ライフサイエンスコーパス: integrin alphavbeta3

1 ly recognize the alphaV or beta3 subunits of integrin alphaVbeta3.

2 s, which arises from defective activation of integrin alphaVbeta3.

3 tic effects of blood clotting and tumor cell integrin alphavbeta3.

4 nectin complexes to induce the activation of integrin alphavbeta3.

5 hibited by blockade of CCN1 and its receptor integrin alphavbeta3.

6 re attributed to the binding of alpha3NC1 to integrin alphavbeta3.

7 NC1 domain was enhanced due to activation of integrin alphavbeta3.

8 ncer cells via a plasma membrane receptor on integrin alphaVbeta3.

9 omain II of CCN1 as a novel binding site for integrin alphavbeta3.

10 xpression of proangiogenic molecules such as integrin alphavbeta3.

11 p66 show dramatically reduced attachment to integrin alphavbeta3.

12 ssion of the transcription factor Hox D3 and integrin alphavbeta3.

13 in expression of both tissue factor (TF) and integrin alphavbeta3.

14 vascularization and of the angiogenic agent, integrin alphavbeta3.

15 oth integrins, HPEV1 may preferentially bind integrin alphavbeta3.

16 ense angiogenesis and vascular expression of integrin alphavbeta3.

17 s mediated in part by productive ligation of integrin alphavbeta3.

18 GDS and LM609, a monoclonal antibody against integrin alphavbeta3.

19 n state of both a growth factor receptor and integrin alphavbeta3.

20 C migration by outside-in signaling from the integrin alphavbeta3.

21 dhesion, spreading, and angiogenesis through integrin alphavbeta3.

22 ating caspase 8 to the cytoplasmic domain of integrin alphavbeta3.

23 t activation protein (FAP), macrophages, and integrin alphavbeta3.

24 ohistochemical analysis, proved positive for integrin alphavbeta3.

25 significantly, the cytokine colocalized with integrin alphaVbeta3.

26 in many tumors in which tumor cells express integrin alphavbeta3.

27 including integrin receptors, in particular integrin alphaVbeta3.

28 d to increased expression of fibronectin and integrin alphavbeta3.

29 lecular imaging has been shown to detect the integrin alphavbeta3.

30 the surface protein aminopeptidase N and of integrin alphavbeta3.

31 onectin (FN) and trigger invasion mainly via integrin-alphavbeta3.

32 and function ofalphaIIbbeta3 and the related integrin, alphaVbeta3.

33 4, and 48 h after injection of (111)In-RGD2 (integrin alphavbeta3), (111)In-anti-F4/80-A3-1 (antimuri

34 1,2-, alpha1,3- and alpha1,6-fucosylation of integrin alphaVbeta3, a critical endometrium receptivity

35 Therefore, we compared the expression of integrin alphaVbeta3, a promiscuous receptor that binds

36 ed imaging tracers allow specific imaging of integrin alphavbeta3, a protein overexpressed during ang

37 The endothelial and smooth muscle integrin alphaVbeta3, a receptor for vitronectin and fib

38 lpha3NC1 domain and transdominantly inhibits integrin alphavbeta3 activation.

39 Here, we demonstrate that integrin alphavbeta3 allows glioblastoma cells to counte

40 h components of the extracellular matrix via integrin alphavbeta3 allows tumor survival and growth.

41 hat KSHV interacts with functionally related integrins (alphaVbeta3, alpha3beta1, and alphaVbeta5) an

42 lood vessels where it codistributes with the integrins alphavbeta3, alpha3beta1, and alpha6beta1.

43 h multiple cell surface receptors, including integrins alphavbeta3, alpha5beta1, alpha6beta1, and hep

44 of monoclonal antibodies (MAbs) specific for integrins alphavbeta3, alphavbeta1, and alphavbeta5, whi

45 e-based nanoparticle therapy that recognizes integrin alphavbeta3 (alphavbeta3-MPs of approximately 1

46 for alphavbeta6 than for other RGD-directed integrins (alphavbeta3, alphavbeta5, and alpha5beta1).

47 tro, and serves as a ligand for cell surface integrins alphavbeta3, alphavbeta5 and alpha9beta1 throu

48 ted cell adhesion and reduced uPA-stimulated integrin alphavbeta3/alphavbeta5 binding to VN by 73%.

49 We now show that RGDfV, an integrin alphavbeta3/alphavbeta5 cyclic function-blockin

50 , the 'eat-me' signal on apoptotic cells and integrins alphavbeta3/alphavbeta5 in macrophages to trig

51 Matrix ligation of integrins alphavbeta3/alphavbeta5 is critical for endoth

52 dothelial apoptosis induced by inhibition of integrins alphavbeta3/alphavbeta5 or by LatB-induced dis

53 dothelial apoptosis induced by inhibition of integrins alphavbeta3/alphavbeta5, and propose a novel m

54 ariant bound to transfected cells expressing integrin alphavbeta3 (also known as the vitronectin rece

55 ished direct solid phase binding to purified integrin alphavbeta3 and abolished alphavbeta3-mediated

56 rmore, galectin-3 promoted the clustering of integrin alphavbeta3 and activated focal adhesion kinase

57 n an alphaA-lacking and an alphaA-containing integrin alphaVbeta3 and alphaMbeta2 (CD11b/CD18), respe

58 molecular drugs, abciximab cross-reacts with integrin alphavbeta3 and alphaMbeta2.

59 onclusion, we found that HPEV1 utilises both integrin alphavbeta3 and alphavbeta1 as receptors; howev

60 dothelial cells through interaction with the integrin alphaVbeta3 and augments growth factor-induced

61 avbeta3 and correlation analysis of vascular integrin alphavbeta3 and autoradiography were completed.

62 tention to their transient overexpression of integrin alphavbeta3 and cautioned against corresponding

63 umor vascular and cell surface expression of integrin alphavbeta3 and correlation analysis of vascula

64 Silencing of integrin alphavbeta3 and deletion of gH prevented phosph

65 cells, targeting the activated conformer of integrin alphavbeta3 and disrupting its functions.

66 romotes melanoma cell invasion by activating integrin alphavbeta3 and down-regulating CD9, a putative

67 aintain proper tubular homeostasis utilizing integrin alphavbeta3 and downstream effectors.

68 ether, our findings establish that activated integrin alphavbeta3 and fibronectin promote lung metast

69 Integrin alphavbeta3 and its ligand fibrinogen appear in

70 ted by an interaction between the tumor cell integrin alphavbeta3 and lymph node vitronectin.

71 lammatory cells and proteolytic enzymes (eg, integrin alphavbeta3 and matrix metalloproteinases), hav

72 tionship between the expression of activated integrin alphavbeta3 and production of enzymatically act

73 and functionally important binding site for integrin alphavbeta3 and provide a new approach for diss

74 ation of SERTs that are tightly modulated by integrin alphavbeta3 and significantly contribute to glo

75 ed with decreased cell surface expression of integrin alphavbeta3 and significantly decreased express

76 come apoptotic in response to antagonists of integrin alphavbeta3 and this leads to the regression of

77 ]-Resveratrol binds to commercially purified integrin alphaVbeta3 and to alphaVbeta3 prepared from MC

78 of bFGF, resulted in enhanced expression of integrin alphavbeta3 and uPA.

79 ed that Hox D3 is required for expression of integrin alphavbeta3 and urokinase plasminogen activator

80 controls the expression of endothelial cell integrin alphavbeta3 and urokinase-type plasminogen acti

81 ecently reported that IGF1 directly binds to integrins (alphavbeta3 and alpha6beta4) and induces tern

82 l-adhesion (2.2-fold), and binding by the VN integrins alphavbeta3 and -beta5 (2.2-fold).

83 These results suggest that integrins alphavbeta3 and alpha4beta1 may serve as recep

84 these findings show that CCN3 is a ligand of integrins alphavbeta3 and alpha5beta1, acts directly upo

85 lpha4beta1 integrin, and antagonists for the integrins alphavbeta3 and alpha5beta1, as well as alpha4

86 CCN3-induced cell migration is dependent on integrins alphavbeta3 and alpha5beta1, whereas alpha6bet

87 D sequence, it binds directly to immobilized integrins alphavbeta3 and alpha5beta1, with half-maximal

88 describe that IL-1beta specifically bound to integrins alphavbeta3 and alpha5beta1.

89 almost completely inhibited; this shows that integrins alphavbeta3 and alphavbeta1 are utilized by th

90 To verify the use of integrins alphavbeta3 and alphavbeta1 as HPEV1 receptors

91 When a combination of MAbs specific for integrins alphavbeta3 and alphavbeta1 were used, virus i

92 e virus utilizes, we tested MAbs specific to integrins alphavbeta3 and alphavbeta1 which reduced infe

93 onformations exhibit differential binding to integrins alphavbeta3 and alphavbeta5 and that T1172 reg

94 ively bound to human cancer cells expressing integrins alphavbeta3 and alphavbeta5 as analyzed by flo

95 -1 leads to colocalization of PAI-1 with the integrins alphavbeta3 and alphavbeta5 at the cell-matrix

96 While integrins alphavbeta3 and alphavbeta5 both promote Ad in

97 Thus, integrins alphavbeta3 and alphavbeta5 differentially reg

98 d alphavbeta6 and not on vitronectin binding integrins alphavbeta3 and alphavbeta5 has been achieved

99 Inhibition of integrins alphavbeta3 and alphavbeta5 in human brain mic

100 n the lungs, and pulmonary T cells expressed integrins alphaVbeta3 and alphaVbeta5 in patients with S

101 to SPARC can be traced to the activation of integrins alphaVbeta3 and alphaVbeta5 on tumor cells.

102 onary infiltrating T lymphocytes may express integrins alphaVbeta3 and alphaVbeta5 that are necessary

103 Integrins alphavbeta3 and alphavbeta5 were detected on t

104 RGD peptidomimetics that target cell surface integrins alphavbeta3 and alphavbeta5 with monoclonal al

105 vestigated the regulation of the activity of integrins alphavbeta3 and alphavbeta5 with regard to the

106 trocytes, synthesize vitronectin and express integrins alphavbeta3 and alphavbeta5.

107 Function blocking antibodies against integrins alphavbeta3 and beta1 and a combination of ant

108 in coreceptor/thrombospondin-1 receptor) and integrins alphavbeta3 and beta1 was assessed by FACS.

109 HTM cells expressed CD47 and integrins alphavbeta3 and beta1.

110 The vitronectin receptor (integrin alphavbeta3) and TF have recently been found to

111 As Hox D3, integrin alphavbeta3, and integrin alpha5beta1 are expre

112 domain, to the GnTV synthesized N-glycans of integrin alphavbeta3, and subsequently activating the si

113 resulted in increased expression of Hox D3, integrin alphavbeta3, and the urokinase plasminogen acti

114 by cultivating FPS cells in the presence of integrin alphavbeta3 antibody or alphavbeta3-directed te

115 fact, matrix metalloproteinase 2 (MMP-2) and integrin alphavbeta3 are functionally associated on the

116 1 is secreted apically, whereas TbetaR-I and integrin alphaVbeta3 are localized basolaterally.

117 DV) have been shown to use the RGD-dependent integrin alphavbeta3 as a cellular receptor on cultured

118 Here we show that HCMV also uses integrin alphavbeta3 as a coreceptor.

119 ells expressed much higher levels of surface integrin alphavbeta3, as shown by affinity chromatograph

120 al structure of the extracellular portion of integrin alphaVbeta3 at 3.1 A resolution.

121 Here we demonstrated that sPLA2-IIA bound to integrin alphavbeta3 at a high affinity (K(D)=2 x 10(-7)

122 by exploiting their selective expression of integrin alphavbeta3 at that metastatic site.

123 F-beta1 secretion and activation mediated by integrin alphaVbeta3 because neutralizing antibodies blo

124 Cellular integrin alphaVbeta3 binds RKRK at the C-terminal tail o

125 e peptide, both of which block T4 binding to integrin alphaVbeta3 but are not agonists.

126 d angiogenic properties that are mediated by integrin alphaVbeta3 but VEGF-independent to the portfol

127 We also found an increase in integrin alphaVbeta3 (but not integrin beta1) expression

128 the sustained activity (4-20 h) depended on integrin alphavbeta3, but not beta1 integrins.

129 with small interfering RNA (siRNA) targeting integrin alphavbeta3, but not other integrin subunits, o

130 Antibody (Ab) to integrin alphaVbeta3, but not to alphaVbeta5, inhibits a

131 izing antibodies to OPN, integrin beta1, and integrin alphavbeta3, but not to CD44, negated the effec

132 ion and suggests that surface trafficking of integrin alphavbeta3 by EMP2 during the window of implan

133 Neutralizing antibodies against the integrin alphavbeta3 (c7E3 Fab and LM609) did not inhibi

134 The (18)F-FPRGD2 uptake was compared with integrin alphavbeta3, CD31, CD105, and Ki-67 using immun

135 Integrin alphaVbeta3 colocalized with areas of increased

136 phase assays established TINag binding with integrin alphavbeta3 comparable with vitronectin.

137 reover, the Ab binds with higher affinity to integrin alphaVbeta3 compared with a second HPA-1a-speci

138 , fibronectin and integrin alpha5beta1, like integrin alphavbeta3, contribute to an angiogenesis path

139 We hypothesized that integrin alphavbeta3 could be an important determinant o

140 The ectodomain of integrin alphaVbeta3 crystallizes in a bent, genuflexed

141 ntly, genetic or pharmacologic inhibition of integrin alphavbeta3 decreased VEGF production and induc

142 Moreover, expression of a dominant negative integrin alphavbeta3-Delta744 or treatment with the anti

143 ndothelial cells in culture, also through an integrin-alphavbeta3-dependent mechanism.

144 ors that function, at least in part, through integrin-alphavbeta3-dependent pathways.

145 s the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo.

146 with cyclic RGD (cRGD) peptides that target integrin alphavbeta3 expressed on cultured human umbilic

147 We show ProAgio induces apoptosis of integrin alphavbeta3-expressing cells by recruiting and

148 -PEG-E[c(RGDyK)](2) ((18)F-FPRGD2) uptake to integrin alphavbeta3 expression and angiogenesis in rena

149 Despite in vivo mapping of integrin alphavbeta3 expression being thoroughly investi

150 in tumor models lacking constitutive tumoral integrin alphavbeta3 expression but may be less useful f

151 illary carcinomas whereas it correlated with integrin alphavbeta3 expression by tumor cells in the cl

152 e significantly correlated (P < 0.0001) with integrin alphavbeta3 expression in renal masses.

153 Integrin alphavbeta3 expression is altered in various di

154 s not inhibit proliferation, suggesting that integrin alphavbeta3 expression is not sufficient to med

155 se of (111)In-RGD2 as a tracer to image only integrin alphavbeta3 expression on blood vessels in the

156 that M. tuberculosis stimulation upregulates integrin alphaVbeta3 expression on monocytes, which upre

157 Abraxane-mediated downregulation of integrin alphavbeta3 expression on tumor endothelial cel

158 bronchial epithelial (NHBE) cells with poor integrin alphavbeta3 expression showed negligible toxici

159 reased collagen I, collagen IV, fibronectin, integrin alphaVbeta3 expression with a reduction in corn

160 RGD2 autoradiography coincided with vascular integrin alphavbeta3 expression, as determined immunohis

161 ed imaging tracers allow specific imaging of integrin alphavbeta3 expression, proteins overexpressed

162 locked the ability of bFGF to induce uPA and integrin alphavbeta3 expression, yet had no effect on EC

163 article probe for PET and MRI scans of tumor integrin alphavbeta3 expression.

164 E-[c(RGDfK)]2 can safely be used for imaging integrin alphaVbeta3 expression.

165 Our results highlight FN assembly and integrin-alphavbeta3 expression as new hallmarks of CAFs

166 Once expressed, integrin alphavbeta3 facilitates VSMC adhesion to VWF in

167 M21-L cells which lack integrin alphavbeta3 failed to associate with thrombi an

168 urokinase plasminogen activator/receptor and integrin alphavbeta3 from the cell surface.

169 The possibility that integrin alphavbeta3 functions as a signaling receptor f

170 lantoic membrane, whereas blockade of FAK or integrin alphavbeta3 had no effect on bFGF-mediated Ras

171 Integrin alphavbeta3 has been implicated as a driver of

172 Integrin alphavbeta3 has been implicated in multiple asp

173 pecific angiogenesis marker, the endothelial integrin alphaVbeta3, has been shown to correlate with t

174 l adhesion molecule-1 (PECAM-1/CD31) and the integrin alphavbeta3 have been implicated in this proces

175 d new roles in the regulation of E-cadherin, integrin alphavbeta3, hypoxia-inducible factor-1alpha, s

176 trin, which shows an inverse selectivity for integrin alphavbeta3 (IC50 = 0.22 nM) over alpha5beta1 (

177 Expression of adhesion receptor integrin alphavbeta3 in an activated functional form str

178 The role of integrin alphavbeta3 in angiogenesis is complex, as evid

179 ts of F-actin, where it colocalized with the integrin alphavbeta3 in cells migrating into a scrape wo

180 al structure of the extracellular segment of integrin alphaVbeta3 in complex with a cyclic peptide pr

181 rain stimulates conformational activation of integrin alphavbeta3 in NIH3T3 cells.

182 8)F-FPRGD2 uptake reflects the expression of integrin alphavbeta3 in renal tumors but represents angi

183 Chinese hamster ovary cells that express the integrin alphavbeta3 in the absence of alpha5beta1 demon

184 These data suggest an important role of integrin alphavbeta3 in the metastasis of RAW117 cells t

185 onstrating the requirement of a fully active integrin alphavbeta3 in this process.

186 The expression of integrin alphaVbeta3 in undifferentiated neuroblastomas

187 DOTA-IO-RGD conjugates bound specifically to integrin alphavbeta3 in vitro.

188 (111)In-RGD2 allows the visualization of integrin alphavbeta3 in xenograft models in which integr

189 Ibbeta3 and the widely expressed nonplatelet integrin alphavbeta3) in two models of atherosclerosis,

190 acellular matrix and by its interaction with integrin alphaVbeta3 increases the motility of EC, which

191 Ligation of the integrin alphavbeta3 inhibits both phagocytosis and migr

192 and proximity ligation assays indicated that integrin alphavbeta3 interacts with glycoprotein H (gH).

193 As integrin alphavbeta3 is associated with breast cancer ce

194 exapeptides as high affinity ligands for the integrin alphavbeta3 is based on two concepts: a) screen

195 is not required for osteoclastogenesis, the integrin alphavbeta3 is essential for normal osteoclast

196 rin alphavbeta3 in xenograft models in which integrin alphavbeta3 is expressed only on the neovascula

197 Although integrin alphavbeta3 is linked to cancer progression, it

198 The interaction of VWC domain with integrin alphaVbeta3 is necessary and requires functiona

199 mong the integrins involved in this process, integrin alphavbeta3 is specific to basic fibroblast gro

200 Integrin alphavbeta3 is specifically but transiently exp

201 Integrin alphaVbeta3 is the vascular cell receptor for t

202 The cell surface molecule, integrin alphavbeta3, is activated through HSC adhesion

203 se) polymerase were inhibited by blockade of integrin alphaVbeta3, Jak2, and activation of phosphatid

204 1 directly bound to soluble and cell-surface integrin alphavbeta3 (K(D) about 1 microm).

205 feration and migration, coupled to decreased integrin alphavbeta3 levels and increased angiopoietin (

206 We found that THs, acting as soluble integrin alphavbeta3 ligands, activated growth-related s

207 t IGROV-1/Pt1 cells expressed high levels of integrin alphaVbeta3, making them attractive to be teste

208 te of phosphorylation, its interactions with integrin alphavbeta3 may play a critical role in cell si

209 nce of arthritic disease, and antagonists of integrin alphavbeta3 may represent a novel therapeutic s

210 (111)In-RGD2 was 1 mug or less for specific integrin alphavbeta3-mediated uptake of the tracer.

211 Integrin alphavbeta3-mediated uptake was also detected i

212 us integrin alpha3beta1, in conjunction with integrin alphavbeta3, modulates cellular responses to th

213 g tumor xenografts in which tumor cells were integrin alphavbeta3-negative.

214 A direct interaction between integrin alphaVbeta3 on endothelial cells and smooth mus

215 All 3 HNSCC xenografts expressed integrin alphavbeta3 on the vessels only.

216 on endothelial cells leads to expression of integrin alphavbeta3 on VSMCs.

217 rthermore, although mAbs specific for either integrin alphavbeta3 or alphavbeta5 inhibited degradatio

218 CHO cells transfected and expressing either integrin alphavbeta3 or integrin alphavbeta1 were used.

219 Jurkat T cells overexpressing integrin alphaVbeta3 or integrin alphaVbeta5 in cocultur

220 by monoclonal antibodies (mAbs) specific for integrins alphavbeta3 or alphavbeta5.

221 f the endothelial cell vitronectin receptor (integrin alphavbeta3), or fibrinogen, another alphavbeta

222 rotein, which we call ProAgio, that binds to integrin alphavbeta3 outside the classical ligand-bindin

223 spartic acid (cRGD) tripeptide for targeting integrin alphavbeta3 overexpressed cancer cells and an a

224 bciximab (P=0.027), a monoclonal antibody to integrin alphaVbeta3 (P=0.027), and chlorpromazine (P=0.

225 variety of monoclonal antibodies against the integrin alphavbeta3 partially inhibited the endothelial

226 These data demonstrate that integrin alphaVbeta3 plays a fundamental, but transient,

227 suggest that the direct binding to IGF-1 to integrin alphavbeta3 plays a role in IGF-1 signaling thr

228 Integrin alphavbeta3 plays a role in insulin-like growth

229 Integrin alphavbeta3 plays a role in insulin-like growth

230 Integrin alphaVbeta3 plays a role in the differentiation

231 However, it correlated only with integrin alphavbeta3-positive vessels in the group of pa

232 In conclusion, binding of resveratrol to integrin alphaVbeta3, principally to the beta3 monomer,

233 Thus, ligation of vascular cell integrin alphavbeta3 promotes a critical and specific ad

234 t regulated by a different alphav-containing integrin, alphavbeta3, promotes upregulation of survivin

235 acid (PLGA)-Chitosan nanoparticle (CSNP) for integrin alphavbeta3 receptor targeted paclitaxel (PTX)

236 t expression, which was mediated through the integrin alphaVbeta3 receptor, whereas periostin-blockin

237 Integrin alphavbeta3 recognizes fibrinogen, von Willebra

238 Interaction of vitronectin with integrin alphavbeta3 results in the continued activation

239 ulation of 5-HT homeostasis and behaviors by integrin alphavbeta3, revealing an important role for in

240 C-Fe3O4 NPs accumulate preferentially in the integrin alphavbeta3-rich tumor area, which are readily

241 Thus, we conclude that OPN/integrin alphavbeta3 signaling participates in the proce

242 es were designed to test the hypothesis that integrin alphavbeta3 signaling promotes the release of i

243 ibutable to changes in the activation of the integrin alphaVbeta3, since blocking alphaVbeta3 in high

244 A signaling axis consisting of the integrin alphavbeta3, Src kinase, and the transcription

245 as a core in assembling signaling molecules (integrin alphavbeta3, Src, cortactin, etc.) involved in

246 Integrin alphavbeta3 suppressed HSC function in the pres

247 e FAK signaling downstream of the Pro32Pro33 integrin alphavbeta3 suppresses SERT activity.

248 Integrin alphaVbeta3 surface expression was specifically

249 arginine-glycine-aspartic (RGD) peptides for integrin alphavbeta3 targeting and macrocyclic 1,4,7,10-

250 t a cationic nanoparticle (NP) coupled to an integrin alphavbeta3-targeting ligand can deliver genes

251 ivated conformation of the adhesion receptor integrin alphavbeta3 that is associated with a metastati

252 However, in some tumor cells that express integrin alphavbeta3, the alpha3NC1 domain does not inhi

253 tein 7 (EGFL7) as a novel specific ligand of integrin alphaVbeta3, thus providing mechanistic insight

254 e to NC1 domains proper, they did adhere via integrin alphavbeta3 to a KRGDS motif located adjacent t

255 r integrin alpha5beta1 ligation in order for integrin alphavbeta3 to internalize its ligand, cells we

256 l from integrin alpha5beta1 is necessary for integrin alphavbeta3 to internalize vitronectin, whereas

257 egrins, CCN1 binds to, and functions through integrin alphavbeta3 to promote pro-angiogenic activitie

258 nistration of a cyclic peptide antagonist of integrin alphavbeta3 to rabbits with antigen-induced art

259 netics and stability of the protein receptor integrin alphavbeta3 to the conformation of the ligand f

260 IGF1 binding to IGF1R induces recruitment of integrin alphavbeta3 to the IGF-IGF1R complex and then b

261 In sum, we show that integrin alphavbeta3 transduces prosurvival signals into

262 er spread area, and for cells overexpressing integrin alphavbeta3 upon stable transfection.

263 n characterized in xenograft models in which integrin alphavbeta3 was constitutively expressed by the

264 Integrin alphavbeta3 was identified as the major galecti

265 lasts to adhere to as well as to migrate via integrin alphavbeta3 was observed, which was associated

266 we show that breast cancer cells expressing integrin alphavbeta3, when engaging the extracellular ma

267 that are addicted to aberrant signaling from integrin alphavbeta3, which activates a PAK4-YAP/TAZ sig

268 of fibronectin and an activated form of the integrin alphavbeta3, which coordinately supported the g

269 t has been proposed that ligand occupancy of integrin alphavbeta3 with extracellular matrix ligands (

270 n or as a native multi-domain form, binds to integrins alphavbeta3 (with a K(D) of 1.36 x 10(-7) m) a

271 HSCs, which indicates that cell adhesion via integrin alphavbeta3 within the BM niche acts as a conte