ライフサイエンスコーパス: integrin alpha2beta1

1 in-1 (Scl1) and the human collagen receptor, integrin alpha2beta1.

2 ngiogenesis in the wild-type mice expressing integrin alpha2beta1.

3 site is for cell spreading activity through integrin alpha2beta1.

4 eceptor glycoprotein (GP) VI, but not to the integrin alpha2beta1.

5 eptor glycoprotein VI (GPVI), but not to the integrin alpha2beta1.

6 or complex and collagen interaction with the integrin alpha2beta1.

7 cross-linking of the collagen receptor, the integrin alpha2beta1.

8 esting that its action is independent of the integrin alpha2beta1.

9 rs by a mechanism different from that of the integrin alpha2beta1.

10 interact with collagen, glycoprotein VI, or integrin alpha2beta1.

11 gens, and the expression of collagen-binding integrin, alpha2beta1.

12 7 may also modulate the function of platelet integrin alpha2beta1, a collagen receptor.

13 exapeptide is recognised specifically by the integrins alpha2beta1, alpha1beta1, alpha10beta1 and alp

14 hed to collagen or fibronectin (which engage integrins alpha2beta1/alpha3beta1 and alpha5beta1, respe

15 was extended to studies of ligand binding by integrins alpha2beta1, alpha4beta1, alpha5beta1, and alp

16 Integrin alpha2beta1 also caused a time-dependent stimul

17 e the RGD motif, and also a MAb specific for integrin alpha2beta1, an integrin that does not recogniz

18 is mediated via the inside-out regulation of integrin alpha2beta1 and activation through the glycopro

19 he progression-associated adhesion receptors integrin alpha2beta1 and CD44 were diminished.

20 Two collagen receptors, integrin alpha2beta1 and glycoprotein VI (GPVI), are exp

21 he different extracellular matrix receptors, integrin alpha2beta1 and glycoprotein VI are the only co

22 ating receptors such as the collagen-binding integrin alpha2beta1 and the von Willebrand factor recep

23 associated with the increased expression of integrin-alpha2beta1 and reduced apoptosis in cells grow

24 adhesion and thrombus growth mediated by the integrins alpha2beta1 and alpha(IIb)beta3.

25 aVbeta6, whereas M3 up-regulates "sedentary" integrins alpha2beta1 and alpha3beta1.

26 in prostate cancer, including CD44+, CD133+, integrin alpha2beta1+, and side population cells.

27 e that Pyk2 regulates PI3Kbeta downstream of integrin alpha2beta1, and document a novel role for Pyk2

28 specific binding sites for glycoprotein VI, integrin alpha2beta1, and vWf, thereby preventing collag

29 Interactions between the integrin, alpha2beta1, and extracellular matrix (ECM), p

30 I-Fc Rgamma may require the collagen-binding integrin alpha2beta1 as a co-receptor, but this model ha

31 and coimmunoprecipitation analysis confirmed integrin alpha2beta1 as a target for this venom protein.

32 s by a mechanism that was reversible by anti-integrin-alpha2beta1 blocking antibodies.

33 action was characterized; pDGE-RGD binds to integrin alpha2beta1 by means of the DGE motif and inhib

34 lls coexpress IL-7R and the collagen-binding integrin alpha2beta1 (CD49b), and IL-7 increases their a

35 ated LWWNSYY to be an effective inhibitor of integrin alpha2beta1-collagen interaction and subsequent

36 Taken together, these results indicate that integrin alpha2beta1 contributes to glomerular injury by

37 It also inhibited integrin alpha2beta1-dependent functions of human endoth

38 in vitro, demonstrating that its effects are integrin alpha2beta1-dependent.

39 Integrin alpha2beta1 failed to stimulate PI3Kbeta in pla

40 became adherent to immobilized collagen (via integrin alpha2beta1), fibronectin (via integrin alpha5b

41 data suggest rhinocetin to be a modulator of integrin alpha2beta1 function and thus may provide valua

42 Integrin alpha2beta1 (glycoprotein [GP] Ia/IIa) is a maj

43 Thus, platelet collagen receptors, the integrin alpha2beta1, glycoprotein VI, and the glycoprot

44 Integrin alpha2beta1 has been proposed to mark a populat

45 llagen receptors, glycoprotein VI (GPVI) and integrin alpha2beta1, have been intensely investigated u

46 nding by blocking glycoprotein VI (GPVI) and integrin alpha2beta1 in our ferric chloride murine throm

47 ulating collagen production, but the role of integrin alpha2beta1 in renal injury is unclear.

48 which binds to GPVI but does not bind to the integrin alpha2beta1, induced Btk tyrosine phosphorylati

49 ese aggregates required functional GPIa/IIa (integrin alpha2beta1) instead of integrin alphaIIbbeta3,

50 Integrin alpha2beta1 is a major receptor required for ac

51 ce GFOGER implies that the collagen receptor integrin alpha2beta1 is affected by LOX.

52 These observations show that the integrin alpha2beta1 is not required for regulation of t

53 Integrin alpha2beta1 is the major receptor for collagens

54 There is a 2-fold variation in platelet integrin alpha2beta1 levels among inbred mouse strains.

55 subunits, as well as by type I collagen (an integrin alpha2beta1 ligand).

56 Integrin alpha2beta1-mediated adhesion of human platelet

57 microvascular endothelial cells derived from integrin alpha2beta1(-/-) mice and by response to endore

58 ence of monoclonal antibodies (MoAbs) to the integrin alpha2beta1 (MoAb 6F1 and MoAb 13), conditions

59 It does not inhibit the closely related integrin alpha2beta1, nor a panel of other integrins tes

60 sible for decreased expression levels of the integrin alpha2beta1 on blood platelets through a mechan

61 Ligation of integrin alpha2beta1 on collagen prevents flow-induced N

62 Our studies demonstrate that both GPVI and integrin alpha2beta1 play significant roles for platelet

63 Because integrin alpha2beta1 plays a critical role during early

64 cument a novel role for Pyk2 and PI3Kbeta in integrin alpha2beta1 promoted inside-out activation of i

65 minin alpha1 LG4 for binding to syndecan and integrin alpha2beta1, respectively.

66 The engagement of integrin-alpha2beta1 seemed to be essential for the surv

67 ion, selective pharmacological inhibition of integrin alpha2beta1 significantly reduced adriamycin-in

68 viously shown that CPP-I is a ligand for the integrin alpha2beta1 suggesting that some of the phenoty

69 ered by function-blocking antibodies against integrin alpha2beta1, the functional endorepellin recept

70 nal antibodies against the alpha2 subunit of integrin alpha2beta1 to platelets and coimmunoprecipitat

71 Overall, these data link integrin-alpha2beta1 to some of the biologic functions t

72 otif and report that, unlike the I domain of integrin alpha2beta1, vWF-A3 continues to bind collagen

73 ocess that requires the presence of abundant integrin alpha2beta1, was also examined.

74 are mediated by the combined actions of the integrin alpha2beta1, which serves as a major collagen-b