ライフサイエンスコーパス: interactome

1 ecific changes together with their 'cellular interactome'.

2 res, and occupying central hubs in the human interactome.

3 the nucleolar large subunit (LSU) processome interactome.

4 indicating the uniqueness of eutherian BetaM interactome.

5 ovide a detailed description of the retromer interactome.

6 ch by characterising all 36 pairs within the interactome.

7 aracteristics in the context of a functional interactome.

8 hroughput technologies for mapping the miRNA interactome.

9 e functions, we have characterized its brain interactome.

10 s, respectively, through regulating the Rac1 interactome.

11 h highly expressed genes that are not in the interactome.

12 lity and proteome perturbations of the ACTN4 interactome.

13 novel insights into the RNA structurome and interactome.

14 NA repair are enriched in the potential TCTP interactome.

15 uitination networks based on the Arabidopsis interactome.

16 be localized in the same neighborhood of the interactome.

17 methylation (DNAm) alterations onto a human interactome.

18 n patterns of disease genes within the human interactome.

19 1 binding to the genome and altered the ESR1 interactome.

20 eractions, resulting in a high-quality Sho1p interactome.

21 associated proteins and construct a V-ATPase interactome.

22 the cardiac mitochondrial dynamism-mitophagy interactome.

23 ms-level view of the histone H3 histone tail interactome.

24 y and had an average centrality in the human interactome.

25 ng motifs and cellular function, that is, an interactome.

26 n of EVI5, which, in turns, affects the EVI5 interactome.

27 test distances among associated genes in the interactome.

28 epending on its subcellular localization and interactome.

29 ncing PrePPI's coverage of the human protein interactome.

30 significant fraction of the protein-protein interactome.

31 NA library to identify the cardiac dysbindin interactome.

32 emonstrating the high complexity of the sRNA interactome.

33 physical interacting proteins in Arabidopsis interactome.

34 t the isoform interactome from the reference interactome.

35 specific interactomes from organism-specific interactomes.

36 le affinity precipitation-MS protein-protein interactomes.

37 nique for constructing human tissue-specific interactomes.

38 ly characterized Nup54.Nup58 and Nup54.Nup62 interactomes.

39 when viewed in the context of proteome-wide interactomes.

40 rigorous, systematic dissection of cellular interactomes.

41 for much better tools to reveal and dissect interactomes.

42 cer-associated PPIs not in other large-scale interactomes.

43 ntify differential co-expression networks or interactomes.

44 new NPC components and report an exhaustive interactome, allowing assignment of trypanosome nucleopo

45 latform with largest connected component and interactome analyses, we validated previously reported a

46 was corroborated by gene ontology and global interactome analyses, which highlighted specific cellula

47 Interactome analysis of intracellularly expressed monobo

48 This study represents the largest membrane interactome analysis of Sho1p to date and complements pa

49 Interactome analysis of the CPEB protein suggests that i

50 Moreover, interactome analysis revealed that (GR)80 preferentially

51 By interactome analysis, (phospho)proteomics, and transcrip

52 a bioanalytical strategy to validate the AR-interactome and define novel AR-interacting proteins inv

53 racterization of the endogenous TBX5 cardiac interactome and demonstrate that TBX5, long considered a

54 investigate the relationship between its RNA interactome and epigenomic landscape, here we report tha

55 Here, we examine the location, protein interactome and function of PhIL1, an IMC-associated pro

56 k reconstruction based on the integration of interactome and gene expression data.

57 nd graphical network parameters of the human interactome and identify discriminatory network patterns

58 rehensive analysis of the CFTR and F508 CFTR interactome and its dynamics during temperature shift an

59 Interactome and Reactome pathway analysis revealed the i

60 The DISC1 Interactome and Regulome showed differential association

61 e describe the functional properties of each interactome and show that these GAP/GEF proteins are hig

62 Overall, our global native-KCC2 interactome and subsequent characterization revealed PAC

63 Yet, given the incompleteness of the interactome and the limited knowledge of disease-associa

64 stress-associated RCD1-transcription factor interactome and to contribute to the emerging understand

65 Mechanistically, in vitro mapping of protein-interactomes and biochemical analysis suggest interactio

66 we isolated 2,876 proteins across 41 in vivo interactomes and determined their protein domain composi

67 rimidinic endonuclease 1 participates in RNA-interactomes and protein-interactomes involved in cancer

68 results, whole-proteomes, organelle-specific interactomes and subcellular localization data are avail

69 ntification and analysis of membrane protein interactomes and their dynamics.

70 e the structures of yet-unexplored microbial interactomes and to focus on well-conserved yet uncharac

71 wn experiments (luminescence-based mammalian interactome), and fluorescence lifetime imaging microsco

72 These data reveal components of the KAR interactome, and they show that GluK1 and Go proteins ar

73 ein function, study conserved aspects of the interactome, and to establish evolutionary correspondenc

74 viral particles to generate two distinct AAV interactomes, and identify several functional classes of

75 Most proteins in the interactome are known RBPs or harbor canonical RBP featu

76 providing validation for the utility of our interactome as a screen for functionally important novel

77 t strongly distinguish drug targets from the interactome as a whole.

78 hrenia candidate genes by DISC1 and its core Interactome as an alternate pathway for schizophrenia ri

79 of tumor-promoting genes, including the GRB2 interactome as well as Forkhead Box M1 and its downstrea

80 r of domain-domain interactions predicted in interactomes as compared to previous approaches.

81 thod for interactome screening, the Bio-Plex Interactome Assay (BPIA), which allows identification of

82 omorbidities such as genetic overlap and the interactome-based association score.

83 udy, we define the disease pathways using an interactome-based extension of known disease-genes and i

84 These tools represent an interactome-based platform to predict molecular commonal

85 bolic disorders for functional analysis, the interactome-based system-level score showed the best agr

86 target interactions within the eight-peptide interactome be disfavoured and that the four desired int

87 The aim of this study was to provide an interactome between miRNAs and their targetome in Chagas

88 Here, we mapped protein interactomes between human host and several influenza A

89 not only reveal new components of the ORF45 interactome, but also demonstrate that the interactions

90 To study these, we inferred the cell-cell interactome by assessing the gene expression of receptor

91 specificity, we identified the human dynein interactome by attaching a promiscuous biotin ligase ('B

92 , we construct the domain-resolved reference interactome by mapping known domain-domain interactions

93 Then, we construct the isoform interactome by predicting that an isoform loses an inter

94 ling peptides and proteins - known as the HS interactome - by acting as a co-receptor or alternative

95 Characterization of the SgK269 "interactome" by mass spectrometry-based proteomics ident

96 Here, we adapted the mRNA-protein interactome capture method to investigate the RNA bindin

97 The earlier protocol (for the RNA interactome capture method) describes how to identify th

98 We used two mRNA interactome capture methods to identify RBPs bound to po

99 RBPs at the systems level, we have employed interactome capture techniques using cells from differen

100 Using mRNA interactome capture, we identified 227 RBPs in zebrafish

101 wever, little is known about how the protein interactome changes across environmental perturbations.

102 or more species, rendering any cross-species interactome comparison immediately useful.

103 f this work, we have assembled cross-species interactome comparisons that will allow interactomics re

104 eins are associated with the increase in its interactome complexity.

105 The resulting protein interactome comprised 76 unique interactions among 24 pr

106 The ATP7A interactome concentrated gene products implicated in neu

107 NA interference perturbation of a Rho GTPase interactome consisting of 219 proteins reveals a limited

108 Functional screening of the 'core' interactome consisting of common interactions identified

109 The STYX interactome contained several F-box proteins, including

110 s reasonable to analyze the chemical-protein interactome (CPI) profiles to predict indications.

111 The availability of interactome data has brought challenges, as these large

112 ion is commonplace and our knowledge base of interactome data is rapidly expanding, we can now begin

113 h experimentally and computationally derived interactome data to build a RIG-I protein interaction ne

114 tation and Integrated Analysis of the 14-3-3 interactome database.

115 ray analysis of CD and UC biopsies and human interactome databases.

116 son's diseases, we show that tissue-specific interactomes derived from our study can be used to const

117 ve but also inefficient to identify numerous interactomes despite their high accuracy.

118 racting proteins, which we designate the "AR-interactome." Despite many years of research, the ligand

119 combination of broad-scale chemogenomic and interactome discovery strategies to generate data-driven

120 Moreover, the interactome-distance between drug targets and disease-re

121 Protein networks, or interactomes, downstream of dysbindin/BLOC-1 remain part

122 The interactome-driven approach here is an effective way for

123 ide a global and integrated view of promoter interactome dynamics during lineage commitment of human

124 osed as a mechanism of rescue; however, CFTR interactome dynamics during temperature shift and inhibi

125 ughput to make it practical to study protein interactome dynamics.

126 We conclude that the ATP7A interactome encompasses a novel COG-dependent mechanism

127 Recent interactome findings suggested that HPr interacts with s

128 The first predicted protein-protein interactome for a bryophyte based on the interolog metho

129 provide information on both the cistrome and interactome for a given protein.

130 cificity, (ii) screened the 1,180,416 member interactome for predicted Tm values and (iii) used predi

131 sequences and searches within the resulting interactome for preferentially interacting peptides.

132 t FissionNet, a proteome-wide binary protein interactome for S. pombe, comprising 2,278 high-quality

133 " (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing.

134 Analysis of the protein interactomes for six activators, including ninein and ni

135 a domain-based method to predict the isoform interactome from the reference interactome.

136 the construction of refined tissue-specific interactomes from organism-specific interactomes.

137 We propose a model of the Pdu interactome, from which selected PPIs are further inspec

138 re we report targeted sequencing of 59 DISC1 Interactome genes and 154 Regulome genes in 654 psychiat

139 ing upstream regulators, and a complex Hippo interactome has been identified.

140 Analysis of organism-specific interactomes has yielded novel insights into cellular fu

141 Efforts to map the human protein interactome have resulted in information about thousands

142 rom the Connectivity Map into the virus-host interactome identified 110 putative druggable antiviral

143 Mass spectrometry of the PRMT1 protein interactome identified the CSNK1a1 kinase, which also pr

144 Comparative analyses of the interactomes identified common and unique interaction pa

145 ative analyses of the influenza-host protein interactomes identified PKP2 as a natural inhibitor of I

146 The resulting MORF-MORF interactome identifies specific heteromeric MORF protein

147 spectrometry to define a comprehensive MITF interactome identifying novel cofactors involved in tran

148 Functional analysis of PSD and non-PSD interactomes illustrates both common and unique function

149 ison of the phosphoinositide-3-kinase (PI3K) interactome in a drosophila S2R+ cell line and several N

150 on and mass spectrometry of the EZH2-protein interactome in estrogen receptor positive, breast cancer

151 monoclonal antibodies, we surveyed the ORF45 interactome in KSHV-infected cells.

152 m MS and immunoblot analyses of the septin-2 interactome in mouse brain, we identified not only SNARE

153 e and provided first insights into the CLIP2 interactome in the context of radiation-associated PTC.

154 unctional proteomics, we identified the KCC2-interactome in the mouse brain to determine KCC2-protein

155 ectrometry to define a high-confidence HDAC3 interactome in vivo that includes the canonical NCoR-HDA

156 Here we present the MARIO (Mapping RNA interactome in vivo) technology to massively reveal RNA-

157 re, the authors characterize the liver HDAC3 interactome in vivo, provide evidence that HDAC3 interac

158 sites, and high-resolution promoter-enhancer interactomes in HPC-7 cells.

159 dynamic and realistic representation of the interactomes in vivo, in a crowded cellular environment,

160 participates in RNA-interactomes and protein-interactomes involved in cancer development, thus indica

161 The experimentally derived RNA interactome is a scale-free network, which is not expect

162 The interactome is coregulated in developing human neocortex

163 ystems-level investigation of the virus-host interactome is critical for understanding the roles of h

164 onal regulator whose comprehensive chromatin interactome is enriched with schizophrenia risk genes.

165 roteins to spread perturbations in the human interactome is larger if the binding drugs have side eff

166 A prominent member of the LARP1 interactome is mTOR whose mRNA transcript is stabilized

167 proteomic methodology, we identify how this interactome is perturbed in atypical parkinsonism-associ

168 The interactome is the deepest reported to date.

169 d highly regulated as MET, together with its interactome, is biologically relevant in normal and path

170 SUMOylation modifies the interactome, localization, activity, and lifespan of its

171 The resulting LSU processome interactome map has enhanced our understanding of the or

172 ntigen 5 (SPAG5) featured prominently in our interactome map of proliferation and we chose to take it

173 most effect on other genes in the resulting interactome map.

174 Viral-host interactomes map the complex architecture of an evolved

175 We apply this 'interactome mapping by high-throughput quantitative prot

176 Finally, cross-species interactome mapping demonstrates that coevolution of int

177 highly efficient CF-based approach to binary interactome mapping.

178 om these data leads to the problem of binary interactome mapping.

179 Pathogenic alterations in interactomes mechanistically underlie diseases.

180 interactome were translated into a novel MET interactome network based on human protein-protein inter

181 ns and established a highly connected MALAT1 interactome network consisting of 788 connections.

182 In the global context of interactome network maps, alternative isoforms tend to b

183 The candidates were translated into interactome networks and analyzed bioinformatically.

184 than 40 years ago, what is known as the mRNA interactome now comprises >1,000 proteins.

185 ings have revealed the presence of circadian interactomes, nuclear "hubs" of genome topology where co

186 tor interaction data, we first identified an interactome of 226 interaction pairs between 93 neuropep

187 putational study aimed at characterizing the interactome of a bacterial microcompartment provides fre

188 Here, we identify the interactome of all DPRs and find that arginine-containin

189 een no systematic study of the extracellular interactome of any human virus.

190 the first time, the extensive human protein interactome of arenavirus nucleoproteins and uncovers a

191 We determined the interactome of C9ORF72 in motor neurons and found that C

192 In this work, we studied the cell-cell interactome of fetal placental trophoblast cells and mat

193 Here, we determine the comprehensive interactome of H2A.Z and identify PWWP2A as a novel H2A.

194 Quantitative proteomics reveals an interactome of known readers as well as protein complexe

195 then used the method to profile the dynamic interactome of lamin A/C in multiple cell and tissue typ

196 We present here the interactome of Nbeal2 with additional validation by reve

197 ermore, we characterized the dynamic protein interactome of NEK1 after DNA damage challenge with cisp

198 We therefore sought to characterize the interactome of ORF45 to provide insights into its roles

199 In this study, we surveyed the interactome of ORF45 using a panel of monoclonal antibod

200 In this work, we have defined the interactome of PAX3-FOXO1 and screened 60 candidate inte

201 Our study extends the known host cell interactome of Rev and XPO1 and further substantiates a

202 des a general strategy for interrogating the interactome of RNA modifications and reveals the biochem

203 CoPIT was used successfully to identify the interactome of the cystic fibrosis transmembrane conduct

204 In the current work, we have mapped the interactome of the enigmatic pseudophosphatase STYX We r

205 of early Dectin-1 signaling, we explored the interactome of the intracellular tail of the receptor in

206 To study the protein interactome of the SMAD protein family we generated a qu

207 To address this, we describe the interactome of the trypanosome NPC, a representative, hi

208 is described to comprehensively annotate the interactome of these messenger molecules.

209 To define the protein interactome of wild-type and ALS-linked MATR3 mutations,

210 Moreover, analysis of the protein interactome of wild-type versus DNA binding deficient FO

211 TT and combinatorially target factors in the interactome of Xist, the noncoding RNA responsible for X

212 DNA interactomes of 80 heterodimers and 22 homodimers reveal

213 Through the characterization of the interactomes of apurinic/apyrimidinic endonuclease 1 wit

214 f this approach to profile the intracellular interactomes of bacterial effectors during infection.

215 We must reliably map the interactomes of cellular macromolecular complexes in ord

216 We reasoned that interactomes of molecules handling metals in neurons sho

217 The protein interactomes of several bacterial species have been comp

218 roach and determined the infection-dependent interactomes of the effectors SidM and LidA, which were

219 we experimentally determined the phage-host interactomes of the phages Dp-1 and Cp-1 and their under

220 of human lymphocytes to classify the vicinal interactomes of the viral Env and Vif proteins as they o

221 Here, we determine the interactomes of three interacting GAP/GEF proteins at th

222 fill this void, in this study, we define the interactomes of two human ANT isoforms.

223 ous chemical space, protein space, and their interactome on a large scale.

224 study has identified key nodes in the locus interactome, paving the way for new molecular insights i

225 Importantly, our compendium of bZIP-DNA interactomes predicted bZIP binding to 156 disease assoc

226 Co-IP-mass spectrometry positioned Psi in an interactome predominantly comprised of RNA Polymerase II

227 on are two components of a cancer regulatory interactome presumed to display correlated signals.

228 ated the expression of two proteins from the interactomes prior to AAV transduction.

229 transcriptome analysis combined with protein interactome profiling identifies secretagogin neurons as

230 ded interacting proteins, suggesting that an interactome protein network may provide a larger genomic

231 eins were analyzed for being enriched in MET interactome proteins.

232 ta from genome-wide RNAi and CRISPR screens, interactome proteomics and phosphoproteomics screens, ca

233 The functional diversity of the CBP/p300 interactome provides an excellent example of the power o

234 tegrating structural domain information with interactomes provides insights into the functional impac

235 This E. coli CEP 'interactome' provides insights into the functional lands

236 adly applicable to elucidating pathogen-host interactomes, providing high-certainty identification of

237 By correcting for the known biases of the interactome, proximity helps us uncover the therapeutic

238 igase Ubr4 is a key component of the podocin interactome purified both from cultured podocytes and na

239 Promoter interactomes reflect lineage relationships of the hemato

240 rality and modularity of these reconstructed interactomes reflect their fundamental mechanistic impor

241 good description of the full protein-protein interactome requires, for some organisms, up to seven di

242 NA translation are highly represented in our interactome result.

243 mRNA and protein interactomes reveal elaborate targeting schemes, yet evi

244 Our initial exploration of this interactome revealed an abundance of miR target sites in

245 Analysis of the Axl interactome revealed binding of Axl to 14-3-3zeta, which

246 Application of EvoTol to the human interactome revealed networks enriched for genes intoler

247 The predicted human isoform interactome reveals extensive network remodeling by alte

248 in-protein interaction trap)-based IRE1alpha interactome screen followed by comparison against functi

249 An 'interactome' screen of all Drosophila cell-surface and s

250 Here we describe a new method for interactome screening, the Bio-Plex Interactome Assay (B

251 Here, we present a novel, deep interactome sequencing approach called CoPIT (co-interac

252 trength scores, are obtained from the Mentha interactome server, or power-users may upload a pre-made

253 The meta-interactome serves as a model for predicting interaction

254 lar complex and distinct proteins in the HTT interactome set identified by mass spectrometry.

255 teractions, protein functions, and even full interactome sizes for species with limited to no experim

256 de an alternative concept to explain how Hox interactome specificity could be achieved during the emb

257 orthologous groups (OGs) the resulting meta-interactome still includes more than 43,000 interactions

258 ecade, several large-scale transcriptome and interactome studies were conducted to understand the com

259 cies have been the subjects of comprehensive interactome studies while several more have had substant

260 Bacteria have been popular subjects of interactome studies: more than six different bacterial s

261 Our proteomic, phosphoproteomic and interactome study in the Drosophila brain provides a sys

262 N are relevant protein partners in the WNT5A interactome, supporting their role in skeletal developme

263 LARP1 associates with an mRNA interactome that is enriched for oncogenic transcripts.

264 signaling pathways and has a complex protein interactome that is enriched in autism spectrum disorder

265 mponents, i.e., the subnetworks of the human interactome that represent the inflammasome, thrombosome

266 is an Ewing sarcoma (ES) oncoprotein with an interactome that we demonstrate to have multiple partner

267 nteracts with a large set of proteins (DISC1 Interactome) that are involved in brain development and

268 lyses allowed us to reconstruct the relevant interactome, thereby forming the regulatory basis for im

269 have been developed for exploring the global interactome, they are limited by high experimental compl

270 monstrate the power of primary cell promoter interactomes to reveal insights into genomic regulatory

271 redistribution of the cREL/p63/p73, and AP-1 interactome, to diminish TAp73 tumor suppressor function

272 e web services to download genome, proteome, interactome, transcriptome, and 3D molecular structure d

273 Through integration of protein interactome, transcriptome, and genome-wide chromatin im

274 nt a systems-level analysis of the organelle interactome using a multispectral image acquisition meth

275 le, we generated a 'domain-level' centrosome interactome using direct protein-protein interaction dat

276 a Oceans project, we studied the photic zone interactome using environmental factors and organismal a

277 rgets, we characterized its TS cell-specific interactome using mass spectrometry.

278 ed for P-body assembly, we analyzed the DDX6 interactome using the tandem-affinity purification metho

279 f singleton disruptive variants in the DISC1 Interactome was associated with low cognitive ability at

280 dition the GRgamma transcriptome and protein interactome was distinct, and with a gene ontology signa

281 This IMP2 interactome was highly enriched for mRNA targets related

282 riptional regulatory network of the gingival interactome was subsequently interrogated with the maste

283 nterrogation of gene regulatory networks, or interactomes, was used to study neuroadaptation processe

284 To gain insight into evolution of BetaM interactome we performed expanded screening of eutherian

285 idating their placement with our nucleoporin interactome, we built a composite structure of the NPC s

286 nockdown, cross-referenced against the LARP1 interactome, we identify BCL2 and BIK as LARP1 mRNA targ

287 systematic analysis of the human NHEJ factor interactome, we identify PAXX as a direct interactor of

288 amine the biological relevance of the capsid interactome, we modulated the expression of two proteins

289 By generating high quality EWS-RNA interactome, we uncovered its specific and prevalent int

290 Myo4p and She3p, their 1:2 stoichiometry and interactome; we furthermore showed that the motor comple

291 s framework, we model the given data into an interactome weight matrix, where the feature-vectors of

292 Proteins in the MET interactome were translated into a novel MET interactome

293 Identification of a complex Nol12 interactome, which includes NONO, Dhx9, DNA-PK and Stau1

294 describe the first Niam embryonic stem cell interactome, which includes proteins with roles in DNA r

295 actors and discover a F508 deletion-specific interactome, which is extensively remodelled upon rescue

296 We next defined the ACTN4 interactome, which was predominantly composed of cytoske

297 ly improves the results for membrane protein interactomes, which have proven to be difficult to ident

298 e module, i.e. the local neighborhood of the interactome whose perturbation is associated with asthma

299 By integrating the Hippo network interactome with our data sets, we identify WW-binding p

300 model protein-protein interaction networks ("interactomes"), yet large-scale determination of isoform