ライフサイエンスコーパス: interleukin-15

1 values areas under the curve >0.70 including interleukin 15.

2 ed by induction of a second cytokine such as interleukin 15.

3 anced expansion with endogenous or exogenous interleukin 15.

4 otential and dependence on the growth factor interleukin 15.

5 factor, platelet-derived growth factor, and interleukin-15.

6 amma directly ex vivo; and were dependent on interleukin-15.

7 alloantigens and dendritic cells and require interleukin-15.

8 In the epithelium, interleukin-15 activates intraepithelial lymphocytes tha

9 N-formyl-methionyl-leucyl-phenylalanine, and interleukin 15, adhesion molecules P-selectin glycoprote

10 CD11c(+)NK1.1(+) cells depended primarily on interleukin 15 and common cytokine receptor gamma chain

11 y production of tumor necrosis factor-alpha, interleukin-15 and interleukin-1alpha, and transforming

12 ing CT-defined small airway abnormality, and interleukin-15 and interleukin-8 concentrations.

13 This division requires interleukin-15 and is markedly increased by inhibition o

14 and obese mGHRKO mice demonstrated a higher interleukin-15 and lower myostatin expression relative t

15 to SVZ neural stem cells (NSCs) that produce interleukin-15 and sustain functionally competent NK cel

16 d siblings in the presence of interleukin 2, interleukin 15, and rapamycin.

17 nterleukin-18, interferon-gamma and possibly interleukin-15, and a cross-talk between B lymphocytes a

18 ector cells (T(CM/E)) was dependent on human interleukin-15, and superior in magnitude and duration t

19 y of adoptively transferred T lymphocytes by interleukin-15, and the safe use of dendritic cell-deriv

20 dominant peptide induced rapid expression of interleukin-15, CD83, cyclo-oxygenase (COX)-2, and CD25

21 nce of small airway abnormality on CT, lower interleukin-15 concentrations, and higher interleukin-8

22 oid system of transgenic mice overexpressing interleukin-15 could be visualized.

23 MIP-2 and KC at the site of infection, while interleukin-15 expression remained relatively unchanged

24 or cytokine genes such as interleukin-12 and interleukin-15 genes enhances the efficacy of the vector

25 C57BL/6 mice genetically deficient in interleukin 15 (IL-15(-/-) mice) were generated by gene

26 lls when CD28 down-regulation was induced by interleukin 15 (IL-15) and IL-12 stimulation.

27 We show that co-expression of interleukin 15 (IL-15) and IL-15 receptor alpha (IL-15Ra

28 Interleukin 15 (IL-15) and IL-2 have distinct immunologi

29 Interleukin 15 (IL-15) and the IL-15 receptor alpha (IL-

30 Two isoforms of human interleukin 15 (IL-15) exist.

31 Lately, interleukin 15 (IL-15) has been implicated both in osteo

32 Increased expression of interleukin 15 (IL-15) in leukemic blasts is associated

33 s developed and used to evaluate the role of interleukin 15 (IL-15) in the modulation of the therapeu

34 Interleukin 15 (IL-15) is a critical factor for the prol

35 Interleukin 15 (IL-15) is a novel cytokine with interleu

36 Interleukin 15 (IL-15) mRNA is expressed in a wide varie

37 Given the central role that interleukin 15 (IL-15) plays in human immunodeficiency v

38 We show here that interleukin 15 (IL-15) potently inhibits spontaneous and

39 ia compared with normoxia and in response to interleukin 15 (IL-15) priming using a 2 x 2 factorial d

40 nfiltration of proliferating NK cells due to interleukin 15 (IL-15) released and presented by the can

41 Interleukin 15 (IL-15), a cytokine that shares many biol

42 this process by limiting the availability of interleukin 15 (IL-15), and administration of IL-15/IL-1

43 The production of interleukin 15 (IL-15), IL-18, gamma interferon (IFN-gam

44 ls from bone marrow precursor cells requires interleukin 15 (IL-15); however, very little is known ab

45 oth the tdTomato red fluorescent protein and interleukin-15 (IL-15) (vMyx-IL-15-tdTr) was constructed

46 Importantly, UV-HSV-1 synergizes with interleukin-15 (IL-15) and IL-2 in inducing activation a

47 cells generated in vitro in the presence of interleukin-15 (IL-15) and/or IL-2 from umbilical cord b

48 Interleukin-2 (IL-2) and interleukin-15 (IL-15) are T-cell tropic factors that sh

49 ed to be mediated primarily by production of interleukin-15 (IL-15) by the mature DCs.

50 Several studies have provided evidence that interleukin-15 (IL-15) can enhance protective immune res

51 We now report that interleukin-15 (IL-15) can induce TNF-alpha production i

52 nflammatory activity in the tissues and with interleukin-15 (IL-15) expression.

53 hematopoietic precursor cells (HPCs) require interleukin-15 (IL-15) for differentiation into human NK

54 activation and were associated with enhanced interleukin-15 (IL-15) gene expression, suggesting a pat

55 ion studies have consistently implicated the interleukin-15 (IL-15) gene in acute lymphoblastic leuke

56 Interleukin-15 (IL-15) has significant potential in canc

57 r frequencies in murine thymus and depend on interleukin-15 (IL-15) in periphery.

58 dentified a previously unrecognized role for interleukin-15 (IL-15) in red blood cell homeostasis and

59 studies have suggested an important role for interleukin-15 (IL-15) in resistance to and memory for T

60 Interleukin-15 (IL-15) in vitro treatment of peripheral

61 Interleukin-15 (IL-15) is a 14- to 15-kDa member of the

62 Interleukin-15 (IL-15) is a cytokine with potential ther

63 Interleukin-15 (IL-15) is a gamma-common cytokine that p

64 Interleukin-15 (IL-15) is a newly described cytokine tha

65 Interleukin-15 (IL-15) is a pleiotropic proinflammatory

66 Interleukin-15 (IL-15) is a pro-inflammatory cytokine el

67 Interleukin-15 (IL-15) is a pro-inflammatory cytokine ex

68 Interleukin-15 (IL-15) is a recently identified growth a

69 Because interleukin-15 (IL-15) is an essential cytokine for NK c

70 Interleukin-15 (IL-15) is an important lymphokine regula

71 Because interleukin-15 (IL-15) is crucial for iNKT development a

72 Interleukin-15 (IL-15) is crucial for the development of

73 Interleukin-15 (IL-15) is essential for natural killer (

74 Interleukin-15 (IL-15) is essential for the development

75 mphopenia in all patients and an increase in interleukin-15 (IL-15) levels in 6 out 8 patients.

76 analyses have shown increased expression of interleukin-15 (IL-15) messenger RNA in the esophagus of

77 sis factor (TNF) and trans-presented (trans) interleukin-15 (IL-15) on DCs, leading to enhanced NK ce

78 progenitors with AFT024 and the addition of interleukin-15 (IL-15) or IL-2 but not IL-7.

79 emonstrate that activation of NK cells using interleukin-15 (IL-15) plus 4-1BBL upregulates activatin

80 Interleukin-15 (IL-15) produced by and trans-presented o

81 ng clonal expansion and contraction, whereas interleukin-15 (IL-15) promoted their survival only duri

82 upstream of an NF-kappaB binding site in the interleukin-15 (IL-15) promoter.

83 The cytokine interleukin-15 (IL-15) promotes proliferation and effect

84 , and he was investigated for defects in the interleukin-15 (IL-15) receptor complex because function

85 enes such as NOTCH1 and RBPJ, as well as the interleukin-15 (IL-15) receptor complex, the latter enha

86 The cytokine interleukin-15 (IL-15) signals through the formation of

87 Interleukin-15 (IL-15) stimulates the diffrentiation and

88 moter element is significantly enhanced upon interleukin-15 (IL-15) stimulation in peripheral blood N

89 ted by activating them via treatment with an interleukin-15 (IL-15) superagonist, IL-15 bound to solu

90 ax vaccine, we generated a recombinant Wyeth interleukin-15 (IL-15) with integrated IL-15, a cytokine

91 Interleukin-15 (IL-15), a 114-amino acid cytokine relate

92 We found that interleukin-15 (IL-15), a cytokine critical for CD8(+) m

93 Interleukin-15 (IL-15), a product of monocytes and other

94 ations in immune regulatory genes, including interleukin-15 (IL-15), IL-6ST, STAT5B, HIVEP1, and IL-9

95 operties of alpha interferon (IFN-alpha) and interleukin-15 (IL-15), this study explored the therapeu

96 pression of the CXCR3 ligand MIG (CXCL9) and interleukin-15 (IL-15), type I interferon (IFN)-inducibl

97 the CD19 antigen in the presence of CD80 and interleukin-15 (IL-15).

98 pleted blood lymphocytes and increased serum interleukin-15 (IL-15).

99 ing IFN-gamma, and was mimicked by exogenous interleukin-15 (IL-15).

100 Here, we describe a human interleukin 15 (IL15) and human signal regulatory protei

101 18; P < or = .0125), including 5 SNPs in the interleukin 15 (IL15) gene.

102 The common gamma (gammac)-chain cytokine interleukin 15 (IL15) is a multifunctional immune-modula

103 actors (EGFs) and innate immunity mediators [interleukin 15 (IL15)].

104 The basal expression of interleukin-15 (Il15) in the gingiva and the basal expre

105 Interleukin-15 (IL15) is a cytokine produced by normal b

106 arly devoid of several lineages dependent on interleukin 15, including memory CD8(+) T cells and matu

107 cytokines interleukin-2, interleukin-7, and interleukin-15 increased the antiviral efficacy of CD127

108 cytokines interleukin-7, interleukin-12, and interleukin-15 indicate that these strategies may be use

109 interleukin-4, interleukin-6, interleukin-9, interleukin-15, interferon-gamma, granulocyte-macrophage

110 to be of benefit in animal models, including interleukin-15, interleukin-17, and interleukin-18, and

111 Interleukin 15 is essential for the development and diff

112 Interleukin-15 is a pleiotropic cytokine that is critica

113 nzyme B gene expression by interleukin-2 and interleukin-15 is inhibited by SET knockdown.

114 In the resistant mice, interleukin-15 mRNA in the gingiva and Selp mRNA in the

115 Inhibition of interleukin-15 or of p38 MAP kinase controlled such acti

116 genic situation, and show that inhibition of interleukin-15 or p38 MAP kinase might have the potentia

117 Different combinations of interleukin-15 or signal transduction inhibitors were ad

118 gher levels of interleukin 10 (p = .031) and interleukin 15 (p = .021) than controls before cytomegal

119 Interleukin 15 plays a key role in activation of leukemi

120 after HSCT and favored by the high levels of interleukin-15 present in patients' sera, immature NK ce

121 a cell-intrinsic manner 'downstream' of the interleukin 15 receptor (IL-15R) and through the transcr

122 cytokines and cytokine receptors, including interleukin 15 receptor alpha (IL15Ralpha) and, even mor

123 by NKG2D and DAP10 to those initiated by the interleukin 15 receptor.

124 Interleukin-15 receptor alpha (IL-15R alpha) is a pleiot

125 lls, which resembles the T-cell phenotype of interleukin-15 receptor alpha chain (IL-15Ralpha) and IL

126 on, whereas mutations in the Ly108 receptor, interleukin-15 receptor alpha, or the transcription fact

127 ockade of IFN-gamma, interleukin-2 (IL-2) or interleukin-15 receptor beta (IL-15Rbeta) prevented dise

128 vels of the interleukin-7 receptor-alpha and interleukin-15 receptor-alpha by T cells.

129 d production of cytokines, and dependence on Interleukin-15, resembling NKT and other innate T cell l

130 expression of CD122, the receptor specifying interleukin 15 responsiveness.

131 in the presence of cytokines (interleukin-7, interleukin-15, stem cell factor, and fms-like tyrosine

132 Interleukin-15/T(IL-15) is a growth factor that utilizes

133 expressed higher levels of HS27, HSP70, and interleukin-15 than controls; their IECs also had ultras

134 reconstituted mice require preactivation by interleukin-15 to reach the functional competence of hum

135 Levels of heat shock protein (HSP) and interleukin 15 were measured by immunohistochemistry, an

136 intraepithelial lymphocytes was regulated by interleukin 15, which induced local chromatin modificati

137 he NK-stimulatory molecules 4-1BB ligand and interleukin 15, which yielded a median greater than 1000

138 Cultured myoblasts were found to produce interleukin-15, which impacts local T-cell activation an