizes beta1-integrin distribution and sphingosine levels in CF epith

190 growth factor receptor (EGFR) interacts with integrins during cell spreading and motility, but little

191 modification of the mechanical properties of integrin-ECM links, which may be harnessed by cells to c

192 Silencing beta1 integrin efficiently inhibited RCP-induced Slug expressi

193 exchange factor (GEF) Brag2, which controls integrin endocytosis and cell adhesion and is impaired i

194 and -impermeant Halo dyes allows imaging of integrin endocytosis and recycling.

195 integrin-binding domain of IGFBP-1, through integrin engagement, focal adhesion kinase, and integrin

196 e pHluorin tag allow direct visualization of integrin exocytosis in live cells and revealed targeted

197 that CM Tln2 is essential for proper beta1D-integrin expression and that Tln1 can substitute for Tln

198 imaging even of tissues with low alphavbeta6 integrin expression density, we anticipate clinical appl

199 alpha5beta1 and alpha6beta4 integrin expression levels were quantified on 20 differe

200 ses by increasing the gut-homing alpha4beta7 integrin expression on Tfh cells.

201 in metastatic cells, rather than changes in integrin expression or focal adhesion phosphorylation.

202 ferences in the chemokine receptor and beta1 integrin expression profiles of progenitors between the

203 cells contingent upon epithelial cell beta4-integrin expression.

204 on the large, >130 A length-scale change in integrin extension, which is well tailored to match the

205 d detachment of A549 cells by targeting cell integrin-extracellular matrix connections (matrilysis) a

206 cross-talk between the LRP4-MuSK pathway and integrin-focal adhesion pathway.

207 ng mechanism by which KCa1.1 regulates beta1-integrin function and therefore invasiveness of RA-FLSs.

208 D1, a cytoskeletal protein involved in beta1-integrin function, causes Kindler syndrome, a genetic di

209 For cells of myeloid origin, while integrins function at the level of adhesion, the importa

210 new susceptibility loci, 3 of which contain integrin genes that encode proteins in pathways that hav

211 econstitutes the collagen-binding domain for integrins GFOGER reverted the assembly of FN induced by

212 FP and its transition dipole relative to the integrin head, and measure orientation with fluorescence

213 first optimized several parameters, such as integrin-immobilization levels, knottin-RGD concentratio

214 pha5beta1 as the primary fibronectin-binding integrin in ASM, and alpha5beta1-specific blockade inhib

215 chi derivative is able to detect alphavbeta3 integrin in human melanoma xenografts in a selective fas

216 samples also reveals a requirement for this integrin in tumorigenesis in vivo.

217 alphavbeta3, revealing an important role for integrins in modulating risk for neuropsychiatric disord

218 Herein, we investigated the role of beta1 integrins in regulating this process.

219 nsisting of alpha and beta subunits; crucial integrins in the kidney collecting system express the be

220 eins, such as Toll-like receptors (TLRs) and integrins, in a gp96-deficient murine cell line.

221 t, a common subunit for all collagen-binding integrins, inhibited the collagen-induced MT1-MMP-depend

222 P-activated protein kinase (AMPK) as a beta1-integrin inhibitor in fibroblasts.

223 intracellular signals from CD36, similar to integrin inside-out signaling.

224 or blocking of Thy-1, or blocking Thy-1-beta integrin interactions, decreased mEV uptake and prevente

225 is vicious cycle by triggering surface beta1-integrin internalization via anti-beta1-integrin antibod

226 ession of Nfatc1, Dc-stamp, Ctsk, and beta 3 integrin is reduced in the osteoclasts with reduced MYO1

227 Conformational activation of integrins is generally required for ligand binding and c

228 Inside-out signaling to integrins is mediated by the small GTPase Ras-proximate-

229 opose that the direct binding to IL-1beta to integrins is primarily important for agonistic IL-1beta

230 ibition of hepatocyte proliferation by beta1-integrin knockdown or p21 overexpression, resulting in t

231 The alphaLbeta2 integrin LFA-1 is known to play a key role in T lymphocy

232 xpression by Treg cells was due, in part, to integrin LFA-1-mediated interactions between Treg cells

233 Disruption of integrin ligation with an RGD-containing peptide abrogat

234 Pharmacological inhibition of integrin linked kinase (ILK), EGFR and NF-kappaB, as wel

235 nt and variants of uncertain significance in integrin-linked kinase (ILK) and filamin-C (FLNC).

236 Kidney AE1 (kAE1), PDLIM5 and integrin-linked kinase (ILK) form a multiprotein complex

237 egrin engagement, focal adhesion kinase, and integrin-linked kinase, enhanced insulin sensitivity and

238 inflammation critically depends on the beta2 integrins lymphocyte function-associated antigen 1 (LFA-

239 The leukocyte integrin Mac-1 (also known as integrin alphaMbeta2, or C

240 molecular brightness of mCherry-tagged beta1-integrins measured using fluorescence correlation spectr

241 Thy-1 and alphavbeta3 integrin mediate bidirectional cell-to-cell communicatio

242 Integrin-mediated adhesion is a central feature of cellu

243 els incorporating LN-511-E8 resulted in firm integrin-mediated adhesion to the scaffold and well-stra

244 eous drug inhibition of myosin II motors and integrin-mediated adhesions.

245 Integrin-mediated attachment to the extracellular matrix

246 increased BTIC growth through an alpha2beta1 integrin-mediated mechanism that elevated NOTCH ligand J

247 ence lifetime imaging microscopy, leading to integrin-mediated phosphorylation of Src and extracellul

248 P into the rigid, ligand-binding head of the integrin, model with Rosetta the orientation of GFP and

249 separation, and subsequently measured single-integrin-molecule adhesion kinetics using an optical tra

250 that renal fibroblasts express three alphav integrins, namely alphavbeta1, alphavbeta3, and alphavbe

251 rimental approaches such as the injection of integrin-neutralizing Abs that inhibit the entry of circ

252 and Ptrh2 expression is decreased in alpha7 integrin null muscle.

253 In contrast, in vivo blocking of beta1 integrins or alpha4 integrins did not affect lung ILC2 n

254 Loss-of-function of Ena/VASP, alpha5beta1-integrins or talin in the somitic cells abolished the FN

255 Cytoskeleton and ligand-bound integrins orient in the same direction as retrograde act

256 tegrin biology, and it has become clear that integrin outside-in signaling is highly complex and invo

257 CD103 cytoplasmic tail triggers alphaEbeta7 integrin outside-in signaling that promotes CD8(+) T-cel

258 ly relate to migration, and surface receptor integrins play critical roles in controlling the organiz

259 hich binds with high affinity to alphaVbeta3 integrins present in both the tumor-associated neovascul

260 nding to the cytoplasmic domain of the beta3 integrin prevents outside-in signaling and infection.

261 nterdigitated interface stabilize a specific integrin/pro-TGF-beta orientation that defines the pathw

262 ubstrates, we show that FN-bound alpha5beta1 integrin promotes tension-dependent malignant transforma

263 The alpha6beta4 integrin protects adherent epithelial and carcinoma cell

264 c hantaviruses bind to the plexin-semaphorin-integrin (PSI) domain of inactive, beta3 integrins.

265 Similar to the alpha7 integrin, Ptrh2 expression was decreased in laminin-alph

266 l outcomes that may involve activation of an integrin/reactive oxygen axis.

267 MDV) mediates cell entry by attachment to an integrin receptor, generally alphavbeta6, via a conserve

268 -ECM contact area and enhances engagement of integrin receptors, locally amplifying ECM input to inte

269 ged by soluble fibrinogen that binds surface integrin receptors.

270 uced epithelial MV miR-17/221 promoted beta1 integrin recycling and presentation back onto the surfac

271 after photobleaching and endocytosis assays, integrin recycling between both sites requires the small

272 n together, our results unveil a new mode of integrin regulation through modification of the mechanic

273 In this study, we show how the integrin-regulatory protein kindlin-2 (FERMT2) promotes

274 domains and isoforms to bind to a variety of integrins result in a wide range of effects.

275 through the RGD sequence to beta3-containing integrin, resulting in increased mineralization by and d

276 progenitor cells were mislocalized in beta1-integrin(RNAi) animals without significantly altered bod

277 mild neuronal activity, to acutely activate integrin signaling and trigger structural modifications

278 r results suggest that alpha-actinin impairs integrin signaling by both undermining talin binding to

279 highlights the previously undefined role of integrin signaling in the pathogenesis of diet-induced h

280 ed in focal adhesions (FAs) and functions in integrin signaling to promote cell motility, invasion, p

281 mild, neuronal activity to acutely activate integrin signaling, induce synaptic bouton enlargement,

282 regulated in a dynamically similar manner as integrin subunit beta3 (>50 fold).

283 beyond those requiring binding to the beta1 integrin subunit NPxY motif.

284 Knocking down DDR2, but not the beta1 integrin subunit, a common subunit for all collagen-bind

285 it of KCa1.1 coimmunoprecipitates with beta1 integrins, suggesting that this physical association und

286 could be shown by using the tumor-specific, integrin-targeting (90)Y-DOTA-RGD and the localized acti

287 elet activation, and the onset of piconewton integrin tension coincides with calcium flux.

288 The distribution of integrin tension was shown to be spatially regulated thr

289 A mutants bound higher levels of alpha5beta1 integrin than wild-type H. pylori, an outcome that requi

290 on the intracellular signals associated with integrins that modulate the autophagy response and dicta

291 Stabilization of the bent conformation by integrin transmembrane and cytoplasmic domains must be o

292 Integrins undergo large-scale conformational changes upo

293 Dysregulation of beta1-integrin underlies Kindler syndrome skin fragility.

294 rather by matrix architecture-induced beta1-integrin upregulation.

295 live cells and revealed targeted delivery of integrin vesicles to focal adhesions.

296 rt that rhAPC binds to human neutrophils via integrin VLA-3 (CD49c/CD29) with a higher affinity compa

297 of activated PC have a stronger affinity for integrin VLA-3, which reveals novel therapeutic possibil

298 hesins invasin and YadA with host cell beta1 integrin, we compared the sterol dependence of wildtype

299 embrane extracellular matrix (ECM) via beta1 integrins which activate both ILK and Rac1 and are requi

300 ions or hemidesmosomes via the engagement of integrins with fibrillar ECM proteins.