ライフサイエンスコーパス: intercalator

1 base pair rise accommodates stacking of the intercalator.

2 y the groove and sequence recognition of the intercalator.

3 which suggests that NSC 314622 is not a DNA intercalator.

4 d 3D self-assembled NP lattices by molecular intercalator.

5 e DNA-binding behaviour of a threading tetra-intercalator.

6 scent probe and stained nonspecifically with intercalator.

7 uplex that selectively binds a complementary intercalator.

8 ution, indicating that the complex is not an intercalator.

9 al DNA through photoreactions with a rhodium intercalator.

10 ence of any DNA aggregation by the DNA-bound intercalators.

11 ng a new paradigm for rational design of DNA intercalators.

12 of some of the most effective anticancer DNA intercalators.

13 ents, makes them potential candidates as DNA intercalators.

14 t closely resembles cytotoxic antineoplastic intercalators.

15 top2, unwound DNA, and are assumed to be DNA intercalators.

16 tivated DNA cleavage assays with the rhodium intercalators.

17 significantly different from those caused by intercalators.

18 ine analogs do not "behave" like classic DNA intercalators.

19 nteractions between caffeine and various DNA intercalators.

20 ng ethidium bromide or SYBR Green I as model intercalators.

21 now tested the hypothesis that the membrane intercalator 1-hexadecanol (HD) similarly associates wit

22 In the absence of any bis-intercalators, 7-9 nucleotides (nt) in each of the stran

23 ric acids (8-oxoxanthine) with the known DNA intercalator acridine orange (AO).

24 lexation between caffeine and the planar DNA intercalator acridine orange.

25 a triple-helical structure stabilized by an intercalator, acridine, attached to the third strand of

26 These results support the hypothesis that intercalators (acting as 'molecular midwives') could hav

27 GC-specific intercalator actinomycin D and three minor groove-binder

28 se reactions are performed in the absence of intercalators, almost exclusively cyclic tetra- and octa

29 ssumption that other charged, pi-stacked DNA intercalators also have approximately these same values,

30 The three intercalators also protected the red cells against lysis

31 f a macrocyclic bisacridine and an antitumor intercalator ametantrone to DNA has been studied.

32 CP-115,953, etoposide, and azatoxin and the intercalators amsacrine and mitoxantrone.

33 These results were compared with a spermine-intercalator analogue.

34 es, covalently crosslinked to a redox-active intercalator and containing the binding site of the test

35 leotides synthesized with a tethered rhodium intercalator and guanine doublets placed before and afte

36 several agents, including adriamycin (a DNA intercalator and inhibitor of topoisomerase II), camptot

37 on complementary stereochemistry between bis-intercalator and junction.

38 wn by comparison with reactions of a rhodium intercalator and methylene blue, respectively.

39 ation occurs in both directions from the NDI intercalator and on both DNA strands of the target, but

40 ff by collisional quenching between adjacent intercalator and reporter dyes.

41 lization, and by comparative analyses of the intercalator and salt induced release from the nucleosom

42 The methoxyacrylyl-anthranilate intercalator and the minor groove binding A-B-C+ risacch

43 Conventional mono-intercalators and bis-intercalators are discussed, follo

44 ction analyses of the complexes between both intercalators and CGTACG.

45 ed xanthine, interacts with polyaromatic DNA intercalators and has been hypothesized to interfere wit

46 dergo conformational changes when exposed to intercalators and may be of relevance when exploring how

47 in creating an artificial nuclease with DNA intercalators and metallopeptides.

48 onspecific binders, and we demonstrated that intercalators and minor groove binders affect the confor

49 La nuclei occurs upon treatment with rhodium intercalators and photoactivation.

50 t DNA nanorails: (i) twist when subjected to intercalators and the amount of twisting is concentratio

51 on that electrostatic attraction between the intercalators and the base pairs in the cleavage complex

52 d macrocyclic diimine and triaza DNA-binding intercalators and their platinum(II) conjugates have bee

53 of structural complexity relative to simple intercalators, and can provide significant insights into

54 Bisnaphthalimide intercalators are anti-tumour agents composed of two pla

55 Although DNA intercalators are believed to inhibit DNA polymerases an

56 Conventional mono-intercalators and bis-intercalators are discussed, followed by unconventional

57 nteractions between those two classes of bis-intercalators are quite different.

58 thesized ferrocenyl (Fc) double-stranded DNA intercalator as a redox marker is presented.

59 his site, consistent with the effect of some intercalators as suppressors of Top2-mediated DNA cleava

60 constructed that contain a tethered rhodium intercalator, as photooxidant, as well as two 5'-GG-3' s

61 mer does not diminish oxidation by a Ru(III) intercalator at a distal guanine doublet, suggesting tha

62 o-tide conjugate was prepared having the NDI intercalator at both the 5'- and 3'-termini.

63 The proposed intercalator-based strategy permits the creation of reco

64 mers also reveal a surprising sensitivity of intercalator binding enthalpy and entropy to the details

65 hat within this set of sequence specific bis-intercalators, both DNA grooves can be accessed, setting

66 The signals obtained from redox-active intercalators bound to DNA-modified gold surfaces displa

67 ontrast to the semi-disordered state of mono-intercalators bound to the same DNA molecule.

68 de (EthBr) is the cheapest and most used DNA intercalators, but presents carcinogenic and teratogenic

69 However, one bis-intercalator--but not its sister with a shorter linker--

70 These applications illustrate how intercalators can be used to facilitate and expand DNA-b

71 Other studies have demonstrated how intercalators can be used to promote the formation of ot

72 Collectively, our results show that DNA intercalators can trigger a common mitochondrial respons

73 r (involving the 222 symmetry) such that the intercalator cavity is flanked by two sets of G x C base

74 The interbend DNA was unwound by use of the intercalator chloroquine, or, alternatively, by raising

75 g the dynamic and equilibrium aspects of DNA-intercalator complex assembly may allow optimization of

76 ting dissociation rate constant of the tetra-intercalator complex dissociating from its preferred bin

77 which the peptide, the metal cation, and the intercalator components of the conjugate are each varied

78 Many different intercalator compounds have been studied because of thei

79 Using intercalator-conjugated AG motif TFOs, we compared the e

80 The results may be useful in the design of intercalator-conjugated oligonucleotides for antisense a

81 nding properties of EDTA.Fe-modified peptide-intercalator conjugates (PICs) are described.

82 g affinity and specificity of aminoglycoside intercalator conjugates can be tuned by optimizing the l

83 rea as a carrier group in cytotoxic platinum-intercalator conjugates prompted us to explore the synth

84 Importantly, the polyamide-intercalator conjugates, which combine sequence-specific

85 Although many natural intercalators contain multiple chiral subunits, only int

86 taarginine units are appended onto a rhodium intercalator containing the sterically expansive chrysen

87 lization) or by adding the triplex selective intercalator coralyne (1000-fold stabilization).

88 n, as did the use of the triplex-stabilizing intercalator coralyne.

89 ffer supplemented with the triplex selective intercalator coralyne.

90 r in the presence of the triplex-stabilizing intercalator coralyne.

91 An intercalator coupled with a de novo-designed alpha helix

92 signal of methylene blue, a redox-active DNA intercalator, coupled to [Fe(CN)6]3-.

93 ic DNA duplexes were prepared with a rhodium intercalator covalently attached to one end and separate

94 DNA hybridization by using the electroactive intercalator daunomycin (DM).

95 All the intercalators decreased accessibility throughout the str

96 dine ring system render these PICs threading intercalators, directing the substituents into both groo

97 A generalized variant of a fluorescent intercalator displacement (FID) assay conducted on a ser

98 se of a technically nondemanding fluorescent intercalator displacement (FID) assay for initial assess

99 o that of distamycin A, using a fluorescence intercalator displacement (FID) assay.

100 sequence selectivity using this fluorescent intercalator displacement (FID) assay.

101 Fluorescent intercalator displacement (FID) is a convenient and prac

102 ing the existing high-throughput fluorescent intercalator displacement (HT-FID) assay developed by Bo

103 A generalized variant of a fluorescent intercalator displacement assay conducted on a series of

104 ed by competition dialysis and a fluorescent intercalator displacement assay.

105 es, allowing the elaboration of a variety of intercalator displacement assays and label-free biosenso

106 The 'fluorescent intercalator displacement replacement' (FIDR) assay is i

107 DNase I footprinting, fluorescence intercalator displacement studies, and circular dichrois

108 ), CD (circular dichroism), FID (fluorescent intercalator displacement), and UV (ultraviolet) thermal

109 , we have reported the NMR analysis of a bis-intercalator-DNA complex in which the peptide linker bet

110 n the same range observed for binding of the intercalators doxorubicin and pyrazoloacridine to DNA.

111 f a bulged DNA site due to the binding of an intercalator drug may perturb the recognition of DNA def

112 also tested positive for DNA in fluorescent intercalator dye and whole genome amplification (WGA) as

113 alation (FIT)-probes, in which two (or more) intercalator dyes of the thiazole orange (TO) family ser

114 somerase II (TOP2) can be interrupted by DNA intercalators (e.g., doxorubicin), enzyme binders (e.g.,

115 Invader probes based on large intercalators efficiently recognize model targets.

116 ns > 10,000-fold greater than those at which intercalators enable polymerization.

117 We found that substitutions closer to the intercalator end of the TFO (positions 4-6) had a more d

118 Finally, intercalators enhance topoisomerase I-mediated cleavage

119 ossible by the stabilisation provided by the intercalator, enhances mismatch discrimination.

120 ns containing caffeine and the nonplanar DNA intercalator ethidium bromide show optical shifts and st

121 lkaloids berberine and palmatine and the DNA intercalator ethidium bromide, revealed a change in the

122 tures of the two oligonucleotides with model intercalators (ethidium bromide andactinomycin D) and mi

123 Standard intercalators (ethidium, daunorubicin, and actinomycin D

124 The classic DNA intercalator, ethidium, was used to probe the effects of

125 Ru(phen)(bpy')(dppz)(2+), and three organic intercalators, ethidium (Et), thionine (Th), and anthraq

126 coli top2 enzymes in the presence of the non-intercalators fluoroquinolone CP-115,953, etoposide, and

127 iation of 32P-labeled duplex DNA with either intercalator followed by denaturing PAGE allows the dete

128 Ethidium bromide has served as a classic DNA intercalator for more than four decades.

129 een cholesterol and endogenous and exogenous intercalators for association with membrane phospholipid

130 Intercalator-free polymerization is not observed, even a

131 -intercalator-functionalized uridine and N2'-intercalator-functionalized 2'-N-methyl-2'-aminouridine

132 modification with +1 interstrand zippers of intercalator-functionalized nucleotides such as 2'-O-(py

133 e, and +1 interstrand zipper arrangements of intercalator-functionalized nucleotides, respectively.

134 be short synthetic routes to a series of O2'-intercalator-functionalized uridine and N2'-intercalator

135 ker length, and surface area of the appended intercalators have marked impact on DNA-hybridization ch

136 In contrast, an alkylating intercalator hedamycin strongly inhibited binding of bot

137 properties of Invader probes based on larger intercalators, i.e., perylene and coronene, expecting th

138 ining an acridine ring system, the strongest intercalator in the series, gave a small but clearly det

139 ity change (DeltaC(p)()) for a series of DNA intercalators, including ethidium, propidium, daunorubic

140 rmini with a naphthalene diimide-based (NDI) intercalator is described.

141 score the fact that the DNA binding of a bis-intercalator is directional and different from the simpl

142 hat delivery of the peptide by the ruthenium intercalator is not essential for cross-linking; peptide

143 by charge transfer from the tethered rhodium intercalator is quantitative, albeit with low photoeffic

144 hat the DNA binding behavior of these simple intercalators is driven almost equally by hydrophobic ef

145 DNA detection, the use of indicators and/or intercalators is necessary to improve electrochemical se

146 Chemotherapy using DNA intercalators is one of the most successful approaches t

147 srupt TOPO II inhibition by the tethered DNA intercalator, it did provide an alternative mode of entr

148 analysis of a complex between a related bis-intercalator known to display altered DNA sequence speci

149 ere synthesized that incorporate a ruthenium intercalator linked covalently to the 5' terminus of one

150 erization is most favored if the size of the intercalator matches that of the base pair; intercalator

151 d COL1A1 expression and suggest that Sp1-DNA intercalators may be an effective and novel approach for

152 a human leukemia cell line, is resistant to intercalator-mediated DNA complex formation and cytotoxi

153 Double strand specific intercalator methylene blue in combination with [Fe(CN)6

154 monstrates that, when administered to cells, intercalators might not only associate with polynucleoti

155 ses as a function of the surface area of the intercalator moiety.

156 east Top2 conferring hypersensitivity to the intercalator N-[4-(9-acridinylamino)-3-methoxyphenyl]met

157 idation of ascorbic acid (AA) by a threading intercalator (N,N'-bis(3-propylimidazole)-1,4,5,8-naphth

158 Conversely, the membrane intercalator, n-octanol, increased cholesterol oxidation

159 ied ligands, including pyrrole polyamide and intercalator natural products, designed hairpin pyrrole-

160 matically (>12 degrees C) in the presence of intercalator-neomycin conjugates (1-4) even at a very lo

161 The binding preference of intercalator-neomycin conjugates (1-4) to poly(dA).2poly

162 odynamic studies on the interactions between intercalator-neomycin conjugates and a DNA polynucleotid

163 ed here suggest that the binding affinity of intercalator-neomycin conjugates for poly(dA).2poly(dT)

164 The thermodynamic parameters of these intercalator-neomycin conjugates with poly(dA).2poly(dT)

165 In contrast to intercalator-neomycin conjugates, the increment of T(m3-

166 also explored, but with a mismatch-specific intercalator, no site-specific hydrolysis was found.

167 ultaneous addition of both EGR1 and TBP, the intercalator nogalamycin prevented EGR1 complex formatio

168 contrast, although they are also DNA-binding intercalators, none of the amide-functionalized anthrace

169 e study the effects of position-specific DNA intercalators on the rate and extent of single-turnover

170 ped spirocyclic molecule, DDI (double-decker intercalator), on the basis of our earlier work with the

171 l method involving elution of histones using intercalators or salt, to assess stability features depe

172 DNA crosslinkers (ultraviolet light) and DNA intercalators (oxaliplatin or adriamycin).

173 d plasmid has also been demonstrated with an intercalator-peptide conjugate containing acidic residue

174 copper, have been delivered to DNA with our intercalator-peptide conjugates to effect oxidative chem

175 o DNA, and the binding constants for several intercalator-peptide conjugates were determined by lumin

176 An unusual intercalator platform is formed by bringing four complex

177 The conventional wisdom argues that DNA intercalators possess a condensed polyaromatic ring wher

178 2D- and 3D-DNA systems, we demonstrate that intercalators present a powerful alternative for the adj

179 Additionally, the rhodium intercalators promote strand cleavage at the mismatch si

180 the MutY binding site using tethered rhodium intercalators promoted cross-linking and yielded informa

181 Fluorescence of the DNA-bound intercalator provides information on the molecule length

182 ty of the duplexes, electrochemical data for intercalator reduction on different mismatch-containing

183 Dumbbell-shaped DNA threading intercalators represent the next order of structural com

184 topo IIbeta expression may contribute to the intercalator resistance of HL-60/AMSA cells.

185 A photoexcited rhodium intercalator, Rh(phi)2DMB3+ (phi = 9,10-phenanthrenequin

186 The intercalator, [Rh(phi)(2)bpy']Cl(3) [phi = 9,10-phenanth

187 Here we show the multi-intercalator [Ru(dppz)2(PIP)](2+) (dppz = dipyridophenaz

188 We also characterized the flexibility of intercalator-saturated dsDNA for the first time.

189 Several of the intercalators show enhanced cytotoxicity compared to pro

190 ng isoamyl alcohol extractions combined with intercalator-specific spin columns, thereby yielding the

191 Sterically demanding intercalators such as [Rh(bpy)2(chrysi)]3+ may have appl

192 rase in mammalian cells, is inhibited by DNA intercalators, such as doxorubicin, in an in vitro assay

193 Here, we propose the use of simple DNA intercalators, such as ethidium bromide, as tools to fac

194 ltured cells, we show that DXR and other DNA intercalators, such as ethidium bromide, can rapidly int

195 lts may in turn guide the rational design of intercalators synthesized for DNA-targeted drugs, optica

196 of novel derivatives of the quinoxaline bis-intercalator TANDEM.

197 Bulky rhodium intercalators target DNA base mismatches with high speci

198 has been designed as a sterically demanding intercalator targeted to destabilized mismatched sites i

199 Our study suggests that improved XR5944 bis-intercalators targeting ERE may be designed through opti

200 n initiation and the utility of the platinum-intercalator technology for the design of sequence-speci

201 meric sequence nonspecifically, the platinum-intercalator technology has the potential to produce tel

202 range (16 to 26 angstroms), with the rhodium intercalator tethered to either end of the duplex assemb

203 ; pluramycin, a minor-major-groove threading intercalator that alkylates N7 of guanine; KMnO4, which

204 free energy landscape for an unconventional intercalator that binds DNA through a novel two-step mec

205 (chrysi)]3+ is a novel, sterically bulky DNA intercalator that has been designed to bind specifically

206 Doxorubicin is an anthracycline DNA intercalator that is among the most commonly used antica

207 ochondria after photoreaction with a rhodium intercalator that penetrates the intact mitochondrial me

208 intercalator matches that of the base pair; intercalators that bind to Watson-Crick base pairs promo

209 DNA intercalators that have high affinity and slow kinetics

210 Here we examined the effect of two DNA intercalators that prevent Sp1 binding on the expression

211 results identify specific binding sites for intercalators that result in trapping of Top2.

212 and structural similarity to a known triplex intercalator, the napthylquinoline MHQ-12.

213 The intercalator (thiazole orange or benzothiazole orange) p

214 ctrochemical data monitoring reduction of an intercalator through DNA films, damage ratios correlate

215 e utilize ethidium bromide (EtBr) as a model intercalator to demonstrate selective and isotropic latt

216 The binding of the Fc intercalator to dsDNA was measured by differential pulse

217 h permits access of the sterically demanding intercalator to the base stack.

218 The binding of intercalators to an Okazaki hairpin of sequence 5'-r(gc)

219 Recent studies have used DNA scaffolds and intercalators to construct supramolecular assemblies tha

220 relevant in understanding binding of certain intercalators to DNA structure associated with the quadr

221 we describe the application of bulky rhodium intercalators to inhibit cellular proliferation differen

222 The results show that the binding of intercalators to Okazaki fragments is accompanied with h

223 base pair-to-dye ratios of 10/1 for the bis-intercalator TOTO-1 and 5/1 for YOYO-1 for all three loc

224 h locus were mixed individually with the bis-intercalators TOTO-1 and YOYO-1 and their corresponding

225 The diverse properties of DNA intercalators, varying in affinity and kinetics over sev

226 Variation of the rhodium intercalator was also explored, but with a mismatch-spec

227 The NDI intercalator was prepared in a single step from the corr

228 In contrast to other bis-intercalators, we find that ligand association is descri

229 NDI and octahedral rhodium intercalators, when tethered directly to the 5' terminus

230 robust DNA structural recognition of chiral intercalators, which are critical for optimizing DNA bin

231 important class of these ligands is that of intercalators, which bind DNA by inserting aromatic moie

232 or groove binding ligands, and then focus on intercalators, which have been probed extensively with t

233 interact with the phenanthroline ring of the intercalators, which may lead to a larger disruption of

234 ncer agents, including camptothecins and DNA intercalators, which reversibly stabilize (trap) top1 ca

235 The NDI intercalator with a free hydroxyl was then added in the

236 effect may be due to complexation of the DNA intercalator with caffeine.

237 ntiplasmodial activity, but it is also a DNA intercalator with cytotoxic properties.

238 XR5944, a deoxyribonucleic acid (DNA) bis-intercalator with potent anticancer activity, can bind t

239 thracycline drug nogalamycin, a non-covalent intercalator with preference for 5'-TG dinucleotides, in

240 d by the binding of ditercalinium, a DNA bis-intercalator with strong anti-tumour properties.

241 ligands based on the derivatization of this intercalator with two neamine moieties (Amt-Nea,Nea) or

242 ators contain multiple chiral subunits, only intercalators with a single chiral unit have been quanti

243 Several intercalators with different complexities, including eth

244 In contrast, the related bis-intercalator WP652 prefers the 5'-PyGTPu tetranucleotide

245 nce intensity response was obtained with the intercalator YOYO-1 using allele 8 of the F13A01 locus,