ライフサイエンスコーパス: integrin alpha2

1 ntal B16-F0 revealed unique up-regulation of integrin alpha2.

2 inding of the natural ligand, collagen I, to integrin alpha2.

3 eading were not inhibited by heparin or anti-integrin alpha2.

4 sting that EGF receptor activation regulates integrin alpha2.

5 peller with their homologous counterparts in integrin alpha2 abrogated C3bi binding, whereas substitu

6 lleles, the -5C allele of GPIbalpha, and the integrin alpha2 allele 1 (T807) each contribute to risk

7 mponents of the extracellular matrix such as integrins alpha2, alphaV, beta1, and beta8.

8 are reflections of greatly reduced levels of integrin alpha2 and alpha3 mRNAs, as well as a smaller r

9 fibroblasts on rec-LG4 was inhibited by anti-integrin alpha2 and beta1 but not by anti-integrin alpha

10 Before EGF stimulation, integrin alpha2 and EGF receptors were associated based

11 cking of F-actin toward the cellular cortex, integrin alpha2 and integrin alphaL toward the cell memb

12 We now report that expression of basal integrin alpha2 and its biological effects are controlle

13 e also reported that the expression of basal integrin alpha2 and its biological effects are criticall

14 in phosphatase-1 (SHP-1) coprecipitated with integrin alpha2 and was phosphorylated in a dynamic fash

15 udies have been performed for platelet GPla (integrin alpha2) and GPIb-IX-V, but there is support for

16 rupting formation of complexes of claudin-7, integrin alpha2, and claudin-1 that normally form in epi

17 These findings define integrin alpha2 as a molecule conferring selective poten

18 ell lysate also demonstrated the presence of integrin alpha2 beta1 along with alpha3 beta1.

19 utative prostate stem cell markers (CD44 and integrins alpha2/beta1), when compared to the rapidly pr

20 Integrin alpha2, but not EGF receptor, was associated wi

21 siRNA-mediated knockdown of integrin alpha2 caused a dose-dependent reduction of SHP

22 activated EGF receptor transiently modulates integrin alpha2 cell surface expression and stimulates i

23 receptor (EGFR)-mediated basal expression of integrin alpha2, cell adhesion and motility in highly pr

24 alpha (TGF-alpha) controls the expression of integrin alpha2, cell adhesion to collagen IV and motili

25 ceptor or expressing a chimera harboring the integrin alpha2 ectodomain fused to the alpha1 intracell

26 reveal a novel functional connection between integrin alpha2 engagement, FAK, ERK, and mu-calpain act

27 iated in part through specific modulation of integrin alpha2 expression and function.

28 tases from individual patients suggests that integrin alpha2 expression contributes to liver metastas

29 The modulation of integrin alpha2 expression corresponded to marked change

30 he EGFR-selective tyrphostin AG1478 restored integrin alpha2 expression within 4 to 8 hours after tre

31 K) inhibitors PD098059 and U0126 showed that integrin alpha2 expression, cell adhesion, and activatio

32 upation) exogenous growth factor does induce integrin alpha2 expression, cell adhesion, and micromoti

33 d by bisindolylmaleimide, which also blocked integrin alpha2 expression, cell adhesion, and motility.

34 We report that EGF induces integrin alpha2 expression, integrin-mediated adhesion,

35 GFr-mediated and EGFr is located upstream of integrin alpha2 expression.

36 The data suggest that blocking the integrin alpha2/FAK/ERK/mu-calpain pathway may be an imp

37 GF treatment resulted in a transient loss of integrin alpha2 from the cell surface.

38 mechanisms underlying EGFR/ERK signaling and integrin alpha2 function in HCT116 cells.

39 between -549 and -351 bp in the promoter of integrin alpha2 gene conferred the inducibility by three

40 s critical role in not only the induction of integrin alpha2 gene expression by three-dimensional col

41 ndirect regulatory mechanism by NF-kappaB in integrin alpha2 gene expression induced by three-dimensi

42 ucibility, indicating that the activation of integrin alpha2 gene expression was possibly mediated by

43 e proximal 5' regulatory region of the human integrin alpha2 gene that is responsible for decreased e

44 lecule inhibitors (SMIs) designed to disrupt integrin alpha2 I or beta1 I-like domain function on ang

45 entical collagen peptide in complex with the integrin alpha2-I domain (IBP(c)) allows the first detai

46 The direct role of integrin alpha2 in hepatic metastasis was shown by compa

47 Specific blocking antibodies (clone P1E6) to integrin alpha2 inhibited FAK activation and cell motili

48 We observed that expression of the integrin alpha2 (ITGA2) gene in host cells was significa

49 Integrin alpha2-mediated binding to collagen type IV (hi

50 g technique, it was shown that ERK-dependent integrin alpha2-mediated cell micromotion signaling is c

51 ppaB, significantly reduced the induction of integrin alpha2 mRNA and protein by the collagen lattice

52 In both of these models, integrin alpha2-null mice developed significantly less p

53 Thus integrin alpha2-null mice represent an example of geneti

54 Here, we subjected wild-type and integrin alpha2-null mice to injury with adriamycin or p

55 ced collagen synthesis in wild-type, but not integrin alpha2-null, mesangial cells in vitro, demonstr

56 NSP4 colocalizes with integrin alpha2 on the basolateral surface of rotavirus-

57 ECs plated on anti-integrin alpha2 or alpha3 antibody were susceptible to T

58 placed with that of the integrin alpha4, the integrin alpha2, or maintained intact.

59 pe, defects in cell spreading, and decreased integrin alpha2 protein expression as detected by Wester

60 trate that astrocytic laminin, by binding to integrin alpha2 receptor, prevents pericyte differentiat

61 r a novel functional interaction between the integrin alpha2 subunit and SHP-1.

62 In contrast, overexpression of the integrin alpha2 subunit had no effect on cell survival.

63 d expression and altered localization of the integrin alpha2 subunit in addition to disrupting format

64 uced by morpholino-mediated knockdown of the integrin alpha2 subunit.

65 in ovarian cancer cells led to reduction in integrin alpha2 surface expression, defects in cell spre

66 lpha2 cell surface expression and stimulates integrin alpha2 trafficking via caveolae/raft-mediated e

67 Moreover, integrin alpha2 was subsequently targeted to the Golgi a

68 ng motif of type 1 collagen and its receptor integrin alpha2 was surprisingly tension-independent to

69 mutants that fail to bind or signal through integrin alpha2 were attenuated in diarrhea induction in

70 After EGF treatment, EGF receptor and integrin alpha2 were internalized and segregated into di