ライフサイエンスコーパス: interlock

1 ding domains arranged so that the bricks can interlock.

2 f these unsynapsed axes were associated with interlocks.

3 32.1 kcal/mol at 150 degrees C) and strongly interlocked.

4 chanisms and movement control strategies are interlocked.

5 methyllanthionine rings, three of which are interlocking.

6 at is topologically isomeric with the doubly interlocked [2]catenane.

7 hanical bonding, in isomeric [3]- and doubly interlocked [2]catenanes controls the formation of TTF r

8 property, the first examples of mechanically interlocked [2]rotaxanes containing ChB-donor groups are

9 the free volume required for rotation of the interlocked 24C6 macrocycle, but the frameworks are inte

10 regio- and diastereoselective manner, giving interlocked 3,4-disubstituted trans-azetidin-2-ones.

11 We discover that a 'nano-interlock' adhesion mechanism is responsible for the adh

12 y unit has a central hinge-an arrangement of interlocked alpha-solenoids-about which it can bend to a

13 This interlocking analysis of IFN-inducible genes, plasma ana

14 two RS-[Au-SR]3 and two RS-[Au-SR]4 motifs, interlocked and capping on a prolate Au8 core.

15 mplex demonstrates that the two hexamers are interlocked and misaligned along the DNA axis and lack A

16 e data provide a powerful model to probe the interlocking and synergistic network of the circadian cl

17 es of erupted teeth failed to grow together, interlock, and function as a unit.

18 This elaborate interlocked anion receptor functions via a novel dynamic

19 posed, including parallel, antiparallel, and interlocked antiparallel stacking conformations.

20 lic Hamilton-like receptor (2b), leads to an interlocked architecture, which was isolated and fully c

21 olecular machines because their mechanically interlocked architectures enable them to contract and ex

22 nd supramolecular cages, open frameworks and interlocked architectures.

23 Since interlocks are potentially deleterious if left unresolve

24 Highly stable permanently interlocked aryleneethynylene molecular cages were synth

25 coated with a shell of organic ligands that interlock as spacers and provide tensile strength.

26 Our analysis reveals that the level of interlocking, as measured by a contraction of the latent

27 their partner cage during the template-free interlocking assembly process.

28 The cooperative slide-and-interlock behavior of the VS domains described by the VS

29 5-HT2CR tone confers vulnerability to these interlocked behaviors.

30 with a triangular cross-section composed of interlocked beta-sheets from each of the three chains.

31 ative models of large alpha-helical bundles, interlocking beta sandwiches, and interleaved alpha/beta

32 ther, and a series of contacts involving two interlocking beta-strands close to the N-terminus are de

33 ntually promote the generation of mechanical interlocking between the adventitious roots of English i

34 loride is interpreted in terms of its unique interlocked binding cavity, defined by the macrocycle is

35 random stacking of metal layers amongst the interlocking boron layers.

36 three-helix bundles of which two helices are interlocked by conserved arginine-glutamate (Arg-Glu) io

37 Two adjacent interlocked cages were covalently married together by in

38 ajor part of the capsid surface is formed by interlocking capsid protein (CA) hexamers.

39 uster formation, as the cyclic components in interlocked catenane and rotaxane structures, for constr

40 NA) in the form of a network of thousands of interlocked circles.

41 es is composed of thousands of topologically interlocked circular DNA molecules that form the kinetop

42 Interlocked circular DNA nanostructures, e.g., catenanes

43 The interlocked complexes are predominantly formed in the re

44 domain specifically prevent assembly of the interlocked complexes without inactivating either RcsF o

45 ween the positively charged and mechanically interlocked components results in the adoption of a co-c

46 ciently large to prevent dissociation of the interlocked components, the strained SREP-ext stereoisom

47 romide anion recognition compared to its non-interlocked components.

48 Mechanically interlocked compounds, such as bistable catenanes and bi

49 In mechanically interlocked compounds, such as rotaxanes and catenanes,

50 A sequence of successive, interlocking conformational changes guides the two subst

51 r composite parts with integrated mechanical interlocking connections.

52 s revealed crystal packing with alternating, interlocked corrugated and distorted hexagonal layers.

53 r templating interactions, three-dimensional interlocked covalent architectures remain difficult to p

54 Ai, and there is an accumulation of multiply interlocked, covalently closed minicircle dimers (fracti

55 a tetrathiafulvalene unit in a mechanically interlocked crown ether occupies the cavity of a cyclobi

56 ffinity of a remote recognition site for the interlocked crown ether ring through electrochemical sti

57 of a stable, neutral, monomeric mechanically interlocked Cu(I) triazolide under aqueous conditions.

58 omo[2]catenane comprised of two mechanically interlocked cyclobis(paraquat-p-phenylene) rings has bee

59 atenane HC(*7+)-composed of two mechanically interlocked cyclobis(paraquat-p-phenylene) rings-with "z

60 the other hand, HIV-1 infection induced more interlocked cytokines network, establishing new strong c

61 rizes the progress made towards mechanically interlocked daisy chains.

62 , and quench-crystallized to form spheres of interlocking dendritic crystals primarily of magnetite (

63 The installation of interlocked dicarba bridges into peptide sequences requi

64 GerBC forms an interlocked dimer in the crystalline state but is predom

65 a(c) signaling complexes and an antiparallel interlocked dimer in the GM-CSF signaling complex with b

66 rm 4 is a zero-nucleotide loop monomer or an interlocked dimer.

67 distances are in approximate agreement with interlocked dimers observed previously by crystallograph

68 o reversibly operate mechanical motion in an interlocked DNA nanostructure opens exciting new avenues

69 Here we report the design of an interlocked DNA nanostructure that is able to fine-tune

70 prospectives and challenges in the field of interlocked DNA nanostructures and the possible applicat

71 nosome mitochondrial genome, is a network of interlocked DNA rings including several thousand minicir

72 netoplast DNA, is a network of topologically interlocked DNA rings including several thousand minicir

73 etoplast DNA (kDNA), is a massive network of interlocked DNA rings, including several thousand minici

74 s a DNA network composed of several thousand interlocked DNA rings.

75 d as a single, massive DNA network formed of interlocked DNA rings.

76 a giant network containing several thousand interlocked DNA rings.

77 Interlocked DNA rotaxanes and their different synthetic

78 rystal structure of PrxIII consisting of two-interlocked dodecameric rings is also evident in dilute

79 a versatile tool for the formation of larger interlocked dsDNA nanostructures, like rotaxanes and cat

80 y loosely topographically organized, forming interlocking feed-forward and feed-back inhibitory circu

81 of activity by a self-regulating network of interlocked feedback and feedforward loops.

82 and suggest that the primary function of the interlocked feedback loop in Drosophila is to drive rhyt

83 CLK-CYC also activates an interlocked feedback loop, which uses the PAR DOMAIN PRO

84 roach was then applied to a model describing interlocked feedback loops governing the synthesis of th

85 oscillator of the plant clock is composed of interlocked feedback loops that involve multiple repress

86 on mutual translational repression, act via interlocked feedback loops to provide robustness to this

87 rks, we find that miR-7 functions in several interlocking feedback and feedforward loops, and propose

88 els, consistent with dynamical properties of interlocking feedback architecture in eukaryotes.

89 The interlocking feedback loop mechanism of the clock is con

90 d by a transcriptional regulatory network of interlocking feedback loops acting on the transcription

91 oscillator in eukaryotes consists of several interlocking feedback loops through which the expression

92 d of four regulators arranged in a series of interlocking feedback loops.

93 dve is a shared component of two opposing, interlocked feedforward loops (FFLs).

94 This interlocked FFL motif may be a general mechanism to cont

95 electron microscopy directly reveal that the interlocking fibrous building blocks further retard crac

96 o such ligands bound to Co(III) afford a non-interlocked "figure-of-eight" complex in 42% yield, the

97 ging using squaraine rotaxane endoperoxides, interlocked fluorescent and chemiluminescent dye molecul

98 The mechanically interlocked framework of the [3]catenanes creates the id

99 es enantiodiscrimination compared to the non-interlocked free axle and macrocycle components.

100 to identify unanticipated scaffolds such as interlocked G-quadruplexes, as well as novel topologies

101 This suggests an interlocking gate mechanism for DNA transport both into

102 example, is controlled by a set of fourteen interlocking genes called the retinal determination (RD)

103 present a one-pot green method to synthesize interlocked graphene-Prussian Blue hybrid composites as

104 nthracene subunit dihedral, 69 degrees); the interlocked, helical, homochiral PTP moieties give rise

105 We conclude that the interlocked helices of LHCII form a rigid core.

106 The conformations of the Arg residues that interlock helix A and B appear to be preserved in the li

107 Interlocking hexagonal subunit assemblies containing 3 a

108 3.1 A resolution, respectively, revealing an interlocking hexamer formed by the action of a crystallo

109 ome segregation during meiosis by physically interlocking homologs until anaphase I.

110 The application of chiral interlocked host molecules for discrimination of guest e

111 t influence of ChB in anion binding by these interlocked host systems.

112 rison to the acyclic XB receptor, due to the interlocked host's unique three-dimensional binding cavi

113 strand comprises "open" CHMP1B subunits that interlock in an elaborate domain-swapped architecture an

114 nds of minicircles and dozens of maxicircles interlocked in a giant network.

115 es between the ketone and the carbanion both interlocked in a tautomeric equilibrium.

116 Simultaneously, it uses diverse, interlocking insider and outsider instrumental strategie

117 The dimeric interfaces are formed by interlocking interactions between the mTOR and raptor su

118 E sequences fold cooperatively and form interlocking interfaces with G5 domains in a head-to-tai

119 llowed by a slow step in which intermediates interlock into capsids.

120 e main wall carbohydrate polymers, which are interlocked into the supramolecular wall structure throu

121 ep that element distinct from larger, though interlocking, issues concerning the nature of adaptive o

122 t species best known for its broad muzzle of interlocking, lancet-shaped teeth, is almost completely

123 ghly complex jigsaw-puzzle-shaped cells with interlocking lobes.

124 Single interlocking loop interruption resulted in pRNA detachme

125 The architecture surrounding the interlocking loops contributes to the stability of the p

126 kits' derived from pRNA structural features: interlocking loops for hand-in-hand interactions, palind

127 ractions, and sequence variation outside the interlocking loops may counterbalance the changes in the

128 hose RNAs that formed a static ring, via the interlocking loops, stayed on the motor.

129 cationic compounds without an ion sheltering interlocked macrocycle (dumbbells).

130 ith void space that allows for motion of the interlocked macrocycle inside the MOF pores, while the m

131 where the molecular chains consist solely of interlocked macrocycles, contain one of the highest conc

132 Catenanes - molecules consisting of interlocked macrocyclic rings - have been prepared by te

133 iazide (BB) to afford a linear, mechanically interlocked, main-chain polymer.

134 none unit and a 1,5-diaminonaphthalene unit, interlocked mechanically by cyclobis(paraquat-p-phenylen

135 eficient 4,4'-bipyridinium (BIPY(2+)) units, interlocked mechanically with the tetracationic cyclopha

136 very different potential recognition sites, interlocked mechanically with the tetracationic cyclopha

137 These results reveal complementary, interlocking mechanisms for regulation of autophagy by n

138 An interlocking mechanistic picture of an insertion and a f

139 Regular interlocking membrane protrusions on fiber cells are rep

140 cubes via chemical bonding to form a kind of interlocked microstructure with high stability and good

141 mitochondrial DNA consisting of thousands of interlocked minicircles and 20-30 maxicircles.

142 t is a giant network containing thousands of interlocked minicircles.

143 orthogonal arrangement such that entwined or interlocked molecular architectures are produced by ring

144 anion-templated synthesis of macrocycles and interlocked molecular architectures, while the study of

145 the rational synthesis of other higher-order interlocked molecular architectures.

146 thesis has provided access to a range of new interlocked molecular architectures.

147 information is critical for the creation of interlocked molecular machines that have predictable ene

148 Three-terminal interlocked molecular species were obtained by dynamic (

149 een prepared, each containing a mechanically interlocked molecule (MIM) as the linker and a copper(II

150 ve been prepared that contain a mechanically interlocked molecule (MIM) as the pillaring strut betwee

151 the incorporation of a bistable mechanically interlocked molecule (MIM) into a robust Zr-based metal-

152 mplated synthesis of a lanthanide-containing interlocked molecule is demonstrated by utilizing a nitr

153 The resulting mechanically interlocked molecule operates as a perfect molecular swi

154 properties of the higher-order mechanically interlocked molecule.

155 e ability of CB-AAC to generate mechanically interlocked molecules (MIMs) - in particular, rotaxanes

156 rotocols to afford a variety of mechanically interlocked molecules (MIMs) and ultimately (ii) on the

157 At equilibrium, these Mechanically Interlocked Molecules (MIMs) undergo thermally activated

158 Since the advent of mechanically interlocked molecules (MIMs), many approaches to templat

159 lective behaviour of switchable mechanically interlocked molecules (MIMs)--specifically, bistable rot

160 ng processes for these types of mechanically interlocked molecules (MIMs).

161 Mechanically interlocked molecules (rotaxanes and catenanes) have alr

162 focus, however, on the functional aspects of interlocked molecules and discuss how these can find app

163 erging as an important class of mechanically interlocked molecules and have attracted much attention

164 particularly in the context of mechanically interlocked molecules and increases our fundamental unde

165 and interactions play in modern syntheses of interlocked molecules and materials, with a particular f

166 These mechanically interlocked molecules are prepared by stoppering kinetic

167 is compelling evidence that the mechanically interlocked molecules are present as a complex mixture o

168 We propose that mechanically interlocked molecules be inserted covalently into the ri

169 Interlocked molecules comprise two or more separate comp

170 Squaraine rotaxanes are mechanically interlocked molecules comprised of a dumbbell shaped squ

171 le to template the formation of mechanically interlocked molecules has led to the design and synthesi

172 catenanes is different from earlier related interlocked molecules in that two donor units stack on e

173 is an approach that integrates mechanically interlocked molecules into complex three-dimensional (3D

174 dimerization into the field of mechanically interlocked molecules introduces a higher level of contr

175 somers in the case of all three mechanically interlocked molecules investigated.

176 Interlocked molecules possess properties and functions t

177 ystems such as bundles, grids, helicates and interlocked molecules that are not synthetically accessi

178 Mechanically interlocked molecules that change their conformation in

179 In donor-acceptor mechanically interlocked molecules that exhibit bistability, the rela

180 Flexibility in pseudorotaxanes and interlocked molecules that rely on interactions between

181 tions to the more labile Co(II) gave neutral interlocked molecules with well-defined co-conformations

182 rategy for the incorporation of mechanically interlocked molecules within porous materials circumvent

183 s the macromolecular version of mechanically interlocked molecules, mechanically interlocked polymers

184 Mechanically interlocked molecules, owing to the particular kind of c

185 ngly simple way of constructing mechanically-interlocked molecules, such as rotaxanes, catenanes, Bor

186 al moment in the development of the field of interlocked molecules.

187 the study of precision-engineered oligomeric interlocked molecules.

188 conventional optics are resolved as distinct interlocking nano-aggregates when imaged via PALM.

189 unique helical microstructure consisting of interlocking nanofibres.

190 It has been proven that the mechanically interlocked nature of the [3]catenanes facilitates the f

191 Confirmation of the interlocked nature of the structure was achieved through

192 ptor [2]catenanes confirm their mechanically interlocked nature, stabilized by [pi...pi], [C-H...pi],

193 The kernel structure unbiasedly reveals four interlocked negative feedback loops contributing to circ

194 In the fruit fly Drosophila melanogaster, interlocked negative transcription/translation feedback

195 suggest that the regulatory network contains interlocked network motifs consisting of a positive feed

196 gulators are arranged together in a complex, interlocking network with many seemingly redundant and o

197 olecules, sheltering the ionic cores with an interlocked neutral macrocycle has considerable effect o

198 n these two metals in addition to mechanical interlocking observed at a larger scale.

199 olyammonium species enabled coordination and interlocking of diolefin polyether fragments around the

200 This work demonstrates the successful interlocking of sequestration-based ultrasensitivity and

201 The dimeric RHH fold is generated by interlocking of two monomers into a 2-fold symmetrical s

202 HIV-1-glycan shield to comprise a network of interlocking oligosaccharides, substantially ordered by

203 cally controlled solution-phase synthesis of interlocked organic cages with high stability.

204 a template-free one-pot synthesis of triply interlocked organic cages.

205 These interlocked organic molecules may prove useful as part o

206 A-DNA hybrid and is stabilized by the highly interlocked organization of protein subunits.

207 bon tetrachloride (-23.5 +/- 0.3 kJ mol(-1)) interlocks our study with Laurence's scale of H-bond bas

208 A template-free triply interlocked Pd6 cage (2) was synthesized by two-componen

209 melanogaster circadian oscillator comprises interlocked per/tim and Clk transcriptional feedback loo

210 The sole isolated interlocked photoproduct (Phi = 0.06) is a [2]rotaxane,

211 Together these interlocking pieces facilitated the identification of mo

212 The properties of mechanically interlocked polymeric systems depend not only on the pro

213 anically interlocked molecules, mechanically interlocked polymers are promising candidates for the cr

214 Analysis of mechanically interlocked polymers by ion mobility mass spectrometry p

215 Mechanically interlocked polymers can possess significant additional

216 f, primarily, the potential for mechanically interlocked polymers to act as dynamic (noncovalent) yet

217 The quest to construct mechanically interlocked polymers, which present precise monodisperse

218 thesis of high order main-chain mechanically interlocked polymers.

219 ulatory interactions, revealing a network of interlocked positive and negative feedback loops.

220 ol of different regulators so as to form two interlocked positive feedback circuits may enable S. mut

221 Dynamical modeling revealed interlocking positive feedback loop architecture, which

222 m expanding or contracting the cavity of the interlocked precursor.

223 menting the extrusion of the thread from the interlocked precursors.

224 ated by complex systems, generally involving interlocked regulatory feedback loops.

225 PLC is thus central to many important interlocking regulatory networks.

226 By late pachytene, no interlocks remain, suggesting that interlock resolution

227 The kallikrein-kinin system, along with the interlocking renin-angiotensin system, is a key regulato

228 ytene, no interlocks remain, suggesting that interlock resolution may be an important and rate-limiti

229 TlInTe2, with interlocked rigid and weakly bound substructures, exhibi

230 closed and opened by moving the mechanically interlocked ring component of the bistable [2]rotaxane c

231 construction of molecular Hopf links (singly interlocked rings), the simplest type of catenane.

232 d acceptor components in at least one of the interlocked rings, thereby possessing unusual and unexpe

233 the presence of an RNA-binding protein, two interlocking RNA coiled coils of double-stranded RNA, a

234 n which the linking ligands are mechanically interlocked rotaxane molecules is reviewed.

235 epresented as a two-dimensional pattern with interlocking S-shaped 12-chain motifs repeating regularl

236 We test our data and model with an interlocking set of consistency checks.

237 te, close-packed to overpacked monolayers of interlocking single layers.

238 Ceramic/polymer composite equipped with 3D interlocking skeleton (3D IL) is developed through a sim

239 The hetero[4]rotaxane contains an interlocked species in which a dibenzo[24]crown-8 ring t

240 benzylalkylammonium unit to form the second interlocked species.

241 eatly enhanced when it is encapsulated as an interlocked squaraine rotaxane.

242 Photooxygenation of permanently interlocked squaraine rotaxanes with anthracene-containi

243 Leigh-type tetralactam macrocycles produces interlocked squaraine rotaxanes.

244 catenane reveals a nearly perfect fit of the interlocked strands, and the ECD spectra show a signific

245 ties of the first indolocarbazole-containing interlocked structure are described.

246 While no evidence of interlocked structure formation was observed following i

247 gnition to facilitate molecular motion in an interlocked structure is described.

248 ative synthesis process and the mechanically interlocked structure of the resulting catenane were est

249 The mechanically interlocked structure was confirmed by X-ray crystallogr

250 axane supported the kinetic inertness of the interlocked structure, where the newly developed stopper

251 range crack energy dissipation enabled by 3D interlocking structure is considered as the primary rein

252 to many fascinating molecules, ranging from interlocked structures to self-replicators.

253 ry brings together individual molecules into interlocked structures, where the assembly has one ident

254 logy provides ready access to functionalized interlocked structures, which can be used as intermediat

255 les include the catenane, rotaxane, and knot interlocked structures.

256 system for the construction of higher order interlocked structures.

257 to support the formation of a wide range of interlocked structures.

258 ation with Sauvage's metal template route to interlocked structures.

259 een incorporated into molecules that contain interlocked subunits, such as rotaxanes and catenanes, a

260 EM, TJ were 30-52% shorter, fewer, and less interlocking, suggesting a weaker seal between endotheli

261 Mechanically interlocked supramolecular assemblies are appealing buil

262 ack-electron transfer indicates that in this interlocked system, as in previously studied covalently

263 f intricate and often beautiful higher order interlocked systems, including Solomon links, Borromean

264 with interpenetrating "zipper-like" aromatic interlocks that result in stiffness and robustness.

265 like hydrogen-bonding array to cooperatively interlock the ends of a foldamer together with its helic

266 ed under reduced conditions, to mechanically interlock the two components.

267 ding beta-hairpin of the alpha-COP CTD, thus interlocking the two proteins.

268 iver transplantation was the product of five interlocking themes.

269 provided an optimal geometry for mechanical interlocking, thereby achieving significant adhesion str

270 Unlike the non-interlocked thread, the rotaxane requires a catalyticall

271 bility and stiffness is a result of a unique interlocking-tile arrangement of the nanoscale graphene

272 rity, the dinuclear and trinuclear helicates interlock to form a [2]catenane and bis[2]catenane, bear

273 cles and dozens of maxicircles topologically interlocked to form a two-dimensional sheet.

274 d X-ray crystallography confirmed the doubly interlocked topology, and subsequent demetalation afford

275 ed, revealing a stable molecular interaction interlocking transcription and translation.

276 the circadian clock consist of three or four interlocked transcriptional feedback loops [3, 4].

277 dian rhythms are generated by well-conserved interlocked transcriptional feedback loops in animals.

278 ndings in mouse embryo fibroblasts reveal an interlocked transcriptional-enzymatic feedback loop that

279 An interlocked transcriptional-translational feedback loop

280 re a similar overall structure consisting of interlocking transcriptional and posttranslational feedb

281 The clock gene circuit in plants comprises interlocking transcriptional feedback loops, reviewed in

282 l-type specification is under the control of interlocking transcriptional feedback loops, with Wor1 b

283 Interlocking transcriptional loops and regulated protein

284 tonomous molecular oscillator, consisting of interlocking transcriptional/translational feedback loop

285 e dimers sterically forced elongation of the interlocked units, and MALLS analysis of the polymer sho

286 and drunk driving laws, and alcohol ignition interlock use.

287 plications of such feedback loops, which are interlocked via cross-regulation of transcription, a min

288 We focus on the evolution of company interlocks, whereby a company director simultaneously si

289 he sides of existing crystallites until they interlock with adjacent crystallites.

290 rrangement of DNA at the optimum spacing can interlock with multiple TLR9 like a zipper, leading to m

291 This design enabled the MNs to mechanically interlock with soft tissues by selective distal swelling

292 model features a cyclic [Au(I)-SR] pentamer interlocked with one staple trimer motif protecting the

293 These human adaptive cycles interlocked with plant and animal cycles.

294 on-rich dibenzo-34-crown-10 ether (BPP34C10) interlocked with rings containing an unsymmetric 4-subst

295 ining a dibenzo-34-crown-10 ether (BPP34C10) interlocked with rings containing two 4,4'-dipyridiniums

296 orms a double negative feedback loop that is interlocked with the core feedback loop.

297 ch the macrocyclic polyether is mechanically interlocked with the cyclobis(paraquat-p-phenylene) (CBP

298 after 4 to 5 months but can be incompletely interlocked with the native bone.

299 biphasic microneedle array that mechanically interlocks with tissue through swellable microneedle tip

300 nonconvex rings with large internal cavities interlock within a 2D layered structure leading to the f