ライフサイエンスコーパス: interferon regulatory factor-3

1 ding kinase 1, inducible IkappaB kinase, and interferon regulatory factor 3.

2 pressing constitutively active NF-kappaB and interferon regulatory factor 3.

3 al responses including activation of PKR and interferon regulatory factor 3.

4 r double-stranded RNA-mediated activation of interferon regulatory factor 3, a transcription factor t

5 al for innate immune signaling of downstream interferon regulatory factor 3 activation and interferon

6 RIG-I binds PAMP RNA and signals interferon regulatory factor 3 activation to induce the

7 ng NF-kappaB, TLR3/4 pathways also stimulate interferon regulatory factor 3 activation.

8 sion of the shRNA results in dimerization of interferon regulatory factor-3, activation of IFN promot

9 Rip1 expression stimulates NF-kappaB but not interferon regulatory factor 3 activity.

10 anscription factors was increased, including interferon regulatory factor 3 and 7 (IRF-3 and IRF-7) a

11 pter-inducing interferon-beta), and affected interferon regulatory factor 3 and 7 (IRF3-IRF7).

12 ciated with increased baseline expression of interferon regulatory factor 3 and 7 mRNAs and productio

13 dent and -independent pathways that activate interferon regulatory factor 3 and cytokine expression.

14 r and blocking downstream activation of both interferon regulatory factor 3 and nuclear factor kappa

15 on and decreased the nuclear accumulation of interferon regulatory factors 3 and 7 (IRF3 and -7) and

16 ase beta (IKKB), IkappaB kinase iota (IKKI), interferon regulatory factors 3 and 7, and rhinovirus in

17 ctivation of the transcription factors IRF3 (interferon regulatory factor 3) and IRF7.

18 ator of interferon genes-TANK-binding kinase-interferon regulatory factor 3 (cGAS-STING-TBK1-IRF3) si

19 PAK1 knockdown did not reduce interferon regulatory factor 3-dependent gene expression

20 Interferon regulatory factor 3 does not appear to be pre

21 l28ra(-/-)), and mice with disruption of the interferon regulatory factor 3 gene (Irf3(-/-)), with or

22 including E6AP, ERC55, paxillin, hDlg, p300, interferon regulatory factor 3, hMCM7, Bak, and E6TP1.

23 s showed greater activation of NF-kappaB and interferon regulatory factor 3 in response to LPS and po

24 directed by a constitutively active form of interferon regulatory factor 3 (IRF-3 5D), and IRF-3 is

25 was associated with nuclear translocation of interferon regulatory factor 3 (IRF-3) and IRF-7.

26 the signal through the transcription factors interferon regulatory factor 3 (IRF-3) and nuclear facto

27 the early IFN-beta and -alpha1 response are interferon regulatory factor 3 (IRF-3) and nuclear facto

28 The transcription factors interferon regulatory factor 3 (IRF-3) and nuclear facto

29 ng pathways that lead to viral activation of interferon regulatory factor 3 (IRF-3) and synthesis of

30 DRAF1 is composed of interferon regulatory factor 3 (IRF-3) and the transcrip

31 ponents of DRAF1 have now been identified as interferon regulatory factor 3 (IRF-3) and the transcrip

32 sponses mediated by the transcription factor interferon regulatory factor 3 (IRF-3) are often vital f

33 actors nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF-3) at a step subsequ

34 Inhibition of phosphorylation of interferon regulatory factor 3 (IRF-3) by the Ebola VP35

35 e models, the antiviral transcription factor interferon regulatory factor 3 (IRF-3) enhances reovirus

36 s found to restore the responsiveness of the interferon regulatory factor 3 (IRF-3) in cells containi

37 Interferon regulatory factor 3 (IRF-3) is a key transcri

38 Interferon regulatory factor 3 (IRF-3) is essential for

39 It is now known that neither STAT1 nor interferon regulatory factor 3 (IRF-3) play essential ro

40 Interferon regulatory factor 3 (IRF-3) plays a central r

41 ltimeric transcription factor containing the interferon regulatory factor 3 (IRF-3) protein and one o

42 The transcription factor interferon regulatory factor 3 (IRF-3) regulates genes i

43 Interferon regulatory factor 3 (IRF-3) undergoes phospho

44 Interferon regulatory factor 3 (IRF-3) was identified as

45 protease, Sendai virus-induced activation of interferon regulatory factor 3 (IRF-3), a key antiviral

46 ron response by inhibiting the activation of interferon regulatory factor 3 (IRF-3), a key regulator

47 Nile virus NY (WNV-NY) delays activation of interferon regulatory factor 3 (IRF-3), a transcription

48 us-induced phosphorylation and activation of interferon regulatory factor 3 (IRF-3), a transcription

49 the latent transcription factors NF-kappaB, interferon regulatory factor 3 (IRF-3), and ATF-2, which

50 n in vitro, class II transactivator (CIITA), interferon regulatory factor 3 (IRF-3), and interferon r

51 yxovirus infection induces apoptosis through interferon regulatory factor 3 (IRF-3), but the exact me

52 actors nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF-3), classically indu

53 ocation of the IFN-beta transcription factor interferon regulatory factor 3 (IRF-3), MHV did not indu

54 ponse, as characterized by the activation of interferon regulatory factor 3 (IRF-3), production of in

55 NF-kappaB and interferon regulatory factor 3 (IRF-3), the two major tr

56 ating signaling that activates NF-kappaB and interferon regulatory factor 3 (IRF-3), thereby inducing

57 hibited poly(I.C)-induced phosphorylation of interferon regulatory factor 3 (IRF-3), which is the key

58 key proapoptotic protein in this pathway is interferon regulatory factor 3 (IRF-3), which upon activ

59 inhibited activation of beta interferon and interferon regulatory factor 3 (IRF-3)-dependent promote

60 HSV-1, we isolated HFs depleted of STAT-1 or interferon regulatory factor 3 (IRF-3).

61 ssembly of a complex between ATF-2-c-jun and interferon regulatory factor 3 (IRF-3).

62 viral activation of the transcription factor interferon regulatory factor 3 (IRF-3).

63 olic RIG-I pathway, requires the presence of interferon regulatory factor 3 (IRF-3).

64 response by sequestration and degradation of interferon regulatory factor 3 (IRF-3).

65 to antagonize the IFN response by inhibiting interferon regulatory factor 3 (IRF-3).

66 Interferon regulatory factor-3 (IRF-3) activation direct

67 involves activation of transcription factors interferon regulatory factor-3 (IRF-3) and NF-kappaB, re

68 and suppressed the downstream activation of interferon regulatory factor-3 (IRF-3) and nuclear facto

69 Here, we show that the human interferon regulatory factor-3 (IRF-3) gene promoter con

70 Interferon regulatory factor-3 (IRF-3) has been implicat

71 this study we have defined the mechanisms of interferon regulatory factor-3 (IRF-3) signaling in prim

72 Interferon regulatory factor-3 (IRF-3) was found to spec

73 s the phosphorylation and effector action of interferon regulatory factor-3 (IRF-3), a key cellular a

74 HeLa cells, EV68 inhibits poly(I.C)-induced interferon regulatory factor 3 (IRF3) activation and bet

75 We have identified potential pathways, via interferon regulatory factor 3 (IRF3) activation or Hoxa

76 (IFN-I) production through inhibition of the interferon regulatory factor 3 (IRF3) activation pathway

77 1 and -2 was required for phosphorylation of interferon regulatory factor 3 (IRF3) and accumulation o

78 sed S. pneumoniae induced phosphorylation of interferon regulatory factor 3 (IRF3) and activating tra

79 onse to microbial components, TBK1 activates interferon regulatory factor 3 (IRF3) and cytokine expre

80 s) required for initiating the activation of interferon regulatory factor 3 (IRF3) and interferon (IF

81 The transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB are

82 stimulator 1 (IPS-1)-mediated activation of interferon regulatory factor 3 (IRF3) and NF-kappaB sign

83 ents and activation of transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB, STI

84 tion of two inducible transcription factors, interferon regulatory factor 3 (IRF3) and NF-kappaB.

85 It is known that STING utilizes interferon regulatory factor 3 (IRF3) and nuclear factor

86 r proteins leading to activation of both the interferon regulatory factor 3 (IRF3) and nuclear factor

87 nscription via transcription factors such as interferon regulatory factor 3 (IRF3) and nuclear factor

88 this leads to sequential phosphorylation of interferon regulatory factor 3 (IRF3) and p65/RelA.

89 phosphorylation of the transcription factor interferon regulatory factor 3 (IRF3) and subsequent exp

90 ds to activation of the transcription factor interferon regulatory factor 3 (IRF3) and subsequent tra

91 -dependent phosphorylation and activation of Interferon Regulatory Factor 3 (IRF3) and the E3 ubiquit

92 TBK1 phosphorylates the transcription factor Interferon Regulatory Factor 3 (IRF3) and the E3 ubiquit

93 then bind to a positively charged surface of interferon regulatory factor 3 (IRF3) and thereby recrui

94 Interferon regulatory factor 3 (IRF3) and type I interfe

95 ls by preventing not only phosphorylation of interferon regulatory factor 3 (IRF3) but also degradati

96 d not bind MDA5 efficiently, did not inhibit interferon regulatory factor 3 (IRF3) dimerization or IF

97 Because the absence of interferon regulatory factor 3 (IRF3) does not increase

98 nse to viral infection by degradation of the interferon regulatory factor 3 (IRF3) has been subject o

99 of the immune signaling transcription factor interferon regulatory factor 3 (IRF3) in response to cyt

100 ndrial antiviral signaling protein (MAVS) or interferon regulatory factor 3 (IRF3) in the IFN inducti

101 on of ZAP occurs under the direct control of interferon regulatory factor 3 (IRF3) independent of int

102 Interferon regulatory factor 3 (IRF3) is a transcription

103 Interferon regulatory factor 3 (IRF3) is an important tr

104 Interferon regulatory factor 3 (IRF3) is known to partic

105 e also induced directly by pathogens via the interferon regulatory factor 3 (IRF3) pathway.

106 y and confirmed that these miRNAs potentiate interferon regulatory factor 3 (IRF3) phosphorylation an

107 (iii) delivery of the viral genome triggers interferon regulatory factor 3 (IRF3) phosphorylation, a

108 nduction of TBK1 alone is not sufficient for interferon regulatory factor 3 (IRF3) phosphorylation.

109 Interferon regulatory factor 3 (IRF3) plays a central ro

110 Interferon regulatory factor 3 (IRF3) regulates hepatocy

111 n cyclic GMP-AMP synthase (cGAS), STING, and interferon regulatory factor 3 (IRF3) signaling.

112 activation of the TANK-binding kinase (TBK1)-interferon regulatory factor 3 (IRF3) signalling axis to

113 tiviral interferon antagonist which degrades interferon regulatory factor 3 (IRF3) through the protea

114 ntly phosphorylates the transcription factor interferon regulatory factor 3 (IRF3) to promote interfe

115 antagonist capable of blocking activation of interferon regulatory factor 3 (IRF3) via the retinoic a

116 ta but not IFN-gamma, and both NF-kappaB and interferon regulatory factor 3 (IRF3) were required.

117 sible for HIV-1 targeting and degradation of interferon regulatory factor 3 (IRF3), a central transcr

118 Viral infection activates interferon regulatory factor 3 (IRF3), a cofactor for th

119 Interferon regulatory factor 3 (IRF3), a key signal medi

120 Interferon regulatory factor 3 (IRF3), a key transcripti

121 cells causes partial proteolytic cleavage of interferon regulatory factor 3 (IRF3), a key transcripti

122 Liver expression of interferon regulatory factor 3 (IRF3), a MyD88-independe

123 ng cause, we determined the effect of E3L on interferon regulatory factor 3 (IRF3), a transcription f

124 N(pro) also targets interferon regulatory factor 3 (IRF3), a transcription f

125 at least in part, of the recently identified interferon regulatory factor 3 (IRF3), but it does not c

126 hondrial antiviral signaling protein (MAVS), interferon regulatory factor 3 (IRF3), or Interferon-alp

127 uit TANK-binding kinase 1 (TBK1) to activate interferon regulatory factor 3 (IRF3), resulting in prod

128 epatitis C virus (HCV) genomic RNA activates interferon regulatory factor 3 (IRF3), thereby inducing

129 E) inhibits TBK1-mediated phosphorylation of interferon regulatory factor 3 (IRF3), which is essentia

130 paB, commonly activated by several TLRs, and interferon regulatory factor 3 (IRF3), which was found t

131 s alcoholic liver disease (ALD) and that the interferon regulatory factor 3 (IRF3),a transcription fa

132 rom the site of inoculation independently of interferon regulatory factor 3 (IRF3)-, IRF7-, and IFNAR

133 We identify an interferon regulatory factor 3 (IRF3)-dependent but type

134 ation of toll-like receptor 4 (TLR4) and its interferon regulatory factor 3 (IRF3)-dependent downstre

135 Interferon regulatory factor 3 (IRF3)-dependent IFN prof

136 identifies both inhibitors and activators of interferon regulatory factor 3 (IRF3)-mediated gene indu

137 rylation of TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3).

138 factor and/or suppressing the activation of interferon regulatory factor 3 (IRF3).

139 ne system by facilitating the degradation of interferon regulatory factor 3 (IRF3).

140 hways that activate the transcription factor interferon regulatory factor 3 (IRF3).

141 lities to modulate apoptosis, NF-kappaB, and interferon regulatory factor 3 (IRF3).

142 a cyclic-GMP-AMP synthase (cGAS), STING, and interferon regulatory factor 3 (IRF3).

143 but is dependent on the transcription factor interferon regulatory factor 3 (IRF3).

144 f the beta interferon gene via activation of interferon regulatory factor 3 (IRF3).

145 IFN-beta promoter when it was stimulated by interferon regulatory factor 3 (IRF3)/5D or its upstream

146 ctivates the transcription factors NFkappaB, interferon regulatory factor-3 (IRF3) and CCAAA/enhancer

147 increased PTEN/TLR4 (Toll-like receptor 4), interferon regulatory factor-3 (IRF3), nuclear factor ka

148 in an MyD88-independent manner that involves interferon regulatory factor-3 (IRF3).

149 lasmic viral PRR by triggering activation of interferon-regulatory factor 3 (IRF3) and production of

150 We also demonstrated that interferon-regulatory factor 3 (IRF3) is transiently rec

151 articular, expression and phosphorylation of interferon-regulatory factor 3 (IRF3) was decreased in E

152 Immediately upon entry, viruses activate interferon-regulatory factor 3 (IRF3), as well as nuclea

153 However, activation of interferon regulatory factor 3 is only essential for ind

154 ion in endotoxin-tolerized cells as shown in interferon regulatory factor-3 knock-out mice.

155 nished alcohol-induced hepatic steatosis and interferon regulatory factor 3-mediated apoptosis.

156 endent of the retinoic acid-inducible gene I/interferon regulatory factor 3 pathway.

157 f interferon genes - tank-binding kinase 1 - interferon regulatory factor 3) pathway, shedding light

158 Furthermore, C. jejuni induced interferon regulatory factor 3 phosphorylation and IFN-b

159 etion of the downstream transcription factor interferon regulatory factor 3 resulted in reduced induc

160 plex virus (HSV)-infected cells and initiate interferon regulatory factor-3 signaling, but it has bee

161 1)-AKT (AKT serine/threonine kinase 1)-IRF3 (interferon regulatory factor 3) signaling cascade leadin

162 hatase 2A (PP2A) as a deactivator of phospho-interferon regulatory factor 3, the key transcription fa

163 Here we report that the virus-encoded interferon regulatory factor 3 (vIRF3) latent viral gene