ライフサイエンスコーパス: integrin beta1

1 F-FVIIa complex with the active conformer of integrin beta1.

2 rives the internalization of the Dab2 cargo, integrin beta1.

3 ading are also improved by overexpression of integrin beta1.

4 mplexes; they are FLNA with PrP or FLNA with integrin beta1.

5 ide exchange factors during the recycling of integrin beta1.

6 a fibroblasts, including integrin alpha4 and integrin beta1.

7 through p38MAPK-dependent phosphorylation of integrin beta1.

8 dition, ACK-2 was co-immunoprecipitated with integrin beta1.

9 conformation and affinity modulation of the integrin beta1.

10 cyte growth factor, serotonin synthesis, and integrin beta1.

11 fects of Klotho can be abolished by blocking integrin beta1.

12 anslational modification of the ECM receptor integrin beta1.

13 extracellular matrix protein laminin, and/or integrin beta1.

14 ng in mesodermal cells through activation of integrin-beta1.

15 among them were RRAS, AXL, ADAM9, FN14, and integrin-beta1.

16 Attenuation of expression of integrin beta1, a major constituent of the integrin rece

17 as a tumor suppressor by directly targeting integrin-beta1, a key regulator of cancer cell metastasi

18 s and membrane traffic in cell migration via integrin beta1 action and actin functions.

19 eness, but the molecular mechanisms by which integrin beta1 activates Arg are unknown.

20 We show that addition of an integrin beta1-activating monoclonal antibody, P4G11, to

21 , and CYTH1-deficient cells showed a reduced integrin beta1 activation response, suggesting that CYTH

22 ubunit and the ECM proteins converges at the integrin beta1 activation to induce FAK activation.

23 1, and consequently reversed TIMP-1-mediated integrin beta1 activation, cell survival signaling and a

24 n protein-dependent fibronectin assembly and integrin beta1 activation, involving the LIMK effectors

25 Pertussis toxin (Ptx) was used to decrease integrin-beta1 active form expression.

26 ked kinase (ILK) is a downstream mediator of integrin beta1 activity in epithelial cells.

27 Surface levels of integrins beta1, alpha1, alpha2, and alpha3 but not alph

28 Integrin beta1 also binds FLNA.

29 Integrin (beta1 and beta2) expression was demonstrated b

30 interactions mediate direct binding between integrin beta1 and Arg in vitro and in cells and activat

31 Recombinant NELL-1 binds to integrin beta1 and consequently induces Wnt/beta-catenin

32 We further showed that IGFBP2 activates integrin beta1 and downstream invasion pathways, require

33 When cells were migrating, integrin beta1 and FAK appeared at polarized lamellipodi

34 show that protein expression levels of both integrin beta1 and FAK are significantly decreased in au

35 g the circular lamellipodium, as revealed by integrin beta1 and FAK staining.

36 B lymphoblasts as a model, we tested whether integrin beta1 and FAK-Src signaling are abnormally regu

37 in vitro and that its activation depends on integrin beta1 and heterotrimeric G proteins of the G12/

38 similar to those in the absence of epidermal integrin beta1 and include Wnt, but not sonic hedgehog,

39 iRNA resulted in perinuclear accumulation of integrin beta1 and its delayed return to the cell surfac

40 and reduced Twist1-induced integrin alpha5, integrin beta1 and MMP9 expression.

41 ssion but leads to dephosphorylation of both integrin beta1 and p38 mitogen-activated protein kinase

42 ciation of EGFR with tyrosine-phosphorylated integrin beta1 and promotes cell proliferation.

43 p38MAPK inhibitor SB203580 dephosphorylates integrin beta1 and that binding of the anti-CD26 antibod

44 athrin structures contain both Dab2 and AP2, integrin beta1 and transferrin localize in separate pits

45 osis of the Dab2- and AP2-dependent cargoes, integrin beta1 and transferrin receptor, respectively.

46 its cell migration and polarized movement of integrin beta1 and vinculin to the leading edge.

47 related with higher levels of membrane-bound integrin-beta1 and also with increased binding to fibron

48 l collecting duct cells had higher levels of integrin-beta1 and fibronectin and displayed increased i

49 This finding might implicate integrin-beta1 and Hck as targets for decreasing MC - Eo

50 interaction with NR1 and NR2B receptors via integrin-beta1 and NO pathways.

51 Antibodies neutralized integrin-beta1 and recognized its active form.

52 te that human erythroblasts express CD44 and integrins beta1 and alpha4, three known receptors for OP

53 Fusion proteins from fibronectin and the integrins beta1 and beta3 served as negative controls.

54 nostaining with antibodies against K3, Cx43, integrin beta1, and collagen IV.

55 he cell surface, TIMP-1 co-localization with integrin beta1, and consequently reversed TIMP-1-mediate

56 Neutralizing antibodies to OPN, integrin beta1, and integrin alphavbeta3, but not to CD4

57 LK), Engulfment and Cell Motility-2 (ELMO2), integrin beta1, and Rac1.

58 sis confirmed CD63 interactions with TIMP-1, integrin beta1, and their co-localizations on the cell s

59 Fibroblast-derived membranes, integrin-beta1, and Hck are involved in MBP1-induced act

60 Here we showed that control, Shp2-/-, integrin beta1-/-, and talin1-/- cell lines all spread t

61 on of SNAIL, matrix metalloproteinase 2, and integrin beta1; and increased cell invasion in 3D organo

62 Here we report that integrin beta1, another cell surface von Willebrand A do

63 Both anti-integrin beta1 antibody and RGD peptides inhibited the a

64 Heparin, EDTA, and anti-integrin beta1 antibody inhibited TM14 binding to dental

65 the initial template with a goat anti-human integrin beta1 antibody.

66 mutant localized to clathrin structures with integrin beta1, AP2, and reduced amounts of Eps15.

67 Together, these results describe a novel integrin beta1-Arg-p190RhoGAP pathway that regulates den

68 Integrin beta1 association with adaptor protein containi

69 in and collagen I, we then evaluate the CD26-integrin beta1 association.

70 UB development was investigated by deleting integrin beta1 at initiation (E10.5) and late (E18.5) st

71 ocal adhesion kinase (FAK) and paxillin with integrin beta1 at the basal cell surface after short ter

72 null mice exhibited significant retention of integrin beta1 at the basolateral membrane and had tubul

73 tif led to reduced endocytosis, retention of integrin beta1 at the cell surface, and defective cell m

74 Deletion of pituitary epithelial integrin beta1 before the onset of angiogenesis resulted

75 Previous studies have shown that the integrin beta1, beta3, and beta5 subunit cytoplasmic dom

76 n the cell surface in close association with integrins beta1, beta4 and beta5.

77 Integrins beta1, beta6, and alpha7 decreased 1.7-fold (P

78 In contrast, integrins beta1, beta6, and beta8 did not have a critica

79 s demonstrate that the intracellular tail of integrin beta1 binds directly to Arg kinase and that thi

80 Following MBP1 binding, integrin-beta1 binds Hck that further transduces the act

81 the infarcted myocardium was observed after integrin beta1 blockade but not integrin alpha4 or CXCR4

82 Because anti-integrin beta1 blocking antibodies also prevent binding

83 pression in A7 cells decreases the amount of integrin beta1 bound to FLNA.

84 Introduction of the integrin beta1- but not the beta3-subunit in GE11 cells

85 disturbing the interaction between AQP2 and integrin beta1 by mutating the RGD motif led to reduced

86 rc complex, activated by upstream reelin and integrin beta1, can initiate a cascade of phosphorylatio

87 ls by preventing normal glycosylation of the integrin beta1 chain of the collagen receptor.

88 h the mutant Ki-Ras protein and the aberrant integrin beta1-chain and increased expression of the mat

89 cts of the oncogenic cellular Ki-ras gene on integrin beta1-chain glycosylation may account, at least

90 Since blocking the glycosylation of integrin beta1-chain inhibited the adherence, polarizati

91 Instead of the mature integrin beta1-chain, a faster migrating beta1-chain int

92 chain and increased expression of the mature integrin beta1-chain.

93 adhesion, as well as N- and VE-cadherin and integrin beta1 cleavage, could be inhibited or significa

94 d increased cell spreading, cell flattening, integrin beta1 clustering and formation of mature focal

95 lines to demonstrate that upon miR-200 loss integrin beta1-collagen I interactions drive 3D in vitro

96 lysates revealed enhanced levels of a SPARC-integrin beta1 complex during stress.

97 ace expression of adhesion molecules such as integrin beta1 concurrent with the loss of cell adhesion

98 ng/polymerizing machinery in order to extend integrin beta1-containing, filopodium-like protrusions (

99 ation and maturation of invadopodia, such as integrin beta1, cortactin, neuronal Wiskott-Aldrich synd

100 Here, the participation of BIG2 in integrin beta1 cycling through actin dynamics during cel

101 identification of an interaction between the integrin beta1 cytoplasmic domain and 14-3-3beta by usin

102 Like several other proteins, the integrin beta1 cytoplasmic domain associated with 14-3-3

103 ed serine/threonine kinase that binds to the integrin beta1 cytoplasmic domain, dramatically stimulat

104 ssion occurs when overexpression of isolated integrin beta1 cytoplasmic domains blocks integrin activ

105 This effect is mediated by the integrin beta1 cytoplasmic tail and does not entail beta

106 first evidence that interaction between the integrin beta1 cytoplasmic tail and kindlin-2, a member

107 main associated protein) associated with the integrin beta1 cytoplasmic tail but not with tails from

108 tructures of KRIT1 with ICAP1 and ICAP1 with integrin beta1 cytoplasmic tail to 2.54 and 3.0 A resolu

109 lysine-rich membrane-proximal segment in the integrin beta1 cytoplasmic tail, that Arg phosphorylates

110 himeric cell surface molecule containing the integrin beta1 cytoplasmic tail.

111 Muscle-specific integrin beta1-deficient mice had no significant differe

112 Integrin beta1-deficient vascular smooth muscle cells di

113 sion and morphogenesis in part by preventing integrin beta1 degradation.

114 nces for endothelial cell performance during integrin beta1-dependent angiogenesis.

115 39 promoted survival of neurons in a laminin-integrin beta1-dependent manner.

116 Within pituitary epithelial cells, integrin beta1 directs a large transcriptional program t

117 , we found that 14-3-3beta co-localized with integrin beta1 during the early stage of cell spreading

118 Of interest, although integrin beta1 endocytosis was impaired, transferrin rec

119 In A7 cells, FLNA, PrP, and integrin beta1 exist as two independent, yet functionall

120 gest that iEC-induced PI formation may alter integrin beta1 expression and posttranslational modifica

121 CD26 depletion does not decrease integrin beta1 expression but leads to dephosphorylation

122 ion, invasion, anchorage-independent growth, integrin beta1 expression, and anoikis resistance with a

123 tion, defective focal adhesions, and reduced integrin beta1 expression.

124 a perturbed ET-1-induced integrin alphaV and integrin beta1 expression.

125 Additionally, integrin beta1d expression and focal adhesion kinase act

126 trogen and progesterone receptors as well as integrin-beta1 expression and the persistent expression

127 an increase in integrin alphaVbeta3 (but not integrin beta1) expression in VSMC that are subjected to

128 Grb2, known to be involved in the effects of integrin beta1-extracellular matrix interactions on acti

129 lates the trafficking and internalization of integrin beta1, facilitating its turnover at focal adhes

130 eta-cell apoptosis through activation of the integrin beta1-FAK/Akt pathway, leading to inhibition of

131 roduction and remodeling leading to elevated integrin beta1/FAK/Src signaling in melanoma cells.

132 Integrin alpha 4 (CD49d), in complex with integrin beta1, forms very late antigen-4 (VLA-4), which

133 We conclude that epithelial integrin beta1 functions as a critical and canonical reg

134 mation in large part are unaffected when the integrin beta1 gene (Itgb1) is inactivated in motor neur

135 Through analysis of integrin beta1(-/-)-->wild-type chimeras, we show that e

136 d apoptosis in vitro via an interaction with integrin beta1 heterodimers that enhances ILK activation

137 ibodies against E-Selectin or CD44H, but not integrin-beta1, ICAM-1 or VCAM-1, largely abolished the

138 expression of early mechanoresponsive genes (integrin beta1 (Igtb1) and cyclooxygenase-2 (Cox-2)) in

139 Dab2 colocalizes with integrin beta1 in coated pits that are dispersed over th

140 Based on the specific expression of integrin beta1 in colonic crypts, the cells were sorted

141 Here, we report that expression of integrin beta1 in embryonic pituitary epithelial cells i

142 We report here that selective loss of integrin beta1 in excitatory neurons leads to reductions

143 yers and PIs revealed a higher expression of integrin beta1 in PIs.

144 of this association by selective removal of INTEGRIN beta1 in RGPs leads to a decrease in progenitor

145 In mice, conditional inactivation of integrin-beta1 in collecting ducts resulted in a dramati

146 autostimulatory loop, we tested the role of integrin-beta1 in vitro and on the cystic development of

147 Glycosylation of beta1 integrin (beta1) in the Golgi complex has been related t

148 Antibody directed against integrin beta1 inhibited FBS-, Fn-, and Lm-mediated inva

149 function-blocking antibodies against alpha6 integrin, beta1 integrin or the laminin-1/E8 domain reco

150 molecules and cytokine receptors, including integrin beta1, integrin alpha4, and CXC chemokine recep

151 les, including fibronectin, integrin alpha3, integrin beta1, integrin beta3, and cadherin 6.

152 eveal distinct functions for the alpha6beta4 integrin, beta1 integrins, and an E3 laminin receptor.

153 face levels and function of beta1-containing integrins, beta1 integrins.

154 uggesting a potential role of the 14-3-3beta/integrin beta1 interaction in the regulation of cell adh

155 The 14-3-3beta/integrin beta1 interaction was confirmed by in vitro bin

156 d CBMC activation is mediated partly by MBP1-integrin-beta1 interaction on the MC surface.

157 2 and ACAP1 had opposing effects on apparent integrin beta1 internalization.

158 slowed, whereas ACAP1 knockdown accelerated, integrin beta1 internalization.

159 Integrin beta1 is critical for basement membrane organiz

160 Integrin beta1 is known to play an essential role in reg

161 ght chain (MLC) by MLC kinase (MLCK) through integrin beta1 is required for actin stress fiber format

162 a provide genetic evidence that a functional integrin-beta1 is required for the early events leading

163 we investigated two potential novel targets: integrin beta1 (ITGB1) and kinesin 2alpha (KIF2A).

164 tified the selective induction of fibroblast integrin beta1 (ITGB1) by hypoxia.

165 Tumor integrin beta1 (ITGB1) contributes to primary tumor grow

166 rupted branching altogether; it also reduced integrin beta1 (Itgb1) levels and attenuated MAPK signal

167 he treatment of antibodies against ITGA2 and integrin beta1 (ITGB1) subunits, as well as by type I co

168 tion of cyclin-dependent kinase 6 (CDK6) and integrin beta1 (ITGB1), which were functionally intercon

169 s from PML-dependent decreased expression of integrin beta1 (ITGB1).

170 ion of miR-29a and enhance the expression of Integrin beta1 (ITGB1).

171 nstream genes, such as negatively regulating integrin beta1 (ITGB1).

172 es revealed that RBP2 promoted expression of integrin-beta1 (ITGB1), which is implicated in lung canc

173 beta1 signaling through Arg recapitulate the integrin beta1 knock-out phenotype in a gene dose-sensit

174 fibronectin production and signaling through integrin beta1, leading to cytoskeletal reorganization w

175 Antibody-mediated blocking of integrin beta1 led to alterations in beta-cell morpholog

176 By manipulating intracellular and surface integrin beta1 levels, we show that migration speed corr

177 esion and spreading on fibronectins, reduced integrin beta1 localization to lipid rafts, and decrease

178 esponds to the specificity loop of beta3, to integrin beta1 markedly enhanced IGF1 binding to beta1,

179 Our analysis of this mutant model shows that integrin beta1-mediated cell-matrix adhesion is a major

180 tors of TGFbeta signaling, lysyl oxidase, or integrin beta1-mediated mechanosignaling reduced or bypa

181 To further explore whether integrin beta1-mediated signaling facilitates proper glo

182 sulinomas as well as in primary islets, with integrin beta1 mRNA and protein detected in all three ce

183 n to facilitate the selective translation of integrin beta1 mRNA, which drives the translationally co

184 resulted in increased miR-6126 and decreased integrin-beta1 mRNA levels in the exosome.

185 This integrin-beta1 N-glycosylation pattern was correlated wi

186 pacities, which were associated with altered integrin-beta1 N-glycosylation, in particular with highe

187 ed limbal epithelial sheets was positive for integrin beta1, negative for K3, but weakly positive for

188 MC integrin-beta1 neutralization inhibits MBP1-induced acti

189 ody 202.36 dephosphorylates both p38MAPK and integrin beta1 on Karpas 299, leading to loss of cell ad

190 pression correlated with the level of active integrin beta1 on the cell surface independent of cell a

191 rtially overcome by antibodies that activate integrin beta1 or by the addition of Mn2+, an integrin a

192 chanical stretch or overexpression of either integrin beta1 or integrin beta3 prevented its down-regu

193 Overexpression of integrin beta1 or MG-132 treatment in mutant EBs largely

194 Inhibition of integrin beta1 or MLCK prevents transition from a quiesc

195 logical indexes as well as the expression of integrin beta1 or N-cadherin.

196 hibiting the binding and/or activity of ILK, integrin beta1, or SPARC resulted in increased apoptosis

197 However, only integrin beta1 participates in the activation of Syk.

198 dermis increased myofibroblast activity and integrin beta1/pFAK/pAKT mechanosignaling in tumor cells

199 In our studies, we found that both MARCO and integrin beta1 play a role in the activation of the Src

200 Mice with podocyte specific deletion of integrin beta1 (podocin-Cre beta1-fl/fl mice) are born n

201 BP-1 that activates the Src/FAK pathway, via integrin beta1, potentiating schwannoma's proliferation

202 However, integrin beta1(-/-) primordial germ cells do not coloniz

203 It also decreases expression of integrin beta1 protein and sensitizes DU145 and LNCaP ce

204 is defective in integrin binding normalizes integrin beta1 protein levels and restores focal adhesio

205 re accompanied by a significant reduction in integrin beta1 protein levels due to accelerated degrada

206 Abi3bp controlled CPC differentiation via integrin-beta1, protein kinase C-zeta, and v-akt murine

207 ription factors Gata-3 and Jun B, as well as integrin beta1, proteoglycan 2, the RhoB oncogene, and d

208 This signaling requires a functional integrin beta1 receptor as showed by RNA interference.

209 three known receptors for OPN, and that the integrin beta1 receptor is involved in transmitting the

210 itical sequence in the cytoplasmic domain of integrin beta1 recognized by ACAP1 and showed that this

211 lation of cell migration through controlling integrin beta1 recycling and localization to lipid rafts

212 e find that ARNO/cytohesin 2 is required for integrin beta1 recycling, whereas GRP1/cytohesin 3 is di

213 ed PIs altered the glycosylation patterns of integrin beta1, resulting in a higher molecular weight f

214 data demonstrate an in vivo crucial role of integrin beta1 signaling events in mediating cross-talk

215 Moreover, genetic manipulations that reduce integrin beta1 signaling through Arg recapitulate the in

216 d reciprocal activation of PI3K-AKT-mTOR and integrin-beta1 signalling.

217 Inhibition of integrin beta1/Src blocked collagen-induced resistance t

218 ly upregulated, accompanied by activation of integrin beta1/Src.

219 Thus, IGFBP-1/integrin beta1/Src/FAK pathway has a crucial role in mer

220 The polypeptide core of the integrin beta1 subunit (beta1) is glycosylated sequentia

221 at the inactivation of the gene encoding the integrin beta1 subunit (Itgb1) with a Cre-loxP approach

222 ACER2DeltaN36 inhibited the glycosylation of integrin beta1 subunit and Lamp1, suggesting that its mi

223 fying enzyme TRAF6 as an interactor with the integrin beta1 subunit and regulator of integrin alpha3b

224 mice with a CNS restricted knock-out of the integrin beta1 subunit gene (Itgb1-CNSko mice) have defe

225 bserved that the tissue-specific loss of the integrin beta1 subunit in striated muscle results in a n

226 Deleting the integrin beta1 subunit in these cells converts them from

227 n Galpha13 and the cytoplasmic domain of the integrin beta1 subunit plays a critical role in beta1-de

228 ed muscle results in a near complete loss of integrin beta1 subunit protein expression concomitant wi

229 Expression of the integrin beta1 subunit was not affected by loss of long

230 ts the ligand-independent association of the integrin beta1 subunit with EGFR and results in inhibiti

231 expression of ligand-induced epitopes on the integrin beta1 subunit, a property consistent with occup

232 Integrin-alpha5 and integrin-beta1 subunits gave a similar staining pattern

233 ile a function-neutralizing antibody against integrin-beta1 suppresses MMP-9-induced phosphorylation

234 ution in membrane-proximal NPIY motif in the integrin beta1 tail and show that this mutant substantia

235 This is the first demonstration that the integrin beta1 tail can regulate centrosome function, th

236 Thus, the integrin beta1 tail plays a key role in regulating the c

237 and a significantly lower expression of the integrin beta1 than Bet v 1-positive TCC.

238 e surface, that KRIT1 directly competes with integrin beta1 to bind ICAP1, and that KRIT1 antagonizes

239 o participates in the regulated recycling of integrin beta1 to control cell migration.

240 not PACSIN2-MA prevents the localization of integrin beta1 to focal adhesions (FA) and filamin to st

241 membrane-mediated rescue requires functional integrin beta1 to maintain epithelial cell-cell adhesion

242 n to lipid rafts, and decreased recycling of integrin beta1 to the plasma membrane.

243 a a G protein, as confirmed by Ptx, to shift integrin-beta1 to its active form.

244 beta1 integrins (beta1) transduce mechanical signals in many c

245 In both cases, lack of epithelial integrin beta1 was associated with a complete absence of

246 Degradation of integrin beta1 was inhibited only in the presence of z-V

247 Cleavage of N- and VE-cadherin and integrin beta1 was observed in immunoblots of cell lysat

248 t which NSCs undergo asymmetrical divisions, integrin beta1 was unevenly distributed in some mitotic

249 re, antibodies that either activate or block integrin beta1 were used to demonstrate that activation

250 nous targets of miR-124, laminin gamma 1 and integrin beta1, were identified, both of which are highl

251 n addition, the p67 LBP+ T cells express the integrin beta1, which associates with alpha6 in the lami

252 EPAC1 promotes activation and trafficking of integrin beta1, which plays an essential role in PDA mig

253 ro-PrP enhances association between FLNA and integrin beta1, which then promotes cell spreading and m

254 tes NR1 and NR2 receptors, and downregulates integrin-beta1, while a function-neutralizing antibody a