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2 actions with the endosomal receptor LAMP1 or interfere at another stage in entry that is common to bo
4 e protein P-glycoprotein, termed transporter interfering compounds (TICs), ranged from 0.05 to 35.03
5 tability without interferences from commonly interfering compounds in biological fluids, including ur
7 histological tissue morphology, resulting in interfered correspondence of MALDI-IMS data with subsequ
13 h as instruments, operators and time did not interfere in the variability of results within laborator
15 complex task and inhibit unwanted actions or interfering information (i.e., inhibitory control) are e
16 ed that allows deconvolution of the strongly interfered measured isotope clusters into linear combina
17 (4.4 ppb) limit of detection, resistance to interfering metals such as cadmium (Cd) and zinc (Zn), a
18 phase and to exclude water along with other interfering molecules from the surface of the internal r
19 ming stimulus, suggesting that 10 Hz flicker interfered more with reactive than proactive selective a
20 or naturally occurring VSV-derived defective interfering particles (DIPs), into the caudate-putamen (
22 nd distinct coding strategies facilitate non-interfering representations of odor identity and intensi
23 eatment with BRD4 inhibitors and c-MYC small interfering RNA (P < 0.01-0.001 for responding cell line
25 ybrids showed that the majority of the small interfering RNA (siRNA) clusters had a higher expression
26 ical translation of therapies based on small interfering RNA (siRNA) is hampered by siRNA's comprehen
28 in human cancer cells, we performed a small interfering RNA (siRNA) library screen targeting the 58
29 way in HL-1 cardiomyocytes with either small interfering RNA (siRNA) or Mdivi-1 caused marked reducti
30 We previously demonstrated that the small interfering RNA (siRNA) pathway and siRNA from a family
33 een fission yeast PAF1 repressing AGO1/small interfering RNA (siRNA)-directed silencing [13, 14] and
34 C5 decreased LSD1 protein acetylation, small interfering RNA (siRNA)-mediated HDAC5 knockdown did not
39 iogenesis of TAS3-derived trans-acting small interfering RNA (ta-siRNA), which represses ARF3 express
41 ckdown with RNA interference for MUC4 (small interfering RNA [siRNA]-MUC4) was used to analyze the ro
42 rporation to glycogen was unaltered by small interfering RNA against DAPK3, palmitate oxidation was i
43 5-HT release were inhibited by Piezo2 small interfering RNA and antagonists (Gd(3+) and D-GsMTx4).
44 70 in C57BL/6 mice by CLIP170-specific small interfering RNA enhanced LPS-induced IL-6 and TNF-alpha
45 SHP-2 down-regulation via silencing of small interfering RNA in endothelial cells enhanced neutrophil
46 raluminal delivery of thrombospondin-2 small interfering RNA inhibits the vascular response to injury
47 ative real-time PCR, Western blotting, small interfering RNA interference, and kinase inhibitors were
52 nucleotide exchange factor, ARNO, by small, interfering RNA or pharmacological inhibitors led to str
53 nhibition of Sirt1 deacetylase through small interfering RNA or selective inhibitor Ex527 greatly enh
54 nchymal cells were engineered to carry short interfering RNA or short hairpin RNA specific to oncogen
56 release, whereas depletion of PinX1 by small interfering RNA promoted apoptosis induced by etoposide
57 -specific nanoparticle-delivered AEG-1 small interfering RNA provided marked protection from HFD-indu
59 sporine A or knockdown of NFATc4 using small interfering RNA suppressed ET-1-induced TRPC6 up-regulat
60 We show that a single transfection of small interfering RNA targeting class II transactivator attenu
61 istocompatibility complex molecules by small interfering RNA targeting of class II transactivator can
62 usceptible to bacterial infection, and small interfering RNA treated-macrophages showed reduction in
64 1, a bacteria-induced plant endogenous small interfering RNA, silences the AtRAP gene, which encodes
66 y using chromatin immunoprecipitation, small interfering RNA-mediated downregulation, and pharmacolog
74 nes, at mRNA and protein levels, after small interfering RNA-mediated silencing of YAP in Sk-Hep1, SN
75 Here, we report the development of small interfering RNA-releasing poly(amine-co-ester) nanoparti
77 in the nucleus, and using inhibitor or small interfering RNAs (siRNAs) against caveolin-1 or Tie2 inh
78 onsteroidal anti-inflammatory drugs or small interfering RNAs (siRNAs) against COX-1 and COX-2, signi
79 sgenes involves abundant 21-nucleotide small interfering RNAs (siRNAs) and low-abundance 22-nucleotid
80 21- to 22-nucleotide or 24-nucleotide small interfering RNAs (siRNAs) generated from previously sile
81 rplay between Global Genome Repair and small interfering RNAs (siRNAs) in the recognition of DNA phot
82 ogy, in vivo applications of synthetic short interfering RNAs (siRNAs) require chemical modifications
83 which inhibit seed color by producing small interfering RNAs (siRNAs) targeting chalcone synthase (C
85 m, microRNAs (miRNAs) and trans-acting small interfering RNAs (ta-siRNAs) mainly inhibit gene express
86 duced accumulation of phased secondary small interfering RNAs from two genomic loci; (3) altered expr
87 d deletion or silencing of MANTIS with small interfering RNAs or GapmeRs inhibited angiogenic sprouti
89 HCV, were transfected these cells with small interfering RNAs targeting inhibitory SMADs to analyze g
90 CRISPR)-Cas9 technology, gene-specific small interfering RNAs, and a newly developed luciferase-based
91 by transfection of primary ASMCs with small interfering RNAs, and the effect on ASMC phenotype was e
92 eukaryotes, RNA silencing, mediated by small interfering RNAs, is an evolutionarily widespread and ve
95 r-penetrating nanoconjugate to deliver small interfering (si) and micro (mi)RNAs to intracranial glio
96 ultrasound is effective in delivering small interfering (si)RNA to C57BL/6 mice with dextran sodium
97 ence of common antioxidants in blood did not interfere significantly with the determination of the co
103 is knowledge allows developing new behaviour interfering strategies, increasing the options for trans
105 ent trials (with task-irrelevant information interfering), versus congruent/baseline trials (less dis
106 s in normal development and signaling and to interfere with aberrant SFK signaling networks in cancer
107 aluate a range of potential factors that may interfere with accurate protein-protein affinity predict
108 rmational changes, substrate composition can interfere with activity, and multistep reactions risk di
109 binding proteins (CLABPs), has been shown to interfere with aggregation of particular misfolded amylo
111 d levels of immunosuppressive exosomes which interfere with anti-leukemia functions of activated immu
112 CMV uses two of its genes: US18 and US20, to interfere with B7-H6 surface expression, in a mechanism
114 ability of several C3b-binding compounds to interfere with binding of the original C3b ligand that g
115 Site-directed mutants at this interface interfere with both Pcdh cis-dimerization and cell surfa
117 that a small molecule inhibitor, designed to interfere with CBFbeta binding to RUNX proteins, impairs
118 ) that function antagonistically to IreK and interfere with cell envelope integrity, antimicrobial re
119 ulture media generate toxic by-products that interfere with cellular functions and cell viability whe
121 h humans and mice in blood-stage malaria and interfere with conventional T helper cell responses and
123 in 3T3-L1 cells, indicating that KDM5 KD may interfere with differentiation in part by impairing prol
124 nd mechanistic poison teniposide (VM26), can interfere with DNA gate dynamics and shorten the dwell t
125 bulin sites, their persistence is thought to interfere with DNA replication by slowing or impeding re
127 coaching pitfalls are identified that could interfere with each of the 3 relationship-building compo
128 atial density that allow the quantum dots to interfere with each other and create artificial crystals
129 effectors that target distinct host nodes or interfere with endogenous host interactions, as well as
130 ple mechanisms by which pathogenic mutations interfere with enzyme function, and a compelling explana
131 ity of multi-valent Fc-based therapeutics to interfere with FcgammaR function and a potential mechani
135 omplexes is not blocked by gp42 and does not interfere with gp42 binding to HLA class II, indicating
138 to the phloem elements or companion cells to interfere with host targets (e.g., proteins or genes), w
139 oosted the research of new compounds able to interfere with HPPD activity to be used for the treatmen
140 evolved numerous strategies to specifically interfere with IFN production or its downstream mediator
141 Clinically applicable interventions that interfere with IL-1 action can improve cardiovascular ou
142 not promising; (ii) Design of inhibitors to interfere with interaction of E2.E3BP with PDK1 and PDK3
145 (4) hepcidin binding should occlude Fpn and interfere with iron export independently of endocytosis.
150 cts depend directly on the drug's ability to interfere with mSTAT3 and mitochondrial function, as dem
153 Here, we demonstrate that caffeine did not interfere with normal retinal vascularization developmen
156 the use of a targeted antioxidant enzyme to interfere with oxidative stress mechanisms in TBI and pr
158 protein NS4B of the Brazilian lineage could interfere with phosphorylation of Akt and mTOR, impairin
159 stead of positively charged residues did not interfere with POMP10 localization, it weakened its inte
160 e transcranial magnetic stimulation (TMS) to interfere with postmovement activity in M1 in two behavi
161 ernal RNAs and proteins that would otherwise interfere with PRC2-dependent reprogramming of PGC chrom
162 of Pck2, whereas it enhanced Pck1 levels to interfere with proper downstream signaling to the cell i
163 we developed specifically to allosterically interfere with PU.1-chromatin binding through interactio
164 articularly well documented but how bacteria interfere with receptor proximal events is far less well
165 and oxygen administration is least likely to interfere with rehabilitation, was more effective than c
166 rough replication defects; transcription can interfere with replication fork progression and stabilit
174 ce and commonality of this viral strategy to interfere with the 5'-to-3'-exoribonuclease component of
175 Manipulations of memory reconsolidation can interfere with the ability of a drug-paired cue to drive
176 ioned-stimulus (US) reactivation paradigm to interfere with the ability of multiple cues to drive dru
177 investigated whether a strategy designed to interfere with the cell death-facilitating properties of
179 chemical inhibitor, AS-48, which appears to interfere with the conformational change in the viral F
181 ss-I by interferons, HDAC inhibitors did not interfere with the expression of immuno-dominant viral p
182 eir proposed dominant-negative role, did not interfere with the expression of most regulated Pax5 tar
183 ion by inducing neutralizing antibodies that interfere with the function of the hemagglutinin protein
184 d derivatives of this compound were found to interfere with the HIV-1 entry process by stabilizing a
185 uncertain whether antibodies against V3 can interfere with the induction of NAbs, but there are good
186 rophage-expressed viral defence systems that interfere with the infection of lytic and temperate phag
187 is for future rational design of agents that interfere with the initiation and formation of a P. ging
189 ed approach to identify small molecules that interfere with the palmitoylation of Ras, a high value t
190 peptide and CSA-13 substrate and they do not interfere with the proliferation and viability of osteob
192 xploration of a novel environment appears to interfere with the representation of the familiar one, l
194 hypothesize that the fusion inhibitors could interfere with the structural changes that occur between
195 ude dimension (e.g. duration in time) should interfere with the subjective estimation of another magn
196 known to what extent residual infection may interfere with the success of pulp regeneration procedur
197 nt the transmission of these pathogens is to interfere with the vector-pathogen interactions, but our
198 on through an off-target effect that did not interfere with their ability to reduce ethanol intake.
200 rdiac implantable electronic device leads to interfere with tricuspid valve (TV) function has gained
202 iverse enteroviruses and coxsackieviruses to interfere with type I IFN induction should restore IFN a
203 result in an antiviral effect, since it may interfere with virus particle formation and virus produc
204 n children suggests that early adversity can interfere with white matter development in key brain reg
205 on and release of the invaginations strongly interfered with bleb formation, cell motility, and the a
206 amide-resistant LREX' cells, Py-Im polyamide interfered with both AR- and GR-driven gene expression,
207 vity of T cells to type I interferons, which interfered with effector T cell function and increased t
209 ficiency virus (BIV) Vif, but not HIV-1 Vif, interfered with HIV-1 production and viral infectivity e
212 dian VAS scores for the degree to which pain interfered with sleep and physical and daily activities
216 ittle effect on previously learned songs but interfered with their ability to adaptively modify the d
221 we show that one such compound, compound 1, interferes with assembly of the conical viral capsid dur
223 by proinflammatory cytokines, including TNF, interferes with bone remodeling during inflammation thro
225 omplex formation prolongs mitotic length and interferes with cell-cycle progression in human cells, a
230 nduction of long-term potentiation, and also interferes with long-lasting potentiation induced either
232 al inhibition or genetic knockdown of DYRK1A interferes with neural specification of human pluripoten
233 his indicates that disruption of MT dynamics interferes with neurite outgrowth, not by disrupting the
234 rate memory performance when prior knowledge interferes with new learning, but the mechanisms that mi
235 ate specific upregulation of Jagged1 neither interferes with prostate epithelial homeostasis nor sign
236 Substitution of a conserved serine (S270A) interferes with SCF(Slmb) binding and stabilizes SMNDelt
237 We find that disruption of the actin network interferes with secretion of the biomineralised elements
239 atory domains: the DNA-binding domain, which interferes with sliding when its range is limited by a t
240 affinity actin binding by SCA5 beta-spectrin interferes with spectrin-actin cytoskeleton dynamics, le
241 e inhibition of the NF-kappaB pathway, NLRC3 interferes with the assembly and activity of the NALP3 i
243 onal polyethylene glycol (PEG) surface layer interferes with the cell-NP interaction in tumors, we us
244 of E. coli TatC, which when modified by DCCD interferes with the deep insertion of a Tat signal pepti
245 Xi(Xist), alters chromatin configuration and interferes with the establishment XCI during in vitro di
248 re and the manner in which the PEG component interferes with the hybridization of the oligonucleotide
251 ly and found that phosphorylation of Ser-324 interferes with the normal microtubule-stabilizing funct
252 change in mitochondrial membrane composition interferes with the proper assembly and activity of mito
253 PD-1), and acquire an anergic phenotype that interferes with their cognate function against Klebsiell
255 rbations in its dynamic profile such that it interferes with transfer of the gamma-phosphate to a pro
256 e, we coin the term 'migrastatics' for drugs interfering with all modes of cancer cell invasion and m
257 MPAR immobilization approaches, we show that interfering with AMPAR surface diffusion markedly impair
258 pothesized to increase HIV infection risk by interfering with barrier protection and facilitating HIV
259 s by altering type 17 inflammation, and thus interfering with BET-dependent chromatin signaling may p
261 cells, but there is no indication for BDE-99 interfering with cellular TH signaling during O4(+) cell
262 have adopted discrete cellular functions by interfering with chemotaxis and by promoting rapid surfa
265 T (Treg)/T helper 2 (Th2)-like cells; (iii) interfering with dendritic cell (DC) effector function;
266 , especially when the risk of the malignancy interfering with either safety or efficacy endpoints is
267 Only a few structurally unrelated compounds interfering with ELAV protein-mRNA complexes have been i
268 troducing a long delay or by optogenetically interfering with encoding, also increases theta-gamma co
269 ic biomarker for tumor progression, and that interfering with GNA13-induced signaling provides a nove
270 bonded beta-hairpin at the fibril edge while interfering with H-bonding to the next incoming monomer
271 The mutations disrupted protein stability by interfering with homodimerization or by causing aggregat
275 Tau interactions with phospholipids without interfering with its ability to form fibrils, thus provi
276 al region of Prx1 inside the matrix, without interfering with its peroxidase activity in vitro Remark
279 hopH2 or RhopH3 disrupts the entire complex, interfering with organellar targeting and subsequent tra
280 e toxicity, they may influence bee health by interfering with quercetin detoxification, thereby compr
281 e pathogens can disrupt the Golgi apparatus, interfering with secretion and compromising intestinal a
283 the transcriptional activity of human HSF1, interfering with the assembly of ATF1-containing transcr
284 AT complex SAGA and disrupts its assembly by interfering with the association of ADA2 with the cataly
286 atial arrangement within the system, without interfering with the catalytic core, similar to structur
287 eostasis and cell viability without directly interfering with the efficacy of this proteasome inhibit
288 gait to the upcoming ground surface without interfering with the exploitation of passive mechanical
289 uppresses the activation of defense genes by interfering with the function of the HAT complex during
290 way, mobile phase protons are prevented from interfering with the process of negative ionization.
291 e-cue memories by destabilizing them through interfering with the reconsolidation process is one pote
292 inflammasome assembly by binding to ASC and interfering with the recruitment of ASC to upstream sens
297 HSP90 inhibition impairs BL cell survival by interfering with tonic BCR signaling, thus providing a m
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