ライフサイエンスコーパス: integrin alpha4beta1

1 EGF-A, induce lymphatic vessel expression of integrin alpha4beta1.

2 lation of the T-cell antigen receptor or the integrin alpha4beta1.

3 cific CD4(+) T cells robustly expressing the integrin alpha4beta1.

4 in that serves as a ligand for the leukocyte integrin, alpha4beta1.

5 ese hamster ovary cells that express defined integrins (alpha4beta1, alpha5beta1, or both), and cell

6 Integrins alpha4beta1, alpha5beta1, alpha6Abeta1, alphav

7 Integrins alpha4beta1, alpha5beta1, and alphavbeta3 and

8 t soluble uPAR (suPAR) specifically binds to integrins alpha4beta1, alpha6beta1, alpha9beta1, and alp

9 st small molecule agonist identified for the integrin alpha4beta1 (also known as very late antigen-4

10 We show here that the fibronectin-binding integrin alpha4beta1 and its ligand fibronectin are nove

11 Our studies show that integrin alpha4beta1 and the signals it transduces regul

12 Intercellular adhesion mediated by integrin alpha4beta1 and vascular cell adhesion molecule

13 These studies indicate that integrin alpha4beta1 and VCAM-1 facilitate a critical ce

14 adhesion mediated by the interaction between integrin alpha4beta1 and VCAM-1 is important in normal p

15 an endothelial cell ligand for two leukocyte integrins (alpha4beta1 and alpha4beta7).

16 The fibronectin (FN)-binding integrins alpha4beta1 and alpha5beta1 confer different c

17 CC chemokine receptor 9, and binding of the integrins alpha4beta1 and alphaLbeta2 to their respectiv

18 This result suggests that at least two integrins, alpha4beta1 and an RGD-directed, non-alpha5be

19 t VEGFR1+ cells express VLA-4 (also known as integrin alpha4beta1), and that tumour-specific growth f

20 ed T cell activation, enhanced expression of integrin alpha4beta1, and infiltration of activated T ce

21 al conformational equilibrium set points for integrin alpha4beta1 are cell type specific and differ f

22 The IDAPS motif implicated in integrin alpha4beta1 binding is at the FN13-14 junction,

23 igand for very late Ag-4 (VLA-4; also called integrin alpha4beta1) binding cells in granulomas, and c

24 Antagonists of integrin alpha4beta1, but not of other integrins, blocke

25 Antagonists of integrin alpha4beta1, but not other integrins, blocked t

26 Chemokine stimulation of integrin alpha4beta1-dependent T lymphocyte adhesion is

27 Stimulation by chemokines of integrin alpha4beta1-dependent T-lymphocyte adhesion is

28 mature naive T cells was sufficient to drive integrin alpha4beta1 expression and CNS migration, where

29 nduced lymphangiogenesis, as genetic loss of integrin alpha4beta1 expression in Tie2Cre+ alpha4(loxp/

30 Progenitor cells, which express integrin alpha4beta1, homed to sites of active tumor neo

31 We demonstrate that ectopic expression of integrin alpha4beta1 in animal cap cells results in atta

32 es indicate the usefulness of antagonists of integrin alpha4beta1 in suppressing macrophage colonizat

33 e sequence recognized by the closely related integrin alpha4beta1, in the inducible endothelial ligan

34 Furthermore, antagonists of integrin-alpha4beta1 inhibited chemotherapy-induced tumo

35 accurately predict poor disease outcome, and integrin alpha4beta1 is a biomarker of lymphatic endothe

36 Integrin alpha4beta1 is a receptor for vascular cell adh

37 Integrin alpha4beta1 is expressed by proliferating but n

38 We conclude that the integrin alpha4beta1 is important for survival of develo

39 We conclude that integrin alpha4beta1 is necessary for CD4(+) T cell-medi

40 e encoding the alpha4 subunit of alpha4beta1 integrin (alpha4beta1) is essential for this migratory p

41 Very late antigen-4 (VLA-4; also called integrin alpha4beta1) is a transmembrane noncovalent het

42 metastatic disease, these results show that integrin alpha4beta1-mediated tumor lymphangiogenesis pr

43 Integrin alpha4beta1 mediates leukocyte recruitment, act

44 alpha9beta1, like the structurally related integrin alpha4beta1, mediates accelerated cell migratio

45 odes promotes tumor metastasis by activating integrin alpha4beta1 on lymph node lymphatic endothelium

46 ecific peptidomimetic ligand (LLP2A) against integrin alpha4beta1 on the MSC surface to a bisphosphon

47 ients, these results indicate that targeting integrin alpha4beta1 or VCAM to inhibit the interactions

48 ereas genetic or pharmacological blockade of integrin alpha4beta1 or VCAM-1 inhibits it.

49 interactions in shear flow of cells bearing integrins alpha4beta1 or alpha4beta7 with VCAM-1 and MAd

50 The most prominent cell-surface integrin alpha4beta1 partner, a 70-kDa protein, was isol

51 Activated integrin alpha4beta1 promotes expansion of the lymphatic

52 The integrin alpha4beta1 recognizes an LDVP sequence in the

53 A non-I-domain integrin, alpha4beta1, recognizes vascular cell adhesion

54 gration, whereas pharmacologic inhibition of integrin alpha4beta1 reduced the abnormal T cell presenc

55 Inhibition of integrin-alpha4beta1, SDF-1alpha, or IL-1beta was suffic

56 In addition, antagonists of integrin alpha4beta1 suppress lymphangiogenesis and tumo

57 mical cross-linking to identify sequences in integrin alpha4beta1 that are involved in its interactio

58 Integrin alpha4beta1 then promotes growth factor and tum

59 n and paxillin with the cytoplasmic tails of integrin-alpha4beta1, thereby stimulating myeloid cell a

60 Erythroid cells express only one integrin, alpha4beta1, throughout differentiation, and i

61 eta (IL-1beta) collaborate with myeloid cell integrin-alpha4beta1 to promote tumor inflammation and g

62 o cell types and was partly dependent on the integrin alpha4beta1 (very late activation 4[VLA-4]) and

63 with monoclonal antibodies (MoAbs) enhanced integrin alpha4beta1 (very late antigen [VLA]-4) and alp

64 Here we show that integrin alpha4beta1 (VLA-4) and VCAM-1 promote close in

65 Here we show that integrin alpha4beta1 (VLA-4) promotes the homing of circ

66 Here, we show that integrin alpha4beta1 (VLA4) promotes the invasion of tum

67 ously shown the constitutive activity of the integrin, alpha4beta1 (VLA4), on a unique subpopulation

68 addition of 12G10 mAb to cells adhering via integrin alpha4beta1 was found to trigger disruption of