ライフサイエンスコーパス: integrin alpha3beta1

1 e transmembrane 4 superfamily (TM4SF) and an integrin (alpha3beta1).

2 , including the scavenger receptor MARCO and integrin alpha3beta1.

3 also form normally in mice deficient in the integrin alpha3beta1.

4 ion of COX-2 by alpha3(IV)NC1 is mediated by integrin alpha3beta1.

5 Integrin alpha3beta1, a major receptor for epidermal adh

6 Integrin alpha3beta1, a major receptor in the epidermis

7 We previously showed that integrin alpha3beta1 activates the Rho family GTPase Rac

8 Interestingly, in cells lacking integrin alpha3beta1, adhesion to the alpha3NC1 domain w

9 ptive neurons express fibronectin receptors, integrin alpha3beta1, alpha4beta1, and alpha5beta1, at h

10 cally associated with Kaposi's sarcoma, uses integrins (alpha3beta1, alphaVbeta3, and alphaVbeta5) an

11 surface receptors, such as heparan sulfate, integrins (alpha3beta1, alphaVbeta3, and alphaVbeta5), a

12 (HMVEC-d) cell surface heparan sulfate (HS), integrins alpha3beta1, alphaVbeta3, and alphaVbeta5, and

13 ed by persistent, disorganized expression of integrin alpha3beta1 and enhanced production of urinary-

14 The interaction between integrin alpha3beta1 and laminin-5 is essential for esta

15 in CD151 forms a stoichiometric complex with integrin alpha3beta1 and regulates its endocytosis.

16 Finally, in vitro studies showed that integrin alpha3beta1 and the Lutheran glycoprotein media

17 with other TM4SF members (CD9 and CD81) and integrins (alpha3beta1 and alpha6beta1).

18 EphA2 was also associated with KSHV and integrins (alpha3beta1 and alphaVbeta3) in LRs early dur

19 igation of the laminin- and collagen-binding integrins alpha3beta1 and alpha2beta1 did not cause thes

20 direct interaction with the laminin-binding integrins alpha3beta1 and alpha6beta1.

21 M on laminin alpha5 may overlap with that of integrins alpha3beta1 and alpha6beta1.

22 Integrins alpha3beta1 and alpha6beta4 are abundant recep

23 Furthermore, laminin-5, a common ligand for integrins alpha3beta1 and alpha6beta4, was detected in t

24 with both of the major laminin-5 receptors, integrins alpha3beta1 and alpha6beta4.

25 Mutation within the synergy site decreased integrin alpha3beta1 binding 17-fold, and the four-Gly i

26 in binding domain led us to hypothesize that integrin alpha3beta1 binding may also be modulated by th

27 pacing of the RGD and synergy sites modulate integrin alpha3beta1 binding to Fn.

28 ing RNA also blocked uPA induction following integrin alpha3beta1 clustering.

29 Mice were immunized with integrin alpha3beta1-containing complexes isolated from

30 Integrin alpha3beta1 coprecipitated and colocalized with

31 the integrin beta1 subunit and regulator of integrin alpha3beta1-dependent Akt activation.

32 tion plays a previously unrecognized role in integrin alpha3beta1-dependent cell signaling required f

33 better substrate than LM-511 for stimulating integrin alpha3beta1-dependent collecting duct cell func

34 mental program; however, the LM types and LM/integrin alpha3beta1-dependent signaling pathways are po

35 llel changes in the expression of laminin 5, integrin alpha3beta1, E-cadherin, and the gap junctional

36 Compared with other integrins, alpha3beta1 exhibited a considerably higher l

37 Integrin alpha3beta1 had the highest affinity for FnIII9

38 The laminin-binding integrin alpha3beta1 has previously been shown to regula

39 In these cells, soluble alpha3NC1 bound integrin alpha3beta1; however, unlike alphavbeta3, alpha

40 Our findings indicate a role for integrin alpha3beta1 in BM stability through fibulin-2 i

41 xplored the role of the prominent epithelial integrin alpha3beta1 in experimental fibrosis by generat

42 alpha1, alpha5, beta1,gamma1; and epithelial integrin alpha3beta1 in human diabetic retinopathy (DR)

43 ion, we were able to detect a new ligand for integrin alpha3beta1 in the epidermal BM, suggesting tha

44 Thus integrin alpha3beta1, in conjunction with integrin alpha

45 Second, integrin alpha3beta1 independently activates two recepto

46 ng that the main podocyte adhesion receptor, integrin alpha3beta1, interacts with the tetraspanin CD1

47 Integrin alpha3beta1 is a cell adhesion receptor for lam

48 Integrin alpha3beta1 is a major receptor for laminin.

49 These findings indicate that integrin alpha3beta1 is a receptor for the alpha3NC1 dom

50 The laminin (LM)-binding integrin alpha3beta1 is crucial for this developmental p

51 The laminin-binding integrin alpha3beta1 is expressed at high levels in lung

52 Integrin alpha3beta1 is highly expressed in breast cance

53 The laminin-binding integrin alpha3beta1 is highly expressed in epidermal ke

54 n, we next investigated the possibility that integrin alpha3beta1 is involved in mediating the prolif

55 First, integrin alpha3beta1 is required for autophagy-induced c

56 The integrin alpha3beta1 is the major mediator of breast car

57 The integrin alpha3beta1 is thought to mediate interactions

58 nase activity, induced apoptosis by reducing integrin alpha3beta1 levels, activating anoikis, and blo

59 We demonstrate that integrin alpha3beta1-mediated cell adhesion to LM-332 mo

60 nd pulmonary fibrogenesis require epithelial integrin alpha3beta1-mediated cross-talk between TGFbeta

61 The integrin alpha3beta1 mediates cellular adhesion to the m

62 oncogenic Ras mutation in the acquisition of integrin alpha3beta1-regulated phenotypes that promote S

63 Integrin alpha3beta1 regulates adhesive interactions of

64 correlated with an altered expression of the integrin alpha3beta1, suggesting that it plays an import

65 gesting that basal keratinocytes can utilize integrin alpha3beta1 to interact with an alternative lig

66 n resonance to determine binding kinetics of integrin alpha3beta1 to the Fn fragments.

67 Several novel molecules, including integrin alpha3beta1, VE-cadherin, ICAM-2, junctional ad

68 val of laminin-adherent cells by maintaining integrin alpha3beta1 via a kinase-independent mechanism.

69 In this study, we report that integrin alpha3beta1 (VLA-3; CD49c/CD29) is dramatically

70 Adhesion of epithelial cells to laminin via integrin alpha3beta1 was previously shown to activate at

71 Integrin alpha3beta1 was required for full FAK auto-phos

72 major cellular receptors for laminin-332 are integrin alpha3beta1, which mediates rapid tumor cell mi

73 nese hamster ovary cells, the interaction of integrin alpha3beta1 with laminin 5 was sufficient to pr