ライフサイエンスコーパス: interleukin-21

1 wnregulation of the T-cell effector cytokine interleukin 21.

2 expression is regulated by interleukin-6 and interleukin-21.

3 ecules interferon-gamma, interleukin-17, and interleukin-21.

4 tched to IgG1 and IgG2b when stimulated with interleukin-21.

5 Similarly, CD4 T cell-secreted interleukin-21, a critical regulator of both peripheral

6 de-pulsed dendritic cells in the presence of interleukin-21 and enriched by peptide-major histocompat

7 The cytokines interleukin-21 and interferon-gamma, which are secreted

8 specialization of CD4(+) T cells to produce interleukin-21 and promote antibody-mediated immunity an

9 pression was associated with interleukin 27, interleukin 21, and interferon gamma expression, rather

10 scriptional regulator Bcl6, the receptor for interleukin-21, and the ancestral polarity protein atypi

11 pecific CXCR5(+) CD4(+) T cells that secrete interleukin-21 are strongly associated with B cell memor

12 mediated by the cytokines interleukin-6 and interleukin-21 but is independent of TH1, TH2, and TH17

13 ls, IgM+CD21-/low-memory B cells, CD4+CXCR5+ interleukin 21+ cells, and T-helper 17 cells, compared w

14 f a pool of activated, and B cell-dependent, interleukin-21-expressing Vbeta4(+)CD4(+) T cells.

15 ), CD4+IL17A+ cells (P < .01), and CD4+CXCR5+interleukin 21+ follicular T-helper (Tfh) cells (P < .01

16 ophages were also analyzed for expression of interleukin 21 (IL-21) and negative regulators of immune

17 Interleukin 21 (IL-21) is a pleiotropic cytokine produce

18 antigen-primed plasma cells failed to induce interleukin 21 (IL-21) or the transcriptional repressor

19 uantification of human and cynomolgus monkey interleukin 21 (IL-21) was developed, qualified, and imp

20 zed proximally to mutating B cells, secreted interleukin 21 (IL-21), induced expression of the transc

21 nsforming growth factor beta1 (TGFbeta1) and interleukin 21 (IL-21), produced by follicular helper T

22 efficacy of CD20-targeted therapy, we fused interleukin 21 (IL-21), which induces direct lymphoma cy

23 was uniquely dependent on iNKT cell-derived interleukin 21 (IL-21).

24 lly, Foxp1 directly and negatively regulated interleukin 21 (IL-21); Foxp1 also dampened expression o

25 was shown to be implicated in regulation of interleukin-21 (IL-21) and IL-17 secretion in mice and h

26 t specialized in helping B lymphocytes, with interleukin-21 (IL-21) and inducible costimulatory molec

27 ighlights the recent identification of human interleukin-21 (IL-21) and interleukin-21 receptor (IL-2

28 mmac-dependent cytokine expression indicated interleukin-21 (IL-21) as a primary candidate optimizing

29 ould be treated by eliminating production of interleukin-21 (IL-21) by donor T cells or IL-21 recepto

30 Interleukin-21 (IL-21) can be produced by CD8 T cells fr

31 ronic HIV-1 control, it is not known whether interleukin-21 (IL-21) contributes to early HIV-1 immuni

32 Interleukin-21 (IL-21) controls the differentiation of T

33 e T-cell co-stimulator (ICOS) expression and interleukin-21 (IL-21) cytokine secretion.

34 Interleukin-21 (IL-21) enhances T helper 1 (Th1) and Th1

35 Interleukin-21 (IL-21) has been implicated in the develo

36 Interleukin-21 (IL-21) has broad actions on T and B cell

37 and indirect immune cell-mediated effects of interleukin-21 (IL-21) in mantle cell lymphoma (MCL), pr

38 y, we have examined the role of the cytokine interleukin-21 (IL-21) in regulating humoral immunity du

39 Interleukin-21 (IL-21) is a cytokine produced by activat

40 Interleukin-21 (IL-21) is a member of the type I cytokin

41 Interleukin-21 (IL-21) is a pleiotropic cytokine that in

42 Interleukin-21 (IL-21) is a proinflammatory cytokine tha

43 Interleukin-21 (IL-21) is a recently identified gamma-ch

44 Interleukin-21 (IL-21) is a T cell-derived cytokine that

45 Interleukin-21 (IL-21) is a type I cytokine that modulat

46 hronic viral infection, we demonstrated that interleukin-21 (IL-21) is an essential component of CD4+

47 The cytokine interleukin-21 (IL-21) is closely related to IL-2 and IL

48 Interleukin-21 (IL-21) plays important roles in regulati

49 phocytic leukemia (B-CLL) cells treated with interleukin-21 (IL-21) produce low levels of granzyme B.

50 In mice, CD4 cell-mediated interleukin-21 (IL-21) production is necessary for the m

51 Interleukin-21 (IL-21), a member of the IL-2 cytokine fa

52 Interleukin-21 (IL-21), a potent immunomodulatory four-a

53 teractions, was maintained by T-cell-derived interleukin-21 (IL-21), and promoted repeated rounds of

54 L) expressed on B cells and was dependent on interleukin-21 (IL-21), IL-6, and signal transducer and

55 In this study, we show that interleukin-21 (IL-21), likely produced by CD4+ T cells,

56 of chronic viral infection demonstrate that interleukin-21 (IL-21), produced primarily by CD4 T cell

57 found that a small subset of gp120-specific interleukin-21 (IL-21)-secreting CXCR5(+) CD4(+) T cells

58 S), immunogenicity, and biomarker profile of interleukin-21 (IL-21).

59 naive B cells to produce immunoglobulins via interleukin-21 (IL-21).

60 s help development of antibody responses via interleukin-21 (IL-21).

61 Our transcriptome analyses identify the interleukin 21 (IL21) gene (Il21) as a direct target of

62 expressed markers of Tfh cells and secreted interleukin 21 in response to HCV exposure.

63 ers have reported increased plasma levels of interleukin-21 in ITP.

64 on, and was not due to the overproduction of interleukin-21 in NOD mice.

65 issue of Immunity have identified a role for interleukin-21 in the development of these specialized c

66 se 1 dose-escalation study of membrane-bound interleukin 21 (mbIL21) expanded donor NK cells infused

67 It remains unclear how interleukin-21 receptor (IL-21R) contributes to type 1 d

68 fication of human interleukin-21 (IL-21) and interleukin-21 receptor (IL-21R) deficiencies as novel e

69 homozygous loss-of-function mutations in the interleukin-21 receptor gene (IL21R; c.G602T, p.Arg201Le

70 nary antitumor activity of recombinant human interleukin-21 (rIL-21).

71 Proliferation induced by CD40(+) interleukin-21 stimulation was completely blocked by CC-

72 unction, which was not enhanced by exogenous interleukin 21 supplementation in HIV-infected, older va

73 ly competent "Tfh-like" cells that expressed interleukin-21, Tfh cell markers, and Bcl6 and rescued G

74 Active production of both interleukin 27 and interleukin 21, together with production of interferon g