ライフサイエンスコーパス: interferon regulatory factor

1 surprisingly, transcriptional activation by interferon regulatory factors.

2 on and was associated with downregulation of interferon regulatory factor 1 (IRF-1) and decreased lev

3 ion and activity of the transcription factor interferon regulatory factor 1 (IRF-1) and expression of

4 ving inhibition of the transcription factors interferon regulatory factor 1 (IRF-1) and upstream stim

5 ion of type I interferon (IFN) signaling and interferon regulatory factor 1 (IRF-1) expression is req

6 The transcription factor interferon regulatory factor 1 (IRF-1) has a demonstrate

7 Interferon regulatory factor 1 (IRF-1) is a transcriptio

8 ion and joint-associated swelling.IMPORTANCE Interferon regulatory factor 1 (IRF-1) is a transcriptio

9 Interferon regulatory factor 1 (IRF-1) is a transcriptio

10 Interferon regulatory factor 1 (IRF-1) is a tumor suppre

11 Here we report that the transcription factor interferon regulatory factor 1 (IRF-1) is required for c

12 growth factor beta (TGF-beta) signaling, and interferon regulatory factor 1 (IRF-1) transactivation.

13 On the other hand, the expression of interferon regulatory factor 1 (IRF-1), which is importa

14 of viral double-stranded RNA, depends on the interferon regulatory factor 1 (IRF1) and IRF2 transcrip

15 b which has full enhancer activity and binds interferon regulatory factor 1 (IRF1) and nuclear factor

16 ransitioned cells are defective in inducible interferon regulatory factor 1 (IRF1) expression by occl

17 association in European Americans was at the interferon regulatory factor 1 (IRF1) locus on 5q31.1.

18 Forkhead box P3 (FOXP3) and interferon regulatory factor 1 (IRF1) showed higher meth

19 ed in the 5'-end of the STAT1-dependent gene interferon regulatory factor 1 (IRF1), but the role of t

20 is highly dynamic at the STAT1 target gene, interferon regulatory factor 1 (IRF1), suggesting that a

21 ession of multiple antiviral ISGs, including interferon regulatory factor 1 (IRF1).

22 man herpesvirus 8 (HHV-8) gene product viral interferon regulatory factor 1 (vIRF-1) is targeted to m

23 Viral interferon regulatory factor 1 (vIRF1), a Kaposi sarcoma

24 One such protein, viral interferon regulatory factor 1 (vIRF1), targets STING by

25 immunity to dietary antigen was dependent on interferon regulatory factor 1 and dissociated from supp

26 rafficking and macrophage recruitment (e.g., interferon regulatory factor 1, CD97), adaptive immune r

27 The current study identifies interferon-regulatory factor 1 (IRF-1) to be one of such

28 lost its transient nature in the absence of interferon-regulatory factor 1 (IRF-1), a transcription

29 expression of the transcription factor IRF1 (interferon-regulatory factor 1), the roles of IRF1 in im

30 tory factor (IRF) family members, especially interferon regulatory factor-1 (IRF-1) and interferon re

31 RPE) through STAT1-mediated up-regulation of Interferon Regulatory Factor-1 (IRF-1) and IRF-8.

32 Interferon regulatory factor-1 (IRF-1) is a transcriptio

33 y SNP (-1623A/G) modified a binding site for interferon regulatory factor-1 (IRF-1), a major interfer

34 Interferon regulatory factor-1 (IRF1) is a tumor suppres

35 The TNF receptors signaled through interferon regulatory factor-1 (IRF1) to induce interfer

36 saccharide-induced nuclear factor-kappaB and interferon regulatory factor-1 activation in RAW 264.7 m

37 nitric oxide synthase and cyclooxygenase-2, interferon regulatory factor-1, interferon-inducible pro

38 ConA induced nuclear translocation of interferon-regulatory factor-1 (IRF1) in hepatocytes in

39 Interferon regulatory factor 2 (IRF2) is a member of a f

40 network showing temporal specificity, and an interferon regulatory factor 2 (IRF2) transcription fact

41 a-replication factor C3 (RFC3), FAM111A, and interferon regulatory factor 2 (IRF2)-were confirmed by

42 ess expression of the transcription cofactor interferon regulatory factor 2-binding protein 2 (IRF2BP

43 h ORF50, immediate early lytic K8, and viral interferon-regulatory factor 2 gene expression.

44 DIF-1 (also known as interferon regulatory factor-2 binding protein 2 [IRF-2B

45 ator of interferon genes-TANK-binding kinase-interferon regulatory factor 3 (cGAS-STING-TBK1-IRF3) si

46 The transcription factors interferon regulatory factor 3 (IRF-3) and nuclear facto

47 sponses mediated by the transcription factor interferon regulatory factor 3 (IRF-3) are often vital f

48 actors nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF-3) at a step subsequ

49 e models, the antiviral transcription factor interferon regulatory factor 3 (IRF-3) enhances reovirus

50 Interferon regulatory factor 3 (IRF-3) plays a central r

51 n in vitro, class II transactivator (CIITA), interferon regulatory factor 3 (IRF-3), and interferon r

52 actors nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF-3), classically indu

53 hibited poly(I.C)-induced phosphorylation of interferon regulatory factor 3 (IRF-3), which is the key

54 key proapoptotic protein in this pathway is interferon regulatory factor 3 (IRF-3), which upon activ

55 olic RIG-I pathway, requires the presence of interferon regulatory factor 3 (IRF-3).

56 response by sequestration and degradation of interferon regulatory factor 3 (IRF-3).

57 HeLa cells, EV68 inhibits poly(I.C)-induced interferon regulatory factor 3 (IRF3) activation and bet

58 (IFN-I) production through inhibition of the interferon regulatory factor 3 (IRF3) activation pathway

59 1 and -2 was required for phosphorylation of interferon regulatory factor 3 (IRF3) and accumulation o

60 sed S. pneumoniae induced phosphorylation of interferon regulatory factor 3 (IRF3) and activating tra

61 s) required for initiating the activation of interferon regulatory factor 3 (IRF3) and interferon (IF

62 stimulator 1 (IPS-1)-mediated activation of interferon regulatory factor 3 (IRF3) and NF-kappaB sign

63 ents and activation of transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB, STI

64 It is known that STING utilizes interferon regulatory factor 3 (IRF3) and nuclear factor

65 r proteins leading to activation of both the interferon regulatory factor 3 (IRF3) and nuclear factor

66 nscription via transcription factors such as interferon regulatory factor 3 (IRF3) and nuclear factor

67 this leads to sequential phosphorylation of interferon regulatory factor 3 (IRF3) and p65/RelA.

68 phosphorylation of the transcription factor interferon regulatory factor 3 (IRF3) and subsequent exp

69 ds to activation of the transcription factor interferon regulatory factor 3 (IRF3) and subsequent tra

70 -dependent phosphorylation and activation of Interferon Regulatory Factor 3 (IRF3) and the E3 ubiquit

71 TBK1 phosphorylates the transcription factor Interferon Regulatory Factor 3 (IRF3) and the E3 ubiquit

72 then bind to a positively charged surface of interferon regulatory factor 3 (IRF3) and thereby recrui

73 Interferon regulatory factor 3 (IRF3) and type I interfe

74 ls by preventing not only phosphorylation of interferon regulatory factor 3 (IRF3) but also degradati

75 d not bind MDA5 efficiently, did not inhibit interferon regulatory factor 3 (IRF3) dimerization or IF

76 Because the absence of interferon regulatory factor 3 (IRF3) does not increase

77 nse to viral infection by degradation of the interferon regulatory factor 3 (IRF3) has been subject o

78 of the immune signaling transcription factor interferon regulatory factor 3 (IRF3) in response to cyt

79 ndrial antiviral signaling protein (MAVS) or interferon regulatory factor 3 (IRF3) in the IFN inducti

80 on of ZAP occurs under the direct control of interferon regulatory factor 3 (IRF3) independent of int

81 Interferon regulatory factor 3 (IRF3) is a transcription

82 Interferon regulatory factor 3 (IRF3) is an important tr

83 e also induced directly by pathogens via the interferon regulatory factor 3 (IRF3) pathway.

84 y and confirmed that these miRNAs potentiate interferon regulatory factor 3 (IRF3) phosphorylation an

85 Interferon regulatory factor 3 (IRF3) plays a central ro

86 Interferon regulatory factor 3 (IRF3) regulates hepatocy

87 n cyclic GMP-AMP synthase (cGAS), STING, and interferon regulatory factor 3 (IRF3) signaling.

88 tiviral interferon antagonist which degrades interferon regulatory factor 3 (IRF3) through the protea

89 ntly phosphorylates the transcription factor interferon regulatory factor 3 (IRF3) to promote interfe

90 antagonist capable of blocking activation of interferon regulatory factor 3 (IRF3) via the retinoic a

91 sible for HIV-1 targeting and degradation of interferon regulatory factor 3 (IRF3), a central transcr

92 Interferon regulatory factor 3 (IRF3), a key signal medi

93 cells causes partial proteolytic cleavage of interferon regulatory factor 3 (IRF3), a key transcripti

94 hondrial antiviral signaling protein (MAVS), interferon regulatory factor 3 (IRF3), or Interferon-alp

95 uit TANK-binding kinase 1 (TBK1) to activate interferon regulatory factor 3 (IRF3), resulting in prod

96 E) inhibits TBK1-mediated phosphorylation of interferon regulatory factor 3 (IRF3), which is essentia

97 s alcoholic liver disease (ALD) and that the interferon regulatory factor 3 (IRF3),a transcription fa

98 rom the site of inoculation independently of interferon regulatory factor 3 (IRF3)-, IRF7-, and IFNAR

99 Interferon regulatory factor 3 (IRF3)-dependent IFN prof

100 lities to modulate apoptosis, NF-kappaB, and interferon regulatory factor 3 (IRF3).

101 a cyclic-GMP-AMP synthase (cGAS), STING, and interferon regulatory factor 3 (IRF3).

102 but is dependent on the transcription factor interferon regulatory factor 3 (IRF3).

103 rylation of TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3).

104 factor and/or suppressing the activation of interferon regulatory factor 3 (IRF3).

105 ne system by facilitating the degradation of interferon regulatory factor 3 (IRF3).

106 hways that activate the transcription factor interferon regulatory factor 3 (IRF3).

107 IFN-beta promoter when it was stimulated by interferon regulatory factor 3 (IRF3)/5D or its upstream

108 Here we report that the virus-encoded interferon regulatory factor 3 (vIRF3) latent viral gene

109 anscription factors was increased, including interferon regulatory factor 3 and 7 (IRF-3 and IRF-7) a

110 pter-inducing interferon-beta), and affected interferon regulatory factor 3 and 7 (IRF3-IRF7).

111 ciated with increased baseline expression of interferon regulatory factor 3 and 7 mRNAs and productio

112 l28ra(-/-)), and mice with disruption of the interferon regulatory factor 3 gene (Irf3(-/-)), with or

113 etion of the downstream transcription factor interferon regulatory factor 3 resulted in reduced induc

114 f interferon genes - tank-binding kinase 1 - interferon regulatory factor 3) pathway, shedding light

115 1)-AKT (AKT serine/threonine kinase 1)-IRF3 (interferon regulatory factor 3) signaling cascade leadin

116 hatase 2A (PP2A) as a deactivator of phospho-interferon regulatory factor 3, the key transcription fa

117 nished alcohol-induced hepatic steatosis and interferon regulatory factor 3-mediated apoptosis.

118 pressing constitutively active NF-kappaB and interferon regulatory factor 3.

119 al responses including activation of PKR and interferon regulatory factor 3.

120 on and decreased the nuclear accumulation of interferon regulatory factors 3 and 7 (IRF3 and -7) and

121 ase beta (IKKB), IkappaB kinase iota (IKKI), interferon regulatory factors 3 and 7, and rhinovirus in

122 We also demonstrated that interferon-regulatory factor 3 (IRF3) is transiently rec

123 articular, expression and phosphorylation of interferon-regulatory factor 3 (IRF3) was decreased in E

124 this study we have defined the mechanisms of interferon regulatory factor-3 (IRF-3) signaling in prim

125 increased PTEN/TLR4 (Toll-like receptor 4), interferon regulatory factor-3 (IRF3), nuclear factor ka

126 in an MyD88-independent manner that involves interferon regulatory factor-3 (IRF3).

127 ion in endotoxin-tolerized cells as shown in interferon regulatory factor-3 knock-out mice.

128 plex virus (HSV)-infected cells and initiate interferon regulatory factor-3 signaling, but it has bee

129 or B cell development and function, cellular interferon regulatory factor 4 (c-IRF4) directly regulat

130 Interferon regulatory factor 4 (IRF-4) is essential for

131 Interferon regulatory factor 4 (IRF-4) plays important f

132 Interferon regulatory factor 4 (IRF4) and IRF8 regulate

133 Here, we identify interferon regulatory factor 4 (IRF4) as a dominant tran

134 es myeloid and B-cell leukemia by inhibiting interferon regulatory factor 4 (IRF4) but through distin

135 th of which are dependent on M2 induction of interferon regulatory factor 4 (IRF4) expression.

136 rtance of the oncogenic transcription factor interferon regulatory factor 4 (IRF4) in hematological m

137 Interferon regulatory factor 4 (IRF4) is a critical tran

138 Interferon regulatory factor 4 (IRF4) is a member of the

139 Interferon regulatory factor 4 (IRF4) is a member of the

140 Interferon regulatory factor 4 (IRF4) is an IRF family t

141 Interferon regulatory factor 4 (IRF4) is central to the

142 Interferon regulatory factor 4 (IRF4) is induced upon th

143 The interferon regulatory factor 4 (IRF4) is known to be hig

144 d chemokine production, lung histopathology, interferon regulatory factor 4 (IRF4) mRNA expression, a

145 Downstream targets of CRBN include interferon regulatory factor 4 (IRF4) previously reporte

146 microbial products, the transcription factor interferon regulatory factor 4 (IRF4) promotes regulator

147 Here, we demonstrated that interferon regulatory factor 4 (IRF4) was a key transcri

148 T) proteins and on the cooperative action of interferon regulatory factor 4 (IRF4) with activator pro

149 r Th17 skewing conditions and phosphorylates interferon regulatory factor 4 (IRF4), a transcription f

150 type is accompanied by a higher induction of interferon regulatory factor 4 (IRF4), a transcriptional

151 Here, we report that interferon regulatory factor 4 (IRF4), dispensable for e

152 et is controlled by the transcription factor interferon regulatory factor 4 (IRF4), which is required

153 ingle-stranded binding proteins (SSBPs), and interferon regulatory factor 4 (IRF4).

154 eta protein led to impaired transcription of interferon regulatory factor 4 (IRF4).

155 y the expression of the transcription factor interferon regulatory factor 4 (IRF4).

156 molecules, IL-2Ralpha, T-bet, IFNgammaR, and interferon regulatory factor 4 (IRF4).

157 ated STAT3 and reduced protein expression of interferon regulatory factor 4 and B-cell lymphoma 6 (BC

158 n and small molecule inhibition downregulate interferon regulatory factor 4 and MYC, and provides an

159 he 3'-untranslated region (UTR) of the IRF4 (interferon regulatory factor 4) gene.

160 of lenalidomide are associated with reduced interferon regulatory factor 4, a downstream target of c

161 hemistry for MYC, BCL2, CD10, BCL6, and MUM1/interferon regulatory factor 4, and fluorescent in situ

162 sion of CCAAT/enhancer-binding protein-beta, interferon regulatory factor 4, and peroxisome prolifera

163 cluding CCAAT/enhancer-binding protein-beta, interferon regulatory factor 4, and peroxisome prolifera

164 tion was found to be driven by 2 variants of interferon regulatory factor 4-dependent dermal type 2 c

165 ough a mechanism that involves activation of interferon regulatory factor 4.

166 We have shown previously that interferon regulatory factors 4 and 8 induce the express

167 The cellular interferon regulatory factor-4 (IRF-4), which is a membe

168 The transcription factor interferon regulatory factor-4 (IRF4) is expressed in B

169 et al. now report an essential role for the interferon regulatory factor-4 in IL-9 production.

170 Genetic variants of interferon regulatory factor 5 (IRF-5) are associated wi

171 The transcription factor interferon regulatory factor 5 (IRF5) exerts crucial fun

172 Variation in the interferon regulatory factor 5 (IRF5) gene has been asso

173 Polymorphisms in the interferon regulatory factor 5 (IRF5) gene have been con

174 Transcription factor interferon regulatory factor 5 (IRF5) has been implicate

175 Similar to Puma, the transcription factor interferon regulatory factor 5 (Irf5) has been reported

176 hether silencing of the transcription factor interferon regulatory factor 5 (IRF5) in cardiac macroph

177 Interferon regulatory factor 5 (IRF5) is a key transcrip

178 Interferon regulatory factor 5 (IRF5) is a member of the

179 Interferon regulatory factor 5 (IRF5) is a molecule of i

180 The transcription factor interferon regulatory factor 5 (IRF5) is essential for t

181 f p53-mediated LMP1 expression, we find that interferon regulatory factor 5 (IRF5), a direct target o

182 4 kinase activity controls the activation of interferon regulatory factor 5 (IRF5), a transcription f

183 henotype due to decreased P-STAT1 (Y701) and interferon regulatory factor 5 compared with NOD mice.

184 Mechanistically, lack of IRAK4 resulted in interferon regulatory factor 5 homodimerization via redu

185 crosis factor-alpha, the chemokine CCL2, and interferon regulatory factor-5 (IRF5), a marker of infla

186 Interferon regulatory factor 6 ( IRF6) acts as a tumor s

187 Mutations and common polymorphisms in interferon regulatory factor 6 ( IRF6) are associated wi

188 Mutations in interferon regulatory factor 6 (IRF6) account for approx

189 Interferon Regulatory Factor 6 (IRF6) and TWIST1 are tra

190 tor-interacting protein kinase 4 (RIPK4) and interferon regulatory factor 6 (IRF6) are critical regul

191 actor beta (TGFbeta) signaling molecules and interferon regulatory factor 6 (Irf6) have been identifi

192 Interferon Regulatory Factor 6 (Irf6)-deficient mice die

193 ion of canonical WNT signaling perturbed p63/interferon regulatory factor 6 (p63/IRF6) signaling, res

194 Mutations in IRF6 (Interferon Regulatory Factor 6) and GRHL3 (Grainyhead-li

195 N-lambda expression by hMPV was dependent on interferon regulatory factor 7 (IRF-7) expression but no

196 interferon regulatory factor 3 (IRF-3), and interferon regulatory factor 7 (IRF-7) were not required

197 otherwise enhanced amounts of the requisite interferon regulatory factor 7 (IRF-7), whose gene expre

198 C in LMP1 signaling leading to NF-kappaB and interferon regulatory factor 7 (IRF7) activation has not

199 f (RHIM) domains of TRIF and RIP1 to disrupt interferon regulatory factor 7 (IRF7) activity, a critic

200 lysine 48-linked polyubiquitination of both interferon regulatory factor 7 (IRF7) and IRF3 followed

201 m, while expression of transcription factors interferon regulatory factor 7 (IRF7) and IRF9, implicat

202 acellular signal-regulated kinase (ERK), and interferon regulatory factor 7 (IRF7) pathways.

203 ly shown that ORF45 suppresses activation of interferon regulatory factor 7 (IRF7), a crucial regulat

204 Interferon regulatory factor 7 (IRF7), a key innate immu

205 nate antiviral immunity by downregulation of interferon regulatory factor 7 (IRF7), an immune factor

206 r MyD88, the downstream transcription factor interferon regulatory factor 7 (IRF7), and type I interf

207 paB)-dependent proinflammatory cytokines and interferon regulatory factor 7 (IRF7)-dependent type I i

208 roteins from human pDCs, pDC-cell lines, and interferon regulatory factor 7 (IRF7)-expressing B-cell

209 specific target of LMP1-induced sumoylation, interferon regulatory factor 7 (IRF7).

210 anistically, IL-33 downregulated viperin and interferon regulatory factor 7 gene expression and rapid

211 mRNAs and production of distinct isoforms of interferon regulatory factor 7 protein.

212 Lastly translocation of interferon regulatory factor 7(IRF7) from the cytosol to

213 The transcription factor IRF7 (interferon regulatory factor 7) is a key regulator of ty

214 cated suppression of antiviral host factors (interferon regulatory factor 7, CXCL10 [gamma interferon

215 IRF7, which encodes the transcription factor interferon regulatory factor 7, in an otherwise healthy

216 ce of hyperconnected hub nodes, most notably interferon regulatory factor 7, which was identified as

217 cent epidemiological studies have identified interferon regulatory factor 8 (IRF8) as a susceptibilit

218 The transcription factor (TF) interferon regulatory factor 8 (IRF8) controls both deve

219 fied novel associations in the chromosome 16 interferon regulatory factor 8 (IRF8) gene (P-value = 2.

220 Interferon regulatory factor 8 (IRF8) is a key regulator

221 Interferon regulatory factor 8 (IRF8) is known to affect

222 The homozygous K108E mutation of interferon regulatory factor 8 (IRF8) is reported to cau

223 Here we show that interferon regulatory factor 8 (IRF8) is required for th

224 Previously, we found that interferon regulatory factor 8 (IRF8), also known as int

225 epressive effect of the transcription factor interferon regulatory factor 8 (IRF8), which is highly e

226 eded the genome-wide significance threshold: interferon regulatory factor 8 (IRF8; rs11644034; p(meta

227 de statistical significance within the IRF8 (interferon regulatory factor 8) gene (combined P values

228 otein Pellino-1 and the transcription factor interferon regulatory factor 8.

229 k between Wnt/beta-catenin signaling and the interferon-regulatory factor 8 (Irf8).

230 y interferon regulatory factor-1 (IRF-1) and interferon regulatory factor-8 (IRF-8 or ICSBP), play im

231 Interferon regulatory factor-8 (IRF-8) is a transcriptio

232 rise from perturbations in the regulation of interferon regulatory factor-8 (IRF-8), an integral tran

233 ongest association for 3 SNPs located in the interferon regulatory factor-8 (IRF8) gene.

234 feron-stimulated gene factor 3 [ISGF3]) with interferon regulatory factor 9 (IRF9) and translocate to

235 d activator of transcription (STAT) 1 and 2, interferon regulatory factor 9, N-myc and STAT interacto

236 In vitro, increased expression of interferon regulatory factor-9 and IRG1 and itaconic aci

237 miR93 inhibits interferon regulatory factor-9 to decrease IRG1-itaconic

238 ed that IRG1 is not an miR93 target but that interferon regulatory factor-9, which can regulate IRG1

239 were conducted to examine the role of miR93-interferon regulatory factor-9-immunoresponsive gene-1 (

240 ulator (NEMO), an essential adaptor bridging interferon-regulatory factor and NF-kappaB activation.

241 cally, we demonstrated that TRIM29 inhibited interferon-regulatory factors and signaling via the tran

242 iallelic mutations in IRF8, which encodes an interferon regulatory factor, as a cause of familial NK

243 ially regulated cell genes identified an ETS-interferon regulatory factor composite element motif tha

244 ent expression of DNA-dependent activator of interferon regulatory factors (DAI, also known as ZBP1 o

245 ceptor 9 (TLR-9), DNA-dependent activator of interferon-regulatory factors (DAI), and absent in melan

246 tion factors from Nuclear Factor (NF)-kB and Interferon Regulatory Factor families.

247 egulatory factor 4 (IRF4) is a member of the interferon regulatory factor family of transcription fac

248 Interferon regulatory factors IRF-3 and IRF-7 are transc

249 gulators of type I and type III interferons, interferon regulatory factor (IRF) 3 and IRF7, were sign

250 kinase-1 (TBK1)-dependent phosphorylation of interferon regulatory factor (IRF) 3 and transcription o

251 rs TRAM and TRIF, resulting in activation of interferon regulatory factor (IRF) 3.

252 Functionally, Batf in cooperation with interferon regulatory factor (IRF) 4 along with Stat3 an

253 e, using 6-week-old mice triply deficient in interferon regulatory factor (IRF) as a model, we show t

254 er of adipocyte inflammation, members of the interferon regulatory factor (IRF) family may also play

255 Interferon regulatory factor (IRF) family members have b

256 Interferon regulatory factor (IRF) family members, espec

257 Members of the interferon regulatory factor (IRF) family of transcripti

258 Here we show that a member of interferon regulatory factor (IRF) family of transcripti

259 IRF4 is a unique member of the interferon regulatory factor (IRF) family playing critic

260 We show here that mutation of the Interferon regulatory factor (Irf) family, Irf6 also res

261 that secretes excess c-di-AMP activates the interferon regulatory factor (IRF) pathway with enhanced

262 Interferon regulatory factor (IRF) regulation of the typ

263 ex pattern of deregulated TFs, we discovered interferon regulatory factor (IRF) sites among the top e

264 Notably, interferon regulatory factor (IRF)-3 and -7 are the key

265 The transcription factor interferon regulatory factor (IRF)-5 is an important mod

266 ctly targeting high mobility group box-1 and interferon regulatory factor (IRF)-5, preventing activat

267 iethylhexyl phthalate suppressed CpG-induced interferon regulatory factor (IRF)-7 expression by suppr

268 R9 induces type I interferons (IFNs) via the interferon regulatory factor (IRF)-7.

269 e shared genes showed sequences required for interferon regulatory factor (IRF)-mediated transcriptio

270 gnaling pathways and cause activation of the interferon regulatory factor (IRF-3) transcription facto

271 Interferon regulatory factors (IRF) have critical functi

272 f transcription 1 [STAT1], protein kinase R, interferon regulatory factors (IRF) IRF-1, IRF-3, IRF-5,

273 of RANTES was regulated by NF-kappaB and the interferon regulatory factors (IRF)-1, IRF-3, and IRF-7

274 ng pathway (preserved STAT1 phosphorylation, interferon regulatory factor [IRF] nuclear translocation

275 The interferon regulatory factor IRF1 plays a crucial role i

276 These include the interferon regulatory factor, IRF1, and the chemokine, C

277 of the PD-L1 transcriptional repressors, the interferon regulatory factors IRF2 and IRF2BP2, which li

278 with ELF4 increases the binding affinity of interferon regulatory factors IRF3 and IRF7, which is me

279 s the activation of the transcription factor interferon regulatory factor (IRF4), which, along with t

280 ron response that could be driven in part by interferon regulatory factors (IRFs) and increased NF-ka

281 ositive-feedback loops mediated by inducible interferon regulatory factors (IRFs) and retinoic acid i

282 Interferon regulatory factors (IRFs) are mediators of th

283 The interferon regulatory factors (IRFs) are transcription f

284 The key role of Interferon regulatory factors (IRFs) as controllers of t

285 ored in cells and mice deficient in specific interferon regulatory factors (IRFs) or the common type

286 Interferon regulatory factors (IRFs) play functionally d

287 LPS and IFN-gamma recruit interferon regulatory factors (IRFs) to the Il23a ISRE i

288 y shown that three KSHV homologs of cellular interferon regulatory factors (IRFs), known as viral IRF

289 known to encode viral homologues to cellular interferon regulatory factors (IRFs), known as vIRFs.

290 eir expression of viral homologs of cellular interferon regulatory factors (IRFs), termed viral IRFs

291 at they express viral homologues to cellular interferon regulatory factors (IRFs), termed viral IRFs

292 und by BLIMP1 in vitro overlaps with that of interferon regulatory factors (IRFs), which respond to i

293 tors; principal among these is the family of interferon regulatory factors (IRFs).

294 e, cyclooxygenase-2) and a MyD88-independent interferon regulatory factor-mediated pathway that regul

295 in melanoma 2 and DNA-dependent activator of interferon regulatory factor) opened a new paradigm: Nuc

296 MAPK), phosphoinositide 3-kinase (PI3K), and interferon regulatory factor pathways.

297 Interferon regulatory factors play an important role in

298 thways involving CREB1, NF-kappaB, STAT, and interferon regulatory factor signaling.

299 ies, including beta-catenin, Ap-1, NFkappaB, interferon regulatory factors, STATs, JUN, and p53.

300 celerating factor; IKK, IkappaB kinase; IRF, interferon regulatory factors; TBK1, TANK-binding kinase