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1 s in normal development and signaling and to interfere with aberrant SFK signaling networks in cancer
2 aluate a range of potential factors that may interfere with accurate protein-protein affinity predict
3 rmational changes, substrate composition can interfere with activity, and multistep reactions risk di
4 binding proteins (CLABPs), has been shown to interfere with aggregation of particular misfolded amylo
5 e, we coin the term 'migrastatics' for drugs interfering with all modes of cancer cell invasion and m
7 e peptidyltransferase center of the ribosome interferes with aminoacyl-tRNA accommodation, suggesting
8 MPAR immobilization approaches, we show that interfering with AMPAR surface diffusion markedly impair
10 w that transcription at intragenic enhancers interferes with and attenuates host gene transcription d
11 d levels of immunosuppressive exosomes which interfere with anti-leukemia functions of activated immu
13 we show that one such compound, compound 1, interferes with assembly of the conical viral capsid dur
15 CMV uses two of its genes: US18 and US20, to interfere with B7-H6 surface expression, in a mechanism
17 pothesized to increase HIV infection risk by interfering with barrier protection and facilitating HIV
19 s by altering type 17 inflammation, and thus interfering with BET-dependent chromatin signaling may p
21 ability of several C3b-binding compounds to interfere with binding of the original C3b ligand that g
22 on and release of the invaginations strongly interfered with bleb formation, cell motility, and the a
23 by proinflammatory cytokines, including TNF, interferes with bone remodeling during inflammation thro
25 amide-resistant LREX' cells, Py-Im polyamide interfered with both AR- and GR-driven gene expression,
29 Thus, magnesium was found to potentially interfere with carotenoid bioaccessibility at various ph
30 that a small molecule inhibitor, designed to interfere with CBFbeta binding to RUNX proteins, impairs
31 irected against the HIV envelope that do not interfere with CD4 binding markedly enhanced the IFN res
33 ) that function antagonistically to IreK and interfere with cell envelope integrity, antimicrobial re
34 omplex formation prolongs mitotic length and interferes with cell-cycle progression in human cells, a
35 ulture media generate toxic by-products that interfere with cellular functions and cell viability whe
36 cells, but there is no indication for BDE-99 interfering with cellular TH signaling during O4(+) cell
37 in endosymbionts that possess the ability to interfere with certain mechanisms of immune function and
39 have adopted discrete cellular functions by interfering with chemotaxis and by promoting rapid surfa
43 h humans and mice in blood-stage malaria and interfere with conventional T helper cell responses and
45 ases 9 and 3, suggesting that Ucp2 knockdown interferes with cytokine triggering of the intrinsic apo
46 s to evade the host immune system, including interfering with cytoskeletal remodeling as a way to blo
47 T (Treg)/T helper 2 (Th2)-like cells; (iii) interfering with dendritic cell (DC) effector function;
50 in 3T3-L1 cells, indicating that KDM5 KD may interfere with differentiation in part by impairing prol
51 nd mechanistic poison teniposide (VM26), can interfere with DNA gate dynamics and shorten the dwell t
52 ts that form DNA adducts in the minor groove interfere with DNA replication and transcription to indu
54 bulin sites, their persistence is thought to interfere with DNA replication by slowing or impeding re
55 Su(H) structure, Ser269 phosphorylation may interfere with DNA-binding, which we confirmed by electr
57 coaching pitfalls are identified that could interfere with each of the 3 relationship-building compo
58 atial density that allow the quantum dots to interfere with each other and create artificial crystals
60 vity of T cells to type I interferons, which interfered with effector T cell function and increased t
61 ert protective effects against misfolding by interfering with eIF2alpha-P dephosphorylation through s
63 , especially when the risk of the malignancy interfering with either safety or efficacy endpoints is
64 ques employed for screening their ability to interfere with ELAV protein-mRNA complexes, drawing conc
65 Only a few structurally unrelated compounds interfering with ELAV protein-mRNA complexes have been i
66 troducing a long delay or by optogenetically interfering with encoding, also increases theta-gamma co
67 (THC) during pregnancy has the potential to interfere with endogenous cannabinoid (CB) regulation of
68 effectors that target distinct host nodes or interfere with endogenous host interactions, as well as
69 ple mechanisms by which pathogenic mutations interfere with enzyme function, and a compelling explana
70 glucocorticoid deficiency in psoriatic skin interferes with epidermal differentiation and promotes a
71 ral cortex and that MT3-MMP loss-of-function interferes with excitatory synapse development in dissoc
72 ity of multi-valent Fc-based therapeutics to interfere with FcgammaR function and a potential mechani
73 Natural organic matter (NOM) is capable of interfering with Fe hydrolysis and influencing the size,
74 on of the VLO during extinction conditioning interfered with fear extinction memory, resulting in sus
80 ic biomarker for tumor progression, and that interfering with GNA13-induced signaling provides a nove
82 omplexes is not blocked by gp42 and does not interfere with gp42 binding to HLA class II, indicating
86 bonded beta-hairpin at the fibril edge while interfering with H-bonding to the next incoming monomer
90 ficiency virus (BIV) Vif, but not HIV-1 Vif, interfered with HIV-1 production and viral infectivity e
91 The mutations disrupted protein stability by interfering with homodimerization or by causing aggregat
92 to the phloem elements or companion cells to interfere with host targets (e.g., proteins or genes), w
94 oosted the research of new compounds able to interfere with HPPD activity to be used for the treatmen
96 increase in 21%, surpassing levels known to interfere with human visitor experience and disrupt wild
97 evolved numerous strategies to specifically interfere with IFN production or its downstream mediator
98 ulfide bridges, computationally predicted to interfere with IFNAR1 dynamics, were experimentally conf
99 with Fab fragments of three murine mAbs that interfere with IgE Ab binding: the two Der p 1-specific
100 Clinically applicable interventions that interfere with IL-1 action can improve cardiovascular ou
104 not promising; (ii) Design of inhibitors to interfere with interaction of E2.E3BP with PDK1 and PDK3
107 dy suggests that agents could be designed to interfere with internalization of Yersinia without distu
109 (4) hepcidin binding should occlude Fpn and interfere with iron export independently of endocytosis.
112 protein kinase A or C phosphorylation sites interfered with its ability to stimulate beta-catenin-de
113 lts indicate that the azido moiety in Kdo-N3 interferes with its utilization and may limit its utilit
114 Tau interactions with phospholipids without interfering with its ability to form fibrils, thus provi
115 receptor internalization, inhibiting PKA II/interfering with its Golgi/TGN localization, silencing r
116 rs interact with the dopaminergic RL system, interfering with its key computation of reward predictio
117 al region of Prx1 inside the matrix, without interfering with its peroxidase activity in vitro Remark
119 nduction of long-term potentiation, and also interferes with long-lasting potentiation induced either
122 By unspecified mechanisms, mutant-DNMT3B interferes with lymphoid-specific pathways resulting in
124 XTRPM6's close homologue XTRPM7, whose loss interferes with mediolateral intercalation, depletion of
130 cts depend directly on the drug's ability to interfere with mSTAT3 and mitochondrial function, as dem
132 regard, drug promiscuity may be leveraged to interfere with multiple receptors: the so-called polypha
133 ted are neurotropic, and that ZIKV infection interferes with multiple aspects of neurodevelopment tha
134 e PYK2, which interacts with NEDD4 and HER3, interfered with NEDD4-HER3 binding, suggesting that the
136 in the CNS may require immune responses that interfere with neural cell function and communication wi
137 al inhibition or genetic knockdown of DYRK1A interferes with neural specification of human pluripoten
138 his indicates that disruption of MT dynamics interferes with neurite outgrowth, not by disrupting the
139 rate memory performance when prior knowledge interferes with new learning, but the mechanisms that mi
143 Here, we demonstrate that caffeine did not interfere with normal retinal vascularization developmen
144 ce in ions, including K(+) and Ca(++) , that interferes with normal cycles of depolarization-repolari
147 IgG1 promote OPA, and that CSP-specific IgG4 interferes with OPA, which we subsequently confirmed by
149 sults suggest that proinflammatory cytokines interfere with oral tolerance induction and that blockin
150 hopH2 or RhopH3 disrupts the entire complex, interfering with organellar targeting and subsequent tra
151 the use of a targeted antioxidant enzyme to interfere with oxidative stress mechanisms in TBI and pr
154 protein NS4B of the Brazilian lineage could interfere with phosphorylation of Akt and mTOR, impairin
155 stead of positively charged residues did not interfere with POMP10 localization, it weakened its inte
156 e transcranial magnetic stimulation (TMS) to interfere with postmovement activity in M1 in two behavi
157 ernal RNAs and proteins that would otherwise interfere with PRC2-dependent reprogramming of PGC chrom
158 of Pck2, whereas it enhanced Pck1 levels to interfere with proper downstream signaling to the cell i
160 ate specific upregulation of Jagged1 neither interferes with prostate epithelial homeostasis nor sign
162 we developed specifically to allosterically interfere with PU.1-chromatin binding through interactio
163 e toxicity, they may influence bee health by interfering with quercetin detoxification, thereby compr
164 antithrombin residues have been suggested to interfere with RCL insertion or the stability of the ant
165 articularly well documented but how bacteria interfere with receptor proximal events is far less well
167 e mental health consequences of injuries can interfere with recovery to pre-injury levels of function
168 and oxygen administration is least likely to interfere with rehabilitation, was more effective than c
169 rough replication defects; transcription can interfere with replication fork progression and stabilit
172 dural memory domain, we used new learning to interfere with restabilization of motor memory acquired
175 Substitution of a conserved serine (S270A) interferes with SCF(Slmb) binding and stabilizes SMNDelt
176 upon EGCG remodeling and suggests that EGCG interferes with secondary nucleation events known to gen
177 We find that disruption of the actin network interferes with secretion of the biomineralised elements
178 e pathogens can disrupt the Golgi apparatus, interfering with secretion and compromising intestinal a
184 dian VAS scores for the degree to which pain interfered with sleep and physical and daily activities
185 atory domains: the DNA-binding domain, which interferes with sliding when its range is limited by a t
186 affinity actin binding by SCA5 beta-spectrin interferes with spectrin-actin cytoskeleton dynamics, le
187 2 receptor could be an efficient strategy to interfere with SplD-induced TH2 inflammation but does no
188 an internal electron transfer mechanism that interferes with stabilization of the polymer's fully oxi
190 1, the chemical inducer of FKBP-DD, does not interfere with stem cell differentiation, whereas tamoxi
192 ell locomotion provides new opportunities to interfere with T cell invasion into specific tissue site
193 s and human pegivirus (formerly named GBV-C) interfere with T-cell receptor (TCR) signaling by novel
194 ce and commonality of this viral strategy to interfere with the 5'-to-3'-exoribonuclease component of
195 Manipulations of memory reconsolidation can interfere with the ability of a drug-paired cue to drive
196 ioned-stimulus (US) reactivation paradigm to interfere with the ability of multiple cues to drive dru
197 investigated whether a strategy designed to interfere with the cell death-facilitating properties of
198 Chronic viruses are particularly able to interfere with the cellular antiviral pathways by severa
200 vidence that intrathecally transplanted NPCs interfere with the CNS-restricted inflammation of EAE by
201 chemical inhibitor, AS-48, which appears to interfere with the conformational change in the viral F
202 cations (3) , or phage-encoded proteins that interfere with the CRISPR-Cas system, known as anti-CRIS
204 r (ETA) antagonist, ambrisentan, designed to interfere with the development of nephropathy in a human
205 f certain cancer-directed therapies that can interfere with the efficacy of treatment, decrease quali
206 ss-I by interferons, HDAC inhibitors did not interfere with the expression of immuno-dominant viral p
207 eir proposed dominant-negative role, did not interfere with the expression of most regulated Pax5 tar
208 ion by inducing neutralizing antibodies that interfere with the function of the hemagglutinin protein
209 d derivatives of this compound were found to interfere with the HIV-1 entry process by stabilizing a
210 and dissemination of the infected cells, and interfere with the host immune system by regulating vira
211 show that over-expression of Hsp104 does not interfere with the incorporation of newly synthesised Su
212 uncertain whether antibodies against V3 can interfere with the induction of NAbs, but there are good
213 rophage-expressed viral defence systems that interfere with the infection of lytic and temperate phag
214 is for future rational design of agents that interfere with the initiation and formation of a P. ging
215 f a protein corona and antibody multivalency interfere with the labeling properties of nanoparticle-a
218 ed approach to identify small molecules that interfere with the palmitoylation of Ras, a high value t
219 ssive secondary structure formation that can interfere with the peptidyltransferase activity of the r
220 peptide and CSA-13 substrate and they do not interfere with the proliferation and viability of osteob
222 uire the introduction of new labels that may interfere with the proper functioning of existing constr
223 xploration of a novel environment appears to interfere with the representation of the familiar one, l
225 hypothesize that the fusion inhibitors could interfere with the structural changes that occur between
226 ude dimension (e.g. duration in time) should interfere with the subjective estimation of another magn
227 known to what extent residual infection may interfere with the success of pulp regeneration procedur
228 nt the transmission of these pathogens is to interfere with the vector-pathogen interactions, but our
231 n from their results was that this inhibitor interfered with the interaction of Wag31 with one of its
232 Synthetic peptides P2 and P4 of PvTRAg38 interfered with the parasite growth independently but ha
235 e inhibition of the NF-kappaB pathway, NLRC3 interferes with the assembly and activity of the NALP3 i
238 onal polyethylene glycol (PEG) surface layer interferes with the cell-NP interaction in tumors, we us
239 of E. coli TatC, which when modified by DCCD interferes with the deep insertion of a Tat signal pepti
240 Xi(Xist), alters chromatin configuration and interferes with the establishment XCI during in vitro di
243 re and the manner in which the PEG component interferes with the hybridization of the oligonucleotide
247 ly and found that phosphorylation of Ser-324 interferes with the normal microtubule-stabilizing funct
249 change in mitochondrial membrane composition interferes with the proper assembly and activity of mito
251 , these methods have limitations: food color interferes with the titrimetric method and the chromatog
252 curred, possibly because the mutated protein interferes with the translation machinery, or because of
256 the transcriptional activity of human HSF1, interfering with the assembly of ATF1-containing transcr
257 AT complex SAGA and disrupts its assembly by interfering with the association of ADA2 with the cataly
259 atial arrangement within the system, without interfering with the catalytic core, similar to structur
260 eostasis and cell viability without directly interfering with the efficacy of this proteasome inhibit
261 gait to the upcoming ground surface without interfering with the exploitation of passive mechanical
262 uppresses the activation of defense genes by interfering with the function of the HAT complex during
263 have implications for therapy development as interfering with the function of this specific axon guid
264 id landscape that disrupt ER proteostasis by interfering with the glycan trimming and dislocation ste
266 shed" construct prevented dislodging without interfering with the other conformations, blocked enzyme
267 dystrophy, but not cone-rod dystrophy, while interfering with the phagocytosis function of RPE associ
268 way, mobile phase protons are prevented from interfering with the process of negative ionization.
269 e-cue memories by destabilizing them through interfering with the reconsolidation process is one pote
270 inflammasome assembly by binding to ASC and interfering with the recruitment of ASC to upstream sens
271 increase of diastolic [Ca(2+) ]i produced by interfering with the SR was accompanied by a decrease of
272 on through an off-target effect that did not interfere with their ability to reduce ethanol intake.
273 ittle effect on previously learned songs but interfered with their ability to adaptively modify the d
274 PD-1), and acquire an anergic phenotype that interferes with their cognate function against Klebsiell
276 RD4 as a new target of PIN1 and suggest that interfering with their interaction could be a potential
284 HSP90 inhibition impairs BL cell survival by interfering with tonic BCR signaling, thus providing a m
286 rbations in its dynamic profile such that it interferes with transfer of the gamma-phosphate to a pro
289 rdiac implantable electronic device leads to interfere with tricuspid valve (TV) function has gained
293 iverse enteroviruses and coxsackieviruses to interfere with type I IFN induction should restore IFN a
294 al assays revealed that the p.G411S mutation interferes with ubiquitin phosphorylation by wild-type P
297 result in an antiviral effect, since it may interfere with virus particle formation and virus produc
298 n children suggests that early adversity can interfere with white matter development in key brain reg
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