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1 Ss) were annotated as noncoding, with 24% in intergenic, 12% in promoters, and 28% in introns, with s
4 essing of preceding genes, and elucidate how intergenic Alu exonisation can contribute to tissue-spec
6 lly greatest in silent or weakly transcribed intergenic and genic regions and accompanied by an incre
14 to identify 4 riboswitches, 13 trans-acting (intergenic), and 22 cis-acting (antisense) small RNAs (t
15 s in different regions of the genome (genic, intergenic, and heterochromatic) and at different distan
16 IC in the 4p16.1 region located mostly in an intergenic area near SLC2A9 that were not driven by link
17 DNA is preferentially hypomethylated within intergenic areas and LINE1 promoter areas of the genome.
21 ant loss of SUMOylation occurred at inactive intergenic chromatin regions that were associated with C
22 n (PCR) analyses: Enterobacterial Repetitive Intergenic Consensus (ERIC) and Random Amplified Polymor
23 irms the previous enterobacterial repetitive intergenic consensus (ERIC)-polymerase chain reaction (P
25 f methylation in the heart, enriched in lone intergenic CpGs and depleted from CpG islands around gen
26 tissues requires assessment of understudied intergenic CpGs distal to gene promoters to reveal the f
27 ogenic activity of AID leading to intra- and intergenic deletions via homologous recombination of seq
29 operon variants with systematically modified intergenic distances and upstream translation rates.
30 of marker genes with operon prediction using intergenic distances, and queries to the carbohydrate-ac
32 ensities of H3K27me3 covering both genes and intergenic DNA, together with very low levels of the rep
35 400Kb upstream to IGFBP5, which overlaps an intergenic ERalpha-bound enhancer that loops to the IGFB
37 ssays demonstrated that hGRbeta binds to the intergenic glucocorticoid response element (GRE) of the
40 e an epigenomic framework for barley whereby intergenic H3K27me3 specifies facultative heterochromati
41 lti-exonic transcripts from 561 intronic and intergenic haploblocks associated with 392 traits and di
44 ell predominantly within introns, exons, and intergenic intervals, while showing a significant deplet
48 dicted in Trichodesmium, when normalized per intergenic kilobase, was comparable and twofold higher t
51 requirements for nuclear localization in an intergenic lncRNA named BORG (BMP2-OP1-responsive gene),
52 an experimental reannotation of the GENCODE intergenic lncRNA populations in matched human and mouse
55 ification of these lncRNAs reveals that most intergenic lncRNAs originate from enhancers rather than
57 ic class of RNAs that includes, for example, intergenic lncRNAs, antisense transcripts, and enhancer
59 atterns, and uncovers two notable classes of intergenic lncRNAs: one showing strong purifying selecti
62 ts were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs
63 rmed on human left/right pairs identified an intergenic long noncoding RNA adjacent to the PITX2 gene
64 identification of 145 previously unannotated intergenic long noncoding RNA transcripts (lncRNA) or is
67 ated 300-500 kb upstream of their associated intergenic microRNAs, suggesting that distal regulatory
69 PRO-seq experiments identified TSSs for 480 intergenic miRNAs, indicating a wide usage of alternativ
72 ings identify Neat1 as a p53-regulated large intergenic ncRNA (lincRNA) with a key role in suppressin
74 onic unprocessed transcript, as well as long intergenic non-coding (lincRNAs) and enhancer-associated
76 ction of microRNAs (miRNAs) are derived from intergenic non-coding loci and the identification of the
77 association between polymorphisms in a long intergenic non-coding RNA (lincRNA) gene (AC011288.2) an
79 hibit distinct messenger RNA (mRNA) and long intergenic non-coding RNA (lincRNA) profiles compared to
82 ication and characterization of a novel long intergenic non-coding RNA with MyoD-regulated and skelet
83 than 3 billion reads identified 22 334 long intergenic non-coding RNAs (lincRNAs) and 6673 pairs of
85 ematic investigation of the capacity of long intergenic non-coding RNAs (lincRNAs) as biomarkers asso
88 transcriptome to detect 6,701 putative long intergenic non-coding transcripts (lincRNAs) expressed i
89 deletion-based approach identified two long intergenic non-coding(linc)RNAs, lincRNA-Cox2 and lincRN
91 e describe the identification of 30 550 long intergenic noncoding RNA (lincRNA) loci (50 566 transcri
92 haracterize the 3D organization of 998 large intergenic noncoding RNA (lincRNA) promoters in two huma
94 e demonstrate that betalinc1 (beta-cell long intergenic noncoding RNA 1), a conserved lncRNA, is nece
95 ong noncoding RNA (lncRNA) Flicr (Foxp3 long intergenic noncoding RNA) is a negative regulator that t
103 tein-coding domains could help identify long intergenic noncoding RNAs (lincRNAs) associated with met
105 xtent to which alternative splicing and long intergenic noncoding RNAs (lincRNAs) contribute to the s
106 ese noncoding RNAs, a growing number of long intergenic noncoding RNAs (lincRNAs) have been described
109 nally, we identify a multitude of novel long intergenic nonprotein coding RNAs (lincRNAs) specificall
110 sized that copy number alterations (CNAs) of intergenic nonprotein-coding domains could help identify
111 HPRT1 function was robust to deletion of any intergenic or deeply intronic non-coding region, indicat
113 ion for the genetic association of HBS1L-MYB intergenic polymorphisms with human erythroid traits and
116 re we document that the arenavirus noncoding intergenic region (IGR) has a high degree of plasticity
119 proach involved replacement of the noncoding intergenic region (IGR) of the L genome segment with the
120 We have recently shown that the noncoding intergenic region (IGR) present in each arenavirus genom
121 on and a point mutation within the L-segment intergenic region (IGR), and three silent changes in the
123 strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid
124 RH50 binds to transcripts of the 23S-4.5S intergenic region and, in its absence, levels of the cor
125 One of these, at chromosome 11p13, is an intergenic region between Ets homologous factor (EHF) an
126 ated within a predicted super-enhancer in an intergenic region between HLA-DRB1 and HLA-DQA1, localiz
127 regions go through substantial changes: the intergenic region between NP and VP35, as well as the fi
129 entified 28 targets of PA2588, including the intergenic region between PA2588 and pqsH, which encodes
130 Tandem repeats were frequently found in the intergenic region between the prophage at the 3' end and
131 G, NID1, DHRS12, ITPK1, ACSF3, TNFRSF13C and intergenic region chr10p12.31 was replicated in a cohort
132 contains hundreds of V(H)s, separated by an intergenic region from Igh Ds, J(H)s, and constant regio
133 ), HDL-cholesterol (PHOSPHO1, SYNGAP1 and an intergenic region in chromosome 2) and triglycerides (MY
135 single-nucleotide polymorphisms (SNPs) in an intergenic region located between the oncogenes MYC and
136 d rs11048230 (P=4.77x10(-8); MAF=0.10) in an intergenic region near RASSF8 (associated with vascular
137 .71 x 10(-10), rs16891982), and revealed the intergenic region of BEND7 and PRPF18 as a novel locus a
141 gle nucleotide polymorphism at the trnL-trnF intergenic region of the chloroplast chromosome was conf
142 ription start site was identified within the intergenic region of the miR-183 cluster, which may regu
144 gnificant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, P = 5.87 x 10 (
145 nflammatory states, maps to the 5' end of an intergenic region on Chr11p13 that is implicated as a mo
146 olymorphisms (SNPs) (r(2)>0.9) located in an intergenic region on chromosome 3q26 were associated wit
147 d loci (CAV1-CAV2, CDKN2B-AS1, SIX1-SIX6, an intergenic region on chromosome 8q22, ABCA1, GAS7, AFAP1
148 ic control region 1 (IGCR1) in the V(H)-to-D intergenic region regulates Igh V(D)J recombination in t
149 pendent reporter gene cassette located in an intergenic region remained silent, indicating that the t
150 f a 605-bp region within the RPA135-tK(CUU)P intergenic region results in a reduction in the RPA135-I
151 S_NmUC isolates was an IS1301 element in the intergenic region separating the capsule ctr-css operons
152 NA genome, with an 827 nt-long 5' UTR and an intergenic region separating two open reading frames.
153 indromic (REP) elements within the yqjH-yqjI intergenic region shows that these sequences are not req
154 a 75-bp sequence within the RPA135-tK(CUU)P intergenic region that is involved in the interaction.
157 4.8 kb miR-183 family cluster, including the intergenic region which contains highly conserved genomi
158 We show that XdhR binds the xdhABC-xdhR intergenic region with high affinity (Kd approximately 0
159 coding RNA complementary to the 4.5S-5S rRNA intergenic region, and its presence correlated with that
160 odels included SNPs in BCL11A, the HBS1L-MYB intergenic region, and the site of the HBB gene cluster,
161 n of a 198-nucleotide sequence into the HN-L intergenic region, resulting in reduced viral gene expre
162 We applied this methodology to the HBS1L-MYB intergenic region, which is associated with red-blood-ce
163 with a transposon insertion in the upstream intergenic region, while FT2c and FT2d obtained a transp
167 dentified signals include two that reside in intergenic regions (1q31.1 and 5p13.1) and three residin
171 orders, including short (4- or 5-nucleotide) intergenic regions (IRs), a single long (144-nucleotide)
174 border regions between domains contain large intergenic regions and a high density of transcription f
175 ng transcriptionally silent chromatin within intergenic regions and at the border of euchromatin and
176 al activity in most non-PcG target genes and intergenic regions and is governed by opposing roaming a
177 i-cistronic operons with rationally designed intergenic regions and systematically increased upstream
178 (rRNA) processing, many coding sequences and intergenic regions appeared to be direct targets of RNas
179 er through the realization that mutations in intergenic regions are actually within unannotated small
180 ell embryos is highly promiscuous, such that intergenic regions are extensively expressed and thousan
185 f somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer g
186 (TUCs) along the genomic sequence; (ii) the intergenic regions in front of the first gene of each TU
187 creases in promoter regions and decreases in intergenic regions in pre-iPSCs, then recovers to an int
189 Microsatellite mapping found a bias toward intergenic regions in the nonconserved microsatellites a
190 t microsatellite mapping found a bias toward intergenic regions in the nonconserved microsatellites a
191 ong noncoding transcripts (>200 nt) from the intergenic regions of annotated protein-coding genes.
192 genomes shows many cases of association with intergenic regions of genes with altered expression due
194 and un-annotated exon boundaries, including intergenic regions of the genome, with high statistical
199 regulated loci correspond to transposons and intergenic regions producing 24-nucleotide siRNAs that g
201 BCG1, CPT1A, MYLIP, TXNIP and SLC7A11) and 2 intergenic regions showed differential methylation in as
202 ed by RNA polymerase II and map to low-copy, intergenic regions similar to PIWI-interacting RNAs (piR
203 cted, nucleotide diversity is much higher in intergenic regions than within gene bodies (regions span
204 evising several methods to select subsets of intergenic regions that can concentrate these rare RNA c
205 To identify a comprehensive set of genes and intergenic regions that impacts fitness in S. elongatus,
206 icient resolution in the larger intronic and intergenic regions to identify copy number changes.
209 Stringtie was then performed to identify the intergenic regions whose expression was influenced by th
212 ores, enriched within gene bodies but not in intergenic regions, and preferentially harbored binding
213 bserve that the genome is more accessible in intergenic regions, and that increased accessibility is
214 introns), while being depleted in coding and intergenic regions, and these findings may have biologic
216 t may be transcribed: coding, noncoding, and intergenic regions, as well as repetitive elements, telo
217 ion in CpG island (CGI) and demethylation in intergenic regions, defined as 'backbone', largely vary
219 d are more likely to occur in the genic than intergenic regions, especially common in the 5'- and 3'-
220 ociated haplotype blocks are in intronic and intergenic regions, hindering their functional evaluatio
221 5' and 3' untranslated regions as well as in intergenic regions, identification and validation of tru
222 WAS) appear to be located within intronic or intergenic regions, which makes it difficult to interpre
243 atory regions as well as with Pax5-activated intergenic repeat elements and 5' distal VH genes were c
244 during early S phase followed by most of the intergenic repetitive regions replicating during middle
247 NAs, LL18/NANCI (Nkx2.1-associated noncoding intergenic RNA) and LL34, play distinct roles in endoder
248 study, we report that HOTAIR (HOX antisense intergenic RNA) is upregulated in tamoxifen-resistant br
249 lncRNA) HOTAIR (for HOX Transcript Antisense Intergenic RNA) mediates a physical interaction between
250 ithin the NANCI (Nkx2.1-associated noncoding intergenic RNA)-Nkx2.1 gene duplex that is essential for
251 s of non-coding RNA including microRNA, long intergenic RNA, small nucleolar RNA, natural antisense t
252 unique expression of coding, noncoding, and intergenic RNAs in the mature mouse brain with RNA-Seq a
253 of the ribosomal DNA (rDNA) repeats and the intergenic sequence between the locus encoding the secon
255 uit fly Drosophila melanogaster relies on an intergenic sequence termed the IRER (irradiation-respons
256 tions in cancer have identified mutations in intergenic sequences encoding regulatory elements-and in
257 duction near genes compared with the rest of intergenic sequences is greater in a species with larger
258 utative mammary-specific enhancer within the intergenic sequences separating the two Stat5 genes.
259 gapless coverage over gene space as well as intergenic sequences such as centromeres, telomeres, tra
261 fragmented, lacking skewed GC and repetitive intergenic sequences, which are gaining importance due t
265 th of purifying selection operating over all intergenic sites is consistently intermediate between th
266 observed in addicted rats occurred mostly at intergenic sites located on long and short interspersed
268 e an intronic SNP in FOXP1 at locus 3p13, an intergenic SNP at 3q28 near TP63, and an intergenic SNP
270 etween LSLs and the maternal genotype for an intergenic SNP on chromosome 10 (rs11008222, combined P
271 n between LSLs and the case genotype for one intergenic SNP on chromosome 16 achieved genome-wide sig
274 that contained a transposon inserted in the intergenic space between sufC and sufD (sufD*), resultin
281 es cerevisiae genome that occurs between the intergenic spacer of the ribosomal DNA (rDNA) repeats an
284 noncoding RNAs from the ribosomal DNA (rDNA) intergenic spacers, consistent with its previously repor
286 P2 and other latency-associated transcripts, intergenic splicing at the BZLF2 locus, and antisense tr
287 and into downstream genes, leading to novel intergenic splicing between exons of neighbouring cellul
289 topographical relationships revealed that an intergenic state, characterized by H3K27me3 and slightly
291 ammatory conditions via the production of an intergenic transcript linking neuronal and immune Fpr ge
293 a novel human locus, H11, located in a safe, intergenic, transcriptionally active region of chromosom
296 authors discovered 2 novel AF variants, the intergenic variant rs72700114, between the genes LINC011
298 summary, we identified and characterized an intergenic VNTR polymorphism in S. pyogenes that affects
300 and silencing were used to identify a novel intergenic Y-linked lncRNA, named lnc-KDM5D-4, and inves
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