ライフサイエンスコーパス: intercalated disk

1 rcomere and cell contacts within the cardiac intercalated disk.

2 3 is no longer specifically localized to the intercalated disk.

3 sodium current magnitude specifically at the intercalated disk.

4 stameres at the sarcolemma and desmosomes at intercalated disks.

5 ral membrane of the cardiomyocyte and in the intercalated disks.

6 itin protein to the transitional junction at intercalated disks.

7 l Cx43, pS368-Cx43 remained predominantly at intercalated disks.

8 led a loss of organization at sarcomeres and intercalated disks.

9 bunit is also present in a small fraction of intercalated disks.

10 re differentially localized to t-tubules and intercalated disks.

11 red muscle-specific protein found at cardiac intercalated disks.

12 th the absence of myofilaments, Z lines, and intercalated disks.

13 sive hypertrophy and the formation of mature intercalated disks.

14 hearts with staining primarily localized to intercalated disks.

15 nculin, connects actin microfilaments to the intercalated disk and membrane costameres of the heart.

16 that dysferlin is normally localized to the intercalated disk and sarcoplasm of the cardiomyocytes.

17 mbrane damage occurs and is localized to the intercalated disk and sarcoplasm.

18 evealed a loss of desmin staining within the intercalated disk and severe cytoplasmic aggregate forma

19 Mutant hearts exhibited disruptions of intercalated disks and costameres accompanied by fibrosi

20 anized sarcomeres and myofibrils, and formed intercalated disks and gap junctions with endogenous (ho

21 Na(v)1.5 plus beta2 and/or beta4 subunits in intercalated disks and Na(v)1.1, Na(v)1.3, and Na(v)1.6

22 Nav1.5 is densely expressed at the intercalated disk, and narrow intercellular separation c

23 in cardiomyocyte cytoplasm, plasma membrane, intercalated disks, and cross striations.

24 d histology but abnormal electrocardiograms, intercalated disks, and ICD-related protein distribution

25 -delta was translocated to the mitochondria, intercalated disks, and nuclei of myocytes in diazoxide-

26 in ventricular myocytes and is localized in intercalated disks as are beta2 and Na(v)1.5.

27 with connexin-43, N-cadherin, and Nav1.5 at intercalated disks but was not detected at the t-tubules

28 A120D filament localization at the intercalated disk explains its clinical arrhythmogenic p

29 ar mechanisms by which Cx43 is lost from the intercalated disk following MI includes an interaction o

30 at N-RAP copurifies with detergent-extracted intercalated disk fragments even though beta-integrin an

31 eta2 subunit are preferentially localized in intercalated disks, identified by immunostaining of conn

32 , alphaCT1-treated hearts maintained Cx43 in intercalated disks (IDs) in the IBZ, whereas by 1 week a

33 The higher K(ATP) channel density at the intercalated disk implies a possible role at the interce

34 2A) are expressed at a higher density at the intercalated disk in mouse and rat hearts, where they co

35 ndon junctions in skeletal muscle and at the intercalated disks in cardiac muscle.

36 endon junction in skeletal muscle and at the intercalated disks in cardiac muscle.

37 e well preserved, including mitochondria and intercalated disks in diazoxide-treated hearts compared

38 the selectivity of gap junction channels at intercalated disks is increased early in ischemia.

39 st that the principal cardiac isoform in the intercalated disks is primarily responsible for action p

40 entially at day 1 but began to organize into intercalated disk-like structures by day 6.

41 action with ZO-1 and undergo initial loss of intercalated disk localization.

42 with similar percents of phosphorylated and intercalated disk-localized Cx43 compared with controls.

43 dies also specifically labeled the subset of intercalated disks located at the ends but not the sides

44 - 0.5; control versus hypertrophy), and more intercalated disks mediating side-to-side coupling (8.2

45 djacent to the fascia adherens region of the intercalated disk membrane, while N-RAP extends approxim

46 Intercalated disk morphology and connexin 43 immunolabel

47 ilonV1 decorated cross-striated elements and intercalated disks of cardiac myocytes.

48 urfaces of the hair cell stereocilia and the intercalated disks of isolated cardiac myocytes, and per

49 hesion molecule predominantly located at the intercalated disks of the cardiomyocyte.

50 We propose that sodium channel complexes at intercalated disks of ventricular myocytes are composed

51 lly, with the Cx40 fraction localized to the intercalated disks on immunohistochemical quantification

52 localize, concentrating at the t-tubular and intercalated disk regions.

53 etergent treatment of the partially purified intercalated disks removed the membrane vesicles and ext

54 -epsilon were translocated to sarcolemma and intercalated disks, respectively.

55 layed branching with distinct differences in intercalated disk size and staining for beta(1)-integrin

56 oss of adult CM rod-shape and sarcomeric and intercalated disk structural disorganization confirmed i

57 rH1 protein localization in terminal intercalated disks suggests that sodium channels may als

58 n are associated with the large fragments of intercalated disks that are present in this preparation,

59 myocytes in the morphant embryos lacked the intercalated disks that were present in controls by 72 a

60 les, because Cx43 was redistributed from the intercalated disk to lateral cell borders in failing tis

61 protein that links adhesion molecules at the intercalated disk to the cytoskeleton.

62 membranes from areas of high Cx43, as at the intercalated disk, to regions of lower Cx43 content, the

63 We partially purified cardiac intercalated disks using low- and high-salt extractions

64 isk, whereas traditional localization at the intercalated disk was preserved.

65 ne, whereas NaV1.5 expression and INa at the intercalated disks were unaffected.

66 form Na(v)1.5 is preferentially localized in intercalated disks, whereas the brain alpha subunit isof

67 AVN; uniform, delicate cross-striations; and intercalated disks, which are broader in the PAVB and fo

68 or adhesion and gap junction proteins of the intercalated disk, yet both proteins were markedly downr