ライフサイエンスコーパス: integrin alpha3

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1 d memory reported previously in mice lacking integrin alpha3.

2 plated on mAbs anti-integrin alpha5 or anti-integrin alpha3.

3 Suppression of integrin alpha3, a laminin receptor subunit, in cells sy

4 Here, we show that palmitoylated integrins (alpha3, alpha6, and beta4 subunits) and tetra

5 artially explain the renal phenotype seen in integrin alpha3 and alpha3/alpha6 subunit-deficient anim

6 solated UB culture models indicate that both integrin alpha3 and alpha6 subunits play a direct role i

7 nd beta1 laminin chains; nidogen-1/entactin; integrin alpha3 and beta1 chains in diabetic and DR corn

8 Integrin alpha3 and dystroglycan can be co-immunoprecipi

9 f glomeruli with perturbed nephrin, podocin, integrin alpha3 and fibronectin expression.

10 eta1 (TGF-beta1) and its downstream targets, integrin-alpha3 and -beta6 and MMP-3 and -9.

11 F, PDGF, and PDGF receptors, upregulation of integrins alpha3 and alpha5, and increased proliferation

12 Here we identify integrin alpha3 as a key mediator of neuronal stability.

13 inal neuron response to "activated" LN-1 are integrins alpha3 beta1 and alpha6 beta1; these are the s

14 uired to fully rescue cell death and restore integrin alpha3 expression.

15 o intracellular PKC helps to explain why the integrin alpha3 extracellular domain is needed for both

16 in Alport mesangial cells and an increase in integrin alpha3 in Alport podocytes.

17 elop normally in mice with selective loss of integrin alpha3 in excitatory forebrain neurons, reachin

18 her, our data support a fundamental role for integrin alpha3 in regulating dendrite arbor stability,

19 identified a pathway involving activation of integrin alpha3 in TA cells that signals through an LATS

20 r adhesion molecules, including fibronectin, integrin alpha3, integrin beta1, integrin beta3, and cad

21 re, gene-dosage experiments demonstrate that integrin alpha3 interacts functionally with the Arg nonr

22 A potential laminin receptor, integrin alpha3, is at the presynaptic side of the wild-

23 al integrin alpha1 and podocyte vimentin and integrin alpha3 may be important features of glomerular

24 However, by P42, integrin alpha3 mutant mice exhibit significant reductio

25 that the developmental defects of TRAF6- and integrin alpha3-null mouse kidneys are similar.

26 -2) and anti-invasive potential (decrease in integrin alpha3) of the combination of GHRH agonist and

27 ng these, 12 antibodies directly recognizing integrin alpha3 or beta1 subunits were eliminated.

28 sed an alanine-to-serine substitution in the integrin alpha3 subunit, thereby introducing an N-glycos

29 ession of wild-type Met, kinase-dead Met, or integrin alpha3 was sufficient to rescue death upon remo

30 on as follows: (i) a stronger interaction of integrin alpha3 with CD9 in KK47 than in YTS1; (ii) conv

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