ライフサイエンスコーパス: intercalated cell

1 tted very well to the function of the B-type intercalated cell.

2 oncocytoma seem to originate from the A-type intercalated cell.

3 decreased size of the apical surface of beta-intercalated cells.

4 position in the ECM underneath adapting beta-intercalated cells.

5 hereas NHE-RF staining was undetectable in A-intercalated cells.

6 almost exclusively to the apical surface of -intercalated cells.

7 t of lumenal H+ secretion by collecting duct intercalated cells.

8 This cell line functionally resembles alpha-intercalated cells.

9 imal tubule brush border and collecting duct intercalated cells.

10 ubated with her serum showed labeling of the intercalated cells.

11 y demonstrated three distinct populations of intercalated cells.

12 an be replaced by the H(+) V-ATPase in renal intercalated cells.

13 ption pathway that we recently discovered in intercalated cells.

14 , suggesting that Aqp2(+) cells give rise to intercalated cells.

15 of two main cell types: principal cells and intercalated cells.

16 enhanced by prorenin receptors (PRRs) on the intercalated cells.

17 ates this differentiation step in the kidney intercalated cells.

18 R607H knockin did not affect type B intercalated cells.

19 clonal cell line (clone C) of rabbit kidney intercalated cells.

20 of the proton pump to the apical membrane of intercalated cells.

21 which closely resemble acid-secreting kidney intercalated cells (10,11).

22 ith AE1 on the basolateral membrane of Alpha intercalated cells (A-IC) in outer medullary collecting

23 H(+) secretion in type A intercalated cells (A-ICs) is regulated by apical vesicl

24 alpha-Intercalated cells (A-ICs) within the collecting duct of

25 this issue, Paragas et al. report that alpha-intercalated cells (A-ICs) within the nephron collecting

26 ion is mediated by highly specialized type A intercalated cells (A-ICs), which contain vacuolar H(+)-

27 revealed the unexpected importance of renal intercalated cells, a subtype of cells present in the co

28 However, it is clear now that intercalated cells absorb NaCl and K(+) and hence may pa

29 the S(3) segment of the proximal tubule and intercalated cells, after intrarenal administration of a

30 role in the terminal differentiation of the intercalated cell: alpha v beta 1 generates polymerized

31 ation in these cells, but unexpectedly, most intercalated cells also had undetectable di-methyl K79,

32 molecule in the terminal differentiation of intercalated cell and perhaps other epithelial cells.

33 ontained primitive cells that expressed both intercalated cell and principal cell proteins, yet the a

34 ney AE1 and beta1 colocalized in renal alpha-intercalated cells and coimmunoprecipitated (together wi

35 In both kidney-intercalated cells and epididymal clear cells, cAMP indu

36 ane and recycling vesicles, including kidney intercalated cells and osteoclasts.

37 immunostaining was weak or absent in type B intercalated cells and principal cells of the cortical c

38 ells results in the absence of typical alpha-intercalated cells and the consequent development of com

39 tubule and connecting segment cells, A-type intercalated cells, and non-A, non-B cells express RhCG

40 Two forms of intercalated cells are present in kidney collecting tubu

41 ically and immunologically distinct types of intercalated cells are present in the mouse kidney.

42 dala central nucleus (lateral division), and intercalated cells, areas known to learn and express ext

43 ecific for principal cells (aquaporin-2) and intercalated cells (band 3 and H(+)-ATPase) show that co

44 e followed intracellular pH in the same beta-intercalated cells before and after acid incubation and

45 by testing whether ammonia stimulates B-type intercalated cell bicarbonate secretion, bicarbonate rea

46 al, mid, and basolateral cytoplasm of type A intercalated cells, but was not observed in the plasma m

47 ion on the basolateral membrane of the alpha-intercalated cell cause autosomal dominant distal renal

48 integrin, and deletion of this gene from the intercalated cell caused a phenotype that was identical

49 d rabbit cell line of collecting duct A-type intercalated cell characteristics (Clone C).

50 Overall, our results suggest that intercalated cells constitute a promising target for pha

51 al cells contain BK-alpha/beta1 channels and intercalated cells contain BK-alpha/beta4 channels.

52 the anion exchanger of a clonal cell line of intercalated cells derived from the kidney can be retarg

53 It resembled a third type of intercalated cell described previously in the rat.

54 Intercalated cells do not participate in cyst expansion

55 nversion of beta-intercalated cells to alpha-intercalated cells during acid incubation depends upon E

56 All types of intercalated cells expressed a4.

57 the differentiation of some alpha- and beta-intercalated cells from Aqp2-expressing progenitor cells

58 Type B intercalated cells had a fairly smooth apical surface, a

59 of vacuolar H(+)-ATPase from collecting duct intercalated cells has been reported.

60 lly and functionally distinct populations of intercalated cells have been described in the collecting

61 CD) by transcellular transport across type B intercalated cells (IC) via an H(+)-ATPase-and pendrin-d

62 of K recycling across the apical membrane in intercalated cells (IC).

63 Renal intercalated cells (ICs) express the proton pumping vacu

64 of the B1 proton pump subunit (ATP6V1B1) in intercalated cells (ICs) leads to type I distal renal tu

65 , most likely occurring in a alpha- and beta-intercalated cells (ICs), respectively.

66 hich mediate Na, K, and water transport, and intercalated cells (ICs), which are specialized for acid

67 a proportional increase in the percentage of intercalated cells (ICs).

68 ant cell type, with more diffuse staining in intercalated cells (ICs).

69 Type A intercalated cells identified by positive Band 3 stainin

70 Intercalated cells identified by positive staining for H

71 ization of AE in cultured cells and in alpha-intercalated cells identified in sections of rat kidney

72 uncovered, which resembles the cortical beta-intercalated cell in ultrastructure, but does not expres

73 tracellular vesicles of acid-secreting alpha-intercalated cells in renal collecting duct.

74 the S(3) segment of the proximal tubule and intercalated cells in the collecting duct, the latter id

75 kidney cells, except acid-base transporting intercalated cells in the collecting duct.

76 The results indicate that intercalated cells in the collecting ducts of both corte

77 Essentially all of the intercalated cells in the cortex of the mutant mice are

78 changer expressed in type B and non-A, non-B intercalated cells in the distal nephron, where it facil

79 xpressed at the basolateral surface of alpha-intercalated cells in the distal nephron.

80 olocalize in the basolateral domain of alpha-intercalated cells in the distal nephron.

81 tinct acid-secreting epithelial cells: The A-intercalated cells in the kidney outer medullary collect

82 et al. find that mice lacking Foxi1 have no intercalated cells in the kidney.

83 ogical characteristics of different types of intercalated cells in the mouse.

84 /HCO3(-) exchange activity in acid-secreting intercalated cells in the OMCD was significantly decreas

85 also be involved in the polarity reversal of intercalated cells in vivo.

86 includes the preservation of H(+)-ATPase in intercalated cells, in patients with presumed voltage de

87 A similar remodeling of beta-intercalated cells, in which the polarity of H(+) pumps

88 gested that the conversion of beta- to alpha-intercalated cells is a manifestation of terminal differ

89 is blocked, the conversion of beta to alpha intercalated cells is prevented and the animals develop

90 hanger in the basolateral membrane of type A intercalated cells is thought to be an essential compone

91 Among GABAergic neurons, the so-called intercalated cells (ITCcs) are critically involved in th

92 The intercalated cells (ITCs) gate amygdala output and thus

93 Intercalated cells (ITCs) of the amygdala are clusters o

94 The intercalated cells (ITCs) of the amygdala have been show

95 Tshz1 is expressed during development of the intercalated cells (ITCs) within the mouse amygdala.

96 ic population of amygdalar interneurons, the intercalated cells (ITCs), is known to play a fundamenta

97 M) protein hensin is able to convert a renal intercalated cell line from a flat, squamous shape into

98 as present in the apical membrane of a renal intercalated cell line when these cells were seeded at l

99 Using a beta intercalated cell line, the cause of this phenotypic cha

100 in phenotype was studied in an immortalized intercalated cell line.

101 ly targeted to the basolateral domain in the intercalated cell line.

102 a 230-kD protein in rabbit kidney and in the intercalated cell line.

103 inhibitory inputs onto neurons of the dorsal intercalated cell mass (ITC) in the amygdala.

104 leus of the amygdala and medial paracapsular intercalated cell mass, relative to C57BL/6J.

105 patches in the lateral nucleus of amygdala, intercalated cell masses (ICM), and the lateral subdivis

106 irect effect on collecting duct principal or intercalated cells may underlie the reduced urinary PGE2

107 ring the response to metabolic acidosis, the intercalated cell of the collecting tubule converts from

108 The intercalated cell of the cortical collecting tubule exis

109 on transporters of the acid-secreting Type A intercalated cell of the renal collecting duct.

110 at pendrin is an apical anion transporter in intercalated cells of CCDs and has an essential role in

111 cells isolated from the proximal tubule and intercalated cells of collecting ducts, we observed coex

112 rin-2, indicating that pendrin is present in intercalated cells of the CCD.

113 ased V-ATPase expression and activity in the intercalated cells of the collecting duct impaired acid-

114 d at the basolateral border of principal and intercalated cells of the collecting duct where it inhib

115 AE1 is mainly active basolaterally in alpha-intercalated cells of the collecting duct, where it is f

116 ven Cl(-)/2HCO3(-) exchanger (NDCBE) in beta-intercalated cells of the collecting duct.

117 The intercalated cells of the collecting tubules of mammalia

118 XGR1 expressed in the type B and non-A-non-B intercalated cells of the connecting tubule (CNT) and th

119 In mouse kidney, the B1-subunit localizes to intercalated cells of the cortical and medullary collect

120 o functional, plasma membrane H(+)ATPases in intercalated cells of the cortical collecting duct and i

121 The renal cystadenomas develop from intercalated cells of the cortical collecting duct and u

122 H recovery rates of individual Atp6v1b1(-/-) intercalated cells of the cortical collecting duct are m

123 density on the apical (luminal) surface of -intercalated cells of the cortical collecting duct of th

124 bule (S1/S2 segment), the loop of Henle, the intercalated cells of the distal convoluted tubule, the

125 pressing the chloride transporter pendrin in intercalated cells of the distal nephron (Tg(B1-hPDS) mi

126 uted tubule, the connecting segment, and all intercalated cells of the entire collecting duct in huma

127 H(+),K(+)-ATPase-mediated H(+) secretion in intercalated cells of the inner cortical collecting duct

128 is expressed in erythrocytes and the A-type intercalated cells of the kidney distal collecting duct.

129 in the erythrocyte and in the acid-secreting intercalated cells of the kidney.

130 t subtypes that resemble the alpha- and beta-intercalated cells of the kidney.

131 Here, we show that intercalated cells of the mouse kidney are an exception

132 orter immunoreactivity is localized to alpha-intercalated cells of the outer medullary collecting duc

133 cells and a chloride/base exchanger in beta-intercalated cells of the renal cortical collecting duct

134 ese mutations affect the physiology of the A-intercalated cells of the renal cortical collecting duct

135 In the medullary intercalated cells of the sham-operated kidneys, relativ

136 In the intercalated cells of this segment, it colocalized with

137 HCO(3)(-) exchange, indicating a reversal of intercalated cell polarity.

138 ype H(+)-ATPase subunits in pendrin-positive intercalated cells (PP-ICs) and ENaC subunits in princip

139 -A, non-B cells express RhCG and that B-type intercalated cells, principal cells, and inner medullary

140 phase, which explains the reduced principal/intercalated cell ratio and may identify the molecular p

141 data suggest that BK-alpha/beta4 channels in intercalated cells reduce cell size, increasing luminal

142 The size of intercalated cells reduced and luminal volume increased

143 s suggest that conversion of polarity of the intercalated cells represents a process of terminal diff

144 Enhancement of inputs to intercalated cells required prefrontal activity during e

145 llecting ducts of the kidney are composed of intercalated cells (responsible for acid/base transport)

146 Functional failure of -intercalated cells results in a group of disorders, the

147 Here, we show that deletion of hensin from intercalated cells results in the absence of typical alp

148 diated by two canonical cell types: the beta-intercalated cell secretes HCO(3) by an apical Cl:HCO(3)

149 and distal professional proton transporting (intercalated) cells sense and respond to changes in pH,

150 ion of NHE-RF and H(+)ATPase in B- but not A-intercalated cells suggests a role in generating, mainta

151 y 20% fewer principal cells and 13%-16% more intercalated cells than control mice.

152 y three-fold greater when positioned next to intercalated cells than next to principal cells.

153 some patients may have autoantibodies to the intercalated cells that are not directed to subunits of

154 cted exclusively within the subpopulation of intercalated cells that express the H(+)-ATPase but not

155 zes to the basolateral membrane of the alpha intercalated cell, the acid secreting cell of the outer

156 rom the BLA to Ce, perhaps through GABAergic intercalated cells, thereby gating the expression of con

157 Hence, the adaptive conversion of beta-intercalated cells to alpha-intercalated cells during ac

158 showed that the conversion of beta to alpha intercalated cell under the influence of acidification o

159 ion can lead to a reduced ratio of principal/intercalated cells using two-dimensional and three-dimen

160 agues describe a new mechanism by which beta-intercalated cells, via release of ATP and prostaglandin

161 apted mice, but expression of Na-K-ATPase in intercalated cells was >10-fold lower.

162 Basolateral NaCl exit from beta-intercalated cells was independent of the Na(+)/K(+)-ATP

163 The effects of ammonia on single CCD intercalated cells was studied by use of measurements of

164 These Aqp2(+) cell-derived intercalated cells were present in both developing and m

165 /HCO3(-) exchange in erythrocytes and kidney intercalated cells where it functions to maintain normal

166 e apical or the basolateral region of B-type intercalated cells, whereas NHE-RF staining was undetect

167 Acid secretion is mediated by the alpha-intercalated cell, which has an apical V-ATPase and a ba

168 er that localizes to type B and non-A, non-B intercalated cells, which are expressed within the aldos

169 lian collecting duct comprises principal and intercalated cells, which maintain sodium/water and acid

170 This B1 isoform is amplified in renal intercalated cells, which play a role in distal urinary

171 A third type of intercalated cell with apical and cytoplasmic H+-ATPase,

172 Type A intercalated cells with apical H+ -ATPase and basolatera

173 Type B intercalated cells with basolateral and cytoplasmic H+-A

174 remnant kidneys, the percentage of medullary intercalated cells with predominant plasma membrane H(+)

175 cortical collecting ducts, the percentage of intercalated cells with well-polarized apical and well-p

176 nregulation and a reduced ratio of principal/intercalated cells, yet lithium induces principal cell p