ライフサイエンスコーパス: interchromosomal

1 referred to as nuclear bodies, are discrete interchromosomal accumulations of several proteins inclu

2 be essential for DSB repair by conservative interchromosomal (allelic) gene conversion.

3 In addition, we were able to trace a likely interchromosomal Alu-mediated fusion between IGSF3 on 1p

4 of gamma-ray-induced DNA damage and on both interchromosomal and direct repeat heteroallelic recombi

5 These rearrangements occur via both interchromosomal and intrachromosomal exchange events be

6 Only one interchromosomal and two intrachromosomal rearrangements

7 entify a lineage-specific and stage-specific interchromosomal association between these two loci that

8 Strikingly, the interchromosomal association of DNA breaks also promotes

9 complex mechanism that involves monoallelic interchromosomal association, alterations in histone met

10 e findings demonstrate that CTCF mediates an interchromosomal association, perhaps by directing dista

11 Thanos describe how viral infection elicits interchromosomal associations between the interferon-bet

12 Interchromosomal associations can regulate gene expressi

13 entiation is restrained by the Th2 locus via interchromosomal associations organized by Oct-1 and CTC

14 e breakpoint data, we established that avian interchromosomal breakpoints appear in the regions of lo

15 t-clipped reads allows Bellerophon to detect interchromosomal breakpoints with high sensitivity, whil

16 Interchromosomal centromeric rearrangements may have fos

17 Interchromosomal changes have been extremely rare.

18 er, in all three cases, gene positioning and interchromosomal clustering are regulated.

19 genes to the nuclear pore complex (NPC) and interchromosomal clustering is mediated by transcription

20 ene positioning at the nuclear periphery and interchromosomal clustering represent interdependent phe

21 to the NPC is independent of transcription, interchromosomal clustering requires transcription.

22 ote positioning at the nuclear periphery and interchromosomal clustering.

23 nct from the molecular mechanism controlling interchromosomal clustering.

24 ode to mediate both targeting to the NPC and interchromosomal clustering.

25 bridization experiments revealed monoallelic interchromosomal colocalization of miR-155 and miR-146a

26 alleles make independent stochastic choices, interchromosomal communication coordinates expression st

27 al volumes) must be two in order to keep the interchromosomal concentrations unchanged.

28 identified within the domains do not display interchromosomal conservation in terms of length, copy n

29 The previously reported interchromosomal conservation of synteny was confirmed,

30 hlight evidence for CTCF-mediated intra- and interchromosomal contacts at several developmentally reg

31 on (MZT) of Drosophila embryogenesis, stable interchromosomal contacts form between maternal and pate

32 ed within the nucleus by chromosome folding, interchromosomal contacts, and interaction with nuclear

33 these rearrangements map to an ape-specific interchromosomal core duplicon that clusters at sites of

34 a subgroup of patients that map to the same interchromosomal core involved in the evolutionary forma

35 We find that interchromosomal crossover recombination with these shor

36 ver, such length variants may cause unequal, interchromosomal crossovers leading to MHC-associated di

37 The interchromosomal distribution of detection frequencies w

38 construct a paralogy map that delineated the interchromosomal distribution of duplicated segments thr

39 at a single gene resolution, we combined the interchromosomal DNA contacts in the yeast genome measur

40 In addition, the exact intra- and interchromosomal DNA duplications were analyzed using Mu

41 levated frequencies of forward mutations and interchromosomal DNA recombination.

42 Thus, while interchromosomal DNA repair does not result in genome in

43 vel mechanism of antibody diversification by interchromosomal DNA transposition and demonstrate the e

44 east 35 regions of the genome via intra- and interchromosomal duplication events.

45 r elucidation of the mechanism of intra- and interchromosomal duplication events.

46 was found to be 94.6%, suggesting that this interchromosomal duplication occurred within recent evol

47 provide molecular evidence for considerable interchromosomal duplication of genic segments during th

48 eat arrays, implicating these repeats in the interchromosomal duplication process.

49 thin the genome, we selected BACs containing interchromosomal duplications and characterized their du

50 Interchromosomal duplications are especially important f

51 somal duplications, but indicate that recent interchromosomal duplications at this centromere have in

52 rsity accompanied by an increasing number of interchromosomal duplications in proximity to the centro

53 the exact DNA duplications revealed that the interchromosomal duplications occurred prior to the intr

54 Recent interchromosomal duplications of ORs have also occurred,

55 Both intra- and interchromosomal duplications of regions of this chromos

56 Regions containing extensive interchromosomal duplications were observed, particularl

57 ysis of the sequence reveals many intra- and interchromosomal duplications, including segmental dupli

58 -exon and intra-exonic deletions, as well as interchromosomal duplications.

59 No evidence of an interchromosomal effect on aneuploidy was found by use o

60 We show that interchromosomal end joining is efficiently suppressed b

61 X-X incompatibilities and instead support an interchromosomal epistatic basis to hybrid female steril

62 what has been observed in vertebrates, where interchromosomal events are commonplace.

63 at any novel gene structures formed by these interchromosomal events would require relocation to a mo

64 solution, enabling examination of intra- and interchromosomal events, and providing a resource for fu

65 plex indels, retrotransposon insertions, and interchromosomal events.

66 ata are consistent with significant aberrant interchromosomal exchange events during meiosis I in the

67 gene, the mutation is not attributable to an interchromosomal exchange or to a chromosomal inversion.

68 a segment within Xq28 has resisted excessive interchromosomal exchange through great ape evolution, p

69 telomeres reflects their high rate of recent interchromosomal exchange.

70 omeric-directed mechanism for non-homologous interchromosomal exchange.

71 owed an unexpectedly high number of proximal interchromosomal exchanges between homologs, occurring i

72 ormal chromosome 22 in these probands showed interchromosomal exchanges in 2/15 informative meioses,

73 ister chromatid together in metaphase and an interchromosomal force that tethers broken sister chroma

74 RCC1 and HENMT1 located 80 Mbp apart and an interchromosomal fusion between RCC1 and ABHD12B.

75 ments and nuclear pore complexes to regulate interchromosomal gene clustering.

76 revertants of TX545 can be generated through interchromosomal gene conversion at the site of inactiva

77 y been observed in specific association with interchromosomal gene conversion in mammalian cells.

78 We also identified interchromosomal gene conversion involving HR and MMEJ a

79 rqh1(+) cells, are predominantly repaired by interchromosomal gene conversion, with HR between sister

80 ir gene rad16(+) were required for efficient interchromosomal gene conversion.

81 ir in this context was predominantly through interchromosomal gene conversion.

82 Rhp55 was required for interchromosomal gene conversion; however, an alternativ

83 loid wheat has undergone massive small-scale interchromosomal gene duplications compared to other gra

84 ver, unequivocal data required to prove that interchromosomal gene regulation truly represents anothe

85 mic distribution of gene families to analyze interchromosomal gene transposition in Drosophila.

86 rachromosomally spreading teleregulation and interchromosomal "gene kissing".

87 U2 genes is intrachromosomal homogenization; interchromosomal genetic exchanges are much rarer, and r

88 e distributed throughout the nucleus with an interchromosomal heterogeneity in size.

89 studies provide an in situ demonstration of interchromosomal heterogeneity in telomere lengths.

90 ling driven by mutated FLT3 and JAK2 confers interchromosomal homologous recombination (iHR), a prece

91 omosomal homologous recombination but not on interchromosomal homologous recombination.

92 heterochromatic silencing and converge into interchromosomal hubs that assemble over the transcripti

93 le-genome sequencing, we identified a 389-kb interchromosomal insertion at an extragenic palindrome s

94 ed translocation, balanced translocation, or interchromosomal insertion.

95 hod accurately predicted the presence of the interchromosomal insertions placed in our simulated data

96 ine demethylase, LSD1, in directing specific interchromosomal interaction loci to distinct interchrom

97 absence of a homolog partner and adjusts the interchromosomal interaction program accordingly.

98 ogression of DNA replication is modulated by interchromosomal interaction proteins.

99 We previously identified a high-frequency interchromosomal interaction within the Saccharomyces ce

100 iotic cells may involve "structure-dependent interchromosomal interaction" (SDIX) checkpoints.

101 Here, we report that ligand induces rapid interchromosomal interactions among subsets of estrogen

102 However, the extent of interchromosomal interactions and the underlying mechani

103 rom diverse systems have shown that distinct interchromosomal interactions are a central component of

104 tween interacting chromatin partners whereby interchromosomal interactions are apparently lost in fav

105 es from diverse organisms show that distinct interchromosomal interactions are associated with many d

106 trates that the indiscriminate properties of interchromosomal interactions are consistent with the we

107 the principles governing their movements and interchromosomal interactions are currently under intens

108 ing such phenomena, our understanding of how interchromosomal interactions are initiated and regulate

109 OR enhancers are characterized by extensive interchromosomal interactions associated with OR transcr

110 trachromosomal interactions, we now describe interchromosomal interactions between the promoter regio

111 Reports of intra- and, remarkably, interchromosomal interactions between these regulatory e

112 Intra- and interchromosomal interactions have been implicated in a

113 Although the extent of the interchromosomal interactions have not been fully explor

114 The discovery of interchromosomal interactions in higher eukaryotes point

115 gulatory surveillance of normal and abnormal interchromosomal interactions in mitotic and meiotic cel

116 pport for the requirement and sufficiency of interchromosomal interactions in singular OR choice and

117 Finally, we discuss the role of intra- and interchromosomal interactions in the control of coregula

118 eb1 was recently shown to mediate long-range interchromosomal interactions in the nucleus through dim

119 Disruption of these interchromosomal interactions results in weak and multig

120 sophila activates transcription and mediates interchromosomal interactions such as transvection.

121 radial positioning and preferred patterns of interchromosomal interactions that are cell-type specifi

122 s a direct mediator of long-range intra- and interchromosomal interactions that can regulate transcri

123 t repressed Hox genes form mutual intra- and interchromosomal interactions with other genes located i

124 rocesses including transcription, intra- and interchromosomal interactions, and chromatin structure.

125 ediates both long-range intrachromosomal and interchromosomal interactions, and highlight CTCF as an

126 inance of intrachromosomal interactions over interchromosomal interactions, consistent with aggregati

127 tein interactions, and are regulated through interchromosomal interactions.

128 the T(H)2 LCR developmentally regulate these interchromosomal interactions.

129 s1 serves as a negative regulator of meiotic interchromosomal interactions.

130 ctions from Hi-C data to identify functional interchromosomal interactions.

131 d Hi-C data, particularly for long-range and interchromosomal interactions.

132 These constraints might limit interchromosomal interactions.

133 ovided increased understanding of intra- and interchromosomal interactions.

134 human cells that account for the majority of interchromosomal interactions.

135 result in large decreases in both intra- and interchromosomal interactions.

136 n of gene expression by mediating intra- and interchromosomal interactions.

137 translocation loci by triggering intra- and interchromosomal interactions.

138 nal genome-wide analyses and identified 1143 interchromosomal LCR substrate pairs, >5 kb in size and

139 To investigate the potential involvement of interchromosomal LCRs in recurrent chromosomal transloca

140 We replicated this pattern of interchromosomal LD between the genes in a separate bipo

141 ker transmission ratio distortion (MTRD) and interchromosomal linkage disequilibrium in populations o

142 d explain how SMCs establish both intra- and interchromosomal links inside the cell and indicate that

143 rrelate with gene conversion, such as intra-/interchromosomal location, level of nucleotide divergenc

144 We found that RE exerted an effect on interchromosomal mating-type switching and on intrachrom

145 T alpha still influenced donor preference in interchromosomal mating-type switching, supporting a rol

146 SIR2 partially repressed interchromosomal meiotic ectopic recombination at RDN1,

147 Additional evidence for interchromosomal NAHR mediated translocation formation w

148 This interchromosomal network was drastically altered in CA1a

149 This probabilistic interchromosomal network was nearly completely different

150 hancers interact with each other, forming an interchromosomal network.

151 leus and form preferred-albeit probabilistic-interchromosomal networks.

152 us and form preferred -albeit probabilistic- interchromosomal networks.

153 omosome ends discourage error-prone NHEJ and interchromosomal NHEJ, preserving chromosome integrity o

154 ur at a similar rate per base pair of DNA as interchromosomal nuclear rearrangements, indicating the

155 The interchromosomal organization of a subset of human chrom

156 Here, we demonstrate that interchromosomal pairing mediates this communication.

157 kpoints of one translocation to 24 bp within interchromosomal paralogous LCRs of approximately 130 kb

158 It had lower levels of interchromosomal partners in 10A which increased strikin

159 groups and we found only a few instances of interchromosomal rearrangement between the zebra finch a

160 Sequence level analysis of an interchromosomal rearrangement during evolution has not

161 ecurrent type of genomic rearrangement, i.e. interchromosomal rearrangements (translocations or inser

162 athway supports the hypothesis that terminal interchromosomal rearrangements are common in regions un

163 They are implicated as truncated forms or interchromosomal rearrangements in a variety of tumors i

164 indicating a duplication and suggesting that interchromosomal rearrangements of maternal origin also

165 s been suggested to cause complex intra- and interchromosomal rearrangements on short timescales.

166 ge has a 30-fold difference in the number of interchromosomal rearrangements relative to felids, whil

167 ionary mechanisms, such as hybridization and interchromosomal rearrangements, that have shaped these

168 ations and two fusion transcripts created by interchromosomal rearrangements.

169 osomal rearrangements are more frequent than interchromosomal rearrangements.

170 e painting demonstrated there to be very few interchromosomal rearrangements.

171 ele (PA200(Delta)) through Cre-loxP-mediated interchromosomal recombination after targeting loxP site

172 kD zein locus in maize has been generated by interchromosomal recombination between chromosomes of tw

173 s with a transgene lacking the 3' enhancers, interchromosomal recombination between the transgenic VD

174 ology were constrained, we have now examined interchromosomal recombination between truncated but ove

175 ent with a translocation mechanism involving interchromosomal recombination by simple exchange of DNA

176 Thus, interchromosomal recombination can be efficiently progra

177 MADM reveals that interchromosomal recombination can be induced efficientl

178 URA3-inverted repeats, increased intra- and interchromosomal recombination in the adjacent region 2,

179 now report the involvement of these genes in interchromosomal recombination occurring via crossovers

180 Interchromosomal recombination of subtelomeres is a pote

181 , RED1 and HOP1 do act in the normal meiotic interchromosomal recombination pathway; they reduce inte

182 romosomal recombination pathway; they reduce interchromosomal recombination to approximately 10% of n

183 However, the rate of interchromosomal recombination was increased in a rad59

184 duplication mutations, intrachromosomal and interchromosomal recombination, and required the wild-ty

185 expression of markers requires Cre-mediated interchromosomal recombination.

186 bility of RE to stimulate different forms of interchromosomal recombination.

187 ces in the chromosome and favors intra- over interchromosomal recombination.

188 ranslocations, some of which may result from interchromosomal recombination.

189 nsive breakage of nuclear DNA and stimulated interchromosomal recombination.

190 hich favours non-homologous end joining over interchromosomal recombination.

191 Interchromosomal recombinations between c-myc and immuno

192 ular machinery for generating characteristic interchromosomal recombinations can be found in all stra

193 The results are in striking contrast with interchromosomal repair of a single DSB in an analogous

194 In subtelomeres, both species show extensive interchromosomal reshuffling, with a higher tempo in S.

195 n subtelomeres are polymorphic patchworks of interchromosomal segmental duplications at the ends of c

196 Subtelomeres are concentrations of interchromosomal segmental duplications capped by telome

197 The duplication, among the largest interchromosomal segmental duplications described in hum

198 Interchromosomal segmental duplications including OR gen

199 ein-coding genes, and identified 8 new large interchromosomal segmental duplications.

200 t the nuclear volume can be divided into the interchromosomal space and the chromosome domains.

201 at they are unable to move freely within the interchromosomal space and thus unable to associate with

202 The interchromosomal spatial positionings of a subset of hum

203 short- and long-distance splicing, including interchromosomal splicing, in individual reads, using pr

204 vel measure of mapping ambiguity to discover interchromosomal SVs from mate-pair and pair-end sequenc

205 ever, MAT alpha donor preference is lost and interchromosomal switching is very inefficient.

206 In interchromosomal switching, with donors on chromosome II

207 ncrease in accompanying mutations, including interchromosomal template switches (ICTS) involving high

208 ealing extensive and preferential intra- and interchromosomal transcription interactomes.

209 Also, vpiT may have undergone interchromosomal translocation or may represent an indep

210 ntra-L1 rearrangements as well as a possible interchromosomal translocation.

211 her intrachromosomal (VDJ) rearrangements or interchromosomal translocations are a consistent feature

212 d breakpoints involving intrachromosomal and interchromosomal translocations between three linkage gr

213 d switch region DNA double-strand breaks and interchromosomal translocations in the Igh locus.

214 4;11) and t(8;12) and potentially many other interchromosomal translocations throughout the human gen

215 xamine the two possible explanations of this interchromosomal uniformity: a common origin, such as ge

216 ation leads to increased aberrant intra- and interchromosomal V(D)J joining events.

217 There was some evidence for interchromosomal variation in the level of interference,

218 ate that mouse rearrangements are more often interchromosomal, whereas intrachromosomal rearrangement