ライフサイエンスコーパス: intermediate

1 ond cleavage from the metallocarboxylic acid intermediate.

2 on state rather than a discrete Meisenheimer intermediate.

3 l is a requisite to form the mixed disulfide intermediate.

4 ss rigid kappa(2)-phosphoramidite-neutral Pd intermediate.

5 sis through a methyl radical/Ni(ii)-thiolate intermediate.

6 ping and processing of the covalent cleavage intermediate.

7 xidase activity via a glutathionyl-cobalamin intermediate.

8 ntiation) happened via an XIST-negative XaXa intermediate.

9 ng material via formation of an allyl iodide intermediate.

10 moderately stable cyano substituted enolate intermediate.

11 reaction of the camphanate-containing triene intermediate.

12 tides, but an increase in TCA and urea cycle intermediates.

13 nally simple fashion without purification of intermediates.

14 eactions that involve both ionic and radical intermediates.

15 that involve the formation of carbocationic intermediates.

16 ct with 2-lithiated indoles to form boronate intermediates.

17 f C2-epimerized (2S)-2-methyl-3-ketoacyl-ACP intermediates.

18 tions involving deprotonation of high-energy intermediates.

19 cenario based on the experimentally observed intermediates.

20 ting that they represented catalase-inactive intermediates.

21 ough a series of nickel-based organometallic intermediates.

22 ide (NMe4F) via aryl fluorosulfonate (ArOFs) intermediates.

23 rade double-stranded RNA (dsRNA) replication intermediates.

24 ty and less accumulation of off-pathway heme intermediates.

25 atmosphere by reaction with biogenic Criegee intermediates.

26 requires extensive uridylation of mRNA decay intermediates.

27 nvolved in the production of the two hydroxy intermediates.

28 terminate their folding process at different intermediates.

29 synthesized to generate and stabilize these intermediates.

30 tion and reactivity of important iron-oxygen intermediates.

31 Adults with low- or intermediate 1-risk MDS or MDS/myeloproliferative neopla

32 tion by H2O2 is well-established, the second intermediate, 1,4,5,8-naphthalenetetrone, is reported fo

33 a result of this study, including a reaction intermediate, 2 Schiff bases, and 28 bis- or tris(pyrazo

34 ), alpha-pinene, limonene and tridecane were intermediate (54-60%), and 2-methoxy-3-(1-methylpropyl)-

35 topic and mesopic conditions, for far (4 m), intermediate (60 cm) and near (33 cm) distances and bino

36 ispersal ability species generate a hump for intermediate abundance classes earlier than the distribu

37 nostructure is kinetically stabilized by the intermediate Ag20 shell, preventing inward diffusion of

38 of the reaction product and several reaction intermediates agree well with the relevant crystal struc

39 We collected data from 68 eyes with intermediate AMD from 68 patients with spectral-domain o

40 fold greater RS content than a US long-grain intermediate-amylose rice.

41 Starting from the same monoboronic ester intermediates, an intermolecular version of this approac

42 mice, we injected retrograde tracer into the intermediate and deep layers of the SCm and SCl, and the

43 trichloroethane (DDT) and its metabolites in intermediate and deep ocean water masses.

44 inds early in their transatlantic journey at intermediate and especially high migration altitudes, st

45 the season progresses, and weak tailwinds at intermediate and high migration altitudes east of the Ca

46 e most severely down-regulated miRNAs at the intermediate and late Braak stages of Alzheimer's diseas

47 A replication and abrogating postreplicative intermediate and late gene transcription.

48 f the viral DNA-dependent RNA polymerase and intermediate and late transcription factors provided evi

49 Intermediate and nonclassical monocytes have longer circ

50 Subsequent labeling of intermediate and nonclassical monocytes is consistent wi

51 Additionally, the model captured intermediate and phenotypic gene expression data.

52 iodine reacts with Mg(2+) to form a soluble intermediate and then an insoluble final product magnesi

53 ography has identified the structures of key intermediates and allowed a complete mechanistic descrip

54 hetic requirements that incorporate unstable intermediates and are therefore highly irreproducible.

55 ctions to maintain homeostasis of glycolytic intermediates and ATP during large shifts in glucose sup

56 iciency reduced the population of processing intermediates and impaired mitochondrial function.

57 mputational chemistry research into reaction intermediates and pathways may further aid in understand

58 rrent recording, we define discrete assembly intermediates and show that the pore is most probably a

59 s for the formation of possible zwitterionic intermediates and subsequent reactions that give rise to

60 , and midlife occupation categorized as low, intermediate, and high to represent hierarchy in the soc

61 re a diverse population of cells (classical, intermediate, and nonclassical) with distinct functions,

62 dentified under coupling conditions, are key intermediates, and [Cu(II)(carb)3](-) serves as the pers

63 Scans were obtained for primary staging of intermediate- and high-risk disease in 25% of patients a

64 the presence of the peptidase, the reactive intermediates are converted to a known genotoxic scaffol

65 ping agents employed to catch these fleeting intermediates are reviewed, exploiting their superior di

66 ed in RPc and that the RNAP conformations of intermediates are significantly different from that of R

67 s also enable the monitoring of possible key intermediates as an essential prerequisite for proposing

68 he expeditious synthesis of a functionalized intermediate bearing structural and stereochemical featu

69 isomerization occurs through an enehydrazine intermediate before the rate-determining cyclization of

70 the Gag293 epitope with a functional avidity intermediate between that of controllers and treated pat

71 This morphological intermediate between two extant classes further confirms

72 n was too fast for direct observation of the intermediates, but they could be caught by alkylation of

73 ricyclic path facilitates trapping of cyclic intermediate by a variety of further reactions and provi

74 -syn conformers into compact, assembly-state intermediates by glucosylceramide (GluCer), without appa

75 Critical Intermediate calculation files provided as Tables S3 and

76 as predicted, a (2R)-2-methyl-3-ketoacyl-ACP intermediate, came from a newly developed coupled ketosy

77 protein interaction within an early assembly intermediate can influence the efficiency of all subsequ

78 on the basis of mixed-valence Ti(3+)/Ti(4+) intermediate catalytic centers revealed by electron spin

79 , which make it possible to observe rare and intermediate cell states that cannot be resolved at the

80 OO, a silicon analogue of the parent Criegee intermediate, CH2OO.

81 nts who were diagnosed with HIT, an at least intermediate clinical HIT-risk (4Ts score >/=4 points),

82 We observed maximal repression with intermediate codon optimality and weak repression with v

83 lizes within the endoplasmic reticulum-Golgi intermediate compartment.

84 ty in patients with LMCA stenosis and low to intermediate-complexity coronary artery disease.

85 Comparison of the intermediate conformational families of K6-, K11-, and K

86 abled the synthesis of an advanced synthetic intermediate containing the EF and G rings of the target

87 % women; aged 55+/-10 years), mostly with an intermediate coronary artery disease probability, betwee

88 idge with transfer of one alkyl group to the intermediate cycloadduct.

89 Reductions in intermediate-density lipoprotein and LDL production also

90 g their origin from low-density lipoprotein, intermediate-density lipoprotein, very-low-density lipop

91 torvastatin decreased the production rate of intermediate-density lipoprotein-apoB (P=0.043) and LDL-

92 isotope minimum (light iron) is observed at intermediate depths (200-1,300 m), contrasting with heav

93 The carbamic acid intermediate, derived from the arylamine starting materi

94 the accumulation of the harmful chlorinated intermediates dichloroethene (DCE) and vinyl chloride (V

95 outputs (products), and outcomes (proximal, intermediate, distal) and applied retrospectively to NTP

96 lpha-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulati

97 lthough the more abundant surface NH4(+),ads intermediates dominate the overall SCR reaction, especia

98 49 (77.8%) had small drusen, 250 (78.1%) had intermediate drusen, and 96 (30.0%) had large drusen.

99 nthesis and removal of a reactive DNA repair intermediate during base excision repair (BER).

100 he peptide SP1 (CA-SP1), which represents an intermediate during maturation of the HIV-1 virus.

101 troscopy to spectrally resolve an oligomeric intermediate during the aggregation of the human islet a

102 lar approaches will help identify additional intermediates during CCC DNA formation and elucidate the

103 Upon chlorination, four chlorinated intermediates, each with one or two chlorines, were iden

104 Due to their intermediate electron-richness, they are not amenable to

105 ith gynecologic carcinomas and sarcomas with intermediate EMT features.

106 Several novel intermediates en route to such species are identified an

107 Together, these reactive intermediates enable the reduction of multiple functiona

108 d approval of a particular new drug using an intermediate end point, such as MRD, would require confi

109 aged catalysts, the minority surface NH3,ads intermediates exhibit a higher specific SCR activity (TO

110 The intermediate filament protein vimentin, which has been p

111 is the gene that encodes the major astrocyte intermediate filament protein.

112 hoA knockout in fibroblasts induced vimentin intermediate filament reorganization, accompanied by red

113 Actomyosin stress fibres, microtubules and intermediate filaments have distinct and complementary r

114 J area, reduces the abnormal accumulation of intermediate filaments in nerve terminals of the neuromu

115 Furthermore, stress fibres and intermediate filaments modulate the mechanical propertie

116 mutant form of the gene encoding for desmin intermediate filaments, p.D399Y.

117 rms interact with plasma membranes, vimentin intermediate filaments, SH3-containing class I myosins,

118 This *CHO is the common intermediate for the formation of both CH4 and C2H4 Thes

119 de evidence for proposed ionic hydrogenation intermediates for glycerol deoxygenation.

120 ecules with improved biological activity, or intermediates for synthetic derivatization.

121 and electronic structure of CuZ degrees , an intermediate form of the Cu4S active site of nitrous oxi

122 f RSNO and a copper(II) thiolate [Cu(II)]-SR intermediate formed upon reaction of an additional equiv

123 eeds via the generation of NHC-bound enolate intermediates formed from the ketoacids in the presence

124 , FAD is reduced and a C4a-hydroperoxyflavin intermediate forms.

125 rfluorescence (vascular network) in early to intermediate frames and as a hyperfluorescent plaque in

126 We show that at intermediate frequencies of spatial disturbance, the abi

127 eration of benzhydryl cation and oxonium ion intermediates from activated alkyl halides.

128 e ( P = .02), with an increased risk for low-intermediate grade (HR, 1.14; 95% CI, 1.01 to 1.29) but

129 or G3, for low-grade [well differentiated], intermediate-grade [moderately differentiated], and high

130 Further analyses demonstrated that the intermediate group not only encompassed comparable OTU r

131 catalytically competent palladacyclic dimer intermediate has been identified.

132 Recently, Criegee intermediates have gained significant attention since a

133 Criegee intermediates have implications as key intermediates in

134 In fundamental physical chemistry, Criegee intermediates have unique and interesting features, whic

135 y these enzymes are unknown, in part because intermediates have yet to be observed.

136 nd concomitant N-O heterolysis liberating an intermediate having a nitrogen radical moiety Fe(III)-N.

137 There was no consistent effect of P4P on intermediate health outcomes (low-strength evidence) and

138 us maintaining a high titer of virus in this intermediate host used to produce virus inoculum for gra

139 ficantly earlier for the unique than for the intermediate hues (Z = -2.9, p = 0.004).

140 (HF) and low frequency (LF) events, whereas intermediate "Hybrid" events, have HF onsets followed by

141 on to nitrite (NO2(-)) via a single obligate intermediate, hydroxylamine (NH2OH).

142 and EFS for European Leukemia Net (ELN) 2010 intermediate I prognostic risk AML (EFS, 26% +/- 4 vs 40

143 tructures; two that appear to be equilibrium intermediates (i.e., populations of new conformers that

144 e for patients treated in the ICU at low and intermediate ICU utilization hospitals was 34 compared w

145 iated repair and that unresolved replication intermediates impair chromosome segregation.

146 Holliday junction (HJ) is a hallmark intermediate in DNA recombination and must be processed

147 onizing radiation and has been invoked as an intermediate in electron transfer in DNA.

148 o high-infection fish, and parasite size was intermediate in F1 hybrid hosts.

149 to provide excision of the 5'-adenylated BER intermediate in mitochondrial extracts.

150 terneurons were most common in the Pv (39%), intermediate in the claustrum (15%), and least common in

151 iral genome maturation complex, an essential intermediate in the development of complex dsDNA viruses

152 napyradiomycin towards 8-amino-flaviolin, an intermediate in the napyradiomycin biosynthetic pathway.

153 es, RB, which have been inferred as reactive intermediates in a number of reactions.

154 iegee intermediates have implications as key intermediates in atmospheric, organic, and enzymatic rea

155 Copper(II) aryl species are proposed key intermediates in Cu-catalyzed cross-coupling reactions.

156 ion in pentose phosphate flux and glycolytic intermediates in HCFs.

157 erotic refilling of tricarboxylic acid cycle intermediates in mouse brain during ischemic stroke.

158 Thus, genomic DNA DSBs act as signaling intermediates in murine macrophages, regulating innate i

159 e enables anaplerotic refilling of TCA cycle intermediates in stroke-affected brain.

160 statins inhibit the production of isoprenoid intermediates in the cholesterol biosynthetic pathway, t

161 We observe the key intermediates in the singlet fission process, including

162 BV infection in vitro, where all replicative intermediates including covalently closed circular DNA (

163 losely related pharmaceuticals and synthetic intermediates, including chiral and achiral drugs and me

164 cription start site, we identified unwrapped intermediates, including hexasomes that lack either prox

165 These reactive intermediates, including metal-superoxo, -(hydro)peroxo,

166 ral researchers proposed the formation of an intermediate iron-peroxo complex but experimental eviden

167 limination mechanism via an unstable Cu(III) intermediate is energetically more feasible than other p

168 a-bond metathesis mechanism in which an Fe-H intermediate is postulated to be a key reactive species.

169 improved understanding of the polymerogenic intermediates is crucial.

170 However, X-ray crystallography of these intermediates is severely hampered by the difficulty in

171 via ring expansion of the metallacyclobutane intermediate, leading to the spin-triplet 12-electron co

172 Novices as well as surgeons with an intermediate level of experience showed improvement in O

173 EECC mechanism through a Ni-centered hydride intermediate like the enzyme.

174 psilon3/epsilon3 patients' macrophages to an intermediate M1-M2 phenotype that is optimal for Abeta p

175 holes (BHs) accreting at very high rates or intermediate-mass BHs.

176 The existence of an intermediate-mass black hole in the centre of one of the

177 However, the existence of intermediate-mass black holes is still uncertain, and th

178 tutively active Hedgehog signaling in murine intermediate mesoderm-derived renal progenitors results

179 gonads, and reproductive ductal systems: the intermediate mesoderm.

180 The intermediate metalated isocyanides are efficiently trapp

181 Unconstrained optimization eliminates intermediate metastable states, indicating that flux is

182 ation altitudes, strong headwinds at low and intermediate migration altitudes within the Caribbean th

183 These intermediate movements are thought to reflect an uninten

184 We find that participants generate intermediate movements only at (slower) speeds where the

185 s to restrict the developmental potential of intermediate neural progenitors (INPs) generated by asym

186 NH3 oxidation by AOB occurs via two obligate intermediates, NH2OH and NO, necessitating a mediator of

187 e typically tightly coupled with the primary intermediate, nitrite, rarely accumulating in coastal en

188 ies of tissue-resident NK cell developmental intermediates, non-NK innate lymphoid cells, and the cap

189 de group allowed the synthesis of an advance intermediate of corresponding (+/-) CPC analogue.

190 The latter serve as dynamic translocation intermediates of FGF2 with a subunit number in the range

191 ake use of substrates and cofactors that are intermediates of metabolic pathways, providing potential

192 c capsid structures resembling the uncoating intermediates of other enteroviruses.

193 at identification and quantification of some intermediates of PFAS precursors (different chain length

194 mechanistic experiments describing proposed intermediates of the cascade reaction and an initial cat

195 in Maillard reaction pathway, other reactive intermediates, often of higher molecular weight than the

196 er stereotype ambivalence, whereas countries intermediate on peace-conflict present higher ambivalenc

197 ctable or metastatic soft-tissue sarcoma, of intermediate or high grade, for which no standard curati

198 , nonrandomized registry of 1661 patients at intermediate or high surgical risk undergoing TAVR with

199 consistent with a number of possible radical intermediates or hypercoordinate silicates.

200 l primary tumor site, nonseminoma histology, intermediate- or poor-risk disease at the time of GCT di

201 testimonies, and legal and policy documents (intermediate outcome).

202 l activity, or both improve health outcomes, intermediate outcomes associated with CVD, or dietary or

203 thiation procedure, the evolution of the MnO intermediate phase and the development of the MnO and Li

204 Pectin extracted from intermediate phases of papaya ripening markedly decrease

205 neuronal cells, and (3) a cell type with an intermediate phenotype, possibly representing radial gli

206 rs involved in synaptic function and related intermediate phenotypes.

207 olding, where partial unfolding of misfolded intermediates plays a key role.

208 ocytes and the accumulation of postselection intermediate populations and accelerated transition into

209 ncentration measurements shows that the mean intermediate precision relative standard deviation is 14

210 The repeatability and intermediate precision varied between 1.2-5.0% and 7.5-1

211 ts within laboratory and consequently in its intermediate precision.

212 via a pure ferromagnetic structure under the intermediate pressure, finally to an "unconfirmed" antif

213 t Pain), patients with stable chest pain and intermediate pretest probability for obstructive coronar

214 ogical accumulation of the heme biosynthesis intermediate protoporphyrin IX (PPIX).

215 rystalline state, we were able to detect the intermediate radical pairs within the ca. 8 ns laser pul

216 Slower and intermediate rates of progression of enteral feeding str

217 ied patients into low (RDW-low and NLR-low), intermediate (RDW-high or NLR-high) and high risk (RDW-h

218 ral natural products from a common synthetic intermediate readily prepared from geranyl acetate.

219 Those lesions might stabilize intermediate receptor conformations along the OFF-ON ene

220 vered to the branched position of a Rh-allyl intermediate.Reduction of allenes poses several challeng

221 e been reported, but palladium fluoroenolate intermediates relevant to such reactions have not been i

222 to reproduce the most salient property of an intermediate representation of a three-level face-proces

223 This lack of awareness of transient intermediates represents lost opportunities for discover

224 FQ resistance and a second set that encodes intermediate resistance levels.

225 ificantly more accurately and precisely than intermediate rewards.

226 +/- 5 at 4 years; Cox P = .002) and for the intermediate risk genotype NPM1 wild-type/FLT3 without i

227 opy surveillance benefits most patients with intermediate-risk adenomas.

228 ation was seen in the use of observation for intermediate-risk disease (11.1%; range, 4.8%-31.5%) and

229 Intermediate-risk patients (2 risk indicators; n = 5,292

230 erogeneity in colorectal cancer incidence in intermediate-risk patients and the effect of surveillanc

231 he treatment of aortic stenosis in high- and intermediate-risk patients, but the generalizability of

232 model; 5-year OS was 95% in low-risk, 70% in intermediate-risk, and 29% in high-risk categories, corr

233 Four to five intermediate-severity stenoses were generated in the lef

234 nergy efficient mass production of small and intermediate size objects.

235 In a region of intermediate soil nitrogen availability, the dominant le

236 ent intermolecular interactions between such intermediate species.

237 wn an energetic minimum for swimming fish at intermediate speeds rather than low speeds.

238 ff base deprotonation at the lumirhodopsin I intermediate stage.

239 BDI systems leads to a zwitterionic twisted intermediate state ((1)p*) and that destabilizing the (1

240 When the VSD activates from the intermediate state to the activated state, the VSD-pore

241 sembly proceeds via a membrane-bound prepore intermediate state, typically consisting of up to approx

242 nt were expressed, having a dark stable blue intermediate state.

243 h-resolution equipment needed to capture the intermediate states of the transformations.

244 l and identify novel putative precursors and intermediate sterols in its production.

245 Finally, an intermediate structure was found containing a beta hairp

246 mL, 0.35-4.00 IU/mL, and >4.00 IU/mL) at the intermediate study visit (day 336) and determined risk o

247 e nitrate without the significant release of intermediates, such as nitrous oxide.

248 FD-deficient RNAi lines accumulated the same intermediate, suggesting that inhibition of Fe-S cluster

249 cal field, Hc2, moderate Hc2 anisotropy, and intermediate Tc.

250 ctal structure with a long-range order at an intermediate temperature of 223 K and a larger strain ra

251 of their compositions, become brittle in the intermediate temperature range of 0.6-0.7 Tg However, mo

252 ceptual sampling scales are segregated by an intermediate temporal regime in the alpha band that like

253 roceeds through a key aminium radical cation intermediate that is generated via electron transfer bet

254 ecular hydride transfer to generate an imine intermediate that is subsequently captured by a nucleoph

255 defined Pd(II)-peroxo complex is a competent intermediate that promotes substrate coordination via pr

256 e target cell membrane, and form a transient intermediate that pulls the viral and cell membranes tog

257 onds in purine nucleosides produces reactive intermediates that are important in nucleic acid oxidati

258 emerging set of catalytic reactions involves intermediates that contain a copper-substituted stereoge

259 osterol 14-alpha demethylase is a key enzyme intermediating the biosynthesis of ergosterol in fungi,

260 ridium(III) metalloindene intermediate; this intermediate then adds a beta-vinyl C-H bond of a second

261 paragraphs dedicated to the detection of the intermediates, theoretical studies, and insights about t

262 nt inhibitor that mimics one of the reaction intermediates, there is an overall decrease in HDX in th

263 tions, to give an iridium(III) metalloindene intermediate; this intermediate then adds a beta-vinyl C

264 eading to o-quinodimethane, which is the key intermediate to benzocyclobutene-type products.

265 izing equivalent from a coproheme compound I intermediate to the reactive deprotonated tyrosine, form

266 ately generate wrist flexion states that are intermediate to training levels.

267 lpha-methylation steps on the last beta-keto intermediate to yield an alpha,alpha-gem-dimethyl produc

268 itical step of trimming piwi-interacting RNA intermediates to achieve optimally sized piwi-interactin

269 hey actively synthesize and export metabolic intermediates to the apical side to nourish the outer re

270 tes and ligand binding enables transcription intermediates to undergo ligand-dependent conformational

271 both functional "molecular metal oxides" and intermediates to understand metal oxide growth from wate

272 alkyl halides and tertiary amines, were the intermediates to yield thioesters.

273 and bloodstream forms, suggesting that this intermediate-type metabolism is dictated by the availabi

274 ave defined transcription-induced nucleosome intermediates using only RNA Polymerase.

275 hat predict visual loss and complications in intermediate uveitis.

276 which allows direct detection of the Criegee intermediate via various spectroscopic tools, including

277 f the conformational flexibility of Ar-Au-Ar intermediates, via systematic modulation of the length o

278 cs can be sufficient for the virus to evolve intermediate viral loads consistent with maximising tran

279 ribute to a large extent to the multitude of intermediates we observed.

280 By using a 3-T MR imaging system, intermediate-weighted turbo spin-echo pulse sequences, a

281 troelectrochemical techniques, two different intermediates were identified as responsible for the cha

282 Several possible reaction intermediates were investigated, and the quaternary ammo

283 The tested TCA intermediates were poor or moderate KDM5B inhibitors, ex

284 Intermediate wettability leads to various interfacial mo

285 The structure is a transition intermediate where loop 83-89 closes to engage Ca(2+) an

286 ith methane that result in a discrete methyl intermediate where the formal oxidation state (FOS) on t

287 gle reaction vessel without isolation of the intermediates, whereby at least one step is catalyzed by

288 e resolve through relatively long-lived late intermediates wherein peptidyl-tRNA enters the P site of

289 presumably via the corresponding ketenimine intermediate which undergoes a photochemical four-electr

290 ves the generation of a dicentric chromosome intermediate, which subsequently undergoes a series of b

291 We found that a prefusion intermediate will assemble with HOPS and the R, Qa, and

292 enase and a subsequent hydratase yielding an intermediate with a tertiary hydroxyl-group.

293 so demonstrate that trapping of the cationic intermediate with benzene does not proceed via a Friedel

294 cumulation of untrimmed piwi-interacting RNA intermediates with 3' end extension, leading to severe r

295 This new synthesis route can produce Criegee intermediates with a high number density, which allows d

296 nd provides a simple recipe for making ionic intermediates with distinct electronic configurations an

297 ce pathway is less likely than one involving intermediates with only copper(I).

298 ially binds to and fills-in short gapped DNA intermediates with RNA and LigC ligates the resulting ni

299 tabolism, there is near complete loss of TCA intermediates, with no compensation from glucose-derived

300 on of benzene from an unstable phosphorus(V) intermediate, yielding (C5 Me5 )2 Th[kappa(2) -(C,C')-(C