ライフサイエンスコーパス: interleukin-7

1 nd enhanced responsiveness of these cells to interleukin 7.

2 ion in response to various concentrations of interleukin 7.

3 s receiving alphaCD25 plus recombinant human interleukin-7.

4 receiving alphaCD25 and/or recombinant human interleukin-7.

5 important for LMP2A-mediated survival in low interleukin-7.

6 or when grown in methylcellulose containing interleukin-7.

7 and with Flt3-Ligand, stem cell factor, and interleukin-7.

8 ne negative mice when cultured in vitro with interleukin-7.

9 lated by the alpha-chain of the receptor for interleukin-7, a cytokine that stimulates B-cell lymphop

10 Using mice deficient in the interleukin 7-activated transcription factor STAT5, we d

11 Interleukin-2, interleukin-4, and interleukin-7 all utilize the common gamma (gamma c) rec

12 roliferation in response to stimulation with interleukin-7 alone.

13 stal structure of the unliganded form of the interleukin-7 alpha receptor (IL-7Ralpha) extracellular

14 owed hyperactivation of STAT5 in response to interleukin-7, an effect that was abrogated by the JAK1/

15 om use of the new immunomodulatory molecules interleukin 7 and anti-programmed cell death 1 in infect

16 generating pro-B colonies in the presence of interleukin 7 and flt3 ligand migrate to thymus-expresse

17 kine and TCR signals, such that signals from interleukin 7 and other common gamma-chain cytokines tra

18 hat two additional TGFbeta-stimulated genes, INTERLEUKIN-7 and CYCLIN D1, are dependent upon the inta

19 the Lyn kinase subfamily (key integrators of interleukin-7 and pre-BCR signaling) and the stage-speci

20 ocytes, increased in vitro responsiveness to interleukin-7, and increased in vitro gamma-interferon p

21 The cytokines interleukin-2, interleukin-7, and interleukin-15 increased the antivira

22 such as parathyroid hormone-related protein, interleukin-7, and interleukin-8 that can recruit or act

23 py with interleukin 2, interferon gamma, and interleukin 7 as an adjunct to drug treatment may improv

24 anied by decreased expression of enterocytic interleukin-7 as well as IEL interleukin-7Ralpha and tra

25 y-stimulating factor, interleukin-1beta, and interleukin-7) as well as soluble interleukin-2 receptor

26 later decrease was predicted by the level of interleukin-7 at enrollment.

27 studies are needed before recombinant human interleukin 7 can be recommended for the treatment of ot

28 mplicates IFNgamma, IFNalpha, interleukin-2, interleukin-7, CTLA-4 (cytotoxic T-lymphocyte-associated

29 cient animals display a phenotype similar to interleukin-7-deficient animals in terms of lymphoid dev

30 both, FL and BM) to support the expansion of Interleukin-7 dependent pre-B cells from the BM.

31 e embryo fibroblasts or bone marrow-derived, interleukin 7-dependent pre-B cells accelerated their pr

32 Interleukin 7-dependent progenitor B-cell clones and lin

33 , we find that E2A proteins are required for interleukin 7-dependent proliferation due, in part, to a

34 SIM-Ig fusion proteins selectively increased interleukin 7-dependent proliferation of pre-B cells.

35 Furthermore, the cloning efficiency of interleukin-7-dependent B-cell precursors was increased

36 We have examined primary murine interleukin-7-dependent bone marrow-derived pro-B cells,

37 mals were able to proliferate in response to interleukin-7-dependent developmental signals in vitro.

38 KIL depends on interleukin-7 for survival and proliferation and is NK1.

39 Interleukin-7 has been shown to enhance T cell reconstit

40 A novel recombinant interleukin-7/hepatocyte growth factor beta-chain (IL-7/

41 ronal differentiation under the influence of interleukin 7 (IL-7) alone or terminal differentiation a

42 or for TSLP consists of a heterodimer of the interleukin 7 (IL-7) alpha chain and a novel protein tha

43 The cytokines interleukin 7 (IL-7) and interleukin 4 (IL-4) regulate l

44 Interleukin 7 (IL-7) and its receptor (IL-7R alpha) are

45 Interleukin 7 (IL-7) and T cell antigen receptor signals

46 unknown reasons requires signaling via both interleukin 7 (IL-7) and the T cell antigen receptor (TC

47 imilarities to FRCs but lacked expression of interleukin 7 (IL-7) and were identified as myofibroblas

48 thymic output is associated with breast milk interleukin 7 (IL-7) concentrations.

49 Elevated levels of interleukin 7 (IL-7) have been correlated with various T

50 ion and proliferated directly in response to interleukin 7 (IL-7) in vitro.

51 Interleukin 7 (IL-7) is a common gamma chain receptor cy

52 Interleukin 7 (IL-7) is critical in maintaining thymic-d

53 Interleukin 7 (IL-7) is the most potent thymopoietic cyt

54 Elevated serum interleukin 7 (IL-7) levels are observed in lymphopenic

55 Interleukin 7 (IL-7) promotes pre-B cell survival and pr

56 Interleukin 7 (IL-7) promotes the survival of TCRbeta(-)

57 We have shown here that interleukin 7 (IL-7) was an important survival factor fo

58 Here, we show that interleukin 7 (IL-7), a nonredundant cytokine that plays

59 in the presence of stem cell factor, Flt3-L, interleukin 7 (IL-7), and IL-3, isolated CD34+ cells dif

60 lation by endothelial cells does not involve interleukin 7 (IL-7), IL-15, CCL19, or CCL21.

61 Culturing CD34(+) progenitors with interleukin 7 (IL-7), IL-15, stem cell factor (SCF), FLT

62 Nuocytes required interleukin 7 (IL-7), IL-33 and Notch signaling for deve

63 osine-kinase (FL) + stem cell factor (SCF) + interleukin 7 (IL-7), or FL + thrombopoietin (Tpo).

64 Interleukin 7 (IL-7), which is required for T cell survi

65 cells in bone marrow due to complete loss of interleukin 7 (IL-7)-dependent B-cell progenitors.

66 Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally characteri

67 ein is the receptor for a recently described interleukin 7 (IL-7)-like factor, thymic stromal lymphop

68 sm for thymopoietic failure is damage to the interleukin 7 (IL-7)-producing thymic epithelial cells (

69 we show that developmental downregulation of interleukin 7 (IL-7)-receptor signaling in small pre-B c

70 Thymic ETPs were not interleukin 7 (IL-7)-responsive and generated B lineage

71 responsive to intrathymic cytokines such as interleukin 7 (IL-7).

72 Cotransfection of the interleukin 7 (IL-7)Ralpha chain cDNA resulted in conver

73 encoded by the E2A gene or the receptor for interleukin 7 (IL-7R) have severe overlapping defects in

74 d, with lower expression of the receptor for interleukin 7 (IL-7R).

75 Loss of interleukin-7 (IL-2) receptor expression has been descri

76 ment with the potent, antiapoptotic cytokine interleukin-7 (IL-7) accelerated neutrophil recruitment

77 Although it is known that interleukin-7 (IL-7) and IL-15 influence the survival an

78 The ability of interleukin-7 (IL-7) and IL-15 to expand and/or augment

79 d two candidate immunostimulatory cytokines: interleukin-7 (IL-7) and IL-15.

80 of CD3-TCR and expanded with the addition of interleukin-7 (IL-7) and IL-15.

81 Pre-B-cell cultures require both soluble interleukin-7 (IL-7) and interactions with stromal cells

82 om the structural and biophysical studies of interleukin-7 (IL-7) and its alpha-receptor (IL-7Ralpha)

83 The interaction between interleukin-7 (IL-7) and its alpha-receptor, IL-7Ralpha,

84 Naive T cells are maintained by interleukin-7 (IL-7) and T cell receptor (TCR) signaling

85 n of the CD127 component of the receptor for interleukin-7 (IL-7) and the transcription factor c-myc.

86 chat et al report mutations in receptors for interleukin-7 (IL-7) and thymic stromal lymphopoietin (T

87 ike tyrosine kinase-3 (Flt3) ligand (FL) and Interleukin-7 (IL-7) are cytokines pivotal for B-cell de

88 Recent evidence has implicated interleukin-7 (IL-7) as a master regulator of T-cell hom

89 Interleukin-7 (IL-7) availability determines the size an

90 SCF in combination with interleukin-7 (IL-7) can also stimulate the combined mye

91 Interleukin-7 (IL-7) can boost CD4 T-cell counts, but op

92 Significant decreases in interleukin-7 (IL-7) colony forming units (CFU) were als

93 Interleukin-7 (IL-7) engages multiple mechanisms to over

94 als are dominated by cytokines, particularly interleukin-7 (IL-7) for murine developing B cells.

95 an bone marrow (BM) stromal cell contact and interleukin-7 (IL-7) for optimal proliferation has been

96 In normal T-cell development interleukin-7 (IL-7) functions as an antiapoptotic facto

97 The cytokine interleukin-7 (IL-7) functions to enhance lymphocyte pro

98 udy examined in murine models the effects of interleukin-7 (IL-7) given to young and middle-aged (9-m

99 Interleukin-7 (IL-7) has emerged as a central regulator

100 In mice, interleukin-7 (IL-7) hastens T-cell reconstitution and m

101 To study interleukin-7 (IL-7) in early thymocyte development, we

102 ce of pmel-1 T cells was highly dependent on interleukin-7 (IL-7) in irradiated mice, and IL-15 when

103 infected subjects receiving suppressive ART, interleukin-7 (IL-7) increases the number of CD4(+) T ce

104 Interestingly, while interleukin-7 (IL-7) induced both cell growth and increa

105 Interleukin-7 (IL-7) induces proliferation and different

106 ated orphan receptor gamma-t (RORgammat) and interleukin-7 (IL-7) influence gammadelta T cell homeost

107 Interleukin-7 (IL-7) inhibits TGF-beta signaling by up-r

108 Interleukin-7 (IL-7) is a cytokine that is required for

109 Interleukin-7 (IL-7) is a homeostatic cytokine for resti

110 We show that interleukin-7 (IL-7) is a key regulator of glucose uptak

111 Interleukin-7 (IL-7) is a nonredundant cytokine that pla

112 Interleukin-7 (IL-7) is a potent immunotherapeutic agent

113 Given that interleukin-7 (IL-7) is a prospective therapeutic immuno

114 Interleukin-7 (IL-7) is a proteinaceous biological respo

115 Interleukin-7 (IL-7) is critical for T-cell development

116 Interleukin-7 (IL-7) is currently used in clinical trial

117 Interleukin-7 (IL-7) is essential to T-cell survival as

118 Interleukin-7 (IL-7) is fundamental for thymopoiesis, T-

119 Interleukin-7 (IL-7) is important for thymopoiesis in mi

120 Interleukin-7 (IL-7) is required for the establishment a

121 Interleukin-7 (IL-7) is the major thymopoietic cytokine.

122 Although elevated interleukin-7 (IL-7) levels have been reported in patien

123 We examined the effects of exogenous interleukin-7 (IL-7) on apoptosis, proliferation, and th

124 meostatic proliferation of infected cells by interleukin-7 (IL-7) or antigenic stimulation, as well a

125 Previously we reported that withdrawal of interleukin-7 (IL-7) or IL-3 produced a rapid intracellu

126 We show that interleukin-7 (IL-7) plays multiple roles in regulating

127 Interleukin-7 (IL-7) potently enhanced thymic-independen

128 ed increased numbers of TECs and intrathymic interleukin-7 (IL-7) production and reorganization of co

129 Soluble interleukin-7 (IL-7) receptor alpha (sCD127) is implicat

130 The antiapoptotic function of the interleukin-7 (IL-7) receptor is related to regulation o

131 Interleukin-7 (IL-7) receptor signaling begins with acti

132 The infection caused a downregulation of the interleukin-7 (IL-7) receptor, needed for survival of co

133 Surface expression of interleukin-7 (IL-7) receptor-alpha (IL-7R alpha), a com

134 geny of My-bi HSCs express lowered levels of interleukin-7 (IL-7) receptor.

135 Interleukin-7 (IL-7) regulates T-cell homeostasis, and i

136 -BCR-mediated functions, leading to enhanced interleukin-7 (IL-7) signaling and elevated levels of RA

137 naive CD4(+) T cells to T-cell receptor and interleukin-7 (IL-7) stimulation were evaluated by using

138 early preB-I cells that required stromal and interleukin-7 (IL-7) support for growth in vitro.

139 med larger colonies in cultures treated with interleukin-7 (IL-7) than control bone marrow B cells di

140 d (FL) has a unique ability to interact with interleukin-7 (IL-7) to directly and selectively promote

141 ty of hematopoietic growth factors including interleukin-7 (IL-7), a cytokine critical for murine B-c

142 Interleukin-7 (IL-7), a cytokine produced by stromal cel

143 hese MTI-mediated effects can be reversed by interleukin-7 (IL-7), an important regulator of early B-

144 a loss of intestinal epithelial cell-derived interleukin-7 (IL-7), and this loss may play an importan

145 erm immunity against reinfection and require interleukin-7 (IL-7), but the mechanisms by which IL-7 c

146 ors were cultured in limiting dilutions with interleukin-7 (IL-7), flt3 ligand (FL), c-kit ligand (KL

147 thymocytes cultured in methylcellulose with interleukin-7 (IL-7), IL-15, and steel factor (SF) forme

148 ed by CD3/CD28 engagement in the presence of interleukin-7 (IL-7), IL-21, and the glycogen synthase-3

149 Exogenous Interleukin-7 (IL-7), in supplement to antiretroviral th

150 ional granulocyte colony-stimulating factor, interleukin-7 (IL-7), or IL-3alpha receptor.

151 nt rabies virus (RABV) that expressed murine interleukin-7 (IL-7), referred to here as rLBNSE-IL-7, w

152 common gamma-chain cytokines (CGCC), such as interleukin-7 (IL-7), render resting CD4 T cells permiss

153 Interleukin-7 (IL-7), the principal homeostatic cytokine

154 nsion of early lymphoid progenitors requires interleukin-7 (IL-7), which functions through gamma(c)-m

155 Interleukin-7 (IL-7)-deficient mice exhibit an early def

156 We established a human interleukin-7 (IL-7)-dependent T-ALL cell line, TAIL7, t

157 We characterize the interleukin-7 (IL-7)-induced stimulation of primary huma

158 y role in the regulation of T-cell levels is interleukin-7 (IL-7).

159 source of lymphopoietic factors that include interleukin-7 (IL-7).

160 11 (45- to 338-fold), RANTES (724-fold), and interleukin-7 (IL-7; 128-fold).

161 ression of multiple hematopoietic cytokines (interleukin-7 [IL-7], Flt3L, stem cell factor [SCF], ThP

162 CXCR4 was required for CLP positioning near Interleukin-7(+) (IL-7) cells and for optimal IL-7 recep

163 Using interleukin 7 (IL7) as a prototypic secreted factor, we

164 Interleukin-7 (IL7) is a hematopoietic cytokine with cri

165 ssful compassionate use of recombinant human interleukin 7 in a patient with idiopathic CD4+ T-cell l

166 r fetal thymocytes, but was not as potent as interleukin 7 in lobe submersion cultures.

167 al to transform primary mouse pro-T cells to interleukin-7-independent growth and were not affected b

168 he growth hormone pathway, and the cytokines interleukin-7, interleukin-12, and interleukin-15 indica

169 eceptor-alpha, interleukin-4, interleukin-5, interleukin-7, interleukin-13, interleukin-17, macrophag

170 cells in vitro in the presence of cytokines (interleukin-7, interleukin-15, stem cell factor, and fms

171 Interleukin-7 is widely accepted as a major homeostatic

172 emonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1,

173 e time of their IRIS events and higher serum interleukin-7 levels, suggesting that the T-cell populat

174 thymic stromal lymphopoietin, an epithelial interleukin 7-like cytokine that enhanced the B cell 'li

175 In mature thymocytes, TAK1 was required for interleukin 7-mediated survival and T cell receptor-depe

176 Interferon-alpha and -beta inhibit the interleukin-7-mediated growth and survival of T and B ly

177 r-old man was treated with recombinant human interleukin 7 on November 1, 2012.

178 factors such as keratinocyte growth factor, interleukin 7 or sex steroid ablation for therapeutic th

179 yte cell lines dependent on interleukin-3 or interleukin-7, or primary lymphocytes dependent on inter

180 T cells (P = 0.05) and circulating levels of interleukin-7 (P = 0.007) were increased compared to con

181 on that is distinguished by requirements for interleukin-7, Pax5, and Ezh2 for rearrangement of the V

182 mainly memory T cells, which correlated with interleukin-7 plasma levels.

183 populations during immune responses, whereas interleukin-7 plays a singularly dominant role, in terms

184 The intrathymic injection of interleukin-7 prior to irradiation conferred radioprotec

185 aneous (s/c) injections of recombinant human interleukin 7 (r-hIL-7) is safe and improves immune CD4

186 set by the proper signaling function of the interleukin 7 receptor (IL-7R) and the pre-T-cell antige

187 The molecular crosstalk between the interleukin 7 receptor (IL-7R) and the precursor to the

188 he pre-B cell antigen receptor (pre-BCR) and interleukin 7 receptor (IL-7R) coordinate pre-B cell pop

189 t to express TCRs can be subdivided based on interleukin 7 receptor (IL-7R) expression.

190 Mice lacking the interleukin 7 receptor (IL-7R) generate alpha/beta T cel

191 (pre-BCR) and escape from signaling via the interleukin 7 receptor (IL-7R).

192 In interleukin 7 receptor (IL-7R)alpha-/- murine thymocytes

193 There was downregulation of interleukin 7 receptor (IL7R) (P = .0001) and chemokine

194 The interleukin 7 receptor (IL7R), which contains a unique a

195 ineage potential was largely associated with interleukin 7 receptor alpha (IL-7R(alpha)) expression a

196 Up-regulation of the B-cell line 2, interleukin 7 receptor alpha and interleuking 2 receptor

197 face expression and RNA levels of CD127, the interleukin 7 receptor alpha chain (IL-7Ralpha).

198 n of a polymorphism in the gene encoding the interleukin 7 receptor alpha chain (IL7R) as a significa

199 o1 deficiency resulted in a severe defect in interleukin 7 receptor alpha-chain (IL-7Ralpha) expressi

200 udy we show that increased expression of the interleukin 7 receptor alpha-chain (IL-7Ralpha) identifi

201 The interleukin 7 receptor alpha-chain (IL-7Ralpha) is essen

202 nnate lymphoid cells (ILCs) that express the interleukin 7 receptor alpha-chain (IL-7Ralpha).

203 cells had markedly reduced expression of the interleukin 7 receptor and exhibited shorter survival.

204 ed fraction of CD8(+) T cells expressing the interleukin 7 receptor at the peak of the response.

205 ), a linchpin in the pre-B-cell receptor and interleukin 7 receptor signaling pathways critical to B-

206 , a c-Kit(hi) progenitor subset positive for interleukin 7 receptor-alpha (IL-7Ralpha) emerged that h

207 pro-B cell stage due to a failure to express interleukin 7 receptor-alpha.

208 e show that neonatal thymi transplanted into interleukin 7 receptor-deficient hosts harbor population

209 have demonstrated that downregulation of the interleukin-7 receptor (CD127) distinguishes Treg cells

210 hed by progressively lower expression of the interleukin-7 receptor (IL-7R alpha) and by lower IL-7 r

211 One unexpected result was the high level of interleukin-7 receptor (IL-7R) gene expression in HS-27a

212 Interleukin-7 receptor (IL-7R) levels are tightly contro

213 group is enriched for genes involved in the interleukin-7 receptor (IL-7R) pathway and T cell recept

214 The interleukin-7 receptor (IL-7R), via its activation of th

215 Here, we show that c-Kit and interleukin-7 receptor (IL-7R)-mediated signals support

216 Expression of the interleukin-7 receptor (IL-7Ralpha) chain marks function

217 tes from mice lacking the alpha-chain of the interleukin-7 receptor (IL-7Ralpha).

218 Human soluble interleukin-7 receptor (sIL7R)alpha circulates in high m

219 only high levels of PD-1 but also decreased interleukin-7 receptor alpha (CD127), an exhausted pheno

220 factor receptor (G-CSFR); and were uniformly interleukin-7 receptor alpha (IL-7Ralpha(-)) AA4.1(Lo),

221 e memory cells without undergoing changes in interleukin-7 receptor alpha (IL-7Ralpha) expression, di

222 Interleukin-7 receptor alpha (IL-7Ralpha) is essential f

223 (Th) cell subsets, ILC subsets positive for interleukin-7 receptor alpha (IL-7Ralpha) produce distin

224 The interleukin-7 receptor alpha (IL-7Ralpha) signaling path

225 ular or to the transmembrane domain (TMD) in interleukin-7 receptor alpha (IL7R) or cytokine receptor

226 elayed T cell responses and decreased CD127 (interleukin-7 receptor alpha [IL-7Ralpha] chain) convers

227 onstrated to regulate the gene expression of interleukin-7 receptor alpha chain (IL-7Ralpha) and post

228 t critically regulates the expression of the interleukin-7 receptor alpha chain (IL-7Ralpha) in T cel

229 Interleukin-7 receptor alpha chain (IL-7Ralpha) is induc

230 increased MS risk is the soluble form of the interleukin-7 receptor alpha chain gene (sIL7R) produced

231 of CD45RB and upregulated expression of the interleukin-7 receptor alpha chain, indicating a transit

232 Furthermore, expression of the interleukin-7 receptor alpha chain, which has been propo

233 x10(-8)), as were a nonsynonymous SNP in the interleukin-7 receptor alpha gene (IL7RA) (P=2.94x10(-7)

234 d- (CD62L-) CC chemokine receptor 7- (CCR7-) interleukin-7 receptor alphaLo (IL-7RalphaLo) phenotype.

235 memory precursors (expressing high levels of interleukin-7 receptor and low levels of killer cell lec

236 cell expansion is driven by signals from the interleukin-7 receptor and the pre-B-cell receptor and i

237 Mice lacking interleukin-7 receptor are lymphopenic, due to a defect

238 Thus ligands of the interleukin-7 receptor deliver an extrinsic signal that

239 f PU.1 as a transcriptional regulator of the interleukin-7 receptor has established one mechanism by

240 We show that activating mutations in the interleukin-7 receptor identified in human pediatric ETP

241 , effector CD8(+) T cells differentiate into interleukin-7 receptor(lo) (IL-7R(lo)) short-lived effec

242 w) cells express B cell leukemia/lymphoma 2, interleukin-7 receptor, and CD5.

243 haracterized by selective down-regulation of interleukin-7 receptor, heightened apoptosis, and poor a

244 apid apoptosis, and failed to upregulate the interleukin-7 receptor, known to be important for T cell

245 ated polyfunctional T helper cells with high interleukin-7 receptor, rapid clonal expansion, and pote

246 vitamin D(3), including genetic variants in interleukin-7 receptor-alpha (IL7RA*C), interleukin-2 re

247 ated STAT5 and high expression levels of the interleukin-7 receptor-alpha and interleukin-15 receptor

248 Functional studies validated interleukin-7 receptor-alpha as a Foxo1 target gene esse

249 Accordingly, populations of CD62L(high) interleukin-7 receptor-positive progenitor central memor

250 t three differentially regulated domains: an interleukin-7-regulated domain consisting of the 5' J558

251 rrow, treatment of isolated pro-B cells with interleukin-7 resulted in a dramatic increase in express

252 Administration of recombinant human interleukin-7 (rhIL-7) to mice increases the exportation

253 tent of TSCM generation might correlate with interleukin 7 serum levels.

254 In contrast, mice deficient for interleukin-7 show a severe lymphopenia in most lymphoid

255 gments has been suggested to be regulated by interleukin 7 signaling in pro-B cells.

256 ric domains in response to downregulation of interleukin 7 signaling.

257 efect in the assembly of antigen receptor or interleukin-7 signaling.

258 eukin-7, or primary lymphocytes dependent on interleukin 7, the phosphatase Cdc25A is the critical me

259 a cells in the presence of interleukin-2 and interleukin-7, the CD34+ cells developed two types of B2

260 genitor, the alpha chain of the receptor for interleukin-7 was not detected by fluorescence-activated

261 interleukin 6 [IL-6], and soluble CD14) and interleukin 7 were measured at antiretroviral therapy (A