ライフサイエンスコーパス: integrin alphav

1 DL) cells have been shown to express several integrins (alphav, alpha5, beta1, beta3) that use RGD (a

2 negative IkappaBalpha perturbed ET-1-induced integrin alphaV and integrin beta1 expression.

3 Integrin-alphaV and -beta1, fibronectin, and versican co

4 ed a direct physical interaction of MBD with integrins alphav and beta1, caveolin-1, and transferrin

5 The level of expression of integrins alphav and beta3 and the amount of assembled F

6 In addition, a cross-talk between EMP2 and integrins alphaV and beta3 was shown in the regulation o

7 In contrast, expression of Mer, integrin alphaV, and NPC1 was required for efficient GP-

8 a tumor vasculature-specific antiangiogenic integrin alphav antagonist and tumor-specific antibody-i

9 urthermore, simultaneous treatments with the integrin alphav antagonist and tumor-specific antibody-I

10 monotherapies with either an antiangiogenic integrin alphav antagonist or antibody-IL-2 fusion prote

11 Systemic administration of neutralizing anti-integrin alphaV antibody or a genetic deficiency of inte

12 Our study demonstrates that the sOPN/integrin alphav axis, which induces T cell chemotaxis to

13 st, is inhibited by blocking the other beta1 integrins, alphav beta1 and alpha5 beta1.

14 of mouse mAb LM609 that is directed to human integrin alphav beta3 and has potential applicability in

15 We have shown that osteopontin binding to integrin alphav beta3 in osteoclasts stimulates gelsolin

16 NA plasmids encoding the individual complete integrin alphaV, beta3, and beta6 subunits were used to

17 fibronectin, and gelatin, and mRNA levels of integrin alphav/beta3 were determined.

18 ine osteoclast precursors bind matrix is the integrin alphav beta5 and that granulocyte-macrophage co

19 Soluble integrin alphav beta5 reacted with seven different Ad se

20 We report here the expression of soluble integrin alphav beta5, which retains the ability to reco

21 conclude that deletion or inhibition of the integrin alphav beta6 did not protect animals from P. ae

22 Deletion of integrin alphav beta6 has been associated with significa

23 Integrin alphaV can form heterodimers with several beta

24 s revealed that PKCalpha was up-regulated by integrin alphav in a three-dimensional microenvironment-

25 In mice, lack of integrin alphav in the immune system resulted in loss of

26 on and blocked the signaling transduction by integrin alphaV, inhibited migration signaling pathways

27 ression of the cell surface molecules alpha6-integrin, alphav-integrin, and the c-kit receptor.

28 These findings suggest that the integrin alphaV is developmentally regulated, has a dist

29 Src interaction with integrin alphaV is required for integrin alphaV-mediated

30 that Periostin (Postn) via interaction with Integrin-alphav (Itgav) regulates HSC proliferation.

31 alpha constitutes a crucial component of the integrin alphav-mediated pathway(s) that promote p53 rel

32 s stable knockdown of PKCalpha inhibited the integrin alphav-mediated relocalization of p53.

33 raction with integrin alphaV is required for integrin alphaV-mediated Src activation, and the subsequ

34 A pathway was identified that involved integrin alphav-mediated up-regulation of PKCalpha and P

35 functionally linked to higher expression of integrin alphaV on effector CD4(+) T cells.

36 ectin and vitronectin, by down-regulation of integrin alphav, or by a peptide corresponding to 13 aa

37 to macrophages and, considering that Mer and integrin alphaV promote phagocytosis of apoptotic cells,

38 zation of sOPN and blockade of its receptor, integrin alphav, significantly inhibited CD4(+) T cell m

39 Our results showed that integrin alphav-specific MAb reduced infectivity by 85%.

40 neration of Tregs required expression of the integrin alphav subunit by DCs; mice that lacked alphav

41 Expression of the integrin alphav subunit was measured in purified subpopu

42 TSRI265) selected for its ability to bind to integrin alphav(v)beta3 and block alpha(v)beta3 interact

43 Integrin alphav was observed to promote a relocalization

44 ntegrin alpha5 whereas surface expression of integrin alphaV was unaffected.

45 microenvironments requires the expression of integrin alphav, which acts to suppress p53 activity.