ライフサイエンスコーパス: integrin alpha5beta1

1 reas it cooperates with talin for activating integrin alpha5beta1.

2 as a molecular bridge between M1 protein and integrin alpha5beta1.

3 by antibodies to the endogenously expressed integrin alpha5beta1.

4 as labeled by antibodies to the RGDS-binding integrin alpha5beta1.

5 h follow ligation of Fn to its receptor, the integrin alpha5beta1.

6 recently in haptotaxis via interaction with integrin alpha5beta1.

7 Fibronectin (FN) depends on the FN receptor Integrin alpha5beta1.

8 eir survival to fibronectin by up-regulating integrin alpha5beta1.

9 t cell migration on fibronectin requires the integrin alpha5beta1.

10 re regulated by adhesion proteins, including integrin alpha5beta1.

11 man Fn, and the epithelial cell Fn receptor, integrin alpha5beta1.

12 (68)Ga-aquibeprin shows high selectivity for integrin alpha5beta1 (50% inhibition concentration [IC50

13 Antagonists of integrin alpha5beta1 activate PKA, which then leads to t

14 he related integrin alphavbeta8, but not the integrins alpha5beta1, alphavbeta3, alphavbeta5 and alph

15 that M4 increases expression of "migratory" integrins alpha5beta1, alphaVbeta5, and alphaVbeta6, whe

16 an antibody against the fibronectin-binding integrin alpha5beta1 also blocked the p70S6K phosphoryla

17 Integrin alpha5beta1 and alphavbeta3 affinities were det

18 GT1b binds to integrin alpha5beta1 and blocks the integrin-fibronectin

19 oprecipitation, while direct binding between integrin alpha5beta1 and CCN2 was confirmed in cell-free

20 CCN2 regulates PSC function via cell surface integrin alpha5beta1 and heparan sulfate proteoglycan re

21 D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during ang

22 Evidence is now provided that the integrin alpha5beta1 and its ligand fibronectin are coor

23 tect and differentiate between two different integrins (alpha5beta1 and alphavbeta3) bound to RGD-con

24 CHO cells express two RGD-binding integrins (alpha5beta1 and alphavbeta5) that, although n

25 Affinity chromatography identified the integrins alpha5beta1 and alpha(v)beta3 as surface recep

26 The fibronectin binding integrins alpha5beta1 and alpha4beta1 generate signals p

27 Integrins alpha5beta1 and alphavbeta3 also localized to

28 e recommendable for complementary mapping of integrins alpha5beta1 and alphavbeta3 by PET, allowing f

29 xenografts (human melanoma, expressing both integrins alpha5beta1 and alphavbeta3) were used.

30 itional evidence of "cross-talk" between the integrins alpha5beta1 and alphavbeta3, and support the i

31 Alternatively spliced forms of CD97 bind integrins alpha5beta1 and alphavbeta3, decay acceleratin

32 are tracers for selective in vivo mapping of integrins alpha5beta1 and alphavbeta3, respectively, by

33 t adhesion response to selective ligands for integrins alpha5beta1 and alphavbeta3, which are both re

34 ich high activity toward fibronectin binding integrins alpha5beta1 and alphavbeta6 and not on vitrone

35 bronectin, whereas other fibronectin-binding integrins, alpha5beta1 and alphaVbeta3, were resident at

36 (via integrin alpha2beta1), fibronectin (via integrin alpha5beta1), and fibrinogen (via integrin alph

37 independent manner by complexing with active integrin alpha5beta1, and mediating beta-arrestin2-depen

38 JSM6427, a specific integrin alpha5beta1 antagonist, significantly inhibited

39 As Hox D3, integrin alphavbeta3, and integrin alpha5beta1 are expressed on tumor blood vessel

40 Fibronectin and its major receptor, integrin alpha5beta1 are required for embryogenesis.

41 P4G11 induces clustering of integrin alpha5beta1 at lateral, intercellular surfaces.

42 tion of fibronectin and acute disruptions of integrin alpha5beta1 binding to fibronectin increases th

43 In the absence of integrin alpha5beta1 binding to fibronectin, convergence

44 Integrin alpha5beta1 binds to an Arg-Gly-Asp (RGD) motif

45 peptide, and novel nonpeptide antagonists of integrin alpha5beta1 blocked angiogenesis induced by sev

46 that cyclic forces applied to a fibronectin-integrin alpha5beta1 bond switch the bond from a short-l

47 al reinforcement strengthens the fibronectin-integrin alpha5beta1 bond through the RGD binding site o

48 recruitment of paxillin to sites of lateral integrin alpha5beta1 clustering and is followed by tight

49 structure of the ligand-binding headpiece of integrin alpha5beta1 complexed with fragments of its phy

50 and monoclonal antibody reporters, to image integrin alpha5beta1 conformation.

51 CCN2 stimulated integrin alpha5beta1-dependent adhesion, migration, and

52 lantoic membrane enhanced angiogenesis in an integrin alpha5beta1-dependent manner.

53 Zyxin silencing led to elevated integrin alpha5beta1-dependent single cell motility.

54 An analysis of HUASMC fibronectin receptor (integrin alpha5beta1) distribution revealed that III1-C

55 Our studies indicate that ligation of integrin alpha5beta1 during angiogenesis suppresses an a

56 -stain electron microscopy, we show that the integrin alpha5beta1 ectodomain adopts extended-closed a

57 nals in an NC cell-autonomous manner through integrin alpha5beta1 expressed by the NC, leading to act

58 Integrin alpha5beta1 expression by FACS and Western blot

59 By regulating cell-cell junctions, integrin alpha5beta1 expression, and cell-extracellular

60 d agrees with the experimental CMR effect of integrin alpha5beta1-fibronectin interaction.

61 tween the ECM component fibronectin (fn) and integrin alpha5beta1 forms a complex with ZO-1 in cells

62 The integrin alpha5beta1 has been previously implicated in t

63 show that the three conformational states of integrin alpha5beta1 have discrete free energies and def

64 To investigate the role of integrin alpha5beta1 in cardiovascular development, we u

65 determine the expression and localization of integrin alpha5beta1 in human retinal pigment epithelium

66 remodeling stem from the role of mesodermal integrin alpha5beta1 in neural crest proliferation and d

67 ate proteoglycans functioned as a partner of integrin alpha5beta1 in regulating adhesion of PSCs to C

68 Thus we propose a novel role for integrin alpha5beta1 in regulating epithelial morphogene

69 demonstrate a requisite role for mesodermal integrin alpha5beta1 in signaling between the mesoderm a

70 ted against the epithelial cell Fn receptor, integrin alpha5beta1, inhibited Fn and FBS-mediated inva

71 by soluble endoglin, RGD peptides, the anti-integrin alpha5beta1 inhibitory antibody LIA1/2 and the

72 The complex of GM3 with tetraspanin CD9 and integrin alpha5beta1 inhibits motility and invasiveness.

73 ix proteins such as FN and the corresponding integrins, alpha5beta1 integrin in particular.

74 nment along AC processes, suggesting that FN-integrin alpha5beta1 interaction is involved in filopodi

75 Strong integrin alpha5beta1 interactions with CD97 have been id

76 Here, we demonstrate that integrin alpha5beta1 interacts directly with Cx43 and th

77 Integrin alpha5beta1 is among the proteins overexpressed

78 Integrin alpha5beta1 is essential for vascular developme

79 the basis of our results, we suggested that integrin alpha5beta1 is involved in BK-induced signaling

80 These data indicate that a signal from integrin alpha5beta1 is necessary for integrin alphavbet

81 Integrin alpha5beta1 is overexpressed in tumor-associate

82 Integrin alpha5beta1 is poorly expressed on normal quies

83 Integrin alpha5beta1 is the first high-affinity cellular

84 r epithelial and A549 cells, suggesting that integrin alpha5beta1 is the major Fn receptor expressed

85 e that a major cell surface receptor for FN, integrin alpha5beta1, is also required for the developme

86 stress-induced conformational activation of integrin alpha5beta1 leading to the opening of the HC.

87 gnetic beads or conformational activation of integrin alpha5beta1 leads to the opening of the Cx43 HC

88 eted cells displayed significantly increased integrin alpha5beta1 levels, accompanied by enhanced adh

89 To determine the requirement for integrin alpha5beta1 ligation in order for integrin alph

90 Thus, fibronectin and integrin alpha5beta1, like integrin alphavbeta3, contrib

91 metry modulates cell shape, adhesion through integrin alpha5beta1, MAPK and STAT activity, and initia

92 aining peptide or antibodies recognizing the integrin alpha5beta1 markedly reduced invasion, suggesti

93 ata indicate that insulin potently activates integrin alpha5beta1 mediated CHO-T cell adhesion, while

94 The integrin alpha5beta1 mediated the effects of FN because

95 gatus CalA is an invasin that interacts with integrin alpha5beta1 on host cells, induces endocytosis

96 uces endocytosis in part by interacting with integrin alpha5beta1 on host cells.

97 One of these receptors, integrin alpha5beta1, plays a critical role in tumor- an

98 Integrin alpha5beta1 production by PSCs was verified by

99 Here we show that the integrin alpha5beta1 promotes endothelial cell survival

100 s study indicates that FN, by binding to the integrin alpha5beta1 receptor, stimulates the expression

101 ion of III13 and III7-11 (which contains the integrin alpha5beta1 recognition site), either as a sing

102 In this report, we demonstrate that integrin alpha5beta1 serves as an alternative coreceptor

103 ha5beta1 mediated CHO-T cell adhesion, while integrin alpha5beta1 signaling in turn enhances insulin

104 ecreased with age, while binding to CD36 and integrin alpha5beta1 significantly increased with age.

105 w molecular weight, nonpeptide antagonist of integrin alpha5beta1, SJ755, can inhibit internalization

106 these established catch-bond formers is the integrin alpha5beta1, the primary receptor for fibronect

107 TbetaRIII-mediated integrin alpha5beta1 trafficking regulates cell adhesion

108 Purified M1 protein failed to associate with integrin alpha5beta1 unless the integrin had been prebou

109 ndothelial endoglin interacts with leukocyte integrin alpha5beta1 via its RGD motif, and this adhesio

110 ed with enhanced adhesion to fibronectin via integrin alpha5beta1 (VLA-5), but not alpha4beta1 (VLA-4

111 Integrin alpha5beta1 was detected in native adult and fe

112 Binding between CCN2 and integrin alpha5beta1 was determined in cell-free systems

113 Expression of integrin alpha5beta1 was examined by immunoprecipitation

114 beta1 are cell type specific and differ from integrin alpha5beta1 when the two integrins are coexpres

115 ne expressing a single fibronectin receptor, integrin alpha5beta1, which was uniformly activated with

116 n between VEGF receptor-2 (Flk-1) and the FN integrin, alpha5beta1, which required intact FN because

117 ipitation of matrix metal-loproteinase-9 and integrin alpha5beta1, while endogenous accumulation of G

118 reduced IE binding to the receptors CD36 and integrin alpha5beta1, while hemoglobin AS did not modify

119 The high affinity interaction of integrin alpha5beta1 with the central cell binding domai