ライフサイエンスコーパス: intermediate phenotype

1 ssortants R(T(VP3)) and T(R(VP3)) induced an intermediate phenotype.

2 erminal portion of EphB2 is truncated had an intermediate phenotype.

3 iously reported, and WeeB cells displayed an intermediate phenotype.

4 of CCR2(+) cells, whereas memTNF mice had an intermediate phenotype.

5 Heterozygotes showed an intermediate phenotype.

6 ytotoxicity, while class 2 mutations have an intermediate phenotype.

7 rs (NA5A14, NA4A19, and NA4A23) exhibited an intermediate phenotype.

8 Mice lacking p50 alone displayed an intermediate phenotype.

9 rozygous for PAR-2 gene disruption showed an intermediate phenotype.

10 rly abrogated; the palm(-) eNOS exhibited an intermediate phenotype.

11 and cells from obligate heterozygotes had an intermediate phenotype.

12 2, that has reduced Snail function showed an intermediate phenotype.

13 e GM2 activator deficiency that manifests an intermediate phenotype.

14 d-S16E-PLB-transduced hES2-vCMs displayed an intermediate phenotype.

15 tisense oligonucleotides to SMA mice with an intermediate phenotype.

16 e adversity is a highly promising depressive intermediate phenotype.

17 n this process, as indicated by its distinct intermediate phenotype.

18 dies may be an especially promising class of intermediate phenotype.

19 henotype but not with the tremor-dominant or intermediate phenotype.

20 as the FasL-defective gld mouse displayed an intermediate phenotype.

21 rs involved in synaptic function and related intermediate phenotypes.

22 rlying mechanism of schizophrenia-associated intermediate phenotypes.

23 Black Swiss mice, showed in most parameters intermediate phenotypes.

24 as assayed via specific hippocampus-related intermediate phenotypes.

25 wed by the F61L and F61W variants, which had intermediate phenotypes.

26 ween them followed by the elimination of all intermediate phenotypes.

27 sessment of the potential role of particular intermediate phenotypes.

28 n whom somatic mosaicism was associated with intermediate phenotypes.

29 dies that might lead to the discovery of new intermediate phenotypes.

30 tal muscular dystrophy, Bethlem myopathy and intermediate phenotypes.

31 The V352/S370 double mutant exhibits an intermediate phenotype (1.6-fold increase), providing a

32 The development of the concept of the "intermediate phenotype," a physiological feature that ma

33 cognitive control, may represent a promising intermediate phenotype across major depressive disorder

34 SNIP) was formed to examine a broad array of intermediate phenotypes across psychotic disorders and t

35 and arousal thresholds that could represent intermediate phenotypes affecting the expression of slee

36 that observed in male mice and discovered an intermediate phenotype after neutering of either sex.

37 Other compound-mutant mice with intermediate phenotypes allow us to determine the distin

38 ing strains and a rheostatic distribution of intermediate phenotypes among the others (Tukey-Kramer h

39 This has led to the pursuit of intermediate phenotypes and a dimensional approach to un

40 n, the clonal spread of penicillin-resistant/intermediate phenotypes and a novel introduction of the

41 However, among intermediate phenotypes and biomarkers, assigning cause

42 tegy for examining both the genetic basis of intermediate phenotypes and functional testing of candid

43 iple testing and study design, definition of intermediate phenotypes and interaction between polymorp

44 2 subjects with STAT3 somatic mosaicism had intermediate phenotypes and were found to have preserved

45 rther two of these mutants, sh2-i (shrunken2 intermediate phenotype) and sh2-7460.

46 mportance of testing links between genotype, intermediate phenotype, and clinical outcome in the same

47 mania consisting of a narrow phenotype, two intermediate phenotypes, and a broad phenotype.

48 mental modifiers; evaluate disease subtypes, intermediate phenotypes, and biomarkers; and investigate

49 tion, to characterize their association with intermediate phenotypes, and to investigate their role i

50 autoimmune ovarian dysgenesis (AOD) and its intermediate phenotypes, antiovarian autoantibody respon

51 Such intermediate phenotypes appear to be closer to underlyin

52 ally important for metabolites because these intermediate phenotypes are closer to the underlying pat

53 ll as other recent results, we conclude that intermediate phenotypes are likely to be most valuable i

54 Intermediate phenotypes are often more closely correlate

55 Intermediate phenotypes are traits positioned somewhere

56 However, intermediate phenotypes are typically tissue and develop

57 Asthma and its associated intermediate phenotypes are under a substantial degree o

58 Endophenotypes (intermediate phenotypes) are objective, heritable, quant

59 ly informative target for genetic studies of intermediate phenotypes as their genetic underpinnings m

60 , these findings suggest the existence of an intermediate phenotype associated with MAD1L1.

61 dy from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium 1) compares

62 rs from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium were studied

63 es from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) sample.

64 The Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) was formed to examine a

65 part of the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP).

66 tant was bigger than pgk3.2 and displayed an intermediate phenotype between the two single mutants in

67 healed (sham) laparotomy group expressed an intermediate phenotype between the uninjured and hernia

68 pocampal and amygdalar volumes (potential CD intermediate phenotypes) between heavy cannabis users an

69 , combined with careful modeling of distinct intermediate phenotypes, can provide insights into the g

70 ve not and subsequently their effects on the intermediate phenotypes cannot be verified.

71 7(high)CD94(-) to CD117(low/-)CD94(+) via an intermediate phenotype (CD117(low)CD94(low/-)).

72 They exhibit a striking PC/myeloid DC intermediate phenotype (CD5(+)CD11c(low)CD45RA(low)CD45R

73 ic disorders and to test the hypothesis that intermediate phenotype characteristics are homogeneous w

74 ficient BALB/c mice, however, demonstrate an intermediate phenotype characterized by chronic lesions

75 strophy types Bethlem and Ullrich as well as intermediate phenotypes characterized by muscle weakness

76 on of phenotypic heterogeneity, quantitative intermediate phenotypes characterizing basal glucose hom

77 SS injury, with heterozygote mice showing an intermediate phenotype compared to wild type (WT).

78 Y14124A showed an intermediate phenotype compared with the double mutation

79 rnation between the two cell types expressed intermediate phenotypes consistent with dual adaptation

80 , double mutants of arf-1.1 and ncs-1 had an intermediate phenotype, consistent with NCS-1 and ARF-1.

81 ce Test, the use of impaired attention as an intermediate phenotype could increase the power of genet

82 We found that intermediate phenotypes could be produced by gradually a

83 Intermediate phenotypes could help clarify the underlyin

84 chiatry has been particularly enamoured with intermediate phenotypes, due to uncertainty about diseas

85 rewards, has been implicated as a potential intermediate phenotype (endophenotype) for addictive dis

86 polyploid morphological divergence from the intermediate phenotype expected (based on progenitor mor

87 enance of anxiety and offered as a potential intermediate phenotype for anxiety disorders.

88 Level of response (LR) to alcohol is an intermediate phenotype for AUDs, and individuals with a

89 This renders brain rhythms an interesting intermediate phenotype for cognitive and behavioral trai

90 measures and suggests that DD is a promising intermediate phenotype for genetic dissection of impulsi

91 ing cognitive control tasks may represent an intermediate phenotype for mood disorders.

92 t the usefulness of cortical thickness as an intermediate phenotype for neuropsychiatric diseases.

93 al and hippocampal activation as a promising intermediate phenotype for psychiatric disease and sugge

94 ain systems-level abnormality is a potential intermediate phenotype for psychiatric disorder, we stud

95 s measured by this approach) is not a strong intermediate phenotype for schizophrenia.

96 e processing may be a functional connectomic intermediate phenotype for schizophrenia.

97 g memory have been studied extensively as an intermediate phenotype for schizophrenia.

98 nfluences anxiety in mice is associated with intermediate phenotypes for human anxiety disorders acro

99 rventions and for identification of suitable intermediate phenotypes for molecular genetic investigat

100 ose of this work was to investigate possible intermediate phenotypes for TB.

101 D, while another 6 SNPs were associated with intermediate phenotypes for TMD.

102 source of potentially useful endophenotypes (intermediate phenotypes) for psychiatric genetics, as th

103 ciations between complex traits and relevant intermediate phenotypes, has therefore remained challeng

104 ch to the analysis of small cohorts in which intermediate phenotypes have been measured.

105 Although a variety of candidate intermediate phenotypes have emerged, few have explicitl

106 It has been proposed that intermediate phenotypes have simpler genetic architectur

107 These findings indicate that LR intermediate phenotypes have utility in genetic approach

108 These intermediate phenotypes identify both affected and unaff

109 ble at Irgb10 and resistant at Iigp2, had an intermediate phenotype implicating the nonredundant role

110 A subset of studies have shown an intermediate phenotype in 577RX individuals, suggesting

111 tability of impaired attention for use as an intermediate phenotype in genetic studies, the authors e

112 er severity grade in PLTP-deficient mice, an intermediate phenotype in PLTP-deficient heterozygotes,

113 be under genetic control and is a candidate intermediate phenotype in schizophrenia.

114 l2), and of 791delG to determine whether the intermediate phenotype in the 791delG heterozygous state

115 Endothelial dysfunction is a critical intermediate phenotype in the pathogenesis of cardiovasc

116 n maturation, these cells give rise to a new intermediate phenotype in which intracellular class II m

117 ects of the HLA-DRB1 locus on asthma and its intermediate phenotypes in Aboriginal people from the Ki

118 SERT-HZ displayed variable and intermediate phenotypes in both experiments.

119 ocus offer a unique opportunity to study the intermediate phenotypes in carriers at high risk for aut

120 ction and structure have been widely used as intermediate phenotypes in clinical trials.

121 risk and heritability estimates, serving as intermediate phenotypes in future genetic studies for ex

122 frontal and temporoparietal P300 changes as intermediate phenotypes in genetic studies of schizophre

123 uggesting that these measures could serve as intermediate phenotypes in genetic studies of schizophre

124 ne expression levels considered as tractable intermediate phenotypes in mapping complex diseases.

125 This analysis illustrates the value of such intermediate phenotypes in mapping susceptibility loci f

126 of wild-type receptor density and displayed intermediate phenotypes in most behavioral tests.

127 rozygous for the Msh2 deficiency display an "intermediate" phenotype in these regards, suggesting tha

128 II (DeltaII; bases 7692 to 7705) produced an intermediate phenotype, in that replicons had marginal R

129 Larvae with mosaic expression of bix have intermediate phenotypes, in which a partial notochord is

130 The intermediate phenotypes include 1) hypomania or mania no

131 9, has been associated with CD diagnosis and intermediate phenotypes, including abstinence-induced wi

132 Significantly, a number of intermediate phenotypes, including Clock/+ phenocopies a

133 rer mice with thin myelin sheaths display an intermediate phenotype indicating that CNS neurons are s

134 Heterozygote animals have an intermediate phenotype indicating there is a threshold r

135 Many candidate gene studies use 'intermediate phenotypes' instead of disease diagnoses.

136 This intermediate phenotype is characterized by an increase i

137 Studying genetic determinants of intermediate phenotypes is a powerful tool to increase o

138 on of preclinical atherosclerotic changes as intermediate phenotypes is also discussed.

139 , the identification and characterization of intermediate phenotypes is substantially more difficult

140 Genome-wide association studies (GWAS) with intermediate phenotypes, like changes in metabolite and

141 Understanding how genetic variation affects intermediate phenotypes, like DNA methylation or gene ex

142 biological mechanisms of a well established intermediate phenotype linked to schizophrenia, and unde

143 al-GlcNAc-Gal-Glc-HepI) structures displayed intermediate phenotypes (<50% killing with 2 mug/ml and

144 The identification of neurobiological intermediate phenotypes may hasten the search for suscep

145 ions due to poor extinction recall may be an intermediate phenotype mediating the effects of genetic

146 number of muscle myofibers, even in mild or intermediate phenotype morphants.

147 ions are semidominant: heterozygotes have an intermediate phenotype most readily identified by palmar

148 One solution is to identify intermediate phenotypes, "narrower" constructs of liabil

149 1 sequence variants than VL, reflecting the 'intermediate phenotype' nature of viral variation; (2) a

150 ned both p53 alleles (MMTV-myc/p53(+/+)); an intermediate phenotype occurred in mice with a single in

151 m total immunoglobulin E (IgE) is a critical intermediate phenotype of allergic diseases.

152 An intermediate phenotype of Bsn(gt) IHCs was also found by

153 ve demonstrated significant linkage to a key intermediate phenotype of COPD on chromosome 2q.

154 istamine sensitization (Bphs) is a monogenic intermediate phenotype of EAE controlled by histamine H(

155 Analysis of the intermediate phenotype of functionally hemizygous Scn8a(

156 specially isoform 1 (NHE-1), is a recognized intermediate phenotype of hypertension.

157 These data support an intermediate phenotype of reduced posterior cortical LFO

158 The intermediate phenotype of RXR alpha heterozygous embryos

159 tion rate of human podocytes, an established intermediate phenotype of SRNS.

160 The intermediate phenotype of the cox24 mutant in the backgr

161 to further analyses in healthy Europeans for intermediate phenotypes of BD, including hippocampal vol

162 We tested the general hypothesis that intermediate phenotypes of cardiac function and calcium

163 s of EAE susceptibility and severity and the intermediate phenotypes of mononuclear cell infiltration

164 Amygdala hypoactivity may represent an intermediate phenotype, offering new insights into effec

165 tivity, so that heterozygote mutants show an intermediate phenotype on cell fate and cell death.

166 monary disease study and five GWA studies of intermediate phenotypes, one each on serum immunoglobuli

167 sing on family-based studies of quantitative intermediate phenotypes or endophenotypes, in tandem wit

168 sk genes is to identify and map quantitative intermediate phenotypes or endophenotypes.

169 The genetic study of behavioral and biologic intermediate phenotypes (or 'endophenotypes') indexing a

170 neuronal cells, and (3) a cell type with an intermediate phenotype, possibly representing radial gli

171 An intermediate phenotype produced by several smaller aliph

172 part of the Bipolar-Schizophrenia Network on Intermediate Phenotypes project.

173 Well-validated animal models and intermediate phenotypes provide crucial tools for geneti

174 independent samples and association with an intermediate phenotype provides strong support for TLR10

175 e polymorphism in ZNF804A suggests that this intermediate phenotype proxies a distinct neural system

176 PTX reflects the genetic control of distinct intermediate phenotypes rather than allelic variation in

177 Increased prefrontal "noise" is an intermediate phenotype related to genetic susceptibility

178 ngs also provide convergent evidence that an intermediate phenotype related to prefrontal cortical fu

179 results identify a potential dynamic network intermediate phenotype related to the genetic liability

180 Genetic studies of intermediate phenotypes related to asthma, which are obj

181 these polymorphisms on body composition and intermediate phenotypes related to obesity was examined

182 Expression of a mutant p53 gene yielded an intermediate phenotype relative to HPV-16 E6, generating

183 itudinal trajectories of adiposity and other intermediate phenotypes relevant to mental health during

184 Imputation of such intermediate phenotypes represents a practical alternati

185 This Bipolar-Schizophrenia Network on Intermediate Phenotypes sample consisted of clinically s

186 ke, obesity, and insulin resistance, with an intermediate phenotype seen in heterozygous null mice on

187 pproach of examining SNPs associated with an intermediate phenotype should be considered as a method

188 Heterozygous animals exhibited an intermediate phenotype, showing a reduction in filensin

189 Such an intermediate phenotype, similarly observed in 100% of Ad

190 e multisite Bipolar-Schizophrenia Network on Intermediate Phenotypes study.

191 e biological origins of heterogeneity of key intermediate phenotypes such as cognition and emotion ca

192 Intermediate phenotypes such as DNA methylation, an epig

193 her inflammatory markers are associated with intermediate phenotypes such as hypertension.

194 n be derived using genetic associations with intermediate phenotypes such as subcomponents of auditor

195 Furthermore, some silencing mutants with an intermediate phenotype, such as sir1, consist of two dis

196 s and are not explained by associations with intermediate phenotypes, such as atopy or lung function.

197 The study of intermediate phenotypes, such as emotion-processing bias

198 n gene variants (polymorphisms) and measured intermediate phenotypes, such as lipid/lipoprotein level

199 tistical methods to quantitate and integrate intermediate phenotypes, such as transcript, protein or

200 kleback hybrids beyond that expected from an intermediate phenotype, suggesting a role for epistasis

201 are wild-type mice, MCP-1(-/-) mice have an intermediate phenotype, suggesting that other CCR2 ligan

202 out of the four mutant Fgf alleles revealed intermediate phenotypes, suggesting a quantitative requi

203 ulture under suboptimal levels of FSS led to intermediate phenotypes, suggesting a threshold effect.

204 er residues could be mutated to give rise to intermediate phenotypes, suggesting they have a role in

205 iameter (LAD) and low voltage area (LVA) are intermediate phenotypes that are associated with AF type

206 In summary, the present study provides intermediate phenotypes that are heritable.

207 ny psychiatric disorders are associated with intermediate phenotypes that can be modeled and studied

208 mal studies, including the identification of intermediate phenotypes that can be studied across speci

209 r autonomic dysfunction syndromes, including intermediate phenotypes that contribute to human hyperte

210 CHGA, a candidate gene for intermediate phenotypes that contribute to hypertension,

211 four-state system consisting of two distinct intermediate phenotypes that differ in differentiation p

212 onses to infused angiotensin II (Ang II) are intermediate phenotypes that may indirectly reflect tiss

213 le and although the absence of Fyn causes an intermediate phenotype, the combined absence of Src and

214 repeated magnetic resonance scans (i.e., an 'intermediate phenotype.') The method combines a machine-

215 functional fine-mapping approach, leveraging intermediate phenotypes to identify functional variant(s

216 ed features may lend further insight into an intermediate phenotype vulnerable for alcohol use and ad

217 t a quantitative biomarker can be used as an intermediate phenotype when investigating the associatio

218 en of the population, and we propose steps ("intermediate phenotypes") whereby in a sex-dependent fas

219 to partition engraftment resistance into its intermediate phenotypes, which are firstly the immune-me

220 le neutralization-sensitive, -resistant, or -intermediate phenotypes, which are independent of genoty

221 lted in a modest expansion of effectors with intermediate phenotypes, which were capable of persistin

222 Again, the development of relevant intermediate phenotypes will make the spurious associati

223 dorsal anterior cingulate may constitute an intermediate phenotype with low effect size for psychosi

224 he mutation of the C-terminal SIM yielded an intermediate phenotype with nuclear and cytoplasmic stai

225 e expression data and other disease relevant intermediate phenotypes with GWAS results could potentia

226 area will require better characterization of intermediate phenotypes with large effect size for the c

227 Composite bundles adopt an intermediate phenotype, with fascin delivering the rigid