ライフサイエンスコーパス: integrin alpha1

1 zation (N-cadherin, PSD-95, RhoA, NCAM1, and integrin alpha1).

2 ted in glomeruli of Alport mice that express integrin alpha1.

3 hibitor or Rac1 inhibitor, or by deletion of integrin alpha1.

4 transcriptase-PCR showed mRNA expression of integrins alpha1, alpha2, alpha3, alpha4, alpha5, alpha7

5 CSE also increased the expression of integrins alpha1, alpha2, and alpha10 (collagen receptor

6 Among those alpha subunits, integrins alpha1, alpha2, and the other four subunits be

7 significantly decreased their expression of integrin alpha1, an adhesion molecule highly expressed b

8 ted in reduced proliferation, migration, and integrin alpha1 and alpha2 integrin expression.

9 results indicate that NSP4 interaction with integrin alpha1 and alpha2 is an important component of

10 ti-integrin alpha2 and beta1 but not by anti-integrin alpha1 and alpha6.

11 We conclude that overexpression of mesangial integrin alpha1 and podocyte vimentin and integrin alpha

12 Integrins alpha1 and alpha2, which contributed only marg

13 Integrin alpha1-blocking and alpha2-blocking antibodies

14 Furthermore, we showed that integrin alpha1 but not alpha2 subunits were expressed o

15 In both developing and adult muscle, the integrin alpha1 chain was selectively associated with pr

16 ition of purified integrin alpha1beta1 or an integrin alpha1 cytoplasmic peptide to which TCPTP has b

17 Integrin alpha1-deficient mice thus provide a geneticall

18 ked reduction of their proliferation on both integrin alpha1-dependent (collagenous) and independent

19 ive immunofluorescence showed an increase in integrin alpha1 expression in Alport mesangial cells and

20 In Alport mice that are also null for integrin alpha1 expression, expansion of the mesangial m

21 Mice with targeted inactivation of the integrin alpha1 gene (alpha1-KO mice) provide a model th

22 Thus, integrin alpha1 has a unique role among the collagen rec

23 nalysis, to examine solution dynamics of the integrin alpha1 I domain induced by the binding of dival

24 oblasts from normal and fibrotic dermis, and integrin alpha1 knockout mice maintain increased collage

25 tolerance and insulin sensitivity in HF-fed integrin alpha1-null (itga1(-/-)) and wild-type (itga1(+

26 Previous work has shown that integrin alpha1-null Alport mice exhibit attenuated glom

27 evated in both integrin alpha1-null mice and integrin alpha1-null Alport mice relative to wild-type m

28 thesis, while overexpression of Cav-1 in the integrin alpha1-null MCs decreases EGFR-mediated ROS pro

29 We further show that integrin alpha1-null MCs have increased levels of activa

30 ibition of ERK increases Cav-1 levels in the integrin alpha1-null MCs.

31 Integrin alpha1-null mesangial cells (MCs) have reduced

32 Integrin alpha1-null mesangial cells have constitutively

33 t studies, we describe the mechanism whereby integrin alpha1-null mesangial cells produce excessive R

34 d MMP-14, was significantly elevated in both integrin alpha1-null mice and integrin alpha1-null Alpor

35 in oxidative stress-mediated damage and why integrin alpha1-null mice are more susceptible to fibros

36 ecies (ROS) production, we demonstrated that integrin alpha1-null mice develop more severe glomerulos

37 We previously demonstrated that integrin alpha1-null mice develop worse fibrosis than wi

38 Integrin alpha1-null mice display marked delays in trans

39 Integrin alpha1-null mice have delayed-onset progressive

40 Finally, we show that glomeruli of integrin alpha1-null mice have reduced levels of Cav-1 a

41 showed previously that tumor angiogenesis in integrin alpha1-null mice is reduced compared to that of

42 f plasma levels of MMP-9 in either normal or integrin alpha1-null mice leads to decreased synthesis o

43 We have observed that in integrin alpha1-null mice synthesis of MMP7 and MMP9 was

44 We have used integrin alpha1-null mice to investigate the role of thi

45 To investigate this possibility, integrin alpha1-null mice were crossed with KrasLA2 mice

46 i and cultured mesangial cells isolated from integrin alpha1-null mice, activation of the p38 and ERK

47 14 expression levels in mesangial cells from integrin alpha1-null mice.

48 , we used blocking antibodies against either integrin alpha1 or alpha2 subunits and VSMCs from mice t

49 port mice with Rac1 inhibitor or deletion of integrin alpha1 reduced mesangial cell process invasion

50 erstood, truncation and point mutants of the integrin alpha1 subunit cytoplasmic tail (amino acids 11

51 These results indicate that loss of the integrin alpha1 subunit decreases the incidence and grow

52 educed Cav-1 levels, and reexpression of the integrin alpha1 subunit increases Cav-1 levels, decrease

53 To determine whether the integrin alpha1 subunit protects against impairments in

54 Cav-1 directly interacts with TCPTP and the integrin alpha1 subunit, 2) pCav-1 is a substrate of TCP