ライフサイエンスコーパス: inter-alpha-inhibitor

1 en characterizing the biological activity of inter-alpha-inhibitor.

2 ons, including the intracellular assembly of inter-alpha-inhibitor.

3 ain influence the structure and stability of inter-alpha-inhibitor.

4 both free TSG-6 (35 kd) and the complex with inter-alpha-inhibitor (120 kd) were present and upregula

5 ow TSG-6 and hyaluronan together can deplete inter-alpha-inhibitor and generate bikunin, as has been

6 Inter-alpha-inhibitor and other bikunin-containing prote

7 ns (HCs) from the serum-derived proteoglycan inter-alpha-inhibitor are covalently attached to the HA

8 analysis shows that only the heavy chains of inter-alpha-inhibitor are incorporated into the cECM and

9 t Ca(2+), induced a conformational change in inter-alpha-inhibitor as evidenced by a decrease in the

10 Inter-alpha-inhibitor-derived bikunin was purified and t

11 The covalent association of inter-alpha-inhibitor-derived heavy chains (HCs) with hy

12 n interacted with all protein components and inter-alpha-inhibitor dissociated when it was degraded.

13 of hyaluronic acid (HA) and proteins of the inter-alpha-inhibitor family plays a critical role in or

14 s serglycin, (ii) the 90-kDa core protein as inter-alpha-inhibitor heavy chain 2 (IalphaIHC2), and (i

15 lated gene 6 (TSG-6) is required to transfer inter-alpha-inhibitor heavy chains (HC) to hyaluronan (H

16 components of the serine protease inhibitor, inter-alpha-inhibitor (I alpha I).

17 Inter alpha inhibitor (IalphaI) is an abundant serum pro

18 complex formed between heavy chains (HCs) of inter-alpha-inhibitor (IalphaI) and hyaluronan (HA) by t

19 nteractions of HA with hyaladherins, such as inter-alpha-inhibitor (IalphaI) and tumor necrosis facto

20 e- and dose-dependent manner and we identify Inter-alpha-inhibitor (IalphaI) as a component in serum

21 Inter-alpha-inhibitor (IalphaI) is a serine proteinase i

22 ctural similarity to bikunin, a component of inter-alpha-inhibitor (IalphaI) known for its inhibition

23 volves the transfer of heavy chains from the inter-alpha-inhibitor (IalphaI) proteoglycan, which has

24 covalent transfer of heavy chains (HCs) from inter-alpha-inhibitor (IalphaI) to hyaluronan (HA) via t

25 lently linked with the heavy chains (HCs) of inter-alpha-inhibitor (IalphaI) via a NaOH-sensitive bon

26 sential 8 (E8) formulation supplemented with inter-alpha-inhibitor (IalphaI), a human serum-derived p

27 SG-6 protein is known to form a complex with inter-alpha-inhibitor (IalphaI), a potent serine proteas

28 ains that are derived from the serum protein inter-alpha-inhibitor (IalphaI), a process that is known

29 Although the proteins inter-alpha-inhibitor (IalphaI), pentraxin 3 (PTX3), and

30 by the cooperative action of three proteins, inter-alpha-inhibitor (IalphaI), pentraxin-3, and TNF-st

31 HA-binding proteins (hyaladherins), such as inter-alpha-inhibitor (IalphaI), versican, and tumor nec

32 ntly modified with heavy chains (HC-HA) from inter-alpha-inhibitor (IalphaI), which functions to incr

33 heavy chains (HCs) of the serum glycoprotein inter-alpha-inhibitor (IalphaI).

34 e extracts together with the heavy chains of inter-alpha-inhibitor (IalphaI).

35 bitor proteins circulating in the plasma are inter-alpha-inhibitor (IalphaI, containing one light pep

36 Inter-alpha-inhibitor interacts with an inflammation-ass

37 Inter-alpha-inhibitor is a proteoglycan of unique struct

38 HA after stabilization in vivo while intact inter-alpha-inhibitor is bound to the HA-enriched cECM b

39 valent interaction of HA and heavy chains of inter-alpha-inhibitor may play an important role in the

40 TSG-6-mediated transfer of heavy chains from inter-alpha-inhibitor onto HA, a process known to be ess

41 complex with the serine protease inhibitor, inter-alpha-inhibitor, potentiates the inhibition of pla

42 Here, we demonstrate that plasma inter-alpha inhibitor protein (IAIP) neutralizes the cyt

43 Inter-alpha inhibitor protein (IalphaIp) is an endogenou

44 Inter-alpha-inhibitor protein (IalphaIp) functions as an

45 nostic significance of serial measurement of inter-alpha inhibitor proteins (IalphaIp) in severely se

46 recently shown that administration of human inter-alpha inhibitor proteins (IalphaIp) very early aft

47 Inter-alpha inhibitor proteins are markedly reduced in s

48 Inter-alpha inhibitor proteins serve as endogenous serin

49 The major forms of human inter-alpha-inhibitor proteins circulating in the plasma

50 complex with chondroitin sulfate moieties of inter-alpha-inhibitor supporting the possibility that HA

51 Two subunits of inter-alpha-inhibitor, the heavy chains, form covalent b

52 ctive and transfer heavy chain subunits from inter-alpha-inhibitor to either free or surface-bound hy

53 es with the heavy chain (HC) of glycoprotein inter-alpha-inhibitor to form pathological HA (HC-HA com

54 the artificial addition of heavy chains from inter-alpha-inhibitor to hyaluronan (HA), by adding reco

55 heavy chains from the chondroitin sulfate of inter-alpha-inhibitor to hyaluronan and consequently to

56 ediates in the transfer of heavy chains from inter-alpha-inhibitor to hyaluronan.

57 was shown to be essential for the ability of inter-alpha-inhibitor to participate in extracellular ma

58 Inter-alpha-inhibitor, TSG-6, and hyaluronan have import

59 PG were only able to accept a single HC from inter-alpha-inhibitor via transfer by TSG-6 and that HCs

60 ccepting only a single heavy chain (HC) from inter-alpha-inhibitor via transfer by tumor necrosis fac

61 that the transfer of heavy chains (HCs) from inter-alpha-inhibitor, via the enzyme TSG-6 (tumor necro

62 e interactions between hyaluronan, TSG-6 and inter-alpha-inhibitor, we recently characterized the for