ライフサイエンスコーパス: intergenerational

1 Our results reveal increased intergenerational and somatic instability of the HD CAG

2 We highlight essential definitions of intergenerational and transgenerational transmission of

3 t instability and fragmentation on seasonal, intergenerational, and evolutionary time scales.

4 We identify an intergenerational association between maternal exposure

5 The data also showed an intergenerational association of FM between mothers and

6 PA and FM in adolescents and to describe the intergenerational association of FM between mothers and

7 Intergenerational association of PTSD is clearly present

8 characteristics of both parents confound the intergenerational association.

9 yzed Illinois vital records to determine the intergenerational birth weight patterns among the descen

10 We have detected intergenerational CAG repeat instability in transgenic m

11 e temporal and geographical implications for intergenerational caregiving.

12 We prospectively examined intergenerational change in BMI and tested the fetal ove

13 The frequency of intergenerational changes was age dependent for both pat

14 ted cloning via artificial nuclear transfer; intergenerational clonality in nature via parthenogenesi

15 forge interdisciplinary, international, and intergenerational collaborations on behalf of the cultur

16 Intergenerational conflict combined with the known benef

17 estriction in a parent's fetal life can have intergenerational consequences in human populations.

18 ological standards provided evidence for the intergenerational continuity of child physical abuse, bu

19 ed anticipation is sometimes associated with intergenerational contraction rather than expansion of t

20 Here, we report an intergenerational correlation in reproductive success in

21 but in asthmatic families a major element of intergenerational correlation is associated with a mater

22 role of the shared environment in explaining intergenerational correlations in birth weight and lengt

23 cant shared-environment contributions to the intergenerational correlations were identified in biomet

24 moderately but significantly contributes to intergenerational correlations.

25 teractions about math at home help break the intergenerational cycle of low math achievement.

26 udies that explore mechanisms underlying the intergenerational cycle of obesity are warranted to iden

27 urished parents, and these may contribute to intergenerational cycles of malnutrition.

28 onutrient malnutrition and can interrupt its intergenerational debilitating effects on national devel

29 In an intergenerational developmental programming model affect

30 ver the mechanisms underlying the direct and intergenerational effect of adiposity on DNA methylation

31 We examined the intergenerational effect of maternal CM exposure on chil

32 The intergenerational effect of treatment was considerable:

33 While this intergenerational effect was not passed down to the F2 g

34 Instead, we found a TNF-alpha-dependent intergenerational effect, as mothers with a deficit in T

35 nity during which substantial life cycle and intergenerational effects can be accrued.

36 wever, the proximate mechanisms behind these intergenerational effects have remained elusive.

37 Emerging evidence on the role of intergenerational effects in determining maternal precon

38 Thus the intergenerational effects of gestational SS involve epig

39 Here, we test the direct effects and intergenerational effects of jasmonic acid (JA) treatmen

40 er association in mothers is consistent with intergenerational effects on intrauterine growth and wit

41 w severe psychophysiological trauma can have intergenerational effects.

42 peats, and Dnmt1 deficiency in mice promoted intergenerational expansion of CAG repeats at the murine

43 the fourth decade of life is associated with intergenerational factors and various aspects of people'

44 Research on intergenerational factors that might also predispose a c

45 we devise a new experimental paradigm, the 'Intergenerational Goods Game'.

46 s in the maternal microbiome just before the intergenerational hand-off of the microbiota.

47 ovide evidence for genetic modifiers of both intergenerational HD CAG repeat instability and striatal

48 nature via parthenogenesis and gynogenesis; intergenerational hemiclonality via hybridogenesis and k

49 ramming in the early origins of obesity, but intergenerational human data are lacking.We prospectivel

50 We sought to test an intergenerational hypothesis, that the childhood SES tha

51 Influence of intergenerational in utero parental energy and nutrient

52 fic influence from fetal environment on this intergenerational increase in adult obesity.

53 characterized by genetic anticipation or the intergenerational increase in disease severity accompani

54 several spinocerebellar ataxias, result from intergenerational increases in the length of a CTG.CAG r

55 Few data exist on the intergenerational influence of calcium intake during pre

56 ults also highlight an apparent long-lasting intergenerational influence of maternal BMI on offspring

57 stnatal growth appears to be under patriline intergenerational influences.

58 in offspring, but mechanisms underlying such intergenerational information transfer remain obscure.

59 y toward expansions over contractions during intergenerational inheritance compared to those in homoz

60 paternal epigenetic factor that may mediate intergenerational inheritance of diet-induced metabolic

61 These intergenerational instabilities increased in frequency a

62 xon 1 with 48 CAG repeats revealed only mild intergenerational instability ( approximately 2% of meio

63 We have observed a high intergenerational instability (46.3%+/-5.1%) of the larg

64 We have detected intergenerational instability and age-related somatic in

65 C transgenic mice with CAG 45 alleles reveal intergenerational instability at an overall rate of appr

66 Intergenerational instability has been described in all

67 As with hairpins, triplex mediates intergenerational instability in 96% of transmissions.

68 ats of certain trinucleotides show extensive intergenerational instability in humans that is associat

69 during germline development contributing to intergenerational instability of CAG repeats in mice and

70 This mechanism involves the expansion and intergenerational instability of stretches of consecutiv

71 ypes in these three genetic backgrounds: the intergenerational instability of the HD CAG repeat and t

72 +) SCA1 counterparts, closely reproduced the intergenerational instability patterns observed in human

73 ic fragment transgenic mice displayed marked intergenerational instability with an obvious expansion

74 this multifamily study, we investigated the intergenerational instability, somatic and germline mosa

75 (HD) gene exhibit striking length-dependent intergenerational instability, typically small size incr

76 dylinositol signaling pathway as a target of intergenerational JA effects.

77 Given these intergenerational mechanisms and physical aggression ons

78 Growing up in a county with 1 SD better intergenerational mobility accounts for approximately 20

79 Chetty and Hendren's county-level measure of intergenerational mobility and children's cognitive and

80 ology is not sufficient to implicate them as intergenerational neural mediators.

81 Here we highlight recent intergenerational neuroimaging studies and provide recom

82 nce supporting the important contribution of intergenerational parental stress in offspring neurodeve

83 lease and limited dispersal of symbionts for intergenerational persistence of mutualisms.

84 demiological studies indeed evidence such an intergenerational predisposition to surgical delivery.

85 for policy interventions designed to sustain intergenerational public goods.

86 aicism that can potentially cause unexpected intergenerational recurrences.

87 ese women, however, there has been a tenfold intergenerational reduction in smoking uptake rates.

88 a common genetic liability accounted for the intergenerational relations.

89 ing potentially significant consequences for intergenerational relationships and caregiving.

90 tability has compromised attempts to measure intergenerational repeat dynamics and infer genotype-phe

91 Although the basis for intergenerational repeat expansion is unclear, repeat tr

92 ations display earlier disease onsets due to intergenerational repeat expansion.

93 ing epigenetic reprogramming may trigger the intergenerational repeat expansions that lead to disease

94 Mice heterozygous for the CAG expansion show intergenerational repeat instability (+2 to -6) at a muc

95 ion of small changes, are reminiscent of the intergenerational repeat instability observed in human p

96 characterized by marked anticipation due to intergenerational repeat instability with a bias toward

97 While the cDNA transgenic mice showed little intergenerational repeat instability, the genomic fragme

98 The authors conclude that the expected intergenerational rise in birth weight does not occur am

99 circumstances had shorter telomeres, as was intergenerational social mobility, but not accumulated d

100 Pedigree analysis of the intergenerational stability of alleles of this haplotype

101 rse sample (n = 147) from the Programming of Intergenerational Stress Mechanisms (PRISM) study (Massa

102 over the domestic cycle are smoothed by the intergenerational structure of complex households and ex

103 Here, we report a direct measurement of the intergenerational substitution rate in the human CR.

104 s wealth: over the short run, the life span, intergenerational succession, and in (legal) perpetuity

105 nerations in the worm Caenorhabditis elegans Intergenerational transfer of dsRNA occurs even in anima

106 Although it is unclear how such intergenerational transfer of information occurs, RNAs f

107 tential for early intervention to reduce the intergenerational transfer of obesity.

108 Intergenerational transfer of wealth has been proposed a

109 transfer at the expense of reduced vertical (intergenerational) transfer and vice versa, a key trade-

110 ever, successful reproduction often involves intergenerational transfers as well as fertility.

111 Previous work has shown formally that intergenerational transfers can explain both these patte

112 a unique framework to test the importance of intergenerational transfers of wealth in driving sibling

113 fertility (the classic effect) and remaining intergenerational transfers to be made to others.

114 GAA*TTC)n sequence, which is unstable during intergenerational transmission and in most patient tissu

115 The repeats expand both somatically and on intergenerational transmission and increased repeat numb

116 genetic risk, however, confounds the entire intergenerational transmission in female offspring.

117 We address the hypothesis that intergenerational transmission may begin during intraute

118 ver-represented in caregivers, with possible intergenerational transmission of abnormal illness behav

119 The extent of the intergenerational transmission of abuse and neglect depe

120 A three-generation longitudinal study of the intergenerational transmission of abuse is also highligh

121 which the effects of early experience on the intergenerational transmission of abusive parenting are

122 ial, the design of studies investigating the intergenerational transmission of child physical abuse.

123 c and environmental processes underlying the intergenerational transmission of childhood conduct prob

124 The mechanisms underlying the intergenerational transmission of conduct problems depen

125 n and measured covariates indicated that the intergenerational transmission of conduct problems for m

126 In contrast, the intergenerational transmission of conduct problems was n

127 perpetuates health inequalities through the intergenerational transmission of disadvantage.

128 a paucity of data from human populations on intergenerational transmission of environmentally induce

129 Mechanistic examination of modes of intergenerational transmission of exposure during pregna

130 ted States, one that could contribute to the intergenerational transmission of health disadvantage.

131 vanced neuroimaging methods to elucidate the intergenerational transmission of human brain circuitry.

132 ed the role of monoaminergic function in the intergenerational transmission of infant abuse in rhesus

133 These results suggest that the intergenerational transmission of infant abuse in rhesus

134 es of maternal rejection plays a role in the intergenerational transmission of infant abuse.

135 t vitellogenin as a likely key player in the intergenerational transmission of information.

136 minant of human behavior and health, and the intergenerational transmission of knowledge regarding th

137 The strongest evidence for the intergenerational transmission of maltreatment indicates

138 ically well-defined Finnish families showing intergenerational transmission of migraine with aura (MA

139 uss the urgent need and challenges to reduce intergenerational transmission of obesity and diabetes.

140 for their children, thus contributing to the intergenerational transmission of poverty.

141 ial pathophysiologic pathway involved in the intergenerational transmission of socioeconomic inequali

142 The involvement of epigenetic mechanisms in intergenerational transmission of stress effects has bee

143 These observations support our hypothesis of intergenerational transmission of the effects of materna

144 e 3' genomic region significantly stabilized intergenerational transmission of the SCA7 CAG92 repeat.

145 We estimate the degree of intergenerational transmission of three different types

146 l PTSD suggests different mechanisms for the intergenerational transmission of trauma-related vulnera

147 We show that intergenerational transmission of wealth and wealth ineq

148 l aggression are generally the product of an intergenerational transmission process occurring through

149 Intergenerational transmission studies suggest that thes

150 ying a potential novel biological pathway of intergenerational transmission that may operate as early

151 The magnitude of the intergenerational transmission was significant for all o

152 on offspring, a concept we refer to here as 'intergenerational transmission', via changes to gametes

153 od malnutrition, including the potential for intergenerational transmission, remain unexplored.

154 sex-specific changes in allele length during intergenerational transmission.

155 nstable, with frequent length changes during intergenerational transmission.

156 ion and cognition, and limited potential for intergenerational transmission.

157 n repeat predisposes it to expansions during intergenerational transmissions leading to fragile X syn

158 cells, albeit on a smaller scale than during intergenerational transmissions.

159 Extrapolations of intergenerational variance in spatial position (sigma(2)