ライフサイエンスコーパス: integrin beta3

1 in animals depleted of platelets or lacking integrin beta3.

2 led by multiple molecular characteristics of integrin beta3.

3 essential regulator of the fast recycling of integrin beta3.

4 nsgenic knockin mice expressing a Pro32Pro33 integrin beta3.

5 d peptide spanning the polymorphic region of integrin beta3, 24AWCSDEALPLGSPRCD39 (LPL).

6 nts with elevated blood 5-HT levels, linking integrin beta3, 5-HT, and ASD risk.

7 ntify a role of kindlin-3 phosphorylation in integrin beta3 activation and provide a basis for functi

8 uired and the proliferation was mediated via integrin beta3/Akt signaling in EOMA cells.

9 an inverse correlation between the level of integrin beta3 and apoptosis (deoxynucleotidyltransferas

10 initiates the calpain-dependent cleavage of integrin beta3 and associated regulatory proteins, resul

11 ordination sites also appear to exist in the integrin beta3 and beta5 subunits.

12 that, upon activation, platelets expressing integrin beta3 and CD40L are required for protecting the

13 SiRNA knockdown of integrin beta3 and inhibition of Akt activity significan

14 ocalization microscopy (SMLM) to investigate integrin beta3 and paxillin in rat embryonic fibroblasts

15 n expression of the efferocytosis-regulating integrin-beta3 and its ligand milk fat globule-epidermal

16 also blunted the de novo renal expression of integrin-beta3 and phosphorylation of focal adhesion kin

17 binant periostin increased the expression of integrin-beta3 and the concomitant phosphorylation of fo

18 ibronectin, integrin alpha3, integrin beta1, integrin beta3, and cadherin 6.

19 aling blocked the tumor-promoting effects of integrin beta3 antagonism.

20 Integrin beta3 antagonist, cilengitide, also enhanced tu

21 However, preclinical and clinical data of integrin beta3 antagonists have demonstrated no benefit

22 sprouting was inhibited by addition of anti-integrin beta3 antibody and pharmacologic inhibitors of

23 at cancer cells with high levels of FGFR and integrin beta3 are resistant to crizotinib treatment, su

24 platelets support HE progression and suggest integrin beta3 as a potential target to treat HE.

25 t of VSMC with small interfering RNA against integrin beta3 as well as VSMC isolated from integrin be

26 We also found that MSA down-regulated integrin beta3 at the levels of mRNA and protein, and di

27 Thus, our findings point to a LSD1-integrin beta3 axis, conferring attributes of invasivene

28 Notably, this novel defined LSD1/integrin beta3 axis, was also detected in human lung ade

29 an antimetastatic therapy based on targeting integrin beta3 (beta3), which is selectively induced on

30 The expressions of integrin beta3, beta5, and beta6 were unaltered.

31 ree survival in breast cancer patients, with integrin beta3-binding protein (ITGB3BP), MAP3K8, NIMA-r

32 ot only by down-regulating the expression of integrin beta3 but also by disorganizing the clustering

33 A SNP in the gene encoding integrin beta3 causes a clinically important maternal-pa

34 that loss of traction force on ligand-bound integrin-beta3 causes recruitment of Dab2/clathrin, resu

35 Finally, we showed that the integrin-beta3 (CD61) signaling pathway was required for

36 We have found that the integrin beta3 chain can be phosphorylated on tyrosine r

37 Calpain inhibition blocked integrin beta3 cleavage and inactivation but not mPTP fo

38 d endocytosis, is not recruited to activated integrin-beta3 clusters on RGD-glass; however, it is rec

39 ion is inhibited on RGD-glass, Dab2 binds to integrin-beta3 clusters.

40 th Dab2 to facilitate the endocytosis of RGD-integrin-beta3 clusters.

41 We hypothesized that integrin beta3 could affect tumor immunity and evaluated

42 izotinib treatment, suggesting that FGFR and integrin beta3 could be used as predictive markers for M

43 n IgC45 domains form a complex not only with integrin beta3 CT but also, surprisingly, with the integ

44 a systematic mutational analysis of both the integrin beta3 cytoplasmic domain and beta3-endonexin to

45 plex between talin and the membrane-proximal integrin beta3 cytoplasmic domain and identify specific

46 n (G protein) Galpha13 directly bound to the integrin beta3 cytoplasmic domain and that Galpha13-inte

47 within the two conserved NXXY motifs in the integrin beta3 cytoplasmic domain blocks Syk binding.

48 rtance of the membrane-distal portion of the integrin beta3 cytoplasmic domain in bidirectional trans

49 ally exclusive but distinct sites within the integrin beta3 cytoplasmic domain in opposing waves.

50 nstructed to identify amino acids within the integrin beta3 cytoplasmic domain that regulate its abil

51 roteolytic events, including cleavage of the integrin beta3 cytoplasmic domain, coincided closely wit

52 n as well as tyrosine phosphorylation of the integrin beta3 cytoplasmic domain, the platelet FcgammaR

53 onexin, which interacts selectively with the integrin beta3 cytoplasmic domain.

54 kIgC4 and SkIgC5) are involved in binding to integrin beta3 cytoplasmic tail (CT), providing a mechan

55 hus, the direct binding of Syk kinase to the integrin beta3 cytoplasmic tail is a novel and functiona

56 C terminus did not affect its binding to the integrin beta3 cytoplasmic tail, but combined biochemica

57 All of these interactions require the integrin beta3 cytoplasmic tail.

58 ivation, which requires that Syk bind to the integrin beta3 cytoplasmic tail.

59 Suppression of integrin beta3 decreased AKT phosphorylation in SAIT301-

60 Integrin beta3-deficient B cells contributed in a slight

61 t with these findings, knockout mice lacking integrin beta3 displayed diminished platelet SERT activi

62 eceptors Flt1 and Flk1, Pdgfb, Pecam1, CD34, integrin beta3, ephrin B2, Tie2, and the noncoding RNA F

63 Dab2 binding to integrin-beta3 excludes other adhesion-related adaptor p

64 express human SERT and an activated form of integrin beta3 exhibited enhanced SERT function that coi

65 th and behavior, we intracranially implanted integrin beta3-expressing GBM cells into beta3 wild type

66 fied a variant associated with reductions in integrin beta3 expression levels that parallel our mouse

67 Thus, an improvement in integrin-beta3 function could stimulate muscle regenerat

68 timulation induced RAP1 activation in WT and integrin beta3 gene knockout (Itgb3-/-) OCs, but its eff

69 We therefore evaluated the integrin-beta3 gene (ITGB3), an integrin gene within an

70 In integrin-beta3 global KO mice, the expression of myogeni

71 either pp60c-src or integrin beta5, but not integrin beta3, have a reduced VP response to VEGF.

72 nd evaluated tumors in mice with deletion of integrin beta3 in macrophage lineage cells (beta3KOM).

73 To demonstrate the functional importance of integrin beta3 in promoting endothelial differentiation,

74 n alphaV antibody or a genetic deficiency of integrin beta3 in the CCL18 overexpression model signifi

75 Moreover, deletion of integrin beta3 in VSMC abolished the stretch protective

76 cell adhesion regulatory domain of the human integrin beta3, inhibited adhesion of human erythroleuke

77 In addition to FGFR3, integrin beta3 is another potential target for combinati

78 Integrin beta3 is critical for tumor invasion, neoangiog

79 and functional ablation assays indicate that integrin beta3 is critical in transduction of shape sign

80 In the arch of the aorta, we find that integrin beta3 is higher than in descending arteries.

81 els of integrin beta5, whereas expression of integrin beta3 is limited to stromal compartments and in

82 utaminase 2 (TG2) acting as a coreceptor for integrin beta3 is required for proper phagocytosis of ap

83 The polymorphic residue 33 of integrin beta3 is responsible for both a B cell response

84 Human platelet Ag (HPA)-1a, located on integrin beta3, is the main target for alloantibodies re

85 ear translocation, synaptopodin degradation, integrin beta3 (ITGB3) activation, and actin fiber loss,

86 with cell-extracellular matrix interactions, integrin beta3 (Itgb3), integrin beta5 (Itgb5), and fibr

87 chemokine C-X3-C motif ligand 1 (CX3CL1) and integrin beta3 (ITGB3).

88 as associated with reduced expression of the integrin-beta3 (Itgbeta3) subunit.

89 integrin beta3 as well as VSMC isolated from integrin beta3 knock-out mice.

90 The mechanism for these responses in integrin-beta3 KO mice included an infiltration of macro

91 e, transplantation of bone marrow cells from integrin-beta3 KO mice into WT mice led to suppression o

92 hiatric disorders.SIGNIFICANCE STATEMENT The integrin beta3 Leu33Pro coding polymorphism has been ass

93 A common isoform of integrin beta3, Leu33Pro is associated with enhanced pla

94 mutant mice and SVAS patients have enhanced integrin beta3 levels, activation, and downstream signal

95 Blockade of dominant SMC integrin (beta3)-matrix interactions may be a valuable a

96 many single-factor ECMs, in part through an integrin beta3-mediated pathway.

97 Thus, integrin beta3-mediated signaling in SMCs links elastin

98 hort of TB patients, significantly increased integrin beta3 mRNA accumulation in induced sputum was d

99 In the arteries of integrin beta3 null mice, there were lower levels of PIN

100 RNA and protein, and disrupted clustering of integrin beta3 on the cell surface.

101 The human integrin beta3 participates in a wide range of adhesive

102 elated to a recently described non-canonical integrin beta3 pathway, were significantly downregulated

103 Our results demonstrate that integrin-beta3 plays a fundamental role in muscle regene

104 r overexpression of either integrin beta1 or integrin beta3 prevented its down-regulation.

105 rtments within the synapse, disrupted by the integrin beta3 Pro33 mutation, is critical for appropria

106 ro, we confirmed that M2 macrophages lacking integrin-beta3 produced more TGF-beta1.

107 hat the Pro33 coding variation in the murine integrin beta3 recapitulates the sex-dependent neurochem

108 les, and hence important for RAB4A-dependent integrin beta3 recycling to plasma membrane.

109 Integrin beta3 regulates cell polarity and migration whe

110 f CD8(+) T cells, macrophages, or macrophage integrin beta3 signaling blocked the tumor-promoting eff

111 During IFNgamma stimulation, integrin beta3 signaling enhanced STAT1-mediated gene ex

112 e feedback loop in M2 myeloid cells, wherein integrin beta3 signaling favored STAT1 activation, an M1

113 These findings show that integrin beta3 signaling intensifies the suppressive eff

114 Integrin beta3 signaling maintains HSCs within the niche

115 ion in the presence of IFNgamma and impaired integrin beta3 signaling mitigated IFNgamma-dependent ne

116 curs in a tension-independent manner through integrin beta3 signaling pathway in human kidney podocyt

117 adhesion kinase and AKT, known mediators of integrin-beta3 signaling that affect cell motility and s

118 cyte damage through downstream activation of integrin-beta3 signaling.

119 educed SERT function indicate that decreased integrin beta3 subunit expression scales down the popula

120 sequences of haploinsufficiency in the mouse integrin beta3 subunit gene (Itgb3) on SERT function and

121 we report that the cytoplasmic domain of the integrin beta3 subunit is a target for limited proteolys

122 Leu33Pro amino acid polymorphism within the integrin beta3 subunit is responsible for generating the

123 titution in the second disulfide loop of the integrin beta3 subunit of the fibrinogen receptor, alpha

124 eptifibatide-dependent antibodies engage the integrin beta3 subunit such that FcgammaRIIa and its dow

125 eotide substitution in the gene encoding the integrin beta3 subunit that resulted in an Arg724Ter mut

126 the Pl(A2) alloantigen form (Pro(33)) of the integrin beta3 subunit was subcloned into this construct

127 of evidence link the ITGB3 gene encoding the integrin beta3 subunit with the serotonin (5-HT) system,

128 e CD47/integrin-associated protein(IAP), the integrin beta3 subunit, and the alpha(v)beta3 integrin c

129 inhibited the purification of CD47/IAP, the integrin beta3 subunit, and the alpha(v)beta3 integrin c

130 protein containing residues P688-T762 of the integrin beta3 subunit, encompassing its transmembrane a

131 We have identified a novel integrin beta3 subunit, termed beta3C, from a human oste

132 sional model of the homologous region in the integrin beta3 subunit.

133 a13 interacts with the cytoplasmic domain of integrin beta3 subunits in platelets via a conserved ExE

134 combination of an Arg and Thr residue in the integrin beta3 tail control the binding specificity for

135 solated subdomains bound specifically to the integrin beta3 tail.

136 Similar interactions were observed for integrin beta3 tails.

137 ir properties and identified the cooperative integrin-beta3-TGFbeta signaling axis as a potential the

138 In this study we identified regions on integrin beta3 that control 7E3 binding.

139 These results suggest that effects of integrin beta3 therapies on immune cells should be consi

140 In this paper, we used membrane-embedded integrin beta3 TMDs bearing environmentally sensitive fl

141 or containing a cDNA cassette encoding human integrin beta3 to restore integrin alphaIIbbeta3 on the

142 The expression density of integrin beta3 was determined by immunohistochemistry on

143 Following muscle injury, integrin-beta3 was initially expressed, mainly in macrop

144 Notably, periostin and integrin-beta3 were highly colocalized in biopsy specime

145 but also by disorganizing the clustering of integrin beta3, which further inhibited the phosphorylat

146 ronectin, fibulin-2, tropomyosin (Tpm1), and integrin-beta3, which play critical roles in matrix depo