ライフサイエンスコーパス: integrin alphaIIb

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1 identified as a binding partner of platelet integrin alphaIIb.

2 Using integrin alphaIIb and RAGE (receptor for advanced glycat

3 Willebrand factor (vWF), glycoprotein Ib-IX, integrin alphaIIb, and mutants of beta3 with truncations

4 The integrin alphaIIb(beta)3 was initially believed to be ex

5 gamma chains contains a binding site for the integrin alphaIIb beta3 (glycoprotein gpIIb/IIIa) recept

6 The integrin alphaIIb beta3 (GPIIb-IIIa) is expressed on the

7 caused by a defect or deficiency in platelet integrin alphaIIb beta3 (GPIIb-IIIa).

8 The platelet-specific integrin alphaIIb beta3 achieves a high affinity binding

9 -dependent aggregation that is a function of integrin alphaIIb beta3 activation.

10 of human platelets, caused by activation of integrin alphaIIb beta3 and its consequent binding of fi

11 de-in signaling, may be a mechanism by which integrin alphaIIb beta3 function is regulated.

12 n of the beta3 subunit of the major platelet integrin alphaIIb beta3 has been shown to occur during t

13 plays an important role in the activation of integrin alphaIIb beta3 induced by VWF and thrombin.

14 Integrin alphaIIb beta3 mediates platelet aggregation an

15 Integrin alphaIIb beta3 requires its cytoplasmic tails t

16 ding on fibrinogen, responses that depend on integrin alphaIIb beta3 signaling.

17 Here, we present the solution structure of integrin alphaIIb beta3 TMCD heterodimer, which reveals

18 ogen is a plasma protein that interacts with integrin alphaIIb beta3 to mediate a variety of platelet

19 We studied the function of the platelet integrin alphaIIb beta3 using a B lymphocyte model in wh

20 antibody (mAb) 7E3 directed to the platelet integrin alphaIIb beta3 was tested for its cross-reactiv

21 owth, and induction of the platelet-specific integrin alphaIIb beta3, all hallmarks of megakaryocytic

22 r SFLLRN promotes the conversion of platelet integrin alphaIIb/beta3 into a fibrinogen-binding form r

23 n of megakaryocyte/platelet lineage-specific integrins alphaIIb/beta3 (CD41/CD61); and upregulation o

24 in beta3 CT but also, surprisingly, with the integrin alphaIIb CT.

25 cs, and resulting ecto-TM domain coupling of integrin alphaIIb in model constructs and relate it to o

26 and binds to a number of effectors, such as integrin alphaIIb, PAK1, and polo-like kinases, in diffe

27 virus (MuLV) vector controlled by the human integrin alphaIIb promoter (nucleotides -889 to +35).

28 (FIX) under control of the platelet-specific integrin alphaIIb promoter, to determine whether ectopic

29 on the beta-propeller domain of the platelet integrin alphaIIb subunit (GPIIb) only when the drug is

30 binds directly to the cytoplasmic domain of integrin alphaIIb subunit containing a conserved PP1c bi

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