ライフサイエンスコーパス: intermediate state

1 nt were expressed, having a dark stable blue intermediate state.

2 ce of the hemifused diaphragm of the prepore intermediate state.

3 -type asparaginase structure in the covalent intermediate state.

4 EMT for the lung cancer cells shows a stable intermediate state.

5 nt tissues, increases the population of this intermediate state.

6 r region for allosteric communication in the intermediate state.

7 ed the probability of contents mixing in the intermediate state.

8 and the flavin chromophore to form a radical intermediate state.

9 lence electronic structure of this transient intermediate state.

10 water-soluble oligomer represents a prepore intermediate state.

11 sive structural characterization of an iGluR intermediate state.

12 binds ssDNA with no evidence for a discrete intermediate state.

13 by preventing the formation of the misfolded intermediate state.

14 ving the formation of a well-defined, stable intermediate state.

15 ganded state of MurA but not the tetrahedral intermediate state.

16 e a highly populated structural mimic of the intermediate state.

17 ency does not require a Blimp1-dependent PGC intermediate state.

18 advancement of the OEC beyond the S(2)Yz(*) intermediate state.

19 pontaneously from the procapsid to the first intermediate state.

20 nts a polymerase:DNA complex in a preternary intermediate state.

21 lularly without the release of sugar from an intermediate state.

22 ied a structural model of an ApoE4 misfolded intermediate state.

23 ative manner compatible with the coiled-coil intermediate state.

24 the virus in a previously undescribed early intermediate state.

25 t will do so by altering the stability of an intermediate state.

26 rwards or backwards from any light-activated intermediate state.

27 antly disulfide chemistry, as well as to any intermediate state.

28 e main contributions in the formation of the intermediate state.

29 pin 2, which facilitates the emergence of an intermediate state.

30 newly discovered site, Na1'', near S1, as an intermediate state.

31 ations: resting, activated and a short-lived intermediate state.

32 critical in achieving and selecting between intermediate states.

33 ulate TL folding in a constrained pathway of intermediate states.

34 ion and identify two previously unidentified intermediate states.

35 the K48 linkage model successfully predicted intermediate states.

36 ual-area-dominant, frontal-area-dominant and intermediate states.

37 ssembly and visualize structural features of intermediate states.

38 between the P and E sites, forming chimeric intermediate states.

39 ted the identification of the most populated intermediate states.

40 n and the design of ligands or drugs to trap intermediate states.

41 step or single step pathways with or without intermediate states.

42 bserved for the highly pliant molten globule intermediate states.

43 le and applicable to other bipolar RRAM with intermediate states.

44 n involves several steps and accumulation of intermediate states.

45 of 1.7-2.7) without significantly populating intermediate states.

46 tes, stabilizing a significant population of intermediate states.

47 conformation as well as two highly populated intermediate states.

48 pture the altered virus in what appear to be intermediate states.

49 structural transitions, populating distinct intermediate states.

50 native structures that possibly lead to such intermediate states.

51 inate between potential structural models of intermediate states.

52 of mechanistic information on transient and intermediate states.

53 BDI systems leads to a zwitterionic twisted intermediate state ((1)p*) and that destabilizing the (1

54 NA damage but remain in the fusion-resistant intermediate state activate differential ataxia telangie

55 l-conjugated peptides trap HA in a transient intermediate state after fusion is triggered but before

56 The prolonged intermediate state allowed us to identify protein substr

57 sted that pore formation constitutes only an intermediate state along the route of PG-1's membrane di

58 For example, the number and nature of intermediate states along the binding pathway is still a

59 nal computations on structural models of the intermediate states along the conformational transition

60 ing mechanism and identify the most relevant intermediate states along the reaction pathway.

61 ryotic neurotransmitter receptors, for which intermediate states also participate in activation.

62 rom luminal cells, possibly via a basal-like intermediate state, although further study using a diffe

63 one to trigger formation of the FI-sensitive intermediate state and another to facilitate subsequent

64 bservations to the existence of at least one intermediate state and at least two energy barriers in t

65 and S20G peptides populate the alpha-helical intermediate state and beta-sheet end state, respectivel

66 th trajectories originate from an on-pathway intermediate state and compete with native folding in a

67 RRM2 construct reduce the population of the intermediate state and enhance DNA/RNA binding.

68 are required for the generation of the early intermediate state and fully reprogrammed iPS cells, and

69 quilibrium that favored the formation of the intermediate state and had an apparent rate constant les

70 These results provide a detailed view of an intermediate state and illustrate the opportunities offe

71 ixtures may both cause the population of the intermediate state and increase aggregate production.

72 ge: a nearly instantaneous crossover into an intermediate state and its decay led by lattice instabil

73 G values) of A1 unfolding from the native to intermediate state and the binding of these conformation

74 accelerate the folding kinetics to both the intermediate state and the native state.

75 ide chains of H40 and H47 are exposed in the intermediate state and undergo significant conformationa

76 rticular, it allows us to identify potential intermediate states and compare them to the experimental

77 rticular, it allows us to identify potential intermediate states and compare them to the experimental

78 dynamics simulations to identify metastable intermediate states and the dynamics of backtracking at

79 rgy of the transition barriers that separate intermediate states and the dynamics of two bilayers as

80 microsecond time-scale reactions are due to intermediate states and the millisecond time-scale react

81 However, the nature of the intermediate states and the underlying mechanism of ultr

82 cription factors (i.e. removing the unstable intermediate states), and that crowding by large molecul

83 reased in going from the active state to the intermediate state, and then increased upon going to the

84 fewer neural transitions due to an unstable intermediate state, and these infrequent transitions pre

85 y landscape of LBP is complex, with multiple intermediate states, and a large fraction of molecules g

86 ence and distant metastasis were included as intermediate states, and deaths from breast cancer, seco

87 ize two alternative native structures, three intermediate states, and numerous misfolded states, the

88 heet core forms early and is present in both intermediate states, and the rate-limiting step which is

89 -bound inactive state; 2), the agonist-bound intermediate state; and (3), the agonist- and G-protein-

90 Between pH 4 and 5, the two intermediate states appeared stable.

91 The origins of formation of an intermediate state are elucidated, viz.

92 A number of intermediate states are also observed in different IgE-F

93 These intermediate states are believed to represent discrete U

94 in linear molecules, we demonstrate that no intermediate states are involved in the triplet formatio

95 tracking occurs in a stepwise mode where two intermediate states are involved.

96 release their RNA, they reverted to the same intermediate state as expanded procapsids (intermediate

97 However, the solution returns many of the intermediate states back to the reactants before the pro

98 in acrylodan-tropomyosin fluorescence as the intermediate state became populated.

99 ur analysis shows that NAT presents a unique intermediate state between healthy and tumor.

100 t neuropathological profile that reflects an intermediate state between no cognitive impairment and d

101 This alteration may reflect an intermediate state between normal innervation and comple

102 netic analysis confirmed the existence of an intermediate state between photoexcitation and proton tr

103 of the closed state with PIP(2) revealed an intermediate state between the closed and open conformat

104 AMZs correspond to an intermediate state between two "end points" represented

105 units can be specialized to assume different intermediate states between closed and open.

106 e-membrane interaction mechanisms, including intermediate states between initial binding and full mem

107 on-state analog structure, F(1)-TS, displays intermediate states between those observed in the ground

108 interaction with the hydrophobic core in the intermediate state but is released from the core in the

109 n pathways arising from the mere presence of intermediate states, but decreases if the contacts in th

110 of its tertiary folding and Mg(2+)-dependent intermediate states by observing selected nucleobases th

111 weezers can track the pseudoknot's unfolding intermediate states by pulling the RNA chain from both e

112 The existence of an ApoE4-specific intermediate state can contribute to the onset of AD by

113 We show that multiple distinct intermediate states can occur during both growth and dis

114 c rates, bond lifetimes, and the presence of intermediate states, can be determined.

115 esize that mutations destabilizing the ApoE4 intermediate state change hinge region dynamics, which p

116 oE variants, only ApoE4 exhibits a misfolded intermediate state characterized by isoform-specific dom

117 heme release and uptake processes occur via intermediate states characterized by a Tyr(75)-iron-boun

118 analysis suggest that T4L populates multiple intermediate states, consistent with the wide range of h

119 s in a three-state process by populating one intermediate state consisting of a folded C-domain and a

120 modeling and experiments, we found multiple intermediate states contributing to EMT and that the rob

121 d unfolded, transition, native, and possible intermediate states correspond to local minima or saddle

122 The intermediate state corresponded closely to a late-foldin

123 Equilibrium experiments showed that many intermediate states could be populated with a homogeneou

124 Neither of these deuterated intermediate states could otherwise form in H2O buffer.

125 loid phase either is maximized or reaches an intermediate state, depending on the deleterious mutatio

126 tin architecture and "spring" to a transient intermediate state directed by DNA sequence information.

127 structures that dominate the ensemble of the intermediate state directly preceding fusion pore format

128 a linear, stepwise bending mechanism with an intermediate state distinguished by a distinct bending a

129 The structures of the intermediate states do not change significantly with mut

130 ndicate that the new structure represents an intermediate state during the transition of the clamp fr

131 osis: one in its resting state and one at an intermediate state during turnover.

132 and a large fraction of molecules go through intermediate states during the unfolding process.

133 hing allowing access to the highly resistive intermediate states; during off-switching the load vanis

134 e state that is lowly populated [equilibrium intermediate state (EIS)].

135 two distinct inactive states, an activation intermediate state en route to activation, and, in the p

136 rajectory samples multiple metastates and an intermediate state en route to the excited state.

137 an incoming nucleotide into this stabilized intermediate state ensures that Tyr(639) closely partici

138 struct a first atomistic conformation of the intermediate state following the 40 degrees substep of r

139 d a conformational flip of the channel as an intermediate state following the ligand binding and quan

140 nal hexapeptide triggers the formation of an intermediate state for folding and aggregation with an u

141 h consensus can be enhanced when there is an intermediate state for indecisive individuals to pass th

142 ing membranes together leads to a long-lived intermediate state for single, extended HA trimers.

143 ectron microscopy reveals a potential fusion intermediate state for uncleaved trimers containing shor

144 conformational changes associated with these intermediate states for P-gp in lipid bilayer nanodiscs.

145 structure, and compactness of the native and intermediate states for the asparagine variants are cons

146 OR) spectroscopies have been used to analyze intermediate states formed during the hydroxylation of (

147 surements revealed that oligomers adopted an intermediate state found during the transition between m

148 wing MT ends by recognizing and promoting an intermediate state generated during GTP hydrolysis.

149 a reaction pathway composed of a sequence of intermediate states generated as a dinitrogen bound to t

150 zing (ATPh) and ATP-gammaS conformations, an intermediate state has been found.

151 The open and intermediate states have a unique open dodecameric ring.

152 or virtually all GPCRs, active agonist-bound intermediate states have been difficult to characterize

153 ates eversion of oxoG by stabilizing several intermediate states, helping the rapidly sliding enzyme

154 ansits between two major brain states via an intermediate state, high-functioning adults with ASD sho

155 ions can be reasonably explained only if the intermediate state I is considered to be a triplex struc

156 allow to switch the ferroic state through an intermediate state in a continuous manner, resulting in

157 n adjacent bilayers, representing a presumed intermediate state in membrane fusion.

158 d debates about the possible existence of an intermediate state in the folding pathway have arisen.

159 We discovered an intermediate state in the pathway to dissociation, a con

160 ibution that occurs between the reactant and intermediate state in the steroid substrate of KSI.

161 on, indicating that they report a pre-active intermediate state in the transition pathway toward acti

162 3 to CuB in the O2 reduction site induces an intermediate state in which a bulge conformation at Ser-

163 An intermediate state in which one DNA arm is unwrapped, pr

164 Translocation proceeds through an intermediate state in which the acceptor ends of the tRN

165 This method has the ability to detect the intermediate states in addition to electrical on and off

166 Brief, intermediate states in binding and gating have been dete

167 Defining these intermediate states in concrete terms is important for p

168 ng Mhp1 crystal structures represent sampled intermediate states in solution.

169 tion of tightly apposed membranes, which are intermediate states in the process of mitochondrial fiss

170 ry of the transient formation of two further intermediate states in the reaction cycle of photosynthe

171 ng' mutations favour structurally 'unlocked' intermediate states in the transport cycle exhibiting in

172 accharide H-bonds takes place in stages with intermediate states in which the interactions are bridge

173 in the "open form" in the apo-TnDhp, in the "intermediate state" in the monometal TnDhp, and in the "

174 eres requires formation and resolution of an intermediate state, in which the cell cycle-dependent Cc

175 ls are transdifferentiated through a plastic intermediate state induced by exposure to non-integrativ

176 in which cells transition through a plastic intermediate state, induced by brief exposure to reprogr

177 The origins of formation of an intermediate state involved in amyloid formation and way

178 of the role of the short-lived and reactive intermediate states involved, will be critical for such

179 e long-lived Mn excited state serving as the intermediate state is considered as the pathway generati

180 An intermediate state is discovered on the sodium release p

181 lyzed by the chloroplast cytochrome b6f This intermediate state is formed by interaction of a radical

182 One major intermediate state is identified along the conformationa

183 The structure of this intermediate state is identified to be monoclinic, but m

184 quential first-order reactions, in which the intermediate state is proposed to correspond to the dupl

185 In modified SOD1, this intermediate state is stabilized as compared to unmodifi

186 formation, a complex process involving many intermediate states, is proposed to be the driving force

187 e-state transition via an on-pathway kinetic intermediate state (KIS), with this difference being rel

188 trameric and pentameric complexes forming as intermediate states leading to the final hexameric or he

189 The lack of information on dynamics and intermediate states makes it difficult to associate the

190 The intermediate state may also serve as a molecular hazard

191 Emission from a dipole forbidden intermediate state may even dominate the corresponding x

192 The cluster analysis suggests that the intermediate state may play a functional role by enhanci

193 arrives with the new bond and stabilizes the intermediate state, may be an unappreciated feature of t

194 The rates of entering and exiting this intermediate state modulate pausing by RNAP.

195 The time spent in the intermediate state must be relatively short compared to

196 ed in the structural modeling of equilibrium intermediate states observed in single-molecule experime

197 Protection maps of these intermediate states obtained at residue-level resolution

198 al descriptions of singlet fission invoke an intermediate state of a pair of spin-triplet excitons co

199 he presence of a novel allosteric site in an intermediate state of c-src that could be potentially us

200 mounting system has enabled us to capture an intermediate state of Ca(2+) binding to the C2A domain o

201 We trapped an intermediate state of class II MHC HLA-DR1 by substituti

202 ion (HJ), or four-way junction, is a central intermediate state of DNA for homologous genetic recombi

203 a model for part of the putative pre-hairpin intermediate state of gp41.

204 This structure likely represents an intermediate state of heterochromatin that can be conver

205 hat this LBD configuration corresponds to an intermediate state of receptor activation.

206 n a compact EF-G conformation that favors an intermediate state of ribosomal subunit rotation.

207 we investigated the equilibrium (un)folding intermediate state of T4 phage gene product 45 (gp45, al

208 d by the DsbB(C41S) mutant used to mimic the intermediate state of the disulfide bond generating reac

209 hermore, we describe a novel structure of an intermediate state of the protein with the external thin

210 ptor-bound conformation and may represent an intermediate state of the trimer.

211 In the intermediate states of dephosphorylation the A-domain re

212 orrect response was finally given, providing intermediate states of evidence accumulation and respons

213 ssembly where each mode implicates different intermediate states of fusion that have been recently id

214 By definition, bistability arises when intermediate states of gene expression are rendered unst

215 tural knowledge of the folded, unfolded, and intermediate states of P4-P6 RNA.

216 nanocrystals to obtain initial structures of intermediate states of photosystem II catalysis at the s

217 chemical characteristics of the resting and intermediate states of phytochromes and other photorecep

218 Little is known about the intermediate states of the F refolding process.

219 , crystal structures were obtained for three intermediate states of the Geobacillus stearothermophilu

220 h-resolution equipment needed to capture the intermediate states of the transformations.

221 veal conformational changes occurring during intermediate states of translocation, including large-sc

222 in, which is an intermediate analog, and the intermediate states of two steroid substrates.

223 olar resistance-switching materials allowing intermediate states of wide-varying resistance values ho

224 To address the possible existence of an intermediate state on the folding pathway, we measure th

225 We conclude that the existence of intermediate states on the folding and unfolding pathway

226 he time for peptide insertion, the number of intermediate states on the folding pathway, and the rate

227 e's inserting end leads to the appearance of intermediate states on the insertion pathway.

228 ify the exchange and measure the lifetime of intermediate states on the millisecond time scale.

229 At each intermediate state, one heptad repeat of the coiled coil

230 pulation by counteracting the benefit of the intermediate state or making it virtually impossible for

231 ent stability differences between native and intermediate states over the pH range 5.5-6.5 and they s

232 e interactions during assembly, i.e., within intermediate states preceding the final nucleocapsid str

233 To probe for intermediate states, preparations were imaged after 5 mi

234 owever, this model requires a non-functional intermediate state prior to the compensatory change.

235 ightly bound toroidal group structures as an intermediate state prior to the emergence of slow compac

236 These structures represent intermediate states relevant to both FeS cluster assembl

237 Crystal structures of this putative early intermediate state reveal reorganization of ionic intera

238 The first is an intermediate state separating the productive elongation

239 sed alphaIIbbeta3 headpiece crystals induced intermediate states similarly to RGDSP.

240 gistic folding mechanism that involves a key intermediate state stabilized by interaction between the

241 that vinculin activation may proceed from an intermediate state stabilized by partial talin-vinculin

242 The simulations started from an intermediate state structure that was generated in an un

243 hanical deformations, while partially folded intermediate states, such as molten globules, are compli

244 rane fusion that extends the lifetime of the intermediate state targeted by FIs.

245 NTP, or in elevated MgCl2 concentrations, an intermediate state termed the "nucleotide-binding" state

246 7, L20, L24 and F74 are modified less in the intermediate state than the denatured state, likely due

247 sical scrapie has a larger population of the intermediate state than the resistant variant.

248 nsiderably more tertiary interactions in the intermediate states than results from previous NMR studi

249 These native basins are connected through an intermediate state that builds up upon binding to the NT

250 The intermediate state that co-expresses the two opposing ma

251 ative state of Im7 is in equilibrium with an intermediate state that is lowly populated [equilibrium

252 ding model for RRM2, with a partially folded intermediate state that is not observed in RRM1.

253 , is populated by a trimeric beta-sheet-rich intermediate state that leads to a stepwise and reversib

254 These levels provide intermediate states that act as "stepping stones" for el

255 th behavioural gregarisation proceed through intermediate states that are not simply partial realisat

256 n to be a highly cooperative process with no intermediate states that are populated to detectable lev

257 Between the two transitions, there are intermediate states that are spectrally isolated here.

258 e higher kinetic stability of the oligomeric intermediate states that it populates relative to those

259 However, some intermediate states that lead to the substrate internali

260 0 K, it transforms into the HDI via a liquid intermediate state, the first direct evidence of Ostwald

261 From this intermediate state, the single photon of interest is the

262 Via two previously unidentified intermediate states, the RNA chain is seen to be pulled

263 Disruption of this intermediate state through mutation reduces both associa

264 We have trapped intermediate states throughout the fibril formation path

265 domain to the IC domain are weakened in the intermediate state, thus decoupling the EC domain from t

266 From an intermediate state to a TS, H(+) can obtain a kinetic en

267 conversion of TD eliminates the pluripotent intermediate state to create cells that are ideal for pe

268 axing to a shorter DNA-ligand complex in the intermediate state to form a molecular lock.

269 When the VSD activates from the intermediate state to the activated state, the VSD-pore

270 ](o) affects the rate of transition from the intermediate state to the active state.

271 ritical for the transition from the inserted intermediate state to the open-channel state in the inse

272 through two semistable, nonlamellar lipidic intermediate states to a fusion pore.

273 erentiate through stereotypical sequences of intermediate states to generate particular mature fates.

274 nuous scale from crystalline, through glassy intermediate states, to chaotic configurations.

275 onal shift from a compact, but heterogeneous intermediate state toward the completely formed set of t

276 We report here an ENDOR study of an S = 1/2 intermediate state trapped during reduction of the binuc

277 sembly proceeds via a membrane-bound prepore intermediate state, typically consisting of up to approx

278 uitin (Ub), which is known to form nonnative intermediate states under a variety of mildly denaturing

279 We find that MalFG alone exists in an intermediate state until MalK binds and converts the mem

280 imental setup sets the lifetime of potential intermediate states upon barnase folding/unfolding in th

281 Our study of transient intermediate states using time-resolved optical and X-ra

282 via parallel pathways on which there are two intermediate states very similar to wild-type UCH-L1.

283 d thermal relaxation procedures, a number of intermediate states was generated and analyzed by DNP-en

284 Despite folding via common intermediate states, we show that the decreased populati

285 been suggested that lamprey may represent an intermediate state where nested Hox expression has not b

286 Our study defines a unique preinsertion intermediate state where the SecA two-helix finger appea

287 cess to the SecYEG complex via a lipid-bound intermediate state, whereas acidic phospholipids alloste

288 rotein beta2-microglobulin that folds via an intermediate state which is believed to be responsible f

289 Furthermore, possible intermediate states which disrupt membranes at pH 6.4 we

290 tly observed an adduct- and mismatch-induced intermediate state, which may be an obligatory step in t

291 first structural model of an ApoE4 misfolded intermediate state, which may serve to elucidate the mol

292 ne insertion of pHLIP involves at least four intermediate states, which are believed to be linked to

293 g damping due to resonant scattering into an intermediate state with a pair of overdamped Leggett mod

294 which proteins of native fold can explore an intermediate state with an increased propensity for form

295 epithelial cells that naturally exist in an intermediate state with bidirectional differentiation po

296 mutants of OXA-24/40 that arrest at the acyl-intermediate state with carbapenem substrates but mainta

297 ture experiment confirms the existence of an intermediate state with disordered bonds.

298 de-bound state, high-energy outward-occluded intermediate state, with a defined ligand binding cavity

299 ssociation proceeds through a complex set of intermediate states, with successful binding events init

300 is used to directly observe and characterize intermediate states without the need to disrupt the stra