ライフサイエンスコーパス: interictal

1 nts are generally regarded as subclinical or interictal.

2 relative to diagnostic evaluation were 0.44 (interictal), 0.75 (postictal) and 0.97 (ictal).

3 Dynamic (18)F-FMZ PET and static interictal (18)F-FDG PET scans were compared in healthy

4 11 +/- 4 y; age range, 6-18 y) who underwent interictal (18)F-FDG PET, followed by 2-stage epilepsy s

5 Interictal 18FDG-PET scans in 17 patients with surgicall

6 onvulsant 4-aminopyridine was used to induce interictal activity and seizures in rat neocortical slic

7 01 prevented the development of epilepsy and interictal activity following SE.

8 Interictal activity in rats sustaining febrile status ep

9 on potentials recorded during electrographic interictal activity in the 'high [K+]o' model of epileps

10 or low concentrations of RuBi-GABA, affected interictal activity or baseline electrical activity in n

11 Neither T2 changes nor interictal activity predicted epileptogenesis.

12 , synchronized bursts (< 500 ms in duration, interictal activity) were seen as described previously.

13 In whole-slice recordings prominent interictal activity, but fewer ictal events were observe

14 genesis and defining the predictive roles of interictal activity, MRI, and inflammatory processes are

15 blood flow changes that are associated with interictal activity.

16 the fraction of neurons that participate in interictal activity.

17 ctal studies) and surgical outcome (4.4% for interictal and 0.0% for postictal studies).

18 relative to diagnostic evaluation (7.4% for interictal and 1.5% for postictal studies) and surgical

19 We conclude that the interictal and early preictal states are dominated by GA

20 These findings indicate that interictal and ictal activity can originate in the same

21 that GABA-mediated signalling contributes to interictal and ictal activity.

22 gone video-EEG monitoring, brain MR imaging, interictal and ictal brain perfusion SPECT, SISCOM, and

23 vitro isolated guinea pig brain during focal interictal and ictal discharges induced in the limbic ne

24 Interictal and ictal discharges represent two different

25 eizures, which included clinical evaluation, interictal and ictal EEG and high-resolution MRI.

26 Interictal and ictal EEG/fMRI can provide helpful inform

27 togenetic specimens, where the occurrence of interictal and ictal epileptiform activity was confirmed

28 hological EEG slowing over both hemispheres, interictal and ictal epileptiform EEG abnormalities limi

29 ings, we examined the cellular correlates of interictal and ictal HFO events.

30 Interictal and ictal scalp electroencephalographic (EEG)

31 ructures stresses the difference between the interictal and ictal states in patients with complex par

32 with unpaired Student's t tests and between interictal and postictal epochs within epileptic patient

33 Ten epileptic men completed both interictal and postictal epochs.

34 Interictal and postictal psychoses, affective disorders,

35 This study evaluates the interictal and postictal secretion of luteinizing hormon

36 been encouraged to perform ictal scanning or interictal and postictal SPECT studies.

37 Data were provided to participants as 10-min interictal and preictal clips, with approximately half o

38 networks involved in the generation of both interictal and PSs in acute models of limbic cortex icto

39 more effective than routine EEG at detecting interictal and subclinical epileptiform activity.

40 This indicates that interictal- and ictal-like discharges share a common pat

41 ilepsy (TLE), there is evidence of ictal and interictal autonomic dysregulation, predominantly with s

42 To determine whether the interictal AV conduction blocks were of cardiac or neura

43 lobe epilepsy during two 24-hour epochs: an interictal baseline and a postictal interval initiated b

44 Interictal baseline epochs were compared to those of hea

45 In two monogenic models of absence epilepsy, interictal beta/gamma power is augmented in homozygous s

46 in dynamics of patients with epilepsy during interictal (between-seizures) activity.

47 ified as a volume-of-distribution (VD), with interictal binding and with binding changes in 14 health

48 ilepsy, to compare the patterns of ictal and interictal blood flow in these patients and to compare t

49 provide a quantitative novel description of interictal brain activity of patients with epilepsy.

50 Interictal brain energy metabolism and glutamate-glutami

51 proved by the inclusion of individual IS and interictal brain SPECT (ITS)-MRI image registration as w

52 In Lis1+/- hippocampus, intense interictal bursting was observed on elevation of extrace

53 ts of neurons during burst generation, while interictal bursts appear to be stochastic events with ce

54 In contrast, neuronal firing order during interictal bursts appeared homogeneous, with no particul

55 at rhythmic population discharges resembling interictal bursts can be induced in hippocampal slices f

56 model (in both sexes) that the frequency of interictal bursts increased after CBZ perfusion.

57 polarizing potentials (GDPs) and spontaneous interictal bursts recorded in bicuculline, a GABA(A) rec

58 the period of post-ictal suppression, during interictal bursts, and also at other times, through more

59 tors shortened the preictal phase, abolished interictal bursts, and attenuated the slow preictal depo

60 ates periodic population discharges known as interictal bursts.

61 ler again in the reduced model incorporating interictal but not ictal measures (R(2) 0.27; Area under

62 cna1-null mice display potentially malignant interictal cardiac abnormalities, including a fivefold i

63 Interictal cerebral blood flow studies, however, using e

64 oreover, we found that, regardless of age or interictal clinical status, all affected subjects had ob

65 meet seizure criteria, also termed the ictal interictal continuum, are pervasive on electroencephalog

66 l biomarkers that might provide insight into interictal cortical function have been described.

67 a median baseline firing rate estimated from interictal discharge-free periods (Kruskal-Wallis one-wa

68 The different patterns of interictal discharge-modulated firing were classified in

69 sly in extracellular field potentials during interictal discharges (IIDs) and also during pharmacolog

70 h-frequency activity was present both during interictal discharges and seizure onset.

71 l disorders are more common among women with interictal discharges as well as women with abnormal hor

72 g rates of individual neurons changed during interictal discharges by determining whether the firing

73 re (VHC), with low frequencies that simulate interictal discharges has shown promising results, with

74 als and single-unit action potentials during interictal discharges in patients with medically intract

75 vity, but depending on the form of epilepsy, interictal discharges may or may not be correlated with

76 Spontaneously occurring interictal discharges occur in human tissue in vitro, re

77 ileptogenic zone than the presence of either interictal discharges or ripples (100-250 Hz).

78 Analysis of these interictal discharges typically manifests as spike-wave

79 Interictal discharges were mapped using both EEG-fMRI he

80 pike wave in epilepsy patients with frequent interictal discharges.

81 These data reveal interictal dysfunctional dynamics within pain pathways i

82 e seizures, neuroimaging findings, ictal and interictal ECoG measures were preoperatively obtained.

83 ts had frontotemporal as well as generalized interictal EEG abnormalities.

84 uster patterns derived from the seizure-free interictal EEG data are higher in epileptogenic zones as

85 dels of absence epilepsy have shown that the interictal EEG displays augmented beta/gamma power in ho

86 of aberrant phase-amplitude coupling in the interictal EEG of both stg/stg and tg/tg mice, compared

87 nts at the site of injection which resembled interictal EEG spikes and rapidly propagated to adjacent

88 To further evaluate the interictal EEG, we quantified phase-amplitude coupling (

89 e reported; and (c) patients had at least an interictal EEG-documented epileptiform abnormality.

90 ant BOLD changes in the area of resection on interictal EEG-fMRI in patients with TLE retrospectively

91 Interictal electroencephalogram (EEG) was normal in all

92 n, family neuropsychiatric history, abnormal interictal electroencephalographic activity, and encepha

93 ; confidence interval = 1.5-6.3; P = 0.003), interictal electroencephalography abnormalities in the f

94 he potential for temporal lobectomy based on interictal electroencephalography and minimally invasive

95 onsequently, Lis1+/- hippocampi are prone to interictal electrographic seizure activity in an elevate

96 We propose that interictal energetic deficiency in the epileptogenic hip

97 t in P20-22 or P17-18 mSMEI, indicating that interictal epileptic activity correlates with seizure su

98 Level Dependent (BOLD) signal correlates of interictal epileptic discharges (IEDs) in 63 consecutive

99 volvement of the hippocampus is suggested by interictal epileptic discharges, increased expression of

100 In partial epilepsies, interictal epileptic spikes (IESs) and fast ripples (FRs

101 It reduced interictal epileptic spikes in vivo and drug-induced epi

102 We evaluated if interictal epileptifom activity and/or elevation of hipp

103 in a significant proportion of rats, and to interictal epileptifom EEG abnormalities in most others,

104 01) localization of seizure onset, bilateral interictal epileptiform activity (p = 0.017), secondary

105 depolarizations resembling those typical of interictal epileptiform activity and proposed that there

106 rtex over the band heterotopia in generating interictal epileptiform activity and seizures in brains

107 The avalanches collected during interictal epileptiform activity had not only a stereoty

108 side the seizure onset zone, suggesting that interictal epileptiform activity in patients with epilep

109 the typical 2-3-hour MEG recording session, interictal epileptiform activity was observed in 16 of 2

110 severe disorders characterized by seizures, interictal epileptiform activity with a disorganized ele

111 deep non-rapid-eye-movement sleep, increase interictal epileptiform activity.

112 n and larger avalanches, particularly during interictal epileptiform activity.

113 2DG (10mM) reduced interictal epileptiform bursts induced by 7.5mM [K(+)](o

114 alohippocampectomy (ATL), but the utility of interictal epileptiform discharge (IED) identification a

115 In two patients, local interictal epileptiform discharge frequencies correlated

116 lize with the seizure onset zone and surface interictal epileptiform discharges (IED).

117 Interictal epileptiform discharges (IEDs) identify epile

118 ronous population activity characteristic of interictal epileptiform discharges (IEDs) to more prolon

119 Interictal epileptiform discharges (IEDs) were identifie

120 h localization-related epilepsy and frequent interictal epileptiform discharges (spikes or spike wave

121 e temporal relationship to the occurrence of interictal epileptiform discharges and may vary in relat

122 -frequency stimulation of the fornix reduces interictal epileptiform discharges and seizures in patie

123 ation have long been recognized to influence interictal epileptiform discharges and seizures.

124 FOs were commonly associated with widespread interictal epileptiform discharges but not with locally

125 n age 33 years, 6 males) with known frequent interictal epileptiform discharges had an [(18)F]GE-179

126 hip between cortisol levels and incidence of interictal epileptiform discharges in people with stress

127 These results suggest that: (i) interictal epileptiform discharges may originate from a

128 Univariate analysis showed that localized interictal epileptiform discharges on scalp EEGs were as

129 Interictal epileptiform discharges were determined in th

130 In addition, interictal epileptiform discharges were recorded in 15 (

131 In these patients, interictal epileptiform discharges, also termed spikes,

132 the generators of scalp EEG events, such as interictal epileptiform discharges, using a biological m

133 hese large-scale events were associated with interictal epileptiform discharges.

134 Hbr), and light scatter (LS) associated with interictal epileptiform events with multiwavelength opti

135 ol, application of DC magnetic fields alters interictal epileptiform spike activity in five of ten pa

136 the temperature dependence and frequency of interictal epileptiform spike activity.

137 ocessing, local field potential dynamics and interictal epileptiform spike generation.

138 Interictal epileptiform spike rate correlated with spect

139 images there was a significant reduction in interictal epileptiform spike rate in the amygdala, hipp

140 on, which predicted significant reduction in interictal epileptiform spike rate.

141 mperature and age dependence of seizures and interictal epileptiform spike-and-wave activity in mSMEI

142 We conclude that interictal epileptiform spikes are modulated by the patt

143 frequency synchronization 200 ms before the interictal epileptiform spikes that arose during this pe

144 Interictal epileptiform spikes were manually marked and

145 at might result from decreased influences of interictal epileptogenic discharges on brain areas invol

146 izure initiation resembles the initiation of interictal events, and seizure propagation respects the

147 prolonged seizures (ictal events) and brief interictal events.

148 Interictal fast ripples proved a significantly more reli

149 ng to the occipital lobe (clinical symptoms, interictal focus, ictal onset, or a lesion on magnetic r

150 Brain development and interictal function are unaffected in many paroxysmal ne

151 somatic pain transmission, shows evidence of interictal functional and structural abnormalities in mi

152 ed disorganised, slow background (n=10), and interictal generalised 2.5-3.0 Hz spike and slow waves (

153 l cortex (metabolic "border zones") based on interictal glucose PET.

154 In the chronic epileptic state, interictal granule cell hyperinhibition extended to the

155 Interictal HFOs were recorded from hippocampal microelec

156 Interictal high frequency oscillations (HFOs), in partic

157 ocessing in migraine, variously described by interictal hyperexcitability, heightened responsiveness,

158 Although interictal hypoperfusion and ictal hyperperfusion are es

159 dicted subjects is similar to the pattern of interictal hypoperfusion and ictal hyperperfusion that h

160 We found that (a) interictal hypoperfusion was easier to demonstrate by SP

161 correlation for the computer-simulated ictal/interictal images and the patient ictal/interictal studi

162 s respond promptly to treatment, whereas the interictal impairments generally persist.

163 wo findings have been shown consistently: an interictal increasing lack of habituation of evoked pote

164 Here, we report on interictal levels of glutamate, glutamine, and GABA in e

165 ntal models of temporal lobe epilepsy (TLE), interictal-like activity (ILA) precedes SZ1 by several d

166 Interictal-like activity induced by incubation of hippoc

167 , and laminar profile of bicuculline-induced interictal-like activity on neocortical slices were anal

168 However, in marked contrast to interictal-like activity, blockade of synaptic transmiss

169 As with interictal-like activity, the first sign of an impending

170 Extracellular cesium causes synchronous, interictal-like bursting and prevents maintenance of lon

171 diated input to CA1 pyramidal neurons during interictal-like bursts.

172 in slices of piriform cortex indicated that interictal-like discharges are generated in a two-stage

173 Furthermore, we report that most interictal-like discharges originating in the overlying

174 As found previously with interictal-like discharges, local application of kynuren

175 pia does not constitute a primary origin for interictal-like epileptiform activity in vitro and is di

176 TTX blocked both ictal- and interictal-like epileptiform activity without affecting

177 saline result mainly in neuronal ictal- and interictal-like epileptiform activity, respectively.

178 t prevent the generation of either ictal- or interictal-like events.

179 he epileptic dentate gyrus display recurrent interictal-like network events with a high diversity in

180 Thus, these interictal-like recurrent macroscopic events are not nec

181 educed ictal activity was also observed when interictal-like responses were evoked by afferent stimul

182 ovides insights into the interpretation of 2 interictal markers observed in intracerebral electroence

183 he reduced model incorporating ictal but not interictal measures (R(2) 0.40; Area under the ROC curve

184 egression model incorporating both ictal and interictal measures [R(2) 0.44; Area under the receiver

185 episodes, many patients describe significant interictal memory difficulties.

186 d indicates that characteristic varieties of interictal memory disturbance co-occur with this form of

187 It is associated with novel forms of interictal memory disturbance: accelerated long-term for

188 er work is required to establish whether the interictal memory impairment is due to physiological or

189 nance imaging in male and female age-matched interictal (migraine free) migraineurs and matched healt

190 attacks of cerebellar ataxia and continuous interictal myokymia.

191 hich epileptic seizures trigger compensatory interictal network inhibition or GABA-mediated neurotrop

192 tive and motor milestones, neuroimaging, and interictal neurological status.

193 al correlates of human epilepsy, we recorded interictal neuronal activity from mesial temporal lobe (

194 dings in 4 families with episodic ataxia and interictal nystagmus (EA-2) linked to chromosome 19p.

195 have drawn no definite conclusions on either interictal or ictal changes in migraineurs compared with

196 hen administered to rats in vivo and induces interictal or ictal patterns of epileptiform activity in

197 severity does not provide information about interictal or sub-clinical epileptiform activity.

198 uromatrix during acute PH attacks and during interictal pain-free states off indomethacin that is dea

199 requent subtle differences between ictal and interictal patterns.

200 A total of 36 subtraction ictal and interictal perfusion studies were analysed in 31 consecu

201 nvestigate state specific (i.e. ictal versus interictal) perfusional limbic networks in patients with

202 ileptic gerbils were disinhibited during the interictal period, IPSPs were recorded in vivo with hipp

203 us of 38 awake epileptic patients during the interictal period.

204 s the epileptogenic focus, both in peri- and interictal period.

205 on of the epileptogenic temporal lobe in the interictal period.

206 esynchronous events, both in comparison with interictal periods preceding the seizure without bursts

207 ant saturation effects are detectable during interictal periods with the PC-SIRS approach in patients

208 for normal function of these networks during interictal periods, a possibility that is eliminated by

209 d microdialysis samples were obtained during interictal periods.

210 th the presence of fear, laughter, or severe interictal personality changes) and an atypical group (4

211 ECT coregistered to MR imaging (SISCOM), and interictal PET with (18)F-FDG.

212 thalamocortical networks of patients in the interictal phase of migraine.

213 thalamocortical networks of patients in the interictal phase of migraine.

214 Interictal population spikes recorded from principal neu

215 to derive the sensitivity and specificity of interictal, postictal or ictal rCBF patterns to identify

216 in seizure generation, and whether discrete interictal, preictal, ictal and post-ictal physiologies

217 tely half of the 60 GB data bundle labelled (interictal/preictal) for algorithm training and half unl

218 gorithms and uploaded their classifications (interictal/preictal) for the unknown testing data, and a

219 This study examined the effects of ECT on interictal quantitative electroencephalograms (EEGs), co

220 aphy-electrocardiography revealed suppressed interictal resting heart-rate variability and episodes o

221 ionally, the pacemaker mechanisms underlying interictal rhythmicity remain conjectural.

222 elations with surgical outcome: detection of interictal ripples (Rs), fast ripples (FRs), and VHFOs;

223 Interictal scalp EEG was localizing in 28 patients (53%)

224 We used simultaneous interictal scalp EEG-fMRI to evaluate its value for pred

225 need to be considered in comparison with an interictal scan and an MRI.

226 y, or postictal scanning in combination with interictal scanning.

227 The identification of decreased interictal single neuronal burst discharge in epileptoge

228 nt positron emission tomography (PET; n=25), interictal single photon emission computed tomography (S

229 Subtraction ictal and interictal single photon emission computed tomography ca

230 Interictal slow activity was more frequently absent in c

231 -electroencephalographically (EEG) monitored interictal SPECT (IISPECT) and hyperperfusion in immedia

232 localization capabilities in a comparison of interictal SPECT and PET (correct localization, P=.999;

233 Ictal versus baseline interictal SPECT difference analysis was performed using

234 tracting ictal (or immediate postictal) from interictal SPECT for 53 patients with refractory epileps

235 he cerebral blood flow pattern and (c) ictal/interictal SPECT images from 15 patients with partial ep

236 he identification of epileptogenic foci than interictal SPECT or scalp EEG in patients without focal

237 hms provide significant improvement in ictal/interictal SPECT registration accuracy and result in a c

238 one or more ictal SPECT scans as well as an interictal SPECT scan.

239 By comparison, four of the interictal SPECT studies showed regional hypoperfusion t

240 Ictal and interictal SPECT studies were performed in 10 patients (

241 T was localizing in 32 of 45 patients (71%), interictal SPECT was localizing in 26 patients (49%) and

242 Technetium-99m-HMPAO interictal SPECT was performed on three pediatric patien

243 Interictal SPECT with 6-8-mm full-width at half-maximum

244 33 cases), and 43% (10 of 23 cases) in PET, interictal SPECT, and postictal SPECT, respectively.

245 ctroencephalography (EEG), brain MR imaging, interictal SPECT, ictal SPECT, subtraction ictal SPECT c

246 nd toward higher incorrect localization with interictal SPECT.

247 ions of diverse etiologies whose EEGs showed interictal spike activity or rhythmic activity at seizur

248 Interictal spike activity was seen at normal body temper

249 Most P20-22 mSMEI had interictal spike activity with elevated body temperature

250 al in epilepsy surgery, we evaluated whether interictal spike frequency measures obtained from extrao

251 Seizure onset zone and interictal spike frequency measures on subdural ECoG rec

252 Yet, the additive clinical impact of interictal spike frequency measures to predict long-term

253 eptiform activity in these structures is the interictal spike, a synchronized burst of action potenti

254 mplete removal of seizure onset zone, higher interictal spike-frequency in the preserved cortex and i

255 nized, large amplitude potentials resembling interictal spikes (IIS) in epilepsy at just 5 weeks of a

256 Interictal spikes (IISs) were induced with iontophoresis

257 e pathways of propagation between sequential interictal spikes (IISs).

258 limbic SLE that PS events are different from interictal spikes and are sustained by synchronous activ

259 suggesting that not only seizures, but also interictal spikes can have negative consequences.

260 ional at baseline, and support the idea that interictal spikes disrupt cognitive processes related to

261 By contrast, frequent interictal spikes during non-rapid eye movement sleep pr

262 positively correlated with the frequency of interictal spikes during the last hour of wakefulness pr

263 Interictal spikes in models of focal seizures and epilep

264 In animal studies, both seizures and interictal spikes induce synaptic potentiation.

265 hese findings suggest that both seizures and interictal spikes may induce long-lasting changes in the

266 ed animals displayed both ictal activity and interictal spikes on EEG analysis, whereas MK-801-piloca

267 ging scanning) and one to the temporal lobe (interictal spikes or seizure onset).

268 inding was the observation that AA broadened interictal spikes recorded in the elevated [K+]o model o

269 ike events (SLEs), but did generate periodic interictal spikes sensitive to the glutamatergic non-NMD

270 duration of the spike and wave components of interictal spikes were analyzed.

271 Two types of interictal spikes were distinguished: type 1, with a spi

272 On scalp EEG, interictal spikes were localized to the temporal lobe in

273 Concomitantly, hippocampal interictal spikes, aberrant oscillations, and neuronal h

274 zure-free outcome included location of scalp interictal spikes, degree of seizure-onset laterality, p

275 examine patterns of seizures and spontaneous interictal spikes, their relationship to each other, and

276 d termination locations, and localization of interictal spikes.

277 euronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased s

278 acute seizures with subsequent reduction in interictal spiking.

279 amine Oxime (Tc-99 m HMPAO) during ictal and interictal state confirmed by video-electroencephalograp

280 poral region and remaining cortex during the interictal state, followed by a surge of cross-correlate

281 ctal/interictal images and the patient ictal/interictal studies (P < 0.05).

282 Interictal studies alone are not reliable.

283 Three interictal studies revealed no abnormal perfusion.

284 Ictal and interictal studies were coregistered with patients' MRI

285 ns using automated software, and ictal minus interictal subtraction images were obtained.

286 neural network, and that the transition from interictal to ictal-like-sustained activity is preceded

287 Interictal very fast ripples (VFRs; 500-1,000Hz) were de

288 with drug-resistant epilepsy and to focus on interictal very high-frequency oscillations (VHFOs) betw

289 We hypothesized that interictal VHFOs are more specific biomarkers for epilep

290 INTERPRETATION: Interictal VHFOs are relatively frequent abnormal phenom