ライフサイエンスコーパス: intercalated disc

1 istinct structural components of the cardiac intercalated disc.

2 assembly of functional gap junctions in the intercalated disc.

3 58stop with other junctional proteins at the intercalated disc.

4 ed disc and complete loss of vinculin at the intercalated disc.

5 d connection between the myocytes called the intercalated disc.

6 and yet its exclusion from the region of the intercalated disc.

7 alcium/calmodulin-dependent kinase II to the intercalated disc.

8 and yet its exclusion from the region of the intercalated disc.

9 connection with membrane proteins within the intercalated disc.

10 within the cardiac transitional junction and intercalated disc.

11 N-cadherin, is an essential component of the intercalated disc.

12 al continuum between cells also populate the intercalated disc.

13 end-end contact between myocytes, within the intercalated disc.

14 at electrically couple cardiomyocytes at the intercalated disc.

15 hat it interacts with other molecules of the intercalated disc.

16 iciently trafficked to adherens junctions at intercalated discs.

17 nexin43, loss of gap junctions, and abnormal intercalated discs.

18 brils, while DARP staining also increased at intercalated discs.

19 ient (Arg975Trp), revealing grossly abnormal intercalated discs.

20 in EDMD are caused by absence of emerin from intercalated discs.

21 line, and CPbeta2 organizes the actin at the intercalated discs.

22 domains of actin that attach to Z bands and intercalated discs.

23 is beta 1 isoform was found in costamers and intercalated discs.

24 ing delivery of Cx43 hemichannels to cardiac intercalated discs.

25 cardial Cx43 gap junction plaque size at the intercalated discs.

26 emains partially stable and localized at the intercalated discs.

27 contribute to losses in Cx43 localization at intercalated discs.

28 nt to reduce levels of Cx43 gap junctions at intercalated discs.

29 3 and the microtubule-capping protein EB1 at intercalated discs.

30 for full-length Cx43 forward trafficking to intercalated discs.

31 e for NMII-B in maintaining the integrity of intercalated discs.

32 (alphaMHC) hearts develop marked widening of intercalated discs.

33 tissues with predominant localization at the intercalated discs.

34 , and disruption of Kv1.5 trafficking to the intercalated discs.

35 smosome-like structures and regional loss of intercalated disc adhesion.

36 the heart protects Cx43 localization to the intercalated discs against acute ischemic injury.

37 beta1 is at the Z-line; beta2 is at the intercalated disc and cell periphery in general.

38 e preceded by ultrastructural defects in the intercalated disc and complete loss of vinculin at the i

39 a mechanism for direct communication between intercalated disc and contractile apparatus.

40 58stop gap junctions to the periphery of the intercalated disc and further revealed an increase in th

41 Ankyrin-G and Na(v)1.5 are both localized at intercalated disc and T-tubule membranes in cardiomyocyt

42 cardiac muscle, dysferlin is located at the intercalated disc and transverse tubule membranes.

43 Cardiac LRP6 is spatially restricted to intercalated discs and binds to gap junction protein con

44 ly expressed in the heart and is enriched at intercalated discs and costameres.

45 ubule interaction with adherens junctions at intercalated discs and reduced connexon delivery and gap

46 myofibrillar collapse with abnormalities of intercalated discs and sarcolemmal membranes.

47 ta resulted in the failure of forming mature intercalated discs and the mislocalization of mXinalpha

48 forms NBCe1 and NBCn1 to lateral sarcolemma, intercalated discs and transverse tubules (t-tubules), w

49 ocalized AKAP100 to the nucleus, sarcolemma, intercalated disc, and at the level of the Z-line.

50 echanotransmission within the sarcomere, the intercalated disc, and at the sarcolemma.

51 f sarcomeric organization, disruption of the intercalated disc, and cell-autonomous loss of cardiomyo

52 and localizes to the Z-disk, cell membrane, intercalated disc, and nuclear membrane of adult rat hea

53 n the adherens junction of the cardiomyocyte intercalated disc, and perturbations in its expression a

54 usion protein was incorporated into Z-bands, intercalated discs, and attachment plaques, as well as i

55 FXR1 associates with intercalated discs, and integral gap junction proteins C

56 remodeling of the ICD by determining the 3D intercalated disc architecture using serial block face s

57 of beta-catenin and ZO-1 at the ventricular intercalated disc are dependent on CAR.

58 , particularly at the ends of the cell where intercalated discs are commonly located, and where NHE1

59 and animal models provide insights into the intercalated disc as a functional unit and into the basi

60 modeling of myofibrils, focal adhesions, and intercalated discs as cooperative ensembles.

61 ls and tissues during myofibrillogenesis and intercalated disc assembly.

62 at AnkG is a key functional component of the intercalated disc at the intersection of 3 complexes oft

63 ression of the truncated DSC2 protein at the intercalated discs but only minor changes in immunoreact

64 erin did recognize both nuclear membrane and intercalated discs but, after affinity purification agai

65 t mice revealed structural remodeling of the intercalated disc characteristic of human patients with

66 ression and localization of gap junction and intercalated disc components.

67 Intercalated discs composed of desmosomes, adherens junc

68 l studies showed that there was a gap at the intercalated disc consisting of cell membranes and a reg

69 The intercalated disc contains different junctional complexe

70 cal changes that occur within the sarcomere, intercalated disc, costamere, and extracellular matrix.

71 d in membrane anchorage complexes, including intercalated discs, costameres, and myotendinous junctio

72 adherin desmoglein 2 (Dsg2) localizes to the intercalated disc coupling adjacent cardiomyocytes.

73 acement fibrosis, interstitial fibrosis, and intercalated disc dissociation.

74 analysis of these hearts revealed disrupted intercalated disc formation and a failure in the attachm

75 known roles in myocyte epithelialization and intercalated disc formation, N-cadherin appears to play

76 The intercalated disc (ICD) is a unique structure to the hea

77 osomes and adherens junctions located at the intercalated disc (ICD) of cardiomyocytes, where it func

78 The intercalated disc (ICD) orchestrates electrochemical and

79 nker proteins resulted in dissolution of the intercalated disc (ICD) structure.

80 The intercalated disc (ID) is a "hot spot" for heart disease

81 ific set of 170 genes encoding cardiomyocyte intercalated disc (ID) proteins are more enriched for as

82 ytoskeletal network that localized mainly at intercalated discs (IDs) and conferred cardioprotection

83 We further localized NOS1AP to cardiomyocyte intercalated discs (IDs) and demonstrate that overexpres

84 ed interruption of DSP-desmin interaction at intercalated discs (IDs) and marked ultra-structural cha

85 g genes, as well as genes that stabilize the intercalated disc in postnatal atrium.

86 chronic uninhibited PKCalpha activity at the intercalated disc in the absence of functional MLP leads

87 tionship of the structural components of the intercalated disc in the working myocardium, thus establ

88 plakoglobin, desmoplakin, and connexin43 at intercalated discs in cardiac myocytes.

89 Intercalated discs in cardiomyocytes from four of six hu

90 Here, we show that iASPP is expressed at intercalated discs in human and mouse postmitotic cardio

91 Nine out of 10 mAbs located DMPK to intercalated discs in human heart, an affected tissue in

92 different emerin epitopes did not recognize intercalated discs in the heart, though they recognized

93 n of force transmission at the thin filament-intercalated disc interface is the likely mechanism by w

94 ONALE: Delivery of Cx43 (connexin 43) to the intercalated disc is a continuous and rapid process crit

95 the chronic PKCalpha signalling chain at the intercalated disc is broken and they remain healthy.

96 t kindlin-2 is an essential component of the intercalated disc, is necessary for cytoskeletal organiz

97 cellular junctions, including the myocardial intercalated disc; it is known to mediate cell-cell reco

98 ents induces excessive mechanical loading of intercalated discs, leading to assembly of stabilizing f

99 Molecular remodeling of the intercalated discs leads to pathogenic activation of the

100 ot only an essential role of mXinbeta in the intercalated disc maturation but also mechanisms of mXin

101 roles of mXinbeta in cardiac development and intercalated disc maturation were investigated.

102 As the intercalated disc matures, we postulated that focal adhe

103 data for the molecular pathway required for intercalated disc Nav1.5 targeting/regulation in heart.

104 Although enriched in the intercalated disc, NaV1.5 is present in different membra

105 of electrical and mechanical junctions into intercalated discs occurs during postnatal development.

106 d-stage DCM, PKCalpha is concentrated at the intercalated disc of cardiomyocytes, where it is sequest

107 teins mXinalpha and mXinbeta localize to the intercalated disc of mouse heart and are implicated in c

108 lized with N-cadherin and connexin-43 in the intercalated discs of adult mouse hearts.

109 onula occludens-1 (ZO-1) localization to the intercalated discs of CAR-cKO mouse hearts at 8 weeks be

110 d of pressure overload (PO) hypertrophy near intercalated discs of cardiomyocytes, where integrins ar

111 essed in cardiomyocytes and localized in the intercalated discs of mouse and human hearts.

112 e is abundant subtype 2 of SK protein in the intercalated discs of myocytes.

113 of SK protein showed increased expression in intercalated discs of myocytes.

114 2 binding was dependent on expression of the intercalated disc plaque protein plakoglobin (Pg) and di

115 to demonstrate distinct hubs at the cardiac intercalated disc, populated by clusters of the adhesion

116 it is also a cardiac binding partner of the intercalated disc protein Myozap.

117 associated with mutations in genes encoding intercalated disc proteins and ultimately results in sud

118 Localization and levels of selected intercalated disc proteins, including signaling molecule

119 the expression or localization of other key intercalated disc proteins.

120 the sarcolemma, colocalized with NHE1 at the intercalated disc regions, increased NHE1 phosphorylatio

121 cant co-localization of PP2A(c) and NHE1, in intercalated disc regions.

122 se mice showed both myofibril disruption and intercalated disc remodeling, as predicted.Therefore, CP

123 ut mice, we provide microscopic evidence for intercalated disc remodeling.

124 the cell-cell interface, suggesting that the intercalated disc required mechanical reinforcement.

125 aV1.5 expression at the lateral membrane and intercalated disc revealed that the lateral membrane poo

126 The intercalated disc serves as an organizing center for var

127 at ankyrin-G links Nav channels with broader intercalated disc signaling/structural nodes, as ankyrin

128 l adherens junctions with dissolution of the intercalated disc structure, expression of the junctiona

129 of N-cadherin resulted in disassembly of the intercalated disc structure, including adherens junction

130 oform metavinculin are protein components of intercalated discs, structures that anchor thin filament

131 these complexes and plays essential roles in intercalated discs that are necessary for muscle cell fu

132 t the cell-cell interface and forming mature intercalated discs that transmitted the systolic load.

133 ary lies between the myofibrillar I-band and intercalated disc thin filaments, identifiable by the pr

134 broad range of tissues and localizes to the intercalated discs, to the perinuclear region, and overl

135 Altered protein constituents of intercalated discs were associated with activation of th

136 s would not be expected if immunostaining at intercalated discs were due to a product of the emerin g

137 e to the heart muscle plasma membrane at the intercalated disc where the myofibrils lead into the adh

138 heart, it is localized predominantly at the intercalated disc, where its function is not known.

139 adherin and beta-catenin localization at the intercalated discs, where both NM II-B and II-C are norm

140 ning in myocyte sarcolemmal membranes and at intercalated discs, whereas caveolin-1 staining was prom

141 lly protects gap junctional communication at intercalated discs, while NBC locally protects t-tubular

142 Alp also colocalizes at the intercalated disc with alpha-actinin and gamma-catenin,

143 were born with a functional heart presenting intercalated discs with incorporated desmosomal proteins

144 PN(Y20C) Tg mice developed HCM and disrupted intercalated discs, with disturbed expression of desmin,

145 ssing beta1 showed altered morphology of the intercalated disc, without the lethality or myofibril di