ライフサイエンスコーパス: interferon receptor

1 ecule in signal transduction from the type I interferon receptor.

2 r to couple another signaling pathway to the interferon receptor.

3 his DDR depends on signaling from the type I interferon receptor.

4 were similar in mice deficient in the type I interferon receptor.

5 ce thresholds in mice lacking the alpha/beta interferon receptor.

6 APAP metabolism in the absence of the type I interferon receptor.

7 gulatory factors (IRFs) or the common type I interferon receptor.

8 feron-beta, which signals through the type I interferon receptor.

9 iffers between receptor tyrosine kinases and interferon receptors.

10 hat K3 and K5 both specifically target gamma interferon receptor 1 (IFN-gammaR1) and induce its ubiqu

11 2Rbeta), IL-15 receptor alpha (IL-15Ralpha), interferon receptor 2, and prostaglandin E synthase.

12 ns, cloning of human IFN-alpha and IFN-beta, interferon receptors, activities and therapeutic uses of

13 Gamma interferon receptor alpha (IFN-gammaR alpha) is stable b

14 e been implicated in signalling derived from interferon receptors, although their precise role in thi

15 The blockade of type I interferon receptor and of AIM2 via the addition of LL-3

16 signaling cascade is activated by the Type I interferon receptor and plays a critical role in interfe

17 nd FcgammaRs in macrophages inhibited type I interferon receptor and Toll-like receptor (TLR) signali

18 infected cells, Jak1 kinase associated with interferon receptors and Stat2 associated with the inter

19 We further defined interferon receptors and the STAT-1 molecule as critical

20 -of-function mutations in the genes encoding interferon-receptor-associated Janus kinase 1 (JAK1) or

21 Tyk2-dependent signaling through the Type I interferon receptor but not Tyk2-independent signaling a

22 advantage of the species specificity of the interferon receptors by analyzing human IFN-alpha-induce

23 mice deficient in the A1 chain of the type I interferon receptor (CD118(-/-)) are susceptible to HSV-

24 We found that downregulation of the type I interferon receptor chain IFNAR1 occurs in human CRC and

25 2-4 is predicted to be another member of the interferon receptor-class II cytokine receptor family.

26 An antibody that neutralizes the type I interferon receptor completely blocks interferon-kappa s

27 or 2.2 (IFNAR2.2) chains of the human type I interferon receptor complex to demonstrate that the inte

28 sms underlying down-regulation of the type I interferon receptor consisting of IFNAR1 and IFNAR2 subu

29 nfection of AG129 mice (alpha/beta and gamma interferon receptor deficient) showed rapid spread and l

30 Engraftment with lymphocytes from type I interferon receptor-deficient (IFN-alphabetaR(-/-)) mice

31 Here we show that gamma interferon receptor-deficient (IFN-gamma R-/-) mice moun

32 r, the trpB mutant remains virulent in gamma interferon receptor-deficient (IFN-gammaR(-/-)) mice, de

33 ary astrocytes, or BMM generated from type I interferon receptor-deficient (IFNAR(-/-)) mice.

34 induced in C57Bl/6 wild-type (WT) and type 1 interferon receptor-deficient (KO) mice for 90 min follo

35 uated, immunogenic, and protective in type 1 interferon receptor-deficient A129 mice.

36 V71 (mEV71) capable of infecting 12-week-old interferon receptor-deficient AG129 mice and used the mo

37 57BL/6 mice and protects type I or type I/II interferon receptor-deficient mice against lethal ZIKV c

38 ot essential for RV7 vaccination since gamma interferon receptor-deficient mice were protected by RV7

39 UNV, adult mice lacking alpha/beta and gamma interferon receptors developed disseminated infection an

40 kappaB; the presence or absence of the gamma interferon receptor did not exhibit discernible differen

41 After infection with D2S10, mice lacking interferon receptors died early without manifesting sign

42 ination of IFNAR1, endocytosis of the type I interferon receptor, down-regulation of IFNAR1 levels, a

43 , consistent with overexpression of the four interferon receptors encoded on chromosome 21, and propo

44 likely via increased gene dosage of the four interferon receptors encoded on chromosome 21, contribut

45 vitamin A modulates the expression of type I interferon receptor enhancing the antireplication effect

46 owed that while cells lacking the alpha/beta interferon receptor exhibited decreased levels of transc

47 that the IL-10R, unlike other members of the interferon receptor family, is highly effective in recru

48 A new member of the interferon receptor family, which we term IL-22R, functi

49 he gamma interferon gene (Ifng) or the gamma interferon receptor gene (Ifngr) have been engineered.

50 e broad species specificity of orthopoxvirus interferon receptors, herpesvirus and poxvirus proteins

51 r to cytokine receptors (R), including gamma interferon receptor (IFN-gammaR), interleukin 1 receptor

52 litis of the great elastic arteries in gamma interferon receptor (IFN-gammaR)-deficient mice with a f

53 form of the beta (betaL) subunits of type I interferon receptor (IFN-R) in mouse cells is sufficient

54 alpha/IFNAR1 and betaL/IFNAR2) of the type I interferon receptor (IFN-R) in the activation of signal

55 orted that mice lacking alpha/beta and gamma interferon receptors (IFN-alpha/betaR and -gammaR) unifo

56 ational analysis of the beta chain of type I interferon receptor (IFNalphaRbetaL/IFNAR2) revealed tha

57 europathogenesis of ZIKV infection in type I interferon receptor IFNAR knockout (Ifnar1 (-/-) ) mice,

58 Moreover, mice deficient in type I interferon receptor (IFNAR knockout [KO] mice) effective

59 ing the ability to signal through the type I interferon receptor (IFNAR(-/-)) cannot control the SPBN

60 ces PDL-1 expression and does so in an alpha interferon receptor (IFNAR) signaling-dependent manner.

61 is initiated through activation of the alpha interferon receptor (IFNAR), regulates the expression of

62 ential stimulator of inflammation-the type I interferon receptor (IFNAR)-and its associated transcrip

63 mologous virulent virus challenges in type I interferon receptor (IFNAR)-knockout mice.

64 e it was evident in murine cells lacking the interferon receptor (IFNAR).

65 usceptibility of mice deleted for the type I interferon receptor (IFNAR-KO) to both HeV and NiV.

66 describe tumor-induced degradation of type I interferon receptor IFNAR1 chain as a new immune-evasion

67 interferon alpha/beta, and mice lacking the interferon receptor (Ifnar1(-/-)) developed neurological

68 Toll-like receptor-4 (TLR4) and type 1 interferon receptor (IFNAR1), key receptors in innate im

69 l receptors, Toll-like receptor 4 and type 1 interferon receptor (IFNAR1), that are required for IPC-

70 Deletion of interferon receptors (Ifnar1 or Ifngr1) does not rescue

71 ed chronic disease in mice lacking the gamma interferon receptor (IFNgammaR(-/-)), v-cyclin.LacZ viru

72 Blocking the interferon receptor (IFNR) prevented HIV-stimulated FasL

73 that B. burgdorferi infection induced type I interferon receptor (IFNR) signaling in lymph nodes in a

74 ation is most likely regulated by the Type I interferon receptor (IFNR)-associated Tyk-2 kinase, as s

75 ulation in mice with null mutations (-/-) in interferon receptors (IFNR) for type I IFNs (IFN-alpha/b

76 bility to modulate signalling from type I/II interferon receptors (IFNRs).

77 fl) C57BL/6 (H-2(b)) mice lacking the type I interferon receptor in a subset of myeloid cells.

78 Priming of the host cell, through TLR4 and interferon receptors, induces caspase-11 expression, and

79 By engaging interferon receptors, interferon activates the JAK-STAT

80 e results indicate that while the alpha/beta interferon receptor is needed to curb viral replication,

81 sh latency in the spleen, we infected type I interferon receptor knockout (IFN-alpha/betaR(-/-)) mice

82 ave previously shown that infection of gamma interferon receptor knockout (IFN-gamma R(-/-)) mice wit

83 However, alpha/beta interferon receptor knockout (IFNAR(-/-)) mice were high

84 Infection of alpha/beta interferon receptor knockout (IFNAR(-/-)) mice with thes

85 riptional response of wild-type (WT), type I interferon receptor knockout (IFNAR1-/-), and STAT1 knoc

86 disease development in alpha/beta and gamma interferon receptor knockout mice, including neurologica

87 by 6 hr of reperfusion in WT but not type 1 interferon receptor KO mice that were protected from IRI

88 Inactivating mutations of the gamma-interferon receptor lead to increased susceptibility to

89 on-alpha/beta receptor 1 chain of the type I interferon receptor, leading to attenuation of IFNalpha

90 ound that deficiency in signaling via type I interferon receptor led to deregulated activation of gro

91 To search for genes which encode human interferon receptor molecules, we applied the technique

92 is of TR339 in 129 Sv/Ev mice and alpha/beta interferon receptor null (IFN-alpha/betaR(-/-)) mice, we

93 n of the G50DblKo mutant by growth on type I interferon receptor null MEFs, infection of IFN-alpha/be

94 global alignment of TF confers homology with interferon receptors of the cytokine receptor super fami

95 Antibody blockade of the type I interferon receptor on human cord blood-derived mast cel

96 he alpha/beta interferon receptor, the gamma interferon receptor, or both.

97 orted that mice lacking alpha/beta and gamma interferon receptors permit high levels of DENV replicat

98 ungs of wild-type and immunodeficient (gamma interferon receptor-/-, Rag1-/-, and tumor necrosis fact

99 SFV-RDR infection of mice lacking alpha/beta interferon receptors resulted in widespread virus distri

100 nduced UCM were entirely dependent on type I interferon receptor signaling.

101 ted with defects in the pathways involved in interferon-receptor signaling and in antigen presentatio

102 both ZAP70 and Lck to the nucleus following interferon receptor stimulation is demonstrated for the

103 Despite a deletion of the type I interferon receptor, strong expression of interferon-sti

104 on human chromosome 21 that comprises three interferon receptor subunits.

105 thal in the brains of adult mice lacking the interferon receptor, suggesting that the viruses can inf

106 embryonic fibroblasts lacking the alpha/beta interferon receptor, the gamma interferon receptor, or b

107 e receptor family (CRF2), which includes the interferon receptors, the interleukin (IL) 10 receptor,

108 and 2, transmits the signal from the type I interferon receptor to the genome.

109 Many of these signals operate downstream of interferon receptors to elicit inflammasome regulators,

110 For example, the interferon receptors transduce regulatory signals throug

111 Signaling through the interferon receptor was necessary for antiviral gene ind

112 , CD80, CD86, PD-L1, CD95 ligand, and type I interferon receptor), we report that IPE cells uniquely

113 Using mice that lack the type I interferon receptor, we examined sexual transmission of

114 In the absence of the alpha/beta interferon receptor, we observed increased viral replica

115 These observations suggest that JAKs provide interferon receptors with a critical catalytic signaling

116 amily of type I IFNs in that it binds to the interferon receptors with high affinity, conferring exce

117 naling following the interaction of cytokine/interferon receptors with their ligands.