ライフサイエンスコーパス: integrin-linked kinase

1 PI 3-kinase, and the Ca2+-independent MLCK, integrin-linked kinase.

2 ion of tensin requires integrins, talin, and integrin-linked kinase.

3 of Akt, which was dependent on the upstream integrin-linked kinase.

4 to promote GSK3beta phosphorylation through integrin-linked kinase.

5 pathway involving annexin A2/CD11b-mediated integrin-linked kinase.

6 to produce fibronectin, which then activates integrin-linked kinase 1 (ILK-1) via alpha4-integrins.

7 ing a yeast two-hybrid screen, we identified integrin-linked kinase 1 (ILK1) as a novel PELP1-binding

8 d secretion of fibronectin that up-regulated integrin-linked kinase 1 (ILK1).

9 I3K, phosphoinositide-dependent kinase-1 and integrin-linked kinase-1 (ILK1).

10 n, to stabilize focal adhesions and activate integrin-linked kinase-1 and phospho Akt.

11 levels of PDGF-AA, platelet glycoprotein VI, integrin-linked kinase-1, high mobility group box-1 prot

12 Ang1-256 increased integrin-linked kinase, a key regulator of integrin sign

13 Blockade of FAK, but not integrin-linked kinase, abolished the tPA-triggered extr

14 SPARC exhibit diminished fibronectin-induced integrin-linked kinase activation and integrin-linked ki

15 ull fibroblasts restores fibronectin-induced integrin-linked kinase activation, downstream signaling,

16 ollowing maspin treatment revealed increased integrin-linked kinase activities and phosphorylated FAK

17 iphosphate with the subsequent inhibition of integrin-linked kinase activity and serine-473 phosphory

18 The integrin-linked kinase activity is involved in transduci

19 Loss of Parvin-beta contributes to increased integrin-linked kinase activity, cell-matrix adhesion, a

20 leads to decreased focal adhesion kinase and integrin-linked kinase activity, which impairs downstrea

21 tion, we show that MMAC1 expression inhibits integrin-linked kinase activity.

22 Furthermore, secreted SPARC activated the integrin-linked kinase/AKT (ILK/AKT) pathway, likely via

23 of glomerular failure, regulates the PINCH-1-integrin-linked kinase-alpha-parvin (PIP) complex format

24 y, using global RNA profiling, we identified integrin-linked kinase and associated cytoskeletal remod

25 presented, including smooth muscle-specific integrin-linked kinase and endothelial-specific focal ad

26 s to focal adhesions where it interacts with integrin-linked kinase and is involved in linking integr

27 lation and decreased phosphorylation of both integrin-linked kinase and protein kinase B/Akt at its S

28 osphorylation at both Ser(19) and Thr(18) by integrin-linked kinase and/or zipper-interacting protein

29 ry protein complex that consists of PINCH-1, integrin-linked kinase, and alpha-parvin, cytoplasmic co

30 Actopaxin (alpha-parvin) is a paxillin, integrin-linked kinase, and F-actin binding focal adhesi

31 molog gene family member A, Cdc42, integrin, integrin-linked kinase, and vascular endothelial growth

32 the constitutive androstane receptor and the integrin-linked kinase are dysregulated in the myostatin

33 eta-integrin), UNC-112 (kindlin), and PAT-4 (integrin-linked kinase) are associated with these struct

34 By phage display, we identify integrin-linked kinase as a potential binding partner of

35 cal adhesions requires both the paxillin and integrin-linked kinase binding sites and that paxillin i

36 xia through a mechanism that is dependent on integrin-linked kinase but is independent of focal adhes

37 th the inactivating lysine mutation restores integrin-linked kinase dependent phosphorylation of seri

38 nduced integrin-linked kinase activation and integrin-linked kinase-dependent cell-contractile signal

39 These data strongly suggest that integrin-linked kinase does not possess serine-473 kinas

40 egrin engagement, focal adhesion kinase, and integrin-linked kinase, enhanced insulin sensitivity and

41 tes, in contrast to controls, showed reduced integrin-linked kinase expression both at baseline and a

42 on occurred concomitantly with a decrease in integrin-linked kinase expression but with no change in

43 ith substantial increases in Akt(Ser473) and integrin-linked kinase expression, both of which promote

44 m-like cells (CSC) through modulation of the integrin-linked kinase ILK.

45 The integrin linked kinase (ILK) is a downstream mediator of

46 TB4 suppression down-regulated both integrin linked kinase (ILK), an activator of smoothened

47 s found that the cellular levels of PINCH-1, integrin linked kinase (ILK), and alpha-parvin, cytoplas

48 Pharmacological inhibition of integrin linked kinase (ILK), EGFR and NF-kappaB, as wel

49 Here, we report that integrin-linked kinase (ILK) (involved in transmission o

50 s associated with the down-regulation of the integrin-linked kinase (ILK) activity.

51 thway governing FLP lifetime, which involves integrin-linked kinase (ILK) and beta-parvin, two integr

52 Integrin-linked kinase (ILK) and caveolin-1 (cav-1) are

53 on protein that forms a ternary complex with integrin-linked kinase (ILK) and CH-ILKBP/actopaxin/alph

54 Integrin-linked kinase (ILK) and estrogen receptor (ER)-

55 nt and variants of uncertain significance in integrin-linked kinase (ILK) and filamin-C (FLNC).

56 mal beta1-integrin signalling intermediates, integrin-linked kinase (ILK) and focal adhesion kinase (

57 have revealed important roles of cytoplasmic integrin-linked kinase (ILK) and its interactive protein

58 ed p-AKT activity results from repression of integrin-linked kinase (ILK) and phosphoinositide-depend

59 ELMO2 can simultaneously bind integrin-linked kinase (ILK) and RhoG, forming tripartit

60 transduction pathways such as TGFbeta/Smad, integrin-linked kinase (ILK) and Wnt/beta-catenin signal

61 We identify the integrin-linked kinase (ILK) as a new partner for ADAM12

62 roteome and have identified septin-5 and the integrin-linked kinase (ILK) as novel calpain substrates

63 In this study, we showed that integrin-linked kinase (ILK) binds with miniature chromo

64 showed that the N-terminus of myopodin binds integrin-linked kinase (ILK) both in vivo and in vitro.

65 moted the recruitment and phosphorylation of integrin-linked kinase (ILK) by TGFBR1.

66 complex components beta-integrin, PINCH, and integrin-linked kinase (ILK) caused formation of multinu

67 and functions as a component of the integrin-integrin-linked kinase (ILK) complex.

68 Integrin-linked kinase (ILK) directly interacts with bet

69 Kidney AE1 (kAE1), PDLIM5 and integrin-linked kinase (ILK) form a multiprotein complex

70 nt, which encodes a nonsense mutation in the integrin-linked kinase (ilk) gene.

71 Integrin-linked kinase (ILK) has been implicated in podo

72 Integrin-linked kinase (ILK) has been implicated in the

73 In this article, we show that expression of integrin-linked kinase (ILK) in myeloid cells is critica

74 t assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK) in the lamellipodia.

75 Here we show that genetic deletion of integrin-linked kinase (ILK) increases NSPC proliferatio

76 Integrin-linked kinase (ILK) is a cell-ECM-adhesion comp

77 Integrin-linked kinase (ILK) is a cytoplasmic effector o

78 Integrin-linked kinase (ILK) is a distinct intracellular

79 Integrin-linked kinase (ILK) is a downstream integrin si

80 Integrin-linked kinase (ILK) is a major structural adapt

81 Integrin-linked kinase (ILK) is a mediator of aggressive

82 The integrin-linked kinase (ILK) is a multidomain focal adhe

83 Integrin-linked kinase (ILK) is a multidomain focal adhe

84 Integrin-linked kinase (ILK) is a multidomain protein th

85 Integrin-linked kinase (ILK) is a multifunctional intrac

86 Integrin-linked kinase (ILK) is a newly identified serin

87 Integrin-linked kinase (ILK) is a phosphoinositide 3-kin

88 Integrin-linked kinase (ILK) is a phosphorylated protein

89 Integrin-linked kinase (ILK) is a protein that plays imp

90 Integrin-linked kinase (ILK) is a recently identified in

91 Integrin-linked kinase (Ilk) is a scaffold and kinase th

92 SIGNIFICANCE STATEMENT: Integrin-linked kinase (ILK) is a scaffolding protein in

93 Integrin-linked kinase (ILK) is a serine-threonine kinas

94 Integrin-linked kinase (Ilk) is a serine/threonine kinas

95 Integrin-linked kinase (ILK) is a serine/threonine kinas

96 Integrin-linked kinase (ILK) is a serine/threonine kinas

97 Integrin-linked kinase (ILK) is a ubiquitously expressed

98 Integrin-linked kinase (ILK) is an important component o

99 Integrin-linked kinase (ILK) is an important protein tha

100 Integrin-linked kinase (ILK) is an intracellular scaffol

101 Integrin-linked kinase (ILK) is an intracellular serine/

102 Integrin-linked kinase (ILK) is associated with the beta

103 rs of shear stress in endothelial cells, and integrin-linked kinase (ILK) is important for blood vess

104 that the cellextracellular signaling protein integrin-linked kinase (ILK) is important in transducing

105 Integrin-linked kinase (ILK) is one of the few evolution

106 Here, we show that integrin-linked kinase (ILK) is required for the formati

107 F decreased adhesion to vitronectin, whereas integrin-linked kinase (ILK) kinase activity was down-re

108 ltiple functions including regulation of the integrin-linked kinase (ILK) level, cell shape, and surv

109 Integrin-linked kinase (ILK) localizes to focal adhesion

110 LIMD2 bound directly to the kinase domain of integrin-linked kinase (ILK) near the active site and st

111 closely linked to genes in the integrin and integrin-linked kinase (ILK) pathways and that these gen

112 Integrin-linked kinase (ILK) plays a pivotal role in con

113 Here we demonstrate that integrin-linked kinase (ILK) plays an important role in

114 Integrin-linked kinase (ILK) represents a relevant targe

115 Fn1 activity focal adhesion kinase (FAK) and integrin-linked kinase (ILK) reveals that FAK, but not I

116 ons were associated with increased levels of integrin-linked kinase (ILK) signaling as demonstrated b

117 n, regulation of the antiviral response, and integrin-linked kinase (ILK) signaling were among the to

118 Furthermore, PAR-2, through integrin-linked kinase (ILK) signaling, including the p-

119 e is mediated by integrins, the relevance of integrin-linked kinase (ILK) signals in podocyte dysfunc

120 ity of glioma cells acting through activated integrin-linked kinase (ILK) to stimulate beta-catenin-T

121 Mammalian integrin-linked kinase (ILK) was identified in a yeast t

122 Here we show that integrin-linked kinase (ILK), a 59-kDa serine-threonine

123 We hypothesized that integrin-linked kinase (ILK), a beta-integrin-binding sc

124 have previously shown that the expression of integrin-linked kinase (ILK), a cytoplasmic component of

125 Furthermore, inhibition of the integrin-linked kinase (ILK), a downstream effector of b

126 We report here that overexpression of integrin-linked kinase (ILK), a newly identified serine/

127 ted the regulation of these processes by the integrin-linked kinase (ILK), a scaffold protein that li

128 SPARC enhanced signaling by integrin-linked kinase (ILK), a serine/threonine kinase

129 Integrin-linked kinase (ILK), a serine/threonine protein

130 alpha-Catulin interacted with integrin-linked kinase (ILK), a serine/threonine protein

131 We show here that integrin-linked kinase (ILK), an intracellular integrin-

132 CH-1 is an adaptor protein that binds to the integrin-linked kinase (ILK), an intracellular serine/th

133 ort here that PINCH is a binding protein for integrin-linked kinase (ILK), an intracellular serine/th

134 otein platforms, which include integrins and integrin-linked kinase (ILK), are critical for hair foll

135 containing serine-threonine protein kinase, integrin-linked kinase (ILK), binds to the cytoplasmic d

136 al migration through a pathway that requires integrin-linked kinase (ILK), Engulfment and Cell Motili

137 matrix metalloproteinase-2, fibronectin, and integrin-linked kinase (ILK), indicating its inability t

138 Signalling is mediated by integrin-linked kinase (ILK), leading to modulation of g

139 actor (BDNF), the expression and activity of integrin-linked kinase (ILK), level of protein kinase B

140 Integrin-linked kinase (ILK), phosphoinositide-dependent

141 The heterotrimeric complex between integrin-linked kinase (ILK), PINCH, and parvin is an es

142 a telangiectasia mutated (ATM) gene product, integrin-linked kinase (ILK), protein kinase Calpha (PKC

143 4 formed a functional complex with PINCH and integrin-linked kinase (ILK), resulting in activation of

144 Here, we show that integrin-linked kinase (ILK), the crucial signal transdu

145 The LIM1 domain of PINCH interacts with integrin-linked kinase (ILK), thereby mediating focal ad

146 To characterize better the function of integrin-linked kinase (ILK), we examined the phenotypic

147 ivating surfaces stimulate Akt signaling via integrin-linked kinase (ILK), which is antagonistic to e

148 In this study we demonstrate that integrin-linked kinase (ILK), which is involved in trans

149 lf5 regulates keratinocyte migration via the integrin-linked kinase (ILK), which, like Klf5, is local

150 -binding protein revealed 100% identity with integrin-linked kinase (ILK)-1, a serine/threonine kinas

151 pectively), two structurally closely related integrin-linked kinase (ILK)-binding focal adhesion prot

152 ere that calponin homology domain-containing integrin-linked kinase (ILK)-binding protein (CH-ILKBP),

153 and fibronectin fibrillogenesis via Src- and integrin-linked kinase (ILK)-dependent signaling.

154 The integrin-linked kinase (ILK)-PINCH-parvin (IPP) complex

155 -3 activation through elevated expression of integrin-linked kinase (ILK).

156 mic kinases, focal adhesion kinase (FAK) and integrin-linked kinase (ILK).

157 s for phosphoinositide 3-kinase activity and integrin-linked kinase (ILK).

158 y five LIM domains, as a binding protein for integrin-linked kinase (ILK).

159 g protein actopaxin and the serine/threonine integrin-linked kinase (ILK).

160 s, we hypothesised that it may interact with integrin-linked kinase (ILK).

161 along with the reported kAE1-binding protein integrin-linked kinase (ILK).

162 und that PGE(2) stimulates the expression of integrin-linked kinase (ILK).

163 critically on the tight binding of PINCH to integrin-linked kinase (ILK).

164 contributes to mitogenesis via activation of Integrin-Linked Kinase (ILK).

165 organs through the alpha(5)beta(1) integrin/integrin-linked kinase (ILK)/Akt pathway.

166 r cells through the alpha(5)beta(1) integrin/integrin-linked kinase (ILK)/Akt, GSK-3beta/Snail/E-cadh

167 similarity to the dominant negative form of integrin-linked kinase (ILK); i.e., viral ORF119L lacks

168 The integrin-linked kinase, ILK, is also essential for integ

169 y, and suggest a novel critical role of this integrin-linked kinase in cell growth, cell survival, an

170 ike receptor 9-mediated AKT activation in an integrin-linked kinase-independent manner.

171 migratory potential when treated with either integrin-linked kinase inhibitor or Rac1 inhibitor, or b

172 ces from different species demonstrates that integrin-linked kinase is not a typical protein kinase a

173 th altered function of alpha3beta1 integrin, integrin-linked kinase, laminin-521, and alpha-actinin 4

174 The median HSP90, HSP70, and integrin-linked kinase levels were 87.5% (n = 14), 124%

175 artments, whereas the activation of the PI3K-integrin-linked kinase-matrix metalloproteinase 2 pathwa

176 n implicated in mediating EMT, in which Smad/integrin-linked kinase may play a central role.

177 s necessary for its activation, possibly via integrin-linked kinase-mediated phosphorylation of Ser-4

178 uding talin, alpha-actinin, filamin, tensin, integrin-linked kinase, melusin, and skelemin.

179 In contrast, integrin-linked kinase mutated in a lysine residue criti

180 Blocking the activity of integrin-linked kinase or protein kinase C mu either by

181 ockdown of the downstream effector of CD11b, integrin-linked kinase, or disruption of its engagement

182 omologue, phosphoinositide-dependent kinase, integrin-linked kinase, or phospho-Akt were detected in

183 d to LIM1 of PINCH1, a core component of the integrin-linked kinase-parvin-pinch complex.

184 plex that includes UNC-112 (kindlin), PAT-4 (integrin-linked kinase), PAT-6 (alpha-parvin/actopaxin),

185 ions were found in genes associated with the integrin-linked kinase pathway, including MYH9 and RHOA.

186 Drosophila have revealed the essential role integrin-linked kinase plays in integrin adhesion - but

187 system we show that expression of wild-type integrin-linked kinase promotes the wortmannin sensitive

188 (1) and resultant inhibition of the integrin/integrin-linked kinase/protein kinase B/Akt signaling pa

189 Integrin-linked kinase reportedly phophorylates serine-4

190 as a potential host antiviral response, and integrin-linked kinase signaling as an entry factor.

191 with PINCH, a LIM-only protein implicated in integrin-linked kinase signaling.

192 ead to maintain barrier function and recruit integrin-linked kinase to adhesion sites, which leads to

193 d CXCR2-driven protein kinase C mu-dependent integrin-linked kinase to be essential for CXCL1-mediate

194 The activity of integrin-linked kinase was required for the effect of SP

195 , paxillin, focal adhesion kinase (FAK), and integrin-linked kinase were not recruited to adhesion si

196 hese LNAI cells show increased expression of integrin-linked kinase, which is putatively responsible