ライフサイエンスコーパス: intermediate filament

1 hilin B2, in the perinuclear organization of intermediate filaments.

2 the cytoskeleton: F-actin, microtubules, and intermediate filaments.

3 maintain their nucleus caged in a network of intermediate filaments.

4 s comprised cytoskeletal proteins as well as intermediate filaments.

5 s, which, in turn, are in close contact with intermediate filaments.

6 ss while producing strong adduct-trapping in intermediate filaments.

7 , where it links desmosomal cadherins to the intermediate filaments.

8 (-) cells, which lack endogenous cytoplasmic intermediate filaments.

9 in addition to the upregulation of vimentin intermediate filaments.

10 ining myelinated axons were small and lacked intermediate filaments.

11 t is not known whether this is also true for intermediate filaments.

12 on-membrane invested cellular organelles and intermediate filaments.

13 , as well as opposing effects from actin and intermediate filaments.

14 Two misregulated genes, intermediate filament-1 (if-1) and calamari (cali), were

15 NF-DP), the medium NF subunit (NFM), and the intermediate filament alpha-internexin (INT) at P4.

16 uced oxidative damage in a subset of nuclear intermediate filament and actin binding proteins in epit

17 s provide radically new insight into keratin intermediate filament and Aire function, along with a mo

18 FiVe1 targets the intermediate filament and mesenchymal marker vimentin (V

19 that steric repulsion is dominant, but both intermediate filaments and actin microfilaments are invo

20 Meanwhile, intermediate filaments and microtubules were each found

21 r suppressor APC as a linker protein between intermediate filaments and microtubules.

22 Although causality between intermediate filaments and plasticity was not directly t

23 ance of cytoskeleton stabilisation proteins, intermediate filaments and proteins involved in posttran

24 cadherin adhesion complex containing keratin intermediate filaments and the catenin-family member pla

25 with a distinctive dual pattern to vimentin intermediate filaments and to membranes at leading edges

26 We found that K17 was released from intermediate filaments and translocated into the nucleus

27 s of cytoskeletal disruption (mainly keratin intermediate filaments) and decreased keratinocyte adhes

28 GFAP is the major astrocytic intermediate filament, and in AxD patient brain tissue G

29 ll cytoskeleton is composed of microtubules, intermediate filaments, and actin that provide a rigid s

30 how that Dlg1 colocalizes with microtubules, intermediate filaments, and Golgi markers.

31 MIL2, in contrast, colocalized with vimentin intermediate filaments, and loss of its function caused

32 stabilize cells by linking actin filaments, intermediate filaments, and microtubules (MTs) to transm

33 he use of microtubules, cytoskeletal motors, intermediate filaments, and septins.

34 Along with microtubules and microfilaments, intermediate filaments are a major component of the euka

35 However, intermediate filaments are emerging as major contributor

36 Intermediate filaments are major cytoskeletal components

37 reach high indentation depths, where desmin intermediate filaments are typically located.

38 Intermediate filaments are unique among cytoskeletal pol

39 ation of, head-rod interactions in assembled intermediate filaments, as well as direct evidence of co

40 ivity, actomyosin bundles, microtubules, and intermediate filaments, as well as the LINC complex, wer

41 Neurofilaments are intermediate filaments assembled from the subunits neuro

42 hannel of nuclear pores, the nexus points of intermediate filament assembly, and the locations of act

43 that compares the developmental profiles of intermediate filaments between cats and humans.

44 nvelope protein that connects the nucleus to intermediate filaments by interacting with plectin.

45 relamin A, a component of the nuclear lamina intermediate filaments, by cleaving it at two sites.

46 In the absence of APC, intermediate filaments collapse and the cells are no lon

47 utophagy-inhibitory Beclin 1/14-3-3/vimentin intermediate filament complex.

48 as an obligate subunit polymer for neuronal intermediate filaments comprising the neurofilament (NF)

49 ies and myopathies that are characterized by intermediate filament-containing inclusions.

50 hat alter cell curvature and mislocalize the intermediate filament crescentin cluster on the back sur

51 An intermediate filament cytokeratin "cage" was not observe

52 formation of an alternative, stress-induced intermediate filament cytoskeleton has cardioprotective

53 The organization of the keratin intermediate filament cytoskeleton is closely linked to

54 with its partners K18 and/or K19 to form the intermediate filament cytoskeleton of hepatocytes and ot

55 Desmoplakin (DP) anchors the intermediate filament cytoskeleton to the desmosomal cad

56 mall heat shock proteins on the keratin 8/18 intermediate filament cytoskeleton using a well-controll

57 structure remains scarce, especially for the intermediate filament cytoskeleton.

58 ll and cell-matrix adhesion molecules to the intermediate filament cytoskeleton.

59 ffect this value; however, the disruption of intermediate filaments decreased the persistence length.

60 Cs also presented in the cytoplasm increased intermediate filaments, dense bodies, and glycogen depos

61 ectories of microtubule segments in actin or intermediate filament-depleted cells, and observed a sig

62 krd1 efficiently interacts with the type III intermediate filament desmin.

63 Desmin intermediate filaments (DIFs) form an intricate meshwork

64 achinery; however, the role of the desmosome-intermediate filament (DSM-IF) network is poorly underst

65 y that is implicated in crosslinking keratin intermediate filaments during hair formation, yet these

66 We studied two aspects of vimentin intermediate filament dynamics-transport of filaments an

67 g cords of cells, where they extend vimentin intermediate filament-enriched protrusions into the 3D E

68 sing long-term 4D imaging, that the vimentin intermediate filament establishes mitotic polarity in ma

69 Vimentin intermediate filament expression is a hallmark of epithe

70 0, Hsp70, Hsp90, and Hsp110 were measured in intermediate filament extracts prepared after a 3-h expo

71 for the vimentin (VIM) gene, a member of the intermediate filament family involved in cell and tissue

72 In cells, keratin intermediate filaments form networks of bundles that are

73 K74 protein results in disruption of keratin intermediate filament formation in cultured cells, most

74 ts including keratin 5 (encoded by KRT5), an intermediate filament-forming protein.

75 Nestin, an intermediate filament found in neural progenitor cells d

76 nnot form filaments by itself in cytoplasmic intermediate filament-free SW13 cells.

77 Expression levels of glial intermediate filaments (GFAP, vimentin) and extracellula

78 Mutations in the astrocyte-specific intermediate filament glial fibrillary acidic protein (G

79 by increased cytoplasmic accumulation of the intermediate filament glial fibrillary acidic protein (G

80 Actomyosin stress fibres, microtubules and intermediate filaments have distinct and complementary r

81 The presence of actin, tubulin, and intermediate filament homologs in these relatively simpl

82 ic screen for defects in the organization of intermediate filaments identified a mutation in the cata

83 ongated, GFAP-positive spindle cells (due to intermediate filaments identified ultrastructurally) wit

84 desmosomal cytolinker protein necessary for intermediate filament (IF) anchorage to sites of robust

85 Intermediate filament (IF) attachment to intercellular j

86 esive junctions and attachment sites for the intermediate filament (IF) cytoskeleton, prominent in ti

87 Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) III protein uniquely found in

88 The intermediate filament (IF) network is known to reorganiz

89 (K5) or keratin 14 (K14) genes, encoding the intermediate filament (IF) network of basal epidermal ke

90 of NMJs by linking them to the postsynaptic intermediate filament (IF) network.

91 lications of the expression of this type III intermediate filament (IF) protein are poorly understood

92 dominant mutations in the gene encoding the intermediate filament (IF) protein GFAP.

93 The intermediate filament (IF) protein nestin coassembles wi

94 s since the complete primary sequence of the intermediate filament (IF) protein vimentin was reported

95 Vimentin, a type III intermediate filament (IF) protein, is phosphorylated pr

96 s previously proposed to resemble eukaryotic intermediate filament (IF) proteins based on structural

97 gigaxonin, an E3 ligase adapter that targets intermediate filament (IF) proteins for degradation in n

98 the molecular and the nano-scale, including intermediate filament (IF) proteins from the cell cytosk

99 Intermediate filament (IF) proteins have been predicted

100 er keratin 14 (K14) or K5, the type I and II intermediate filament (IF) proteins tasked with forming

101 in keratin 14 (K14) or K5, the type I and II intermediate filament (IF) proteins that copolymerize to

102 Keratins, the largest subgroup of intermediate filament (IF) proteins, form a network of 1

103 Intermediate filament (IF) proteins, including nuclear l

104 alpha-Internexin is one of the neuronal intermediate filament (IF) proteins, which also include

105 ns are important functional determinants for intermediate filament (IF) proteins.

106 Keratins are the intermediate filament (IF)-forming proteins of epithelia

107 Intermediate filament (IF)-like cytoskeleton emerges as

108 Intermediate filaments (IF) are major constituents of th

109 Genes encoding the proteins of cytoskeletal intermediate filaments (IF) are tightly regulated, and t

110 ortex suggests that the alpha-keratin- based intermediate filaments (IFs) align with the hair's axis,

111 Intermediate filaments (IFs) are a component of the cyto

112 Intermediate filaments (IFs) are abundant structures fou

113 Actin filaments, microtubules, and intermediate filaments (IFs) are central elements of the

114 Intermediate filaments (IFs) are components of the cytos

115 Intermediate filaments (IFs) are composed of one or more

116 Intermediate filaments (IFs) are cytoskeletal polymers t

117 Intermediate filaments (IFs) are encoded by the largest

118 The type III intermediate filaments (IFs) are essential cytoskeletal

119 Intermediate filaments (IFs) are key players in the cont

120 Intermediate filaments (IFs) are key to the mechanical s

121 Vimentin intermediate filaments (IFs) are part of a family of pro

122 ether with actin filaments and microtubules, intermediate filaments (IFs) are the basic cytoskeletal

123 is accompanied by massive disorganization of intermediate filaments (IFs) both in neurons and many no

124 Intermediate filaments (IFs) form a dense and dynamic ne

125 Keratin intermediate filaments (IFs) form cross-linked arrays to

126 Keratin intermediate filaments (IFs) fulfill an important functi

127 s characterized by the overexpression of the intermediate filaments (IFs) glial fibrillary acidic pro

128 tin filaments, little is known about whether intermediate filaments (IFs) have an influence on MT dyn

129 Intermediate filaments (IFs) in cardiomyocytes consist p

130 e of structural support fulfilled by keratin intermediate filaments (IFs) in surface epithelia likely

131 In GAN, aggregates of intermediate filaments (IFs) represent the main patholog

132 n of the third major cytoskeletal component, intermediate filaments (IFs).

133 We propose that the length of intermediate filaments in cells is regulated by the oppo

134 Desmoplakin (DP) serves to anchor intermediate filaments in desmosomal complexes.

135 t loss of sacsin effects the organization of intermediate filaments in multiple cell types, which imp

136 J area, reduces the abnormal accumulation of intermediate filaments in nerve terminals of the neuromu

137 organization, and dynamics of K14-containing intermediate filaments in skin keratinocytes.

138 embly, organization, and dynamics of keratin intermediate filaments in skin keratinocytes.

139 nerate force, but the precise involvement of intermediate filaments in these processes remains unclea

140 (dynamic cytoskeletal structures and static intermediate filaments) in that it uses ATP hydrolysis t

141 nvestigated the role of vimentin, a type III intermediate filament, in this process using three well-

142 e subsequently been demonstrated in neuronal intermediate filament inclusion disease and atypical fro

143 Neuronal intermediate filament inclusion disease and atypical fro

144 while the clinical presentation in neuronal intermediate filament inclusion disease was more heterog

145 ions were often 'Pick body-like' in neuronal intermediate filament inclusion disease, and annular and

146 ore heterogeneous in the cases with neuronal intermediate filament inclusion disease, often being nor

147 d inclusions subgroup compared with neuronal intermediate filament inclusion disease.

148 In both species, levels of intermediate filaments increased considerably throughout

149 In striated muscle, desmin intermediate filaments interlink the contractile myofibr

150 ical integrity in the mesendoderm by keratin intermediate filaments is required to balance stresses w

151 cking of the bacterium specifically requires intermediate filaments, is a process distinct from pore

152 High levels of the intermediate filament keratin 17 (K17) correlate with a

153 Vimentin and the intestinal epithelial intermediate filament keratin 18 interact with the C-ter

154 We reported that the intermediate filament keratin 6a (K6a) is constitutively

155 Here, we demonstrate that the intermediate filament keratin-19 (Krt19) marks long-live

156 The effects of shear stress on the keratin intermediate filament (KIF) cytoskeleton of cultured hum

157 Keratin intermediate filaments (KIFs) form a fibrous polymer net

158 Keratin intermediate filaments (KIFs) protect the epidermis agai

159 brioid bacterium Caulobacter crescentus, the intermediate filament-like protein crescentin forms a ce

160 Crescentin, a bacterial intermediate filament-like protein, is required for the

161 of the nuclear lamina, a dynamic meshwork of intermediate filaments lining the nuclear envelope inner

162 myosin contractility with the nucleoskeleton-intermediate filament linker protein nesprin-3 pulled th

163 Its intestinal intermediate filaments localize exclusively to the endot

164 fact, several studies suggest that in vivo, intermediate filaments may lengthen by end-to-end anneal

165 Furthermore, stress fibres and intermediate filaments modulate the mechanical propertie

166 To investigate if loss of sacsin affects intermediate filaments more generally, the distribution

167 1 caused partial collapse of the cytoplasmic intermediate filament network and mislocalized to the nu

168 ggregates and redistribution of the vimentin intermediate filament network and retrograde motor prote

169 d that plectin deficiency leads to increased intermediate filament network and sarcomere dynamics, ma

170 nduce spatial reorganization of the vimentin intermediate filament network in cells.

171 The cytoplasmic association of AIRE with the intermediate filament network in human epidermal and fol

172 are phosphoglycoproteins and form the major intermediate filament network of simple epithelia.

173 ced intestinal tube stability due to altered intermediate filament network phosphorylation.

174 esions induces reorganization of the keratin intermediate filament network toward these stressed site

175 HDAC6-induced reorganization of the vimentin intermediate filament network.

176 ent light chain variants results in abnormal intermediate filament networks associated with defects i

177 Intermediate filament networks in the cytoplasm and nucl

178 to maintain the integrity of desmosomes and intermediate filament networks in vitro and in vivo.

179 lecular motor activity, we conclude that the intermediate filament networks maintain nuclear mechanic

180 of desmosomes, adhesive junctions that link intermediate filament networks to sites of strong interc

181 e modulated by structural changes in keratin intermediate filament networks.

182 ed organization of the perinuclear actin and intermediate filament networks.

183 alpha-Internexin is a member of the neuronal intermediate filament (nIF) protein family, which also i

184 ibrillary acidic protein (GFAP) is the major intermediate filament of mature astrocytes in the mammal

185 provides an excellent model system to study intermediate filament organization and function in vivo.

186 mutant form of the gene encoding for desmin intermediate filaments, p.D399Y.

187 that vimentin, a protein comprising type III intermediate filament, participates in such cross-talk f

188 odel null for the gene encoding the type III intermediate filament peripherin (Prph).

189 The physiological significance of intermediate filament phosphorylation during mitosis for

190 Increased intermediate filament phosphorylation was detected by tw

191 ing the first credible evidence that keratin intermediate filaments play a unique and essential role

192 nvestigate the roles of vimentin, a type III intermediate filament protein and a marker of epithelial

193 Importantly, dL5 fusions to an intermediate filament protein CreS are significantly les

194 urvature in a manner similar to deleting the intermediate filament protein crescentin, but it does no

195 ntified a novel association of AIRE with the intermediate filament protein cytokeratin 17 (K17) in th

196 The intermediate filament protein desmin is encoded by the g

197 ticular, we show that S-nitrosylation of the intermediate filament protein desmin is significantly in

198 Mutations in the DES gene coding for the intermediate filament protein desmin may cause skeletal

199 ive cells was also positive for vimentin, an intermediate filament protein expressed by mesenchymal c

200 Peripherin, a neuronal intermediate filament protein implicated in neurodegener

201 Desmin is an intermediate filament protein in skeletal muscle that fo

202 Expression of the intermediate filament protein keratin 17 (K17) is robust

203 The intermediate filament protein keratin 17 (Krt17) shows h

204 The intermediate filament protein keratin 8 (K8) and its cro

205 between tTG and the breast-cancer marker and intermediate filament protein keratin-19.

206 of the nuclear membrane is enriched with the intermediate filament protein lamin A.

207 The intermediate filament protein lamin B2 (LB2), normally a

208 We also have determined that the intermediate filament protein nestin correlates with tum

209 The intermediate filament protein Nestin labels populations

210 We found that the intermediate filament protein nestin physically interact

211 The intermediate filament protein Nestin serves as a biomark

212 These cells expressed the type VI intermediate filament protein nestin whose expression wa

213 IDE is known to bind the cytoplasmic intermediate filament protein nestin with high affinity.

214 ibrillary acidic protein (GFAP) is the major intermediate filament protein of astrocytes in the verte

215 pinal fluid that is specific for a cytosolic intermediate filament protein of astrocytes.

216 Aberrant induction of expression of the intermediate filament protein peripherin, which is assoc

217 Keratin 8 (K8) is a major intermediate filament protein present in enterocytes and

218 The intermediate filament protein synemin is present in astr

219 Taken together, Nes-S is a new neuronal intermediate filament protein that exerts a cytoprotecti

220 BioID to lamin-A (LaA), a well-characterized intermediate filament protein that is a constituent of t

221 Keratin 17 (K17) is a type I intermediate filament protein that is constitutively exp

222 GFAP is an intermediate filament protein that is expressed predomin

223 ive slime of hagfishes contains thousands of intermediate filament protein threads that are manufactu

224 se to perform superresolution imaging of the intermediate filament protein vimentin by stimulated emi

225 The intermediate filament protein vimentin is involved in th

226 tor for activated C kinase 1 (RACK1) and the intermediate filament protein vimentin that correlated w

227 The intermediate filament protein vimentin, which has been p

228 Focusing on the intermediate filament protein vimentin, which is frequen

229 elastic behavior of in vitro networks of the intermediate filament protein vimentin.

230 llular histone proteins H2A, H3, and H4; the intermediate filament protein vimentin; the major HSV-1

231 Vimentin is an intermediate filament protein whose expression correlate

232 Keratin 9 (K9) is a type I intermediate filament protein whose expression is confin

233 s in GFAP, which encodes the major astrocyte intermediate filament protein, glial fibrillary acidic p

234 The accumulation of the intermediate filament protein, glial fibrillary acidic p

235 ns of the expression of vimentin, a type III intermediate filament protein, in alveolar epithelial ce

236 6 (KRT16 in human, Krt16 in mouse), a type I intermediate filament protein, is constitutively express

237 ysfunctional mutations in desmin, a type III intermediate filament protein, or alphaB-crystallin, a c

238 rker doublecortin and of the neuron-specific intermediate filament protein, peripherin, and by RA-sti

239 Vimentin, an abundant intermediate filament protein, presumably has an importa

240 d that vimentin, a leucine zipper-containing intermediate filament protein, suppresses ATF4-dependent

241 (ALYEQEIR, EAEEEKKVEGAGEEQAAAK) and another intermediate filament protein, vimentin (FADLSEAANR).

242 The intermediate filament protein, vimentin, was upregulated

243 patterns and function of internexin neuronal intermediate filament protein-alpha a (inaa), the encodi

244 is the gene that encodes the major astrocyte intermediate filament protein.

245 bules and microfilaments, but its effects on intermediate filament proteins (IFs) are unknown.

246 Simple-type epithelial keratins are intermediate filament proteins important for mechanical

247 understanding the role of Akt signaling and intermediate filament proteins in autophagy and cancer.

248 embly dynamics of neurofilament and vimentin intermediate filament proteins in cultured cells using c

249 at aberrant hyperphosphorylation of neuronal intermediate filament proteins is involved in AD.

250 ility of the nucleus comes from meshworks of intermediate filament proteins known as lamins forming t

251 in the LMNA gene, which encodes the nuclear intermediate filament proteins lamin A and C, two major

252 in keratin 8 (K8) and keratin 18 (K18), the intermediate filament proteins of hepatocytes, predispos

253 Keratins are cytoplasmic intermediate filament proteins providing crucial structu

254 We deleted the genes encoding two intermediate filament proteins required for astrocyte ac

255 In addition, several intermediate filament proteins such as vimentin and anne

256 It is composed mainly of lamins, which are intermediate filament proteins that assemble into a fila

257 Lamins are intermediate filament proteins that assemble into a mesh

258 Lamins are intermediate filament proteins that form a scaffold, ter

259 ed its interactions with 14-3-3 and vimentin intermediate filament proteins, and vimentin depletion i

260 Lamins, the type V nuclear intermediate filament proteins, are reported to function

261 unterparts of eukaryotic actin, tubulin, and intermediate filament proteins, but they also have cytos

262 evelopment and function depend on the type V intermediate filament proteins, the lamins, which are ma

263 vement of the auxiliary beta subunit through intermediate filament proteins.

264 (K8/18) are simple epithelial cell-specific intermediate filament proteins.

265 ions at late times, containing predominantly intermediate filament proteins.

266 nd keratin 18 (K18), two epithelial-specific intermediate filament proteins.

267 Keratins 8 and 18 (K8/K18) are the intermediate filaments proteins of simple-type digestive

268 suggests that the mammalian cytoskeleton and intermediate filaments provide the physical scaffold for

269 also the trophectoderm-specific cytokeratin intermediate filament, recognised by Troma1, are greatly

270 hoA knockout in fibroblasts induced vimentin intermediate filament reorganization, accompanied by red

271 d PV IgG-triggered dsg3 endocytosis, keratin intermediate filament retraction, and loss of cell-cell

272 The latter slot intermediate filament rods into basic PRD domain grooves

273 rms interact with plasma membranes, vimentin intermediate filaments, SH3-containing class I myosins,

274 This intermediate filament subtype switching induced dysregul

275 wide hypocellular layer formed by bundles of intermediate filaments surrounded the central canal both

276 cardiomyocytes of the extrasarcomeric desmin intermediate filament system is frequently observed.

277 ng link between the nuclear envelope and the intermediate filament system seems to be dispensable for

278 ation of MTs facilitates an interaction with intermediate filaments that complex with the sarcomere,

279 ope (NE) is lined with lamins, a meshwork of intermediate filaments that provides structural support

280 In addition to binding intermediate filaments, the desmosomal protein desmoplak

281 plakin repeat domain (PRD) which recognizes intermediate filaments through an unresolved mechanism.

282 tabilizes a complex of solubilized actin and intermediate filaments to maintain a pool of "bioavailab

283 lectin is a prototypical plakin that tethers intermediate filaments to membrane-associated complexes.

284 Although nesprin-3 connects intermediate filaments to the nucleus, no functional con

285 The LMNA gene encodes lamins A and C, two intermediate filament-type proteins that are important d

286 hus, our data identify a protective role for intermediate filament upregulation during astrocyte acti

287 Depolymerization of vimentin intermediate filaments using a dominant-negative vimenti

288 Because FA maturation involves the vimentin intermediate filament (vIF) network, we also examined th

289 Vimentin intermediate filaments (VIF) extend throughout the rear

290 he association of mitochondria with vimentin intermediate filaments (VIFs) measurably increases their

291 rtially through a novel interaction with the intermediate filament vimentin (Vim).

292 s, the mRNA levels for the gene encoding the intermediate filament vimentin are higher in the mutant-

293 Previously, we identified the intermediate filament vimentin as an extracellular membr

294 n a genome-wide selection, we identified the intermediate filament vimentin as required for infection

295 The intermediate filament vimentin is required for cells to

296 ion within the cell and colocalized with the intermediate filament vimentin, suggesting that CS induc

297 e 9H4, revealed its ability to recognize the intermediate filament vimentin.

298 Consistent with its role as an intermediate filament, vimentin acted as a scaffold to r

299 We focus here on desmin, a type III intermediate filament, which is specifically expressed i

300 We examined levels of these intermediate filaments within cat and human primary visu