ライフサイエンスコーパス: interleukin-12

1 or necrosis factor alpha, interleukin-6, and interleukin-12).

2 or necrosis factor alpha, interleukin 6, and interleukin 12.

3 itric oxide, tumor necrosis factor alpha, or interleukin-12.

4 naling of proinflammatory cytokines, such as interleukin-12.

5 TRIF, and induction of interferon-gamma and interleukin-12.

6 pha, monocyte chemoattractant protein-1, and interleukin-12.

7 helminth antigens generally fail to produce interleukin-12.

8 en naive CD8+ T cells are stimulated without interleukin-12.

9 ivated in vitro with mouse thyroglobulin and interleukin-12.

10 ired gamma interferon but was independent of interleukin-12.

11 ctivated dendritic cells producing IFN-I and interleukin-12.

12 rculating IFN-gamma or the IFN-gamma inducer interleukin-12.

13 anulocyte colony-stimulating factor (G-CSF), interleukin-12/23 (IL-12/23), and IL-13 trended signific

14 nderwent randomization to treatment with the interleukin-12/23 monoclonal antibody (one 45-mg dose, o

15 occurred in 79% of patients treated with the interleukin-12/23 monoclonal antibody as compared with 7

16 bo crossed over to receive one 90-mg dose of interleukin-12/23 monoclonal antibody at week 20.

17 demonstrates the therapeutic efficacy of an interleukin-12/23 monoclonal antibody in psoriasis and p

18 evaluated the safety and efficacy of a human interleukin-12/23 monoclonal antibody in treating psoria

19 Patients assigned to the interleukin-12/23 monoclonal antibody received one addit

20 in 52% of patients who received 45 mg of the interleukin-12/23 monoclonal antibody, in 59% of those w

21 d provides further evidence of a role of the interleukin-12/23 p40 cytokines in the pathophysiology o

22 noclonal antibody against the p40 subunit of interleukin-12/23.

23 on dendritic cells; increased production of interleukin-12/23p40 (IL-12/23p40), gamma interferon (IF

24 erbated production of dendritic-cell-derived interleukin-12/23p40 and tumour necrosis factor-alpha, i

25 ic signs of colon inflammation, secretion of interleukin-12/23p40 in colonic explant cultures, serolo

26 We demonstrate that interleukin-12, a heterodimeric pro-inflammatory cytokin

27 Herein, we showed interleukin-12 acting via the transcription factor STAT4

28 g a recombinant adenovirus vector expressing interleukin-12 (Ad5IL-12) to target natural killer (NK)

29 d gene 3 (Ebi3, which encodes IL-27beta) and interleukin-12 alpha (Il12a, which encodes IL-12alpha/p3

30 timulate immature dendritic cells to secrete interleukin 12 and induce IFN-gamma in peripheral blood

31 Human interleukin 12 and interleukin 23 (IL12/23) influence su

32 like receptor (TLR) stimulation resulting in interleukin 12 and other inflammatory cytokine expressio

33 n, NK cells are activated by cytokines (e.g. interleukin 12 and type I interferons), which are produc

34 lated with an increase in H. pylori-specific interleukin-12 and both immunoglobulin G1 (IgG1) and IgG

35 ficient mice, upregulating the expression of interleukin-12 and costimulatory molecules on those cell

36 els of inflammation) by high availability of interleukin-12 and IFN-gamma, ultimately leading to comp

37 ogether with the IFN-gamma-inducing cytokine interleukin-12 and IFN-gamma-inducible chemokines such a

38 ceptor (TCR) signaling and cytokines such as interleukin-12 and interferon gamma (IFN-gamma).

39 of the ability of dendritic cells to induce interleukin-12 and interferon-beta in the context of bot

40 l inflammatory disease can occur with excess interleukin-12 and interferon-gamma production alone and

41 cruitment to the joint, orchestrated through interleukin-12 and interferon-gamma.

42 ditional pro-inflammatory cytokines, such as interleukin-12 and interferon-gamma.

43 roinflammatory cytokine induction (including interleukin-12 and interleukin-18), but was bereft of in

44 interferon gamma by NK cells in response to interleukin-12 and interleukin-18, providing a mechanist

45 , they are less responsive to stimulation by interleukin-12 and interleukin-18.

46 Interleukin-12 and interleukin-23 are inflammatory cytok

47 ompared two biologic agents, ustekinumab (an interleukin-12 and interleukin-23 blocker) and etanercep

48 oted Toll-like receptor-induced secretion of interleukin-12 and interleukin-23 by DCs in an autocrine

49 Cytokines interleukin-12 and interleukin-23 have been implicated i

50 nterleukin-23 signaling, and ustekinumab, an interleukin-12 and interleukin-23 inhibitor, in patients

51 kinumab, a human monoclonal antibody against interleukin-12 and interleukin-23, is unknown.

52 a monoclonal antibody to the p40 subunit of interleukin-12 and interleukin-23, was evaluated as an i

53 ed from MS patients produce higher levels of interleukin-12 and interleukin-6, whereas pDCs account f

54 lysis of the immunostimulatory properties of interleukin-12 and its derivatives surprisingly revealed

55 0 macrophages showed increased production of interleukin-12 and nitric oxide but reduced interleukin-

56 ng motion, podosome formation, production of interleukin-12 and other cytokines, and presentation of

57 e receptor-mediated stimulation by producing interleukin-12 and process and present antigen.

58 of key proinflammatory cytokines, including interleukin-12 and the chemokine MCP-1, both known to co

59 binds the p40 subunit of interleukin-23 and interleukin-12 and thereby blocks the activity of these

60 s in part through differential regulation of interleukin-12 and transforming growth factor beta produ

61 mpanied by elevated production of DC-derived interleukin-12 and tumor necrosis factor-alpha.

62 Interleukins 12 and 23 have important roles in the patho

63 Findings suggest that interleukins 12 and 23 might affect clinical symptoms an

64 noclonal antibody against the p40 subunit of interleukins 12 and 23, ustekinumab, were used to treat

65 ytokines such as type I interferons (IFN-I), interleukin 12, and gamma interferon.

66 Nod1 stimulation did not induce TNFalpha, interleukin 12, and interferon gamma, suggesting that th

67 or necrosis factor alpha, interleukin 1beta, interleukin 12, and interleukin 17; the chemokines CCL2,

68 oinflammatory cytokines, including IFNgamma, interleukin 12, and interleukin 2 in plasma of Pip4k2c(-

69 mma when stimulated with IL-18 combined with interleukin 12, and the latter was expressed in vivo dur

70 ction showed higher levels of interleukin-4, interleukin-12, and eotaxin mRNA expression, whereas sig

71 nificantly higher T-helper (Th) 1 cytokines, interleukin-12, and interferon-gamma.

72 ne pathway, and the cytokines interleukin-7, interleukin-12, and interleukin-15 indicate that these s

73 1)34.5 viruses, M002, which expresses murine interleukin-12, and its parent virus, R3659, were serial

74 g TLR4 expression and intensifies TNF-alpha, interleukin-12, and matrix metalloproteinase-9 productio

75 otein-1-gamma, B-lymphocyte chemoattractant, interleukin-12, and subsequent circulation helper T cell

76 f tumor necrosis factor alpha (TNFalpha) and interleukin-12, and up-regulation of vascular endothelia

77 Silencing Foxo1 ablated interleukin-12- and rapamycin-enhanced CD8(+) T cell mem

78 These mice were treated with either anti-interleukin-12 (anti-IL-12)/23p40 antibody or murine TNF

79 ses of CTLA-4(+/+)Tc0 CTL, generated without interleukin-12, are hypoproliferative within the cardiac

80 teritidis) infection covering 15 years in an interleukin-12 beta1 receptor-deficient individual that

81 y-promoting cytokine secretion, particularly interleukin-12, both of which were independently trigger

82 d elevated secretion of gamma interferon and interleukin-12, but no interleukin-4, suggesting an indu

83 d production of the STAT1-dependent cytokine interleukin-12 by dendritic cells and increased parasite

84 e production of the proinflammatory cytokine interleukin-12 by dendritic cells in response to invadin

85 cytes from OVA-sensitized mice secreted more interleukin-12 compared with gal3(+/+) splenocytes.

86 rgeting CTLA-4 solely or in conjunction with interleukin-12 could influence effector CD8+ T cell resp

87 tion was associated with increased levels of interleukin-12, decreased levels of CCL4, increased chem

88 s examining the integrated role of dll4 with interleukin-12 demonstrated that, together, both of thes

89 agic pathogens, probably because of impaired interleukin 12-dependent interferon gamma production.

90 restored the efficacy of PD-1 blockade in an interleukin-12-dependent manner by increasing the recrui

91 ession, thereby showing the importance of an Interleukin-12-dependent, Interferon-gamma-independent s

92 acid-sensing TLR3, TLR7 and TLR9 in inducing interleukin 12, development of a TH1 response, and resis

93 Crohn's disease inflammation is caused by an interleukin-12-driven Th1 response, which resulted in th

94 ent activation/maturation with high CD86 and interleukin-12 expression.

95 is armed with an immunomodulatory cytokine, interleukin 12 (G47-mIL12).

96 henotype as indicated by increased levels of interleukin-12, gamma interferon, and inducible nitric o

97 ociated secretory phenotypes (interleukin-8, interleukin-12, GRO, and MDC).

98 d to synthesize the c-Rel-dependent cytokine interleukin-12, had impaired up-regulation of costimulat

99 ed significantly higher expression levels of interleukin 12, IFN-gamma, and chemokines (IP-10/CXCL-10

100 Levels of Th1 cytokines, including interleukin 12, IFN-gamma, TNFalpha, and the Th1-associa

101 ory M1-phenotype with enhanced expression of interleukin-12, IFNgamma, and SDF-1alpha and increased N

102 n led to a rapid increase in serum levels of interleukin 12 (IL-12) and gamma interferon (IFN-gamma).

103 t most returned to baseline by 28 dpi except interleukin 12 (IL-12) and gamma interferon.

104 of apoptosis and/or increased production of interleukin 12 (IL-12) and granulocyte-macrophage colony

105 Cytokines such as interleukin 12 (IL-12) and IL-18 are critical regulators

106 Interleukin 12 (IL-12) and IL-18 regulated this conversi

107 The proinflammatory cytokines interleukin 12 (IL-12) and IL-23 connect innate response

108 ndii stimulates production of high levels of interleukin 12 (IL-12) and interferon gamma (IFN-gamma)

109 ng BAFF or APRIL multitrimers, together with interleukin 12 (IL-12) and membrane-bound HIV-1 Env gp14

110 However, this subset did not produce interleukin 12 (IL-12) but upregulated CD103, which is e

111 The interleukin 12 (IL-12) DNA plasmid expresses human IL-12

112 ere we show that intravaginally administered interleukin 12 (IL-12) encapsulated in sustained-release

113 The interleukin 12 (IL-12) family is unique in having the on

114 Expression of interleukin 12 (IL-12) from NV1042 virus, a derivative o

115 ssion of the cellular hematopoietic cytokine interleukin 12 (IL-12) in HCMV-infected cells but not in

116 Interleukin 12 (IL-12) is a major inducer of interferon

117 Furthermore, IgA(-/-) mice displayed reduced interleukin 12 (IL-12) levels at early time points, and

118 s, blocking gamma interferon (IFN-gamma) and interleukin 12 (IL-12) p40 release but promoting IL-4, I

119 Whereas interleukin 12 (IL-12) produced by antigen-presenting ce

120 e activating DC stimulus and led to enhanced interleukin 12 (IL-12) production and T-cell responses o

121 eviously found that treatment with exogenous interleukin 12 (IL-12) protects against F. tularensis in

122 A potential mechanism is the reduction of interleukin 12 (IL-12) secretion during acute measles, r

123 ia enhanced gamma interferon (IFN-gamma) and interleukin 12 (IL-12) secretion; however, the mechanism

124 gamma interferon (IFN-gamma), and an innate interleukin 12 (IL-12) signal from infected MPhi.

125 mice produced significantly more TNF-alpha, interleukin 12 (IL-12), and IL-18 in response to P. cari

126 nes tumor necrosis factor alpha (TNF-alpha), interleukin 12 (IL-12), and interferon gamma (IFN-gamma)

127 nterleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor alpha

128 by significant gamma interferon (IFN-gamma), interleukin 12 (IL-12), IL-2, IL-10, and IL-17 productio

129 The receptors for interleukin 12 (IL-12), IL-4 and IL-6 are required for d

130 Although serum levels of interleukin 12 (IL-12), IL-6, tumor necrosis factor alph

131 ection (postimmunization) is increased in an interleukin 12 (IL-12)-dependent manner.

132 mmatory cytokines and chemokines, especially interleukin 12 (IL-12).

133 trations of interferon gamma (IFN-gamma) and interleukin 12 (IL-12).

134 set of T-helper 2 immunity in the absence of interleukin 12 (IL-12).

135 berculosis, underlined the importance of the interleukin 12 (IL-12)/interferon gamma (IFN-gamma) circ

136 nization using recombinant CPAF (rCPAF) plus interleukin-12 (IL-12) (rCPAF+IL-12 immunization) was us

137 e, CEA] inhibit the secretion of the dimeric interleukin-12 (IL-12) alphabeta and beta2 forms with id

138 ive resistance was associated with increased interleukin-12 (IL-12) and decreased IL-10 pulmonary lev

139 arch were to characterize heparin binding to interleukin-12 (IL-12) and determine the mechanism(s) by

140 Sustained intratumoral delivery of interleukin-12 (IL-12) and granulocyte macrophage colony

141 IFN-gamma)-producing cells in the absence of interleukin-12 (IL-12) and IFN-gamma.

142 H. pylori induced interleukin-12 (IL-12) and IL-10 through TLR4/MyD88 sign

143 populations of uNK cells were activated with interleukin-12 (IL-12) and IL-15, and conditioned media

144 ceptor engagement but not following combined interleukin-12 (IL-12) and IL-18 stimulation.

145 Conversely, PI3Ks negatively regulated interleukin-12 (IL-12) and IL-18-induced IFN-gamma by mo

146 Interleukin-12 (IL-12) and IL-23 are heterodimeric cytok

147 enance of Th1 and Th17 cells, by stimulating interleukin-12 (IL-12) and IL-23 production, but inhibit

148 Tlr7(-/-) mice and macrophages had reduced interleukin-12 (IL-12) and IL-23 responses after WNV inf

149 The relative contributions of interleukin-12 (IL-12) and IL-23 to viral pathogenesis h

150 R or M51R-F vector induced the production of interleukin-12 (IL-12) and IL-6 and increased surface ex

151 aracterized by the significant production of interleukin-12 (IL-12) and IL-6.

152 We determined that interleukin-12 (IL-12) and interferon-gamma (IFN-gamma)

153 triggers then actively regulates host innate interleukin-12 (IL-12) and interferon-gamma (IFN-gamma)

154 hat brief stimulation of memory T cells with interleukin-12 (IL-12) and interleukin-18 (IL-18) result

155 activation by suppressing the production of interleukin-12 (IL-12) and nitric oxide.

156 cells from BR mice respond to the virus with interleukin-12 (IL-12) and those from PE mice with IL-10

157 production of the proinflammatory cytokines interleukin-12 (IL-12) and tumor necrosis factor alpha (

158 during primary F. tularensis infections, and interleukin-12 (IL-12) appears to be an essential coacti

159 inistration of inactivated LVS together with interleukin-12 (IL-12) as an adjuvant.

160 fection site tissues of normal mice produced interleukin-12 (IL-12) but not IL-10 and were characteri

161 Additionally, secretion of interleukin-12 (IL-12) by CD8alpha(+) DCs suggests a rol

162 udies have shown that mucosal application of interleukin-12 (IL-12) can stimulate elevated secretory

163 compound 37 that showed good TYK2 enzyme and interleukin-12 (IL-12) cell potency, as well as acceptab

164 pneumoniae respiratory disease severity with interleukin-12 (IL-12) concentration in respiratory secr

165 pneumoniae respiratory disease severity with interleukin-12 (IL-12) concentrations in respiratory sec

166 The interleukin-12 (IL-12) cytokine induces the differentiat

167 h multigenic SIV plasmid DNA with or without interleukin-12 (IL-12) DNA or IL-15 DNA.

168 Herein, we demonstrate that interleukin-12 (IL-12) enhanced and sustained antigen an

169 Interleukin-12 (IL-12) enhances Th1-type T-cell response

170 Interleukin-12 (IL-12) has emerged as one of the most po

171 pled to MyD88 and mediates the production of interleukin-12 (IL-12) in dendritic cells infected with

172 oma cell lines blocked the production of the interleukin-12 (IL-12) in human monocyte-derived dendrit

173 ttle is known about the role of the cytokine interleukin-12 (IL-12) in Pneumocystis pneumonia or its

174 Secretion of IFN-gamma is stimulated by interleukin-12 (IL-12) in the brain, as neutralization o

175 ly demonstrated that NK cells activated with interleukin-12 (IL-12) in the presence of immobilized Ig

176 Interleukin-12 (IL-12) is a pleiotropic cytokine that is

177 Interleukin-12 (IL-12) is a potent T(H)1 cytokine with r

178 Interleukin-12 (IL-12) is critical for resistance to Tox

179 tokine receptor-deficient mice, we show that interleukin-12 (IL-12) is indispensible for mouse cytome

180 ivation of the cells with either recombinant interleukin-12 (IL-12) or IL-18.

181 Interleukin-12 (IL-12) orchestrates acquired resistance

182 ion, GSH depletion and the downregulation of interleukin-12 (IL-12) p40 mRNA were correlated with the

183 expression levels of MHC class II and higher interleukin-12 (IL-12) p40 production upon rickettsial i

184 less activation and decreased production of interleukin-12 (IL-12) p40.

185 e production of the proinflammatory cytokine interleukin-12 (IL-12) p40.

186 cktail, elicited type I interferon (IFN) and interleukin-12 (IL-12) p70 production and the appearance

187 h)17 cytokines gamma interferon (IFN-gamma), interleukin-12 (IL-12) p70, tumor necrosis factor alpha

188 ng the ability of dendritic cells to produce interleukin-12 (IL-12) p70.

189 nts contingent upon T cell receptor (TCR) or interleukin-12 (IL-12) plus IL-18 signaling.

190 K cell activation was controlled by systemic interleukin-12 (IL-12) produced by Batf3-dependent dendr

191 ined, we have previously shown that systemic interleukin-12 (IL-12) production is suppressed during c

192 s to intracellular pathogens in part through interleukin-12 (IL-12) production, although the relative

193 Since CD40 signaling contributes to interleukin-12 (IL-12) production, we examined IL-12 fro

194 nocytes were the primary cellular sources of interleukin-12 (IL-12) production.

195 ust splenic gamma interferon (IFN-gamma) and interleukin-12 (IL-12) recall responses with negligible

196 ever, inborn errors in STAT4, which controls interleukin-12 (IL-12) responses, have not yet been repo

197 ge colony-stimulating factor (GM-CSF) but no interleukin-12 (IL-12) responses.

198 1-beta/CCL4, MIG/CXCL9, and severe defect of interleukin-12 (IL-12) secretion.

199 major parasites prime human DC for efficient interleukin-12 (IL-12) secretion.

200 Specifically, we found that interleukin-12 (IL-12) signaling shortly after immunizat

201 ed to cross-prime CD8(+) T cells and produce interleukin-12 (IL-12) that promotes cytotoxicity.

202 The ability of exogenous interleukin-12 (IL-12) to elicit protective innate immun

203 Upon CPAF-plus-interleukin-12 (IL-12) vaccination, HLA-DR4 tg animals e

204 The cytokine interleukin-12 (IL-12) was thought to have a central rol

205 ted a significant and chronic suppression of interleukin-12 (IL-12), a key host defense cytokine.

206 Analysis of the production of interleukin-12 (IL-12), alpha interferon (IFN-alpha), an

207 had YAHL and measured interleukin-2 (IL-2), interleukin-12 (IL-12), and interferon-gamma (IFN-gamma)

208 tumor necrosis factor alpha (TNF-alpha) and interleukin-12 (IL-12), and promotes systemic colonizati

209 Antibody-based neutralization of interleukin-12 (IL-12), but not IL-10, produced by M1 ma

210 oduction of gamma interferon (IFN-gamma) and interleukin-12 (IL-12), followed by a protective T cell

211 ficient animals, which are unable to produce interleukin-12 (IL-12), have a serious defect in expansi

212 interferon (IFN-gamma)-inducible protein 10, interleukin-12 (IL-12), IFN-gamma, and IL-6.

213 This study explored the role of interleukin-12 (IL-12), IL-23, and the regulatory cytoki

214 different components of the pathway such as interleukin-12 (IL-12), IL-23, IL-17A, and IL-17RA have

215 ed significantly greater dendritic cell (DC) interleukin-12 (IL-12), IL-27, and IL-10 immunity than M

216 , CD80, and CD86 as well as the secretion of interleukin-12 (IL-12), IL-6, and type I IFN.

217 and other proinflammatory cytokines, such as interleukin-12 (IL-12), interferon gamma (IFN-gamma), an

218 here they induce inflammatory DCs to produce interleukin-12 (IL-12), thereby promoting type 1 polariz

219 on (IFN-gamma) in an antigen-independent and interleukin-12 (IL-12)- and IL-18-dependent manner withi

220 Experiments in interleukin-12 (IL-12)-/- and IL-4-/- mice, in which pol

221 porated recombinant DNA (rDNA) along with an interleukin-12 (IL-12)-expressing plasmid (EP rDNA plus

222 Stat1 activation in the host is required for interleukin-12 (IL-12)-mediated generation of CTL activi

223 c antigen through T-cell receptor (TCR)- and interleukin-12 (IL-12)-mediated signals.

224 ion 4 (Stat4) and T-bet are required for the interleukin-12 (IL-12)-stimulated development of T helpe

225 e phenotype when cultured in the presence of interleukin-12 (IL-12).

226 ts UVB-induced immunosuppression by inducing interleukin-12 (IL-12).

227 t expression of the proinflammatory cytokine interleukin-12 (IL-12).

228 ucing NK cells that had been stimulated with interleukin-12 (IL-12)/IL-15.

229 on on monocytes and its regulatory effect on interleukin-12 (IL-12)/IL-23 production by CD14(+) monoc

230 ated liposomal doxorubicin (20 mg/m(2)) plus interleukin-12 (IL-12; 300 ng/kg subcutaneously twice we

231 gamma(1)34.5-deleted HSV-1 expressing murine interleukin-12 (IL-12; M002) prolonged survival of immun

232 egulation of CD40 or secretion of cytokines (interleukin 12 [IL-12], IL-10, tumor necrosis factor alp

233 umor necrosis factor alpha [TNF-alpha]; Th1, interleukin-12 [IL-12] and gamma interferon [IFN-gamma];

234 es (tumor necrosis factor alpha [TNF-alpha], interleukin-12 [IL-12], gamma interferon [IFN-gamma], an

235 urface receptors, cytokines, and chemokines (interleukin-12 [IL-12], IL-2, IL-1alpha, IL-1beta, IL-6,

236 aneously proliferated ex vivo in a cytokine (interleukin-12 [IL-12]/IL-9/IL-15)-dependent manner, whi

237 ceptibility is heritable and linked to lower interleukin 12 (IL12) levels, which can also result from

238 ells and natural killer cells in response to interleukin 12 (IL12).

239 Interleukin-12 (IL12) is an important cytokine that link

240 3 and interleukin 4 and augmented levels of interleukin 12 in bronchoalveolar lavage fluid.

241 in T cells and found that it was induced by interleukin-12 in human and mouse T cells in a Stat4-dep

242 phocytes during viral infections and produce interleukin-12 in response to pathogens.

243 ild-type mice, as well as copious amounts of interleukin-12, indicating that Ym1-secreting p47(phox-/

244 As in the presence of a low concentration of interleukin-12 induced CD69 expression, interferon-gamma

245 also known as Cytip, CASP, and PSCDBP) is an interleukin-12-induced gene expressed exclusively in hem

246 nt selective elimination driven, in part, by interleukin-12-induced intrinsic expression of the Th1-c

247 STAT4 has a prominent role in mediating interleukin-12-induced T-helper cell type 1 lineage diff

248 her admission serum levels of interleukin-2, interleukin-12, interferon-gamma, and tumor necrosis fac

249 ient, while another had functional defect in interleukin-12/interferon-gamma axis.

250 nterleukin-6, interleukin-9, interleukin-10, interleukin-12, interleukin-13, tumor necrosis factor-al

251 factor-alpha, interleukin-6, interleukin-10, interleukin-12, interleukin-17) at day 1 and day 8.

252 plified the effects of lipopolysaccharide on interleukin-12, interleukin-23, and matrix metalloprotei

253 nterleukin-6, interleukin-8, interleukin-10, interleukin-12/interleukin-23p40, interleukin-13, interl

254 hen administered to Cryptosporidium-infected interleukin 12 knockout mice at 8-15 mg/kg/d for 1 week.

255 Interleukin 12-mediated polarization of CSF clones induc

256 w)CD56(dim) NK cells because of differential interleukin-12-mediated STAT4 phosphorylation.

257 ls of HLA-I with activated NKp30/MAPK/IL-12 (interleukin-12) or IL-2 (interleukin-2) pathway was susc

258 ded on interleukin-23 p19 secretion, whereas interleukin-12 p35 secretion controlled wasting disease

259 or and decreased levels of interferon gamma, interleukin 12 p40, interleukin 12 p70, and interleukin

260 ased levels of gamma interferon (IFN-gamma), interleukin-12 p40 (IL-12p40), and IL-2.

261 ct the events that lead to the production of interleukin-12 p40 (IL-12p40), which is required for res

262 factor-alpha and interferon-gamma as well as interleukin-12 p40 and interleukin-23 p40 secretion.

263 d production of the proinflammatory cytokine interleukin-12 p40 through GPR84.

264 r (EGF), vascular endothelial growth factor, interleukin-12 (p40/70), and regulated on activation, no

265 els of interferon gamma, interleukin 12 p40, interleukin 12 p70, and interleukin 10 compared with con

266 duction of proinflammatory cytokines such as interleukin-12 p70 in DCs, but did not alter levels of m

267 enhanced their production of type I IFN and interleukin-12 (p70), augmented their capacity to proces

268 kin 17 and cytokines in the interferon-gamma/interleukin 12 pathway.

269 hed for complement cascade genes and for the interleukin-12 pathway.

270 (EP) or codelivered with a plasmid encoding interleukin-12 (pIL-12).

271 -/-Tc12) OT-1 effectors, differentiated with interleukin-12 present, are hyperproliferative in vitro,

272 It enhances interleukin 12 production by macrophages, and several of

273 ount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polariza

274 ng in dendritic cells, which was crucial for interleukin 12 production through the phosphorylation of

275 d DC activation as demonstrated by decreased interleukin-12 production and attenuated expression of a

276 gondii profilin (TgPRF) and is required for interleukin-12 production and induction of immune respon

277 ubset is a prominent source of IFN-alpha and interleukin-12 production and should be further evaluate

278 e neoplastic lesions and increased levels of interleukin-12 production by the DC.

279 tigen-presenting cells, leading to increased interleukin-12 production in splenocytes.

280 d by high CD40 surface expression as well as interleukin-12 production, which are frequently seen in

281 We show here that interleukin-12 receptor beta1 (IL-12Rbeta1)-mediated sig

282 (PBMCs) and inflamed lungs, the majority of interleukin-12 receptor beta1 (IL12RB1) mRNAs contain a

283 High expression of tumor interleukin-12 receptor beta2 (IL-12Rbeta2) was associat

284 activate dendritic cells in vitro leading to interleukin-12 release.

285 ing effector cytokines, interferon-alpha and interleukin-12, respectively, in response to Toll-like r

286 t stimulatory cytokines interferon-alpha and interleukin-12, respectively.

287 receptor monoclonal antibody or recombinant interleukin 12 restored a robust anti-parasite TH1 respo

288 cient HLA-DQ8 transgenic mice with defective interleukin-12 signaling.

289 ctivated transcription of the genes encoding interleukin 12 subunit p40 (IL-12p40), IL-12p35 and IL-2

290 ion proteins based on antibody fragments and interleukin-12 subunit mutants.

291 roduced less tumor necrosis factor alpha and interleukin 12 than wild-type cells upon stimulation wit

292 has been shown to inhibit the production of interleukin-12, the cytokine that is pivotal in establis

293 leukin-8, interleukin-10, interleukin-1beta, interleukin-12, tumor necrosis factor-alpha, and interfe

294 We now show that interleukin-12, type I interferon, and transforming grow

295 e, we found that CD83, CD80, CD86, CD40, and interleukin-12 upregulation were significantly impaired

296 ytes, to sites of bacteria propagation where interleukin-12 was expressed in the spleen.

297 interferon, tumor necrosis factor alpha, and interleukin-12) were not necessary for E. muris-induced

298 atory cytokines, including interleukin 6 and interleukin 12, were significantly lower in the bronchoa

299 atory and proinflammatory mediators, such as interleukin-12, while downregulating coinhibitory PD-L1

300 eron-gamma, tumor necrosis factor-alpha, and interleukin-12) within atherosclerotic lesions and splee