ライフサイエンスコーパス: interleukin-18

1 ugh expression, activation, and secretion of interleukin-18.

2 ponsive to stimulation by interleukin-12 and interleukin-18.

3 We show that interleukin-18, a gene linked to diseases with sex-speci

4 We hypothesize that interleukin-18, a proinflammatory cytokine, induces endo

5 Apart from urine clusterin and interleukin-18, all other urinary biomarkers were elevat

6 on decreased expression of gamma interferon, interleukin-18, alpha interferon 16, and RNase L.

7 Here we show that interleukin 18, an anorexigenic cytokine, can act on neu

8 expression of the pro-inflammatory cytokine interleukin 18 and decreased expression of Serpin a3b, a

9 formities had significantly higher levels of interleukin 18 and IP-10 but lower levels of hepatocyte

10 Interleukin 18 and kidney injury molecule 1 discriminate

11 ition is more strongly associated with urine interleukin 18 and kidney injury molecule 1 in children

12 For interleukin 18 and kidney injury molecule 1, the areas u

13 For interleukin 18 and kidney injury molecule 1, the odds ra

14 ation of the cytokines interleukin-1beta and interleukin-18 and a lytic form of cell death termed pyr

15 the spleen and liver and reduced amounts of interleukin-18 and alpha/beta interferon secreted in the

16 leukin-10 and 1.7- and 3.0-fold increases in interleukin-18 and CCR 5, respectively.

17 Interleukin-18 and IL-1beta, which are cytokines of the

18 Myocardial protein expression of interleukin-18 and monocyte chemoattractant protein-1, k

19 inflammatory cytokines interleukin-1beta and interleukin-18 and pyroptosis, a form of phagocyte cell

20 inflammatory cytokines interleukin-1beta and interleukin-18 and pyroptotic cell death that causes the

21 lation between the pro-inflammatory cytokine interleukin-18 and the anti-atherogenic adipokine adipon

22 ytes are a source of biologically functional interleukin-18 and thus are capable of playing an initia

23 nd ultrasensitive detection of the cytokines interleukin-18 and tumor necrosis factor-alpha.

24 nflammatory cytokines (interleukin 1beta and interleukin 18) and the antiinflammatory cytokine interl

25 peck-like protein containing a CARD), IL-18 (Interleukin-18) and IL-1beta (Interleukin- 1Beta) in obe

26 r (TNF) alpha, interleukin 1beta (IL-1beta), interleukin 18, and interleukin 6; chemokines CCL2, CCL4

27 (neutrophil gelatinase-associated lipocalin, interleukin 18, and kidney injury molecule-1).

28 in 6, interferon gamma-inducible protein 10, interleukin 18, and tumor necrosis factor alpha) and neg

29 MAIT cells was dependent on monocyte-derived interleukin 18, and was reduced in patients with HCV inf

30 ncluding interleukin-15, interleukin-17, and interleukin-18, and clinical trials of these agents are

31 ver-type fatty acid binding protein, urinary interleukin-18, and cystatin C) were measured in 1,635 u

32 had higher systemic levels of interleukin-6, interleukin-18, and tumor necrosis factor alpha than tho

33 nterleukin-6, interleukin-8, interleukin-10, interleukin-18, and tumor necrosis factor-alpha.

34 nterleukin-6, interleukin-8, interleukin-10, interleukin-18, and tumor necrosis factor-R2 were each s

35 the interleukin 10 receptor alpha chain and interleukin 18, are excellent candidates for Ibdq1.

36 To accomplish this, interleukin-18 binding protein (IL-18BP) and tumor necro

37 Treatment with interleukin-18 binding protein decreased inflammation as

38 s have potential implications for the use of interleukin-18 binding protein for treatment of chronic

39 by blocking its biological activity with the interleukin-18 binding protein in the murine model of se

40 rleukin-6, were randomized to receive either interleukin-18 binding protein or vehicle approximately

41 se mice with a predicted low mortality rate, interleukin-18 binding protein significantly increased m

42 In mice with increased risk of dying, interleukin-18 binding protein slightly decreased mortal

43 IFN-gamma) receptor, IFN resistance protein, interleukin-18 binding protein, IFN-alpha/beta binding p

44 sis had decreased survival when treated with interleukin-18 binding protein.

45 th factors, transforming growth factor beta, interleukin-18-binding protein, semaphorin, and five ser

46 ompatibility complex class I molecule and an interleukin-18-binding protein.

47 ts through larger increases in RE, PGLO, and interleukin-18 but without impacting the RAAS.

48 kine induction (including interleukin-12 and interleukin-18), but was bereft of interferon-alpha indu

49 This bioactivity is neutralized by anti-interleukin-18, but not anti-interleukin-12 antibodies.

50 inflammatory cytokines interleukin-1beta and interleukin-18 by macrophages in response to alum in vit

51 of cg03636183 in F2RL3 were associated with interleukin-18 concentration (-0.11 pg/mL, 95% CI: -0.19

52 Recently, the interleukin-18 cytokine gene (IL18) was reported to be a

53 ule-1 increased over time, and the levels of interleukin-18 declined over time.

54 In the second stage, endogenous IL-1beta and interleukin 18 further amplify IL-36gamma synthesis.

55 A homologue of interleukin 18 has been identified from rainbow trout, O

56 Interleukin-18 has been demonstrated to be an important

57 Serum interleukin-18 has been reported to be elevated in patie

58 Human interleukin-18 (hIL-18) is a cytokine that plays an impo

59 5% amino acid sequence identities with human interleukin-18 (hIL-18)-binding protein (hIL-18BP), a na

60 recently shown that early administration of interleukin 18 (IL-18) after bone marrow transplantation

61 Circulating levels of the cytokine interleukin 18 (IL-18) are elevated in obesity.

62 hylococcus are capable of causing release of interleukin 18 (IL-18) from keratinocytes and that S. au

63 The cytokine interleukin 18 (IL-18) is also cleaved by caspase-1 and

64 Interleukin 18 (IL-18) promotes atherosclerotic plaque f

65 ly resistant A/J mice released low levels of interleukin 18 (IL-18) upon infection with Salmonella ty

66 ammation-associated genes, such as those for interleukin 18 (IL-18), IL-18BP, and caspase 1.

67 (6 x 10(6) CFU) resulted in the induction of interleukin 18 (IL-18), tumor necrosis factor alpha (TNF

68 me intracellular parasitic protozoa involves interleukin 18 (IL-18)-mediated interferon gamma (IFN-ga

69 ation with EPA led to a greater reduction in interleukin-18 (IL-18) (-7.0% +/- 2.8% compared with -0.

70 The unique cytokine interleukin-18 (IL-18) acts synergistically with IL-12 t

71 ls of gamma interferon and reduced levels of interleukin-18 (IL-18) and IL-10 in the serum of the Del

72 Because interleukin-18 (IL-18) and IL-12 stimulate IFN-gamma pro

73 ivating caspase-1, resulting in secretion of interleukin-18 (IL-18) and IL-1beta.

74 vestigated the in vitro effects of combining interleukin-18 (IL-18) and IL-2 on human lymphocytes.

75 tinocytes results in increased production of interleukin-18 (IL-18) binding protein (IL-18BP).

76 r viral immune-modulatory genes, encoding an interleukin-18 (IL-18) binding protein, an IL-1beta rece

77 Interleukin-18 (IL-18) can regulate osteoblast and osteo

78 Interleukin-18 (IL-18) functions as a proinflammatory cy

79 ported to promote NSCLC development, whereas interleukin-18 (IL-18) has an undefined role.

80 Interleukin-18 (IL-18) has potent immunomodulatory effec

81 inflammatory protein 1 beta (MIP-1beta), and interleukin-18 (IL-18) in 131 patients with chronic HCV

82 The in vivo role of endogenous interleukin-18 (IL-18) in modulating gamma interferon (I

83 Interleukin-18 (IL-18) is a costimulatory factor for int

84 Interleukin-18 (IL-18) is a critical proinflammatory cyt

85 Interleukin-18 (IL-18) is a newly described cytokine, fo

86 Interleukin-18 (IL-18) is a novel proinflammatory cytoki

87 Interleukin-18 (IL-18) is a pleiotropic cytokine central

88 Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory

89 Interleukin-18 (IL-18) is a pro-inflammatory cytokine, a

90 Interleukin-18 (IL-18) is a proinflammatory cytokine imp

91 Interleukin-18 (IL-18) is a unique cytokine that modulat

92 Interleukin-18 (IL-18) is an important regulator of inna

93 Interleukin-18 (IL-18) is reported as an important regul

94 Administration of Cas-1 products, interleukin-18 (IL-18) or IL-1beta, protected three of t

95 Interleukin-18 (IL-18) produced by activated antigen-pre

96 Interleukin-18 (IL-18) promotes inflammatory responses t

97 Administration of exogenous interleukin-18 (IL-18) regulates experimental acute graf

98 mory T cells with interleukin-12 (IL-12) and interleukin-18 (IL-18) results in tightly regulated prog

99 tatic growth, which was mediated by impaired interleukin-18 (IL-18) signaling.

100 proinflammatory and proatherogenic cytokine interleukin-18 (IL-18) stimulates SMC proliferation, we

101 Here we show that interleukin-18 (IL-18) suppresses adiponectin transcript

102 The use of interleukin-18 (IL-18) together with IL-12 induced high

103 ranscription of the proinflammatory cytokine interleukin-18 (IL-18) was significantly higher in PVAN

104 Equivalent levels of active interleukin-18 (IL-18) were detected in the lungs of mic

105 n hosts encode homologous proteins that bind interleukin-18 (IL-18) with high affinity and inhibit IL

106 Interleukin-18 (IL-18), a pro-inflammatory cytokine, is

107 ere prevalent and included gamma interferon, interleukin-18 (IL-18), and the immunosuppressive, fibro

108 e the level of Toll-like receptor 4 (TLR-4), interleukin-18 (IL-18), and uric acid as markers of the

109 It has recently been suggested that, interleukin-18 (IL-18), in addition to IL-12, contribute

110 phil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1)

111 mphocytes activation by differentiating into interleukin-18 (IL-18)- and IL-15-producing cells in an

112 ophages activated NK cells in a contact- and interleukin-18 (IL-18)-dependent manner, whereas monocyt

113 anism in the spleen, but both pyroptosis and interleukin-18 (IL-18)-driven natural killer (NK) cell r

114 lso called interleukin-1gamma (IL-1gamma) or interleukin-18 (IL-18).

115 ection have identified a protective role for interleukin-18 (IL-18).

116 of the inflammasome and limits secretion of interleukin-18 (IL-18).

117 ease of the interferon gamma inducing factor interleukin-18 (IL-18).

118 Existing evidence suggests that interleukin-18 (IL-18; an IL-1 family cytokine) is eleva

119 actor (bFGF; P = .04) and increase in plasma interleukin-18 (IL-18; P < .01).

120 Interleukin-18 (IL18) participates in atherogenesis thro

121 unctional polymorphisms in the gene encoding interleukin-18 (IL18), a cytokine belonging to the IL-1

122 lational activation of interleukin-1beta and interleukin-18 in inflammation and apoptosis.

123 trophil gelatinase-associated lipocalin, and interleukin-18 in predicting early graft function after

124 rthermore, we demonstrated the importance of interleukin-18 in preventing alveolar macrophage endotox

125 xpression in il-18r-/- mice and injection of interleukin-18 in rag2-/- and micro-/- mice.

126 We sought to determine the role of interleukin-18 in sepsis by blocking its biological acti

127 ed with type A F. tularensis did not release interleukin-18 in vitro, a response that requires the ac

128 Interleukin-18 (interferon-gamma-inducing factor) is ano

129 locyte-macrophage colony-stimulating factor, interleukin-18, interferon-gamma and possibly interleuki

130 eukin-23p40, interleukin-13, interleukin-17, interleukin-18, interferongamma, transforming growth fac

131 erging or enlarged roles for interleukin-10, interleukin-18, interleukin-9, chemokines, activation of

132 Interleukin-18 is a potent inducer of interferon-gamma b

133 Human keratinocyte-secreted interleukin-18 is biologically active, in that condition

134 Interferon-gamma-inducing factor (IGIF, interleukin-18) is a recently described cytokine that sh

135 The baseline plasma interleukin-18 level after 6 months of the AD was predic

136 cts suggest that cigarette smoking increases interleukin-18 levels through the decrease in DNA methyl

137 il gelatinase-associated lipocalin and serum interleukin-18 levels were not different between groups.

138 atients showed elevated NLRP3, caspase-1 and interleukin-18 messenger RNA expression and, using a mou

139 phage endotoxin tolerance through studies of interleukin-18 messenger RNA expression in il-18r-/- mic

140 r oncolytic HSV-1 vectors, expressing murine interleukin 18 (mIL-18), soluble murine B7-1 [B7-1-immun

141 nterleukin-6, interleukin-8, interleukin-10, interleukin-18, monocyte chemotactic protein-1, high-mob

142 Interleukin-18 mRNA and intracellular protein levels are

143 selected non-bone marrow derived skin cells, interleukin-18 mRNA is constitutively expressed by human

144 Pro-interleukin-18 must be cleaved by interleukin-1-beta-con

145 in use, and additional agents that modulate interleukin-18, myeloid-related proteins 8 and 14, natur

146 ostoperative (0-6 hours after surgery) urine interleukin 18, neutrophil gelatinase-associated lipocal

147 and the decreases in both CRP (P = .01) and interleukin 18 (P = .02) levels were smaller in underwei

148 The roles of the interleukin 1 (IL-1) and interleukin 18 pathways in host defense are well establi

149 Increased expression of pro-interleukin-18 (pro-IL-18) mRNA and activated IL-18 prot

150 By immunohistochemistry, interleukin-18 protein is detected in basal keratinocyte

151 sults in the secretion of immunoprecipitable interleukin-18 protein.

152 y NK cells in response to interleukin-12 and interleukin-18, providing a mechanistic link between CD3

153 g Tlr1, Tlr3, Tlr6, Tlr7, Tlr9, Tlr11 or the interleukin-18 receptor (IL-18R).

154 ludes the type I interleukin-1 receptor, the interleukin-18 receptor, and a growing family of Toll-li

155 ooth muscle cells (VSMCs) express functional interleukin-18 receptors (IL-18Rs), composed of alpha an

156 e knockout of a single Toll-like receptor or interleukin 18 resulted only in minor impairment of bact

157 -) mice were given injections of recombinant interleukin 18 (rIL18) or saline (control) during DSS ad

158 on-beta production and gasdermin D-dependent interleukin-18 secretion.

159 with Toll-like receptor, interleukin-1, and interleukin-18 signaling.

160 nes, including the key Th1-inducing cytokine interleukin-18, upon Salmonella challenge than those fro

161 ain replicating HCV and respond by producing interleukin-18 via the inflammasome and by activating NK

162 ne associated, while the caspase-1 substrate interleukin-18 was cytosolic.

163 regulation of endothelin receptor type B and interleukin-18 was validated.

164 ome in monocytes, or after neutralization of interleukin-18, which is regulated by the inflammasome.